Synergistic hierarchical silicone-modified polysaccharide hybrid as a soft scaffold to control cell adhesion and proliferation

In this study, a new type of polydimethylsiloxane-modified chitosan (PMSC) amphiphilic hydrogel was developed as a soft substrate to explore cellular responses for dermal reconstruction. The hydrogel wettability, mechanical stiffness and topography were controllable through manipulation of the degree of esterification (DE) between hydrophobic polydimethylsiloxane (PDMS) and hydrophilic N,O-(carboxymethyl)-chitosan (NOCC). Based on microphase separation, the incorporation of PDMS into NOCC increased the stiffness of the hybrid through the formation of self-assembled aggregates, which also provided anchor sites for cell adhesion. As the DE exceeded 0.39, the size of the PDMS-rich aggregates changed from nanoscale to microscale. Subsequently, the hierarchical architecture resulted in an increase in the tensile modulus of the hybrid gel up to fourfold, which simultaneously provided mechano-topographic guidance and allowed the cells to completely spread to form spindle shapes instead of forming a spherical morphology, as on NOCC (DE = 0). The results revealed that the incorporation of hydrophobic PDMS not only impeded acidic damage resulting from NOCC but also acted as an adhesion modification agent to facilitate long-term cell adhesion and proliferation on the soft substrate. As proved by the promotion on long-term type-I collagen production, the PMSC hybrid with self-assembled mechano-topography offers great promise as an advanced scaffold material for use in healing applications.     

指按法动力学参数的量化测定与比较分析

目的:通过对不同组别人群指按法动力学参数的量化测定与比较分析,观察其操作是否具有一致性,为指按法的量化与规范化、临床教学提供一定的依据.方法:应用MFF多点薄膜压力测试系统,检测并记录3组不同推拿年限的操作者进行手法操作过程中的动态图形,并保存分析相应的参数数据.结果:3组指按法的平均作用力为本科生组轻度(5.99±2...     

Preventing the progression of text neck in a young man: A case report

Text neck describes an overuse injury of the cervical spine resulting from the repetitive stress of prolonged forward head flexion while looking down on a mobile screen. This case report describes a 24-year-old young man who presented with a 12-month history of head and neck pain and paresthesia of the right upper limb. The patient worked as a YouTuber and has been editing and posting videos on the website for three years. One year prior to referral for chiropractic assessment, the patient first visited his family physician for similar complaints. Based on cervical radiographs, the diagnosis of cervical spondylosis was given. Previous management included pain medication and muscle relaxants. Interventions included repeated physical therapy, cervical traction, and acupuncture, with some temporary relief during the subsequent year. However, severe flare-up of the symptoms occurred, which was brought about by working for extended periods on his smartphone, for which the patient sought chiropractic attention. X-ray imaging showed cervical kyphosis with C5 vertebral rotation, hypertonicity of the paraspinal muscles, and paresthesia in the right C6 dermatome distribution, which were consistent with text neck syndrome associated with cervical spondylosis and right C6 radiculopathy. The intervention consisted of improving posture while texting, cervical manipulation, and extension traction therapy. After 9 months of treatment sessions, the symptomatic and functional improvement was reflected by the radiographic changes in the cervical curve correction and the normalized paraspinal muscle tension on surface electromyology. Frequent breaks along with correct posture while using smartphones will be the key entities to prevent the occurrence of text neck syndrome.     

A clinical crossover trial of the effect of manipulative therapy on pain and passive and active range of motion of the painful hip

ObjectivesThis study aims to determine whether manipulative therapy of the hip joint can increase range of motion (ROM) and/or decrease pain in individuals experiencing symptomatic hip pain.MethodsNon-disabled young adults were recruited on campus of a chiropractic college for this randomized crossover study. Subjects’ hip active and passive ROM and pain perception were measured. Subjects then received a drop-piece hip manipulation (DPHM) or an alternative treatment, followed by measurement of active and passive ROM and pain.ResultsEight males and 12 females (n=20) between the ages of 21–32 years completed the study. Statistically significant improvements in numeric pain scale (NRS) and passive abduction were observed for the manipulation group when compared to the alternative treatment. No significant change was observed for all other hip ranges.ConclusionsDPHM of the symptomatic hip joint in a small sample of young adults resulted in statistically significant improvements in pain and passive abduction when compared to sham manipulation. Due to low sample size, further research is recommended.     

