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171.
CD30 and Epstein–Barr virus RNA expression in sclerosing angiomatoid nodular transformation of spleen 总被引:1,自引:0,他引:1
Weinreb I Bailey D Battaglia D Kennedy M Perez-Ordoñez B 《Virchows Archiv : an international journal of pathology》2007,451(1):73-79
Sclerosing angiomatoid nodular transformation (SANT) is a splenic lesion composed of angiomatoid/vascular nodules surrounded
by hyalinized/sclerotic stroma, fibroblasts, myofibroblasts, and inflammatory cells. The endothelium within the nodules has
a phenotype resembling splenic sinusoids, capillaries, and small veins. Martel et al. (Am J Surg Pathol 28:1268–1279, 2004) suggested that SANT may represent the final pathway of a variety of splenic lesions including inflammatory pseudotumors
(IPTs). Epstein–Barr virus (EBV) has a role in the genesis of some splenic IPTs, but its presence in SANT has not been investigated.
Six cases of SANT are reported. All were stained for CD31, CD34, CD8, CD68, smooth muscle actin, muscle-specific actin, and
CD30 and were tested for EBV by in situ hybridization (EBER). All cases showed angiomatoid nodules with complex expression
of CD31, CD34, and CD8, with focal CD68. Expression of CD30 by endothelial cells was also seen. One case had small diffuse
areas lacking nodules resembling an IPT and was positive for EBV. The inflammatory cells and the normal spleen were negative
for CD30 and EBER. In conclusion, SANT shows upregulation of CD30 with respect to normal spleen. The presence of EBV in the
stromal cells of a case supports the notion that a subset of SANT may be related to IPT. 相似文献
172.
患者女,27岁,主因体检时发现左肺门占位1个月余入院。查体及实验室检查未见异常。CT扫描示:左肺门处可见一类圆形肿物,边缘光滑清晰,大小约2.0cm×2.5cm;增强扫描见左肺门病变边缘呈轻度增强,中心区无增强,纵隔内未见异常肿大淋巴结影(图1)。诊断:左肺门占位,考虑良性可能性大。电子支气管镜检查:左主支气管近上下叶开口处1cm前壁略突出,舌叶部分黏膜苍白、增厚,与周围色泽不同。后行手术,术中见肿物位于左肺门处、上下叶之间,左肺上叶脏层胸膜下、直径约3cm,包膜完整,完整切除肿物送病理。病理诊断:左肺上叶硬化性血管瘤。讨论肺硬化性血… 相似文献
173.
Colin T. Shearn David J. Orlicky Dennis R. Petersen 《Experimental and molecular pathology》2018,104(1):1-8
Objective
Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic liver disease that is characterized by severe peri-biliary tract inflammation and fibrosis, elevated oxidative stress and hepatocellular injury. A hallmark of PSC patients is the concurrent diagnosis of Inflammatory Bowel Disease occurring in approximately 70%–80% of PSC patients (PSC/IBD). The objective of this study was to determine the impact of end stage PSC/IBD on cellular antioxidant responses and the formation of protein carbonylation.Methods
Using hepatic tissue and whole cell extracts isolated from age-matched healthy humans and patients diagnosed with end stage PSC/IBD, overall inflammation, oxidative stress, and protein carbonylation were assessed by Western blotting, and immunohistochemistry.Results
Increased immunohistochemical staining for CD3 + (lymphocyte), CD68 (Kupffer cell) and myeloperoxidase (neutrophil) colocalized with the extensive Picrosirius red stained fibrosis confirming the inflammatory aspect of PSC. Importantly, the increased inflammation also colocalized with elevated periportal post-translational modification by the reactive aldehydes 4-HNE, MDA and acrolein. 4-HNE, MDA and acrolein IHC all displayed a significant component in hepatocytes adjacent to fibrotic regions. Furthermore, acrolein was also elevated within the nuclei of periportal inflammatory cells whereas MDA staining was increased in hepatocytes across the lobule. Prussian Blue staining, when compared to the positive controls (ALD, NASH), did not display any evidence of iron accumulation in PSC/IBD livers. Western analysis of PSC/IBD anti-oxidant responses revealed elevated expression of SOD2, GSTπ as well as upregulation of Akt Ser473 phosphorylation. In contrast, expression of GSTμ, GSTA4, catalase, Gpx1 and Hsp70 were suppressed. These data were further supported by a significant decrease in measured GST activity. Dysregulation of anti-oxidant responses in the periportal region of the liver was supported by elevated SOD2 and GSTπ IHC signals in periportal hepatocytes and cholangiocytes. Expression of the Nrf2-regulated proteins HO-1, NAD(P)H quinone reductase (NQO1) and Gpx1 was primarily localized to macrophages. In contrast, catalase staining decreased within periportal hepatocytes and was not evident within cholangiocytes.Conclusions
Results herein provide additional evidence that cholestasis induces significant increases in periportal oxidative stress and suggest that there are significant differences in the cellular and subcellular generation of reactive aldehydes formed during cholestatic liver injury. Furthermore, these data suggest that anti-oxidant responses are dysregulated during end-stage PSC/IBD supporting pathological data. This work was funded by NIH5R37AA009300-22 D.R.P. 相似文献174.
