全文获取类型
收费全文 | 20625篇 |
免费 | 1293篇 |
国内免费 | 406篇 |
专业分类
耳鼻咽喉 | 290篇 |
儿科学 | 478篇 |
妇产科学 | 83篇 |
基础医学 | 2333篇 |
口腔科学 | 1070篇 |
临床医学 | 1375篇 |
内科学 | 1932篇 |
皮肤病学 | 1857篇 |
神经病学 | 441篇 |
特种医学 | 868篇 |
外科学 | 6721篇 |
综合类 | 1996篇 |
现状与发展 | 2篇 |
预防医学 | 541篇 |
眼科学 | 352篇 |
药学 | 1261篇 |
10篇 | |
中国医学 | 301篇 |
肿瘤学 | 413篇 |
出版年
2024年 | 76篇 |
2023年 | 444篇 |
2022年 | 545篇 |
2021年 | 763篇 |
2020年 | 722篇 |
2019年 | 772篇 |
2018年 | 758篇 |
2017年 | 718篇 |
2016年 | 676篇 |
2015年 | 694篇 |
2014年 | 1329篇 |
2013年 | 1394篇 |
2012年 | 1040篇 |
2011年 | 1240篇 |
2010年 | 943篇 |
2009年 | 942篇 |
2008年 | 1018篇 |
2007年 | 925篇 |
2006年 | 854篇 |
2005年 | 784篇 |
2004年 | 693篇 |
2003年 | 558篇 |
2002年 | 462篇 |
2001年 | 432篇 |
2000年 | 347篇 |
1999年 | 333篇 |
1998年 | 310篇 |
1997年 | 266篇 |
1996年 | 242篇 |
1995年 | 216篇 |
1994年 | 204篇 |
1993年 | 154篇 |
1992年 | 147篇 |
1991年 | 120篇 |
1990年 | 106篇 |
1989年 | 105篇 |
1988年 | 84篇 |
1987年 | 76篇 |
1986年 | 78篇 |
1985年 | 78篇 |
1984年 | 74篇 |
1983年 | 47篇 |
1982年 | 71篇 |
1981年 | 67篇 |
1980年 | 68篇 |
1979年 | 56篇 |
1978年 | 43篇 |
1977年 | 35篇 |
1976年 | 39篇 |
1975年 | 31篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
91.
Summary This technique for reconstruction of the short philtrum requires an understanding of the viscoelastic properties of the skin and how to use these to increase skin dimensions. This is combined with contouring and splinting with a subcutaneous cartilage graft. Three representative cases are presented to illustrate the method to achieve an aesthetically acceptable lip and its long-term follow-up. No complications have been encountered using this over a 15-year period. The technique can be combined with other secondary reconstructive procedures on the lip and palate.
Work completed at: Providence Hospital, 16001 West Nine Mile Road, P.O. Box 2043, Southfield, Michigan 48037, USA 相似文献
92.
The infeasibility of using ten-ring irradiated grafts for tracheal allotransplantation even with omentopexy 总被引:2,自引:0,他引:2
In our previous study, we demonstrated that high-dose 60Co irradiation was able to prevent rejection of canine tracheal allografts. To determine the maximum possible length of these grafts, in the present study we attempted to transplant five-ring and ten-ring tracheal allografts in two groups of five dogs each. Either five or ten rings were excised from donor tracheas and irradiated with 100,000 cGy of 60Co. The irradiated tracheal grafts were transplanted to replace either five- or ten-ring sections of the mediastinal tracheas removed from the recipient dogs. The grafts were covered with omental pedicles and no immunosuppressants were used. Graft incorporation was achieved in four of the five dogs in the five-ring group, and three of these dogs survived for more than 700 days. However, four of the five animals in the ten-ring group died from tracheostenosis accompanied by ischemia within 3 weeks. These findings demonstrate the impossibility of performing ten-ring tracheal allotransplantation using irradiated grafts, even with omentopexy. 相似文献
93.
