腹腔镜手术与开腹穿孔修补术治疗胃十二指肠溃疡穿孔疗效对比

目的：探讨腹腔镜手术与开腹穿孔修补术在胃十二指肠溃疡穿孔治疗中效果对比。方法该院2009年11月-2014年11月共收治胃十二指肠溃疡穿孔86例,随机分为对照组和观察组,对照组采用开腹十二指肠溃疡穿孔修补术治疗;观察组采用腹腔镜胃十二指肠溃疡穿孔修补术。比较两组患者的手术时间、术中出血量等及术后并发症情况。结果观察组术中出血量(5.8±1.3)mL、住院时间(5.2±1.1)d显著少于对照组(16.3±2.5)mL、(8.5±1.2)d,胃肠道功能恢复时间(2.1±0.6)d显著早于对照组(3.3±1.0)d,观察组治疗过程中并发症发生率(4.7%)显著低于对照组(23.3%),差异有统计学意义(P<0.05)。结论腹腔镜胃十二指肠溃疡穿孔较开腹手术术中出血量少,住院时间短,胃肠道功能恢复时间短,术后并发症发生率低,为治疗胃十二指肠溃疡穿孔的较好术式,值得临床推广应用。     

超声在胃肠道穿孔诊断及定位诊断中的价值

目的：研究分析超声在胃肠道穿孔诊断和定位诊断中的价值。方法回顾性分析该院收治的30例经手术病理证实的消化道穿孔患者的病历资料,并进行超声诊断和X线平片进行诊断,观察分析胃肠道穿孔患者诊断中引起急腹症的胆囊、胰腺、胃、肠道等有无病变及肠间有无积液及腹腔有无游离气体等。结果超声发现膈下游离气体者26例（86.7%）,胃肠道穿孔患者经过X线平片诊断出20例（66.7%）,超声诊断检出率高于X线片平面检出率,差异有统计学意义（P<0.05）。结论胃肠道穿孔患者进行超声检查,诊断价值相对较高,还能实现定位诊断,是常规检查有效的手段之一,值得临床推广应用。     

微波治疗外伤性鼓膜穿孔的效果分析

目的：对微波治疗外伤性鼓膜穿孔的效果展开对比分析。方法对该院于2011年5月—2013年10月收治的64例外伤性鼓膜穿孔患者进行研究,并将其分为治疗组和对照组,均为32例,通过不同治疗方法对两组患者临床治疗效果展开对比分析。结果治疗组患者临床治疗总有效率为90.63%、鼓膜穿孔愈合时间为(16.23±2.21)d同对照组患者的65.62%和(19.86±2.71)d相比,P<0.05;对两组患者治疗前语频区气导弹听阈情况展开对比,P>0.05;治疗后,两组患者语频区气导弹听阈显著优于治疗前的,且治疗组患者治疗后语频区气导弹听阈显著优于对照组患者的,P<0.05。结论在治疗外伤性鼓膜穿孔疾病临床上微波治疗方法效果较为理想。     

Low recurrence rate after endoscopic resection in non-ampullary duodenal lesions: A 16-year single-center retrospective study

Endoscopic resection (ER) for non-ampullary duodenal lesions (NADLs) is technically more difficult than lesions of the stomach. However, endoscopic treatment of duodenal lesions has been increasingly performed in recent years. This study aimed to evaluate the efficacy and safety of ER for NADLs.Patients who underwent ER for NADLs between 2004 and 2019 were retrospectively reviewed. Clinical and pathologic features of the lesions including the clinical outcomes and adverse events were analyzed.The study included 80 patients with NADLs. The mean age of patients was 59.3 years (22–80 years), the mean size of the lesion was 8.8 ± 7.0 mm, and the mean procedure time was 13.2 ± 11.2 min. Half (40/80) of the lesions were in the duodenal bulb including the superior duodenal angle. Final histological data showed 56 adenomas (70.5%), 13 Brunner gland tumors (16.2%), and 4 pyloric gland tumors (5.0%). The final diagnoses of 5 lesions after ER showed higher-grade dysplasia compared to pre-ER biopsy findings. The en bloc resection rate was 93.8% (75/80), and the complete resection rate with clear margins was 90.0% (72/80). Micro-perforation occurred in 2 of 80 patients and was successfully treated with conservative treatment. There were no cases of delayed bleeding. The mean follow-up period was 27.0 months (2–119 months) with no cases of recurrence.ER may be an effective treatment for NADLs with favorable long-term outcomes. However, the possibility of perforation complications should always be considered during ER.     

成功救治肺源性心脏病并发胃肠道穿孔、脓毒症休克一例

脓毒症是患者入住ICU的常见病因,也是ICU患者死亡的主要原因之一。急性肾功能损伤是脓毒症常见脏器损伤,且与患者病死率相关。慢性阻塞性肺疾病患者由于长期肺动脉高压会导致肺源性心脏病,并进一步引起右心肥大甚至心功能不全,严重影响患者心肺功能。嘉兴市第二医院收治1例老年肺源性心脏病并发胃肠道穿孔、脓毒症休克患者,术后出现低心排、急性肾功能损伤及体循环淤滞,经相关积极救治后顺利出院,现将本例的临床资料及诊疗体会报道如下。     

Novel navigation technique for the endodontic treatment of a molar with pulp canal calcification and apical pathology

Apical periodontitis, the inflammation of periapical tissue, commonly requires root canal treatment to achieve apical healing. However, if it is accompanied by pulp canal calcification, the treatment becomes complicated, and locating the root canal can be challenging. This case report describes a novel approach for treating a molar with pulp canal calcification and apical pathology. Due to the risk of perforation during treatment, a digitally printed template was used to assist in accurately locating the root canal. After six months, the patient was asymptomatic and the periradicular radiolucency was gradually reducing in size.     