175.
目的:分析肺硬化性血管瘤(PSH)的CT表现,探讨其CT征象.材料与方法:回顾性分析经病理证实12例肺硬化性血管瘤患者的CT影像学资料,所有患者均行CT平扫,其中8例行增强扫描,对病灶的部位、形态、瘤周界面、密度及强化特征等进行观察分析.结果:12例病变中,1例为多发,11例为单发,直径约0.2~7.3cm,平均为2.7cm,呈圆形或类圆形11例,略呈浅分叶状1例,CT平扫密度均匀11例,3例见沙粒状钙化,8例增强扫描,6例见“贴边血管征”,1例见明显不均匀的“花斑样”强化,1例无明显强化.结论:PSH的CT表现有一定的特异性,CT增强检查能够为其诊断提供较多有价值的信息. 相似文献
176.
Nieun Seo So Yeon Kim Seung Soo Lee Jae Ho Byun Jin Hee Kim Hyoung Jung Kim Moon-Gyu Lee 《Korean journal of radiology》2016,17(1):25-38
Sclerosing cholangitis is a spectrum of chronic progressive cholestatic liver disease characterized by inflammation, fibrosis, and stricture of the bile ducts, which can be classified as primary and secondary sclerosing cholangitis. Primary sclerosing cholangitis is a chronic progressive liver disease of unknown cause. On the other hand, secondary sclerosing cholangitis has identifiable causes that include immunoglobulin G4-related sclerosing disease, recurrent pyogenic cholangitis, ischemic cholangitis, acquired immunodeficiency syndrome-related cholangitis, and eosinophilic cholangitis. In this review, we suggest a systemic approach to the differential diagnosis of sclerosing cholangitis based on the clinical and laboratory findings, as well as the typical imaging features on computed tomography and magnetic resonance (MR) imaging with MR cholangiography. Familiarity with various etiologies of sclerosing cholangitis and awareness of their typical clinical and imaging findings are essential for an accurate diagnosis and appropriate management. 相似文献
177.
脾硬化性血管瘤样结节样转化1例 总被引:1,自引:1,他引:0
患者女,41岁,主因“左上腹阵发性隐痛1个月,加重1天伴绞痛1h”入院.查体未见明显异常,肿瘤标志物、血常规、肝肾功能、电解质均正常.CT:脾实质前部团块状稍低密度灶,边界不清,密度欠均匀,增强呈向心性强化,动脉期病灶边缘环状强化,门静脉期强化范围稍扩大,延迟期强化范围推进至病灶中央,但中央裂隙样低密度灶始终未见强化. 相似文献
178.
179.
《Orbit (Amsterdam, Netherlands)》2013,32(2):106-109
Introduction: To report a case of idiopathic orbital sclerosing inflammation (ISOI) with intranasal extension.Material and Methods: The patient presented with a 6-month history of epiphora, upper eyelid swelling, ptosis and mild orbital pain. Ophthalmologic examination, CT, MRI and biopsy with surgical debulking were performed.Results: MRI revealed a homogeneously enhancing diffuse right orbital mass in the inferonasal quadrant of the orbit, which extended to the nasal cavity up to inferior nasal concha, maxillary and ethmoid sinuses. Histological analysis showed dense collagenous tissue with sparse infiltration of mixed inflammatory cells. Inmunohistochemical analysis confirmed polyclonality. The diagnosis of idiopathic sclerosing orbital inflammation was made and 80?mg/day of oral prednisolone was prescribed. At last follow up, one year later, there was no clinical evidence of recurrent orbital disease.Conclusion: ISOI can present with extraorbital extension. Corticosteroids are a reasonable first-line treatment, until the pathogenesis is better understood. 相似文献
180.
目的探讨肺硬化性血管瘤(PSH)的多层螺旋CT表现与特点,提高对本病的认识。方法回顾性分析26例经手术或穿刺病理证实的PSH的多层螺旋CT表现。所有病例行胸部多层CT平扫和(或)增强扫描,三维重建后进行图像观察。结果病灶均为单发,右肺12例,左肺14例;大小以1.5-3.0cm多见(65.4%),平均(25.5±15.4)mm;病灶形态以圆形或类圆形为主(80.8%),少数呈不规则形;边缘多光滑(88.5%);多数无分叶(73.1%);密度多均匀(88.5%),少数可见钙化(26.9%);强化可均匀、可不均匀(比例约1:1),平均增强程度约(41.1±27.4)HU;网格征(76.9%)及贴边血管征(38.4%)较多见。延时扫描表现为持续强化,灌注成像表现为高血流灌注。结论PSH具有肺内良性肿瘤的特点,明显强化、容易出现钙化、网格征、贴边血管征等征象,对诊断PSH具有重要提示意义。 相似文献