C. Boutoleau B. Guillon F. Martinez M. Vercelletto A. Faure J. R. Fève 《European journal of neurology》2003,10(5):521-523
The first case of Creutzfeldt-Jakob disease (CJD) related to the use of a dura mater graft of cadaveric origin was identified in 1987 and this procedure is now considered as one of the main causes of iatrogenic CJD. Although the decontamination procedure for the preparation of graft material was modified, the product was withdrawn from the market in many countries a few years later and replaced by synthetic material. In this context, two patients treated in our institution developed CJD following a cadaveric dural graft performed after cerebral and lumbar trauma. Their clinical presentation, showing predominant cerebellar symptoms, late deterioration and myoclonic jerks, and a rapid disease course until death, was similar to that of previously reported cases involving the iatrogenic form. As the graft for one of the patients was performed in 1991 (several years after modification of the decontamination procedure), this fourth reported case suggests that the risk of iatrogenic CJD may have persisted in some patients treated after 1987, when grafts of cadaveric origin were totally abandoned. 相似文献
94.
Axonal regeneration after transection is a complex biological process. It is not merely a process of tissue repair, but rather
of cellular repair of a large number of nerve cells. Regeneration involves restoration of the original morphology of each
single cell, rather than proliferation. Techniques in microneurosurgical reconstruction of peripheral nerve injuries have
improved over the last two decades, with subsequent improvement in functional results. Nerve autografts are now routinely
used to guide the regrowth of the proximal nerves to distal nerve segments. However, the limited source of expendable cutaneous
nerves restricts the use of nerve grafting techniques and is associated with significant morbidity. With extensive injuries
there is an insufficient quantity of nerve autograft material to facilitate optimal repair. In future, the use of artificial
conduits or nerve allografts could provide a limitless source of material to reconstruct otherwise irreparable traumatic nerve
injuries. Establishment of appropriate strategies to suppress host-immune reaction or donor antigenicity would facilitate
clinical allogeneic nerve transplantation.
Guest lecture presented at the 69th Annual Meeting of the Japanese Orthopaedic Association in Tokyo on April 13, 1996. 相似文献
95.
癌基因c-fos、c-jun蛋白在鳞状细胞癌皮损中的表达及意义 总被引:3,自引:0,他引:3
目的 探讨癌基因c fos、c jun的表达与皮肤鳞癌发生和发展的关系。 方法 采用免疫组化法对 6 0例皮肤鳞癌的c fos、c jun的表达情况进行检测 ,并与正常皮肤组织进行对照。 结果 c fos、c jun在正常皮肤组织不表达 ,在皮肤鳞癌中的表达阳性率分别为 6 1.7%和 4 8.3% ,其表达水平与癌组织的分化程度有关 (P <0 .0 5 ) ,肿瘤的分化程度越高其表达水平越高。 结论 c fos、c jun的表达水平可作为判定皮肤鳞癌分化的指标。 相似文献
96.
Liver and intestine transplantation 总被引:1,自引:0,他引:1
Robert S. Brown Sarah H. Rush Hugo R. Rosen Alan N. Langnas Goran B. Klintmalm Douglas W. Hanto Jeffrey D. Punch 《American journal of transplantation》2004,4(S9):81-92
The most significant development in liver transplantation in the USA over the past year was the full implementation of the MELD- and PELD-based allocation policy in March 2002, which shifted emphasis from waiting time within broad medical urgency status to prioritization by risk of waiting list death. The implementation of this system has led to a decrease in pretransplant mortality without increasing post-transplant mortality, despite a higher severity of illness at the time of transplant.
The trend over the last few years of rapidly increasing numbers of adult living donor liver transplants was reversed in 2002 by a decline of more than 30% in the number of these procedures. In 2002, a greater percentage of women received livers from living donors (43%) than deceased donors (34%), possibly because of size considerations.
From 1993 to 2001, the waiting list increased more than sixfold, from 2902 patients to 18 047 patients. For the first time since 1993, the waiting list size decreased in 2002, dropping 6% to 16 974 candidates. The percentage of temporarily inactive liver candidates also increased from 2001, thus the net decrease in the active waiting list for 2002 was 12%. This may reflect a trend toward less pre-emptive listing practices under MELD.
