Kutanes großzelliganaplastisches Ki-1 (CD 30) positives T-Zell-Lymphom

Zusammenfassung Es wird über eine 72j?hrige Patientin mit einem ungew?hnlich ausgedehnten Substanzdefekt im Bereich des rechten Unterbauches berichtet. Die Diagnose eines gro?zellig-anaplastischen T-Zell-Lymphoms wurde aufgrund lichtmikroskopischer und immunhistochemischer Untersuchungen gestellt. Eine eindeutige extrakutane Manifestation des Lymphoms war zum Diagnosezeitpunkt nicht nachweisbar. Durch eine Tumorbestrahlung mit schnellen Elektronen sowie eine anschlie?ende Chemotherapie wurde eine Vollremission erzielt. Eingegangen am 2. September 1994 Angenommen am 17. Mai 1995     

Lipoatrophy is a thing of the past,or is it?

We describe the development of severe lipoatrophy in a patient treated with biphasic aspart. This complication of insulin therapy was common in the past with the use of animal insulins and became less common with the increasing purification of these and the introduction of recombinant human insulin. This patient developed severe lipoatrophy with the use of a premixed insulin containing the analogue insulin aspart. Lipoatrophy although rare can still occur even with the use of technologically advanced insulin preparations.     

Bulbar palsy in senile onset familial amyloid polyneuropathy (30Val→Met): transthyretin-amyloid deposits in the hypoglossal nerve root

Japanese familial amyloid polyneuropathy (FAP type I) is characterized clinically by autonomic and sensorimotor polyneuropathy. Bulbar palsy or lower cranial amyloid neuropathy has not been reported in this disease. We report a 72-year-old man with senile onset FAP type I, who developed bulbar palsy and sensorimotor polyneuropathy without autonomic failures. He noticed dysesthesia and muscle weakness in the feet at the age of 67 years. Neurological examination showed bulbar signs and sensorimotor polyneuropathy, but not autonomic neuropathy. Electromyography showed denervation in the tongue and extremities. Sural nerve biopsy revealed a profound reduction of myelinated fibers. Neuropathological studies indicated axonal degeneration and transthyretin-amyloid deposits in the peripheral nerves and hypoglossal nerves or roots. DNA analysis demonstrated transthyretin^Met30' mutation. We provide the novel possibility that bulbar palsy, due to amyloid neuropathy, can occur in FAP type I.     

Intercarpal arthrodesis in the management of chronic carpal instability after trauma

A retrospective review of five patients with chronic carpal instability resulting from trauma suggests that this condition can be successfully treated by intercarpal arthrodesis. Scaphoid-lunate fusion was used to treat chronic dorsal intercalary segment instability, while scaphoid-capitate-lunate fusion was used to treat chronic palmar intercalary segment instability. Results after intercarpal arthrodesis were consistently good, with restoration of painless function, preservation of grip strength, and a high degree of patient satisfaction. Although a fibrous union was obtained in two of the three scaphoid-lunate arthrodeses, this did not prejudice a good clinical outcome. These results compare favorably to those with other treatment modalities, including ligamentous reconstructions with tendons. Based on these findings, a more extensive clinical trial of intercarpal arthrodesis to treat chronic carpal instability appears warranted.     

Electrochemical disinfection of marine bacteria attached on a plastic electrode

A plastic electrode, which consisted of graphite and silicone rubber, was employed for the electrochemical disinfection of attached marine bacteria, Vibrio alginolyticus. The viability of the bacteria attached on the electrode depended on the applied potential and time. Marine bacteria attached on a basal plane pyrolytic graphite electrode could be disinfected at potentials above 0.8 V vs. a saturated calomel electrode (SCE) applied for 20 min. The bacteria attached on a graphite—silicone electrode were disinfected at 1.0 V vs. SCE and 1.5 V vs. SCE, and 5.6 × 10³ cells/cm² of attached bacteria were disinfected to less than 5% of the initial number at times above 10 min. The residual chlorine concentration was less than the regulated value (0.02 ppm) and the pH value did not change after a potential of 1.5 V vs. SCE was applied to the graphite—silicone electrode for 30 min.     

弓形虫P30-P22复合DNA疫苗免疫小鼠诱导的体液免疫应答

目的通过肌内注射弓形虫DNA疫苗PCDNA3．1-P30-P22直接免疫小鼠，观察其诱导的体液免疫应答及保护性作用。方法大量制备重组真核表达质粒PCDNA3．1-P30-P22，肌内注射免疫小鼠，ELISA法测定其抗体滴度的变化，用弓形虫作致死性攻击感染。结果实验组抗体水平明显高于对照组，二者存在显著性差异(P＜0．05)；攻击感染后实验组小鼠存活时间明显延长(P＜0．05)。结论重组真核表达质粒PCDNA3．1-P30-P22肌注BALB/C系小鼠可诱导一定的体液免疫应答，对攻击感染具有一定的保护性。     

Serum levels of 3,5,3′-Triiodothyronine, 3,3′,5′-triiodothyronine and thyroxine in acute myocardial infarction

Summary The serum levels of thyroxine (T4), 3,5,3′-triiodothyronine (T3) and 3,3′,5′-triiodothyronine (rT3) were monitored by a radioimmunoassay (RIA) method over the first 9 days of disease in 27 patients with acute myocardial infarction (AMI) admitted to a coronary care unit. The data were subjected to statistical analysis by computer and compared with normal values previously obtained in a group of 60 healthy adult volunteers by the same RIA method. In terms of the mean % difference between the normal subjects and the patients with AMI, we observed, on day 1, a decrease of 33% in T3(p<0.01), an increase of 78% in rT3 (p<0.01), and a decrease of 13% (p<0.05) in T4. Over the 9 days studied the serum values of T3 decreased and tended to become stabilized, at about day 9, at levels lower than the initial values; the rT3 had returned to normal by day 9, and it was not possible to demonstrate any statistical significance. in the peak value of day 1. T4 showed no statistically significant variation with time. The patients that died within 30 days of the initial symptoms differed from the survivors in that their rT3 levels were significantly higher. The patients receiving corticosteroid and digitalis therapy bad higher rT3 levels than those not receiving such therapy. The results confirm that in the initial phase of AMI there may be a shift in the peripheral conversion of T4 from T3 to rT3. This behaviour seems to be influenced by the severity of the diseae, the diet and therapy with corticosteroids and digitalis. Presented in part at the 14th International Congress of Internal Medicine, Rome, October 15–19. 1978.     

Repair of Sinus of Valsalva Aneurysm Associated with Aortoventricular Discontinuity

The case of a patient with unruptured sinus of Valsalva aneurysm with absence of the intervalvular lamina fibrosa is presented. The association of Valsalva aneurysm and aortic subvalvular defects has been explained as a deficiency of elastic tissue at the aortic root or maldevelopment of the fibrous trigone. Valvular aortic insufficiency with histological evidence of myxoid changes required prosthetic replacement. Myxomatous changes in the fibrous trigone and aortic annulus can explain this unusual, complex anomaly. Accurate preoperative diagnosis may require special views and simultaneous left and right injections at cineangiography. Techniques of repair that have been successful are reviewed, and the essential features of adequate correction are outlined.