Improved single visit management of old infected iatrogenic root perforations using Biodentine®

Aim

The aim of this retrospective observational case series study was to evaluate the middle term outcomes on endodontic management of old infected iatrogenic root perforations using Biodentine. The treatments were always concluded in a single visit, without previous medication with calcium hydroxide. Our goal was to facilitate this kind of treatments and to make them more reproducible and manageable even for a general practitioner or a student.

Abnormal septal convexity into the left ventricle occurs in subclinical hypertrophic cardiomyopathy

Background

Sarcomeric gene mutations cause hypertrophic cardiomyopathy (HCM). In gene mutation carriers without left ventricular (LV) hypertrophy (G + LVH-), subclinical imaging biomarkers are recognized as predictors of overt HCM, consisting of anterior mitral valve leaflet elongation, myocardial crypts, hyperdynamic LV ejection fraction, and abnormal apical trabeculation. Reverse curvature of the interventricular septum (into the LV) is characteristic of overt HCM. We aimed to assess LV septal convexity in subclinical HCM.

Methods

Cardiovascular magnetic resonance was performed on 36 G + LVH- individuals (31 ± 14 years, 33 % males) with a pathogenic sarcomere mutation, and 36 sex and age-matched healthy controls (33 ± 12 years, 33 % males). Septal convexity (SCx) was measured in the apical four chamber view perpendicular to a reference line connecting the mid-septal wall at tricuspid valve insertion level and the apical right ventricular insertion point.

Results

Septal convexity was increased in G + LVH- compared to controls (maximal distance of endocardium to reference line: 5.0 ± 2.5 mm vs. 1.6 ± 2.4 mm, p ≤ 0.0001). Expected findings occurred in G + LVH- individuals: longer anterior mitral valve leaflet (23.5 ± 3.0 mm vs. 19.9 ± 3.1 mm, p ≤ 0.0001), higher relative wall thickness (0.31 ± 0.05 vs. 0.29 ± 0.04, p ≤ 0.05), higher LV ejection fraction (70.8 ± 4.3 % vs. 68.3 ± 4.4 %, p ≤ 0.05), and smaller LV end-systolic volume index (21.4 ± 4.4 ml/m²vs. 23.7 ± 5.8 ml/m², p ≤ 0.05). Other morphologic measurements (LV angles, sphericity index, and eccentricity index) were not different between G + LVH- and controls.

Conclusions

Septal convexity is an additional previously undescribed feature of subclinical HCM.     

Coronary artery perforation: How to treat it?

Coronary artery perforation fortunately represents a rare complication of coronary catheterization but, if not properly and promptly treated, it is burdened by a high mortality rate. Rates of coronary perforation may be potentially higher when atherectomy devices are used or very complex calcified lesions are treated. Cardiac tamponade constitutes the most severe clinical consequence.We report the case of an intra-stent coronary perforation at the end of revascularization of a non-ST elevation myocardial infarction (NSTEMI), followed by an immediate impairment of hemodynamic compensation, due to significant pericardial effusion and subsequent cardiac tamponade.The use of covered stents has revolutionized the management of coronary perforation and this has meant that the use of emergency CABG has decreased over the years with satisfactory immediate and short-term outcomes, reducing the incidence of acute cardiac tamponade and mortality without surgery.     

Mutation in the alpha-cardiac actin gene associated with apical hypertrophic cardiomyopathy, left ventricular non-compaction, and septal defects.

AIMS: The E101K mutation in the alpha-cardiac actin gene (ACTC) has been associated with apical hypertrophic cardiomyopathy (HCM). As prominent trabeculations were described in some carriers, we screened for the E101K mutation in our index patients with HCM, dilated cardiomyopathy (DCM), or left ventricular non-compaction (LVNC). METHODS AND RESULTS: Clinical, echocardiographic, and genetic screening by restriction fragment length polymorphism of the ACTC E101K mutation in 247 families with HCM, DCM, or LVNC. The mutation was found in five index patients (one with LVNC and four with HCM). Clinical and morphological data were obtained from 94 family members. Forty-six individuals had cardiomyopathy (43 with the mutation and three with no genetic study): 23 fulfilled criteria for LVNC, 22 were diagnosed as apical HCM, and one had been diagnosed as restrictive cardiomyopathy. There had been one heart transplant and one congestive heart failure death in patients with severe diastolic dysfunction, and five premature sudden deaths. The E101K mutation was not found in 48 unaffected relatives. Septal defects (eight atrial and one ventricular) were found in nine mutant carriers from four families, and were absent in relatives without the mutation (P = 0.003). CONCLUSION: LVNC and HCM may appear as overlapping entities. The ACTC E101K mutation should be considered in the genetic diagnosis of LVNC, apical HCM, and septal defects.