Intestine transplantation remains a low-volume procedure limited to a few transplant centers and is still accompanied by significant pre- and post-transplantation risks. As this procedure matures, its application may increase to include recipients at an earlier stage of their disease with better likelihood of success. 相似文献
The trend over the last few years of rapidly increasing numbers of adult living donor liver transplants was reversed in 2002 by a decline of more than 30% in the number of these procedures. In 2002, a greater percentage of women received livers from living donors (43%) than deceased donors (34%), possibly because of size considerations.
From 1993 to 2001, the waiting list increased more than sixfold, from 2902 patients to 18 047 patients. For the first time since 1993, the waiting list size decreased in 2002, dropping 6% to 16 974 candidates. The percentage of temporarily inactive liver candidates also increased from 2001, thus the net decrease in the active waiting list for 2002 was 12%. This may reflect a trend toward less pre-emptive listing practices under MELD.
Intestine transplantation remains a low-volume procedure limited to a few transplant centers and is still accompanied by significant pre- and post-transplantation risks. As this procedure matures, its application may increase to include recipients at an earlier stage of their disease with better likelihood of success. 相似文献
97.
目的:探索能减少并发症,减轻病人经济负担,有效预防移植肾急性排斥反应的多克隆抗体的合理使用方案。方法:选择肾移植患者80例,根据使用多克隆抗体的时间不同分3组,观察病人血CD3+细胞数变化、急性排斥反应及并发症发生率,作前瞻性研究。结果:3组病人急性排斥反应率,术后5d内CD3+细胞数无统计学差异,而使用抗淋巴细胞免疫球蛋白(ALG)时间较长者,术后6d后CD3+细胞数少于其他组,巨细胞病毒(CMV)病及一般感染率明显高于其他组。结论:术后间歇使用小剂量tients′ATG及术后连续3~6d使用常规剂量ALG是一种有效、安全、价廉的免疫抑制方案。 相似文献
98.
应用自体髂松质骨髓颗粒植入整复10例单侧上颌齿槽突裂,并关闭口鼻瘘。10例伤口一期愈合,术后观察3~6个月,外观改善明显,X线检查有明显骨形成,骨密度近似正常骨组织,两者间无明显界限。 相似文献
99.
Hiroko Sasahara Susumu Sueyoshi Toshiaki Tanaka Hiromasa Fujita Kazuo Shirouzu 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(5):231-239
Objective: The purpose of this experimental study was to investigate whether aortic stent grafting can be applied to the treatment of
an esophageal cancer involving the thoracic aorta. Methods: The canine thoracic aorta was partially resected without aorta being clamped after emplacement of an endovascular stent graft.
Study I; The aortic whole layer of 1 cm in length and 1/4 of the circumference was resected and was covered by a free fascia
patch of the abdominal rectal muscle immediately after stent graft placement. Study II; The aortic adventitia and the outer
half of the media of the same size was resected on day 3, 7,14, 21, and on day 28, after the stent graft placement. The resected
portion was covered by the free fascia patch in half experimental dogs, and was uncovered in the others. Study III; The aortic
adventitia and the outer half of the media of 1 cm in length and 1/2 of the circumference was resected and was uncovered on
day 7 after stent graft placement. Histological examinations were performed on day 28 and at one year after aortic resection.
Results: The aortic wall could be resected in all cases with no complication, except in resection of 1/2 the circumference where the
aorta had become narrow. There was no difference in healing of the resected portion of the aorta between with and without
fascia covering. Conclusion: An aortic endovascular stent graft could be applied to surgery for an esophageal cancer involving the aorta. 相似文献
100.
异体造血干细胞移植的重要并发症是移植物抗宿主病(GVHD),免疫抑制剂是有效防治GVHD的一类药物.在异体造血干细胞移植后应用免疫抑制剂,使得GVHD发生率下降,严重程度减轻.本文对几类主要的免疫抑制剂的作用机理以及在异体造血干细胞移植中作为预防和治疗GVHD的应用作一综述. 相似文献