基于满秩平行因子分析方法研究左氧氟沙星两种结构型体的荧光光谱及其与酸碱度的关系

目的以满秩平行因子分析方法研究左氧氟沙星两种结构型体的荧光光谱及其与酸碱度的关系。方法测定pH值2．78—7．83范围内左氧氟沙星的三维荧光光谱,并对其三维荧光光谱数据进行满秩平行因子分析。结果测定了左氧氟沙星不同pH值下的三维荧光光谱,得到了其两种不同结构型体（氢键结构型体和双极离子结构型体）的激发光谱、发射光谱和浓度变化曲线。结论获得左氧氟沙星两种不同结构型体的荧光光谱及其在pH值2．78—7．83范围内的浓度变化趋势,为左氧氟沙星的代谢研究提供了更多的基础信息。     

动态心电图在冠心病患者中的应用价值研究

目的：探讨动态心电图在冠心病患者中的应用价值。方法：选取怀疑冠心病的患者96例为研究对象,对其采用24h动态心电图进行检查,并行检查,将结果做对照。结果：经研究统计发现,24h动态心电图总阳性率与冠脉造影比较差异无统计学意义（P〉0.05）,且多支病变患者阳性确诊率高于单支病变患者（P〈0.05）。结论：动态心电图在冠心病患者中有较高的应用价值,且其具有无创、价廉等优点,值得进一步研究探讨及应用。     

不同负压值在负压伤口治疗中的作用

采用负压封闭辅助闭合(vacuum-assisted closure,VAC)技术实施负压伤口治疗是近十几年来提出的伤口治疗新方法,其中负压值的选择是此方法的研究重点。文中针对不同负压值对于伤口血流变化、渗液移除、减少细菌量和促进伤口肉芽组织生长等方面的影响作一综述。     

信息熵与P值

采用PxLog2Px计算出设计的苯和放射职业人员及正常人(对照组)的外周血淋巴细胞染色体畸变、SCE实验信息。通过分析,该法中的相对熵、剩余度指标比常规统计方法中P值作出的判断推理更为客观细致,且计算简便,易于掌握。     

Does postnatal depression screening work? Throwing out the bathwater, keeping the baby

Background

Rates of help-seeking for Postnatal Depression (PND) are generally low and population screening has the potential to increase diagnosis rates. Of central importance is the screening instrument's Positive Predictive Value (PPV), which is itself influenced by the prevalence of the condition. When PPV exceeds prevalence, screening defines a screen-positive group with a higher prevalence to which diagnostic-stage procedures can be targeted, a necessary component of a screening program's potential for cost-effectiveness.

Methods

Employing the best available estimates of the prevalence of PND we applied Bayes’ Theorem to map the parameter space for the Positive Predictive Value of the Edinburgh Postnatal Depression Scale (EPDS) across a realistic range of values. Only seven methodologically comparable validation studies are available for major depression and/or minor depression.

Results

Screening with the EPDS always facilitated an increase in identification rates, over the key range of prevalence values. The EPDS defined a sub-group with prevalence between 5-fold and 17-fold greater than the general population. A central estimate of PPV (at a prevalence of 6.8%) was 62%.

Limitations

Few high-quality data are available for analysis and therefore better estimates, of both PND prevalence and of screening accuracy, in the populations where screening takes place are needed.

Conclusions

Our estimates of PPV indicate that population screening with an instrument at least as accurate as the EPDS could successfully increase the number of cases identified and, therefore, treatment rates. Comparisons with the performance of physical health-screening programs appear favourable. Appropriate training for health professionals is essential to minimize potential harms, and following all positive screening results with a formal diagnostic procedure is likely to be useful both clinically and in terms of health system costs.     

Evaluation of clinical safety and tolerance of a Lactobacillus reuteri NCIMB 30242 supplement capsule: A randomized control trial

A significant number of human clinical trials have reported no adverse effects associated with consumption of Lactobacillus reuteri (L. reuteri). In the present study, the clinical safety and toxicology of oral ingestion of supplement capsules containing L. reuteri NCIMB 30242 was investigated. A randomized group of 131 subjects received a dose of 2.9 × 10⁹ CFU L. reuteri NCIMB 30242 capsules (n = 67) or placebo capsules (n = 64) twice daily for 9 weeks. Clinical chemistry and hematological parameters of safety were analyzed. The frequency, duration and intensity of adverse events (AE)s and clinical significance of safety parameters were recorded for both groups. No clinically significant differences between the probiotic capsule and placebo capsule treated groups were detected in either the blood clinical chemistry or hematology results. The frequency and intensity of AEs was similar in the two groups. These results demonstrate that administration of a twice daily dose of 2.9 × 10⁹ CFU was safe and well tolerated in the population evaluated over 9 weeks.     