针刺配合推拿、跌打追风酒外敷治疗肩周炎的临床疗效分析

目的:探寻肩周炎患者临床有效的治疗方法。方法:从我院2018年治疗的肩周炎患者中随机抽取80例,采取双盲筛选法将其均分为对照组与观察组各40例,分别接受针刺治疗及针刺+推拿+跌打追风酒外敷治疗,对比两组临床效果。结果:观察组总有效率、治疗满意度均显著高于对照组(P<0.05)。结论:针刺+推拿+跌打追风酒外敷联合治疗方案可有效改善肩周炎患者的临床症状,促使患者早日恢复,值得临床广泛推广运用。     

针刺手法效应规律及神经电信息机制研究

针刺手法是影响针刺疗效的关键,然而其作用规律、机制尚不完全清楚。天津中医药大学实验针灸学研究中心郭义教授团队与天津大学电气自动化与信息工程学院王江教授团队,长期以来围绕针刺手法作用规律及神经电信息机制开展合作研究,构建了常见针刺手法的数学模型,用数学语言解析了针刺手法操作过程,实现了针刺手法的科学表征;揭示了基于神经电信息的针刺手法部分作用规律;刻画了针刺手法电信号的非线性动力学特征,明确不同针刺手法诱发神经电信息编码存在差异,是针刺手法效应差异的机制之一。研究成果为针刺手法的科学性奠定了提供了实验依据,对针刺手法的传承、应用和发展具有促进作用。     

Flexible Manipulation of the Reflected Wavefront Using Acoustic Metasurface with Split Hollow Cuboid

This work proposes a method for actively constructing acoustic metasurface (AMS) based on the split hollow cuboid (SHC) structure of local resonance, with the designed AMS flexibly manipulating the direction of reflected acoustic waves at a given frequency range. The AMS was obtained by precisely adjusting any one or two types of structural parameters of the SHC unit, which included the diameter of the split hole, the length, width, height, and shell thickness of the SHC. The simulation results showed that the AMS can flexibly manipulate the direction of the reflected acoustic waves, and the anomalous reflection angle obeys the generalized Snell’s law. Furthermore, among the five structural parameters, the AMS’s response frequency band is widest with the hole diameter and height, followed by the length and width, and narrowest with the shell thickness. It is worth noting that comprehensive manipulation of two parameters not only broadens the response frequency band, but also strengthens the effect of the anomalous reflection at the same response frequency. The subwavelength size of the AMS constructed with such a comprehensive method has the advantages of a small size, wide response band, simple preparation, and flexible modulation, and can be widely used in various fields, such as medical imaging and underwater stealth.     

踝关节骨折的手术治疗和手法复位治疗效果比较分析

目的比较手法复位和手术治疗两种方法治疗踝关节骨折的临床疗效,为踝关节骨折治疗方法的选择提供依据。方法选取2007年12月至2013年6月北京密云县医院收治的踝关节骨折患者106例,根据患者自愿和病情情况,将106例踝关节骨折患者分为手术组(50例)和手法复位组(56例)。比较两组患者的复位情况。结果手法复位组骨折复位优良率和踝关节功能恢复优良率分别为82.14%和87.50%,均显著低于手术治疗组的96.00%和94.00%(Z=8.947,2.989,P均<0.05)。手法复位组平均住院天数为(5.5±3.4)d,平均住院费用为(2503.1±534.6)元,并发症发生率为3.57%,显著低于手术治疗组(P<0.05)。结论手术治疗和手法复位治疗踝关节骨折各有优缺点,在具体治疗中,需要根据患者情况和意愿选择合适的治疗方法。     

傍针刺配合一指禅治疗顽固性面瘫临床观察

目的观察傍针刺配合一指禅推治疗顽固性面瘫的临床疗效。方法将60例患者随机分为治疗组（傍针刺组）和对照组（单针刺组）,每组30例,进行两组疗效对比。结果治疗组总有效率为93．3％,对照组总有效率为76．7％,治疗组总有效率优于对照组,两者比较差异具有统计学意义（P〈0．05）。结论傍针刺配合一指禅推是治疗顽固性面瘫的一种有效的方法。     

脊柱三扳法对早中期强直性脊柱炎胸腰椎活动的影响

目的探讨脊柱三扳法治疗早中期强直性脊柱炎(AS)的疗效。方法 60例AS早中期患者按照进入研究的顺序分为药物组(n=30)和手法组(n=30)。药物组口服柳氮磺胺吡啶和正清风痛宁缓释片;手法组在此基础上接受脊椎三扳手法。按自行研制AS调查表在治疗前和治疗后第1、3、6个月对两组患者进行随访。结果治疗3个月时,手法组的腰椎活动度和指-地距离优于药物组(P<0.05);治疗6个月时,手法组腰椎活动度、指-地距离、胸廓活动度和VAS评分均优于药物组(P<0.05)。结论脊柱三扳法可以改善早中期AS患者的胸腰椎活动范围。