大学生生命观系列调查与研究

考察大学生对生命意识、生命伦理、生命价值的系列生命观态度,以具体的数据分析为依据帮助大学生树立正确的生命观,促进大学生的健康发展。结果显示绝大多数学生的生命观还处于青年特有的发展期,大学生对自己生命的满意度一般,有将近1/3的学生对生命的负面感受较深刻,近40%的学生有明显的生存压力感受。大部分同学对自杀持否定态度,但对自杀是人生悲剧的看法有近1/4的学生不认同,有近2/5的同学对死亡的理解存在问题。城乡调查者存在一些差别:农村同学中有负面的生命体验感和生存压力很大的比例远远高于城市同学,但在对自杀与死亡认知中珍视生命的态度却更为强烈。在生命伦理观中大学生的传统观念较强,尊重需求强烈。在生命价值观中生命质量的观念较为明显。     

胎心监护联合胎儿大脑中动脉血流S/D值、血清雌三醇检测评估新生儿预后的临床应用

目的探讨胎心监护联合胎儿大脑中动脉血流S/D值、血清雌三醇检测评估新生儿预后的临床应用。方法对2009年7月~2012年1月在我科分娩的2 450例孕妇进行胎心监护及血清雌三醇、胎儿大脑中动脉血流S/D值测定,分析其与新生儿预后的关系。结果一种检查方法的假阳性率为27.9%,两种联合检查假阳性率为5.4%,三种联合检查的假阳性率为0.6%,明显低于一种及两种联合检测（P〈0.05）。结论多因素联合监测发现胎儿窘迫的假阳性率减少,可降低剖宫产率并降低新生儿的并发症发生率。     

常规超声与超声弹性成像对乳头溢液的诊断价值分析

目的探讨常规超声与超声弹性成像对乳头溢液的诊断价值,分析其效果。方法选择2010年9月～2012年3月50例经手术病理证实为乳头溢液的患者作为研究对象,患者在术前进行常规超声及实时超声弹性成像检查,采用平行于乳腺导管的放射状方法对其进行扫描检查,要针对患者的乳晕区域的扩张导管以及占位的常规超声声像图的表现而为患者诊断,诊断结果有BI-RADS1～5级,实时弹性的成像要依据病灶的成像特征进行分析,分为1～5级,此次所有患者的全部病变均或者手术的病理。结果笔者所在医院此次研究的50例患者,其中良性病变为40个,恶性病变为10个,在常规超声的基础上加强使用弹性成像,对病变诊断的敏感度达到100%。结论常规超声如果发现导管扩张伴有内部局限性回声病变,则应为患者使用超声弹性成像检查,可有效提高诊断的特异性。     

Posterior pelvic pain provocation test is negative in patients with lumbar herniated discs

The classification of pelvic girdle pain can only be reached after lumbar causes have been excluded by a clinical examination. During clinical examination, the posterior pelvic pain provocation test is a well-established method for verifying pelvic girdle pain. However, a criticism of pelvic pain provocation tests is that they may have an effect on lumbar structures, thus yielding false-positive results. The posterior pelvic pain provocation test was performed with four groups of patients: patients with computed tomography-verified disc herniations (1) on the waiting list for surgery (14 women; 9 men); (2) 6 weeks after disc surgery (18 women, 12 men); (3) pregnant women seeking care for pelvic girdle pain (n = 25); and (4) women with persistent pelvic girdle pain after delivery (n = 32). The sensitivity of the posterior pelvic pain provocation test was 0.88 and the specificity was 0.89. The positive predictive value was 0.89 and the negative predictive value was 0.87. Analysis of only women showed similar results. In our study, the posterior pelvic pain provocation test was negative in patients with a well-defined lumbar diagnosis of lumbar disc herniation, both before and after disc surgery. Our results are an important step toward the more accurate classification of lumbopelvic pain.