叶酸受体在中枢神经系统肿瘤中的研究进展

叶酸受体是一种锚着于膜上的糖蛋白,对叶酸具有高度亲和力,在正常组织分布较少,而在多种恶性肿瘤有过度表达,以叶酸受体为作用靶点,使药物与特异性配体结合即可将药物主动靶向肿瘤细胞.本文就叶酸和叶酸受体的组成、生物学特性、在中枢神经系统肿瘤中的分布特点,以及叶酸受体介导主动靶向肿瘤细胞治疗的研究进展进行综述.     

A bibliometric study of scientific literature on obesity research in PubMed (1988–2007)

This article describes a bibliometric review of the publications on obesity research in PubMed over the last 20 years. We used Medline via the PubMed online service of the US National Library of Medicine from 1988 to 2007. The search strategy was: ([obesity] in MesH). A total of 58 325 references were retrieved, 25.5% in 1988–1997, and 74.5% in 1998–2007. The growth in the number of publications showed an exponential increase. The references were published in 3613 different journals, with 20 journals contributing 25% of obesity literature. The two journals contributing most were the International Journal of Obesity (5.1%), Obesity‐Obesity Research (2.9%). North America and Europe were the most productive world areas with 44.1% and 37.9% of the literature, respectively. The US was the predominant country in number of publications, followed by the United Kingdom, Japan and Italy. The ranking of production changed when the number of publications was normalized by population, gross domestic product and obesity prevalence by countries. The great increase of publications on obesity during the period 1988–2007 was particularly evident in the second decade of the period which is concordant with the worldwide obesity epidemic. USA and Europe were leaders in the production of scientific articles on obesity.     

The Mixed Evidence for Brief Intervention in Emergency Departments,Trauma Care Centers,and Inpatient Hospital Settings: What Should We Do?

Background: This qualitative review is based on a symposia presented at the 2009 annual conference of the Research Society on Alcoholism (Baird et al., 2009; Field et al., 2009; Monti et al., 2009; Saitz et al., 2009a). The purpose is to describe the mixed evidence supporting brief interventions in the emergency department, trauma care, and in‐patient medical care settings; examine potential moderators of treatment outcome in light of the mixed evidence; and identify methods to move the research and practice of brief interventions beyond their current state. Methods: By drawing upon existing reviews and selected individual studies, we provide examples that reflect the current complexity of research in this area and propose steps for advancing the field. Results: Emergency departments, inpatient hospital settings, and trauma care settings represent three unique contexts within which brief interventions have been tested. While the general efficacy of brief alcohol interventions in these settings has been recognized, the evidence is increasingly mixed. Recent studies investigating potential moderators of treatment outcomes suggest that a more sophisticated approach to evaluating the effectiveness of brief interventions across varying patient populations is needed to further understand its effectiveness. Conclusions: Current dissemination efforts represent a significant advance in broadening the base of treatment for alcohol problems by providing an evidence‐based intervention in health care settings and should not be curtailed. However, additional research is required to enhance treatment outcomes, refine current practice guidelines, and continue to bridge the gap between science and practice. Given the current state of research, a multisetting clinical trial is recommended to account for potential contextual differences while controlling for study design.     

针灸防治缺血再灌注损伤机制的研究进展

综合介绍了近年来针灸在防治缺血再灌注损伤的研究进展,侧重从实验研究方向来提高机制认识水平,揭示针灸研究的科学性及有效性,推动针刺疗法的广泛应用,并为提高临床疗效服务。     

心肌细胞缺氧／复氧损伤模型研究与应用进展

心肌细胞缺氧,复氧损伤模型是体外筛选抗心肌缺血,再灌注损伤活性物质的模拟模型,有效建立该模型是筛选结果可靠的保证。本文从心肌细胞缺氧,复氧损伤模型建立的一般程序,心肌细胞种类的选择与培养,心肌细胞缺氧腹氧损伤模型建立的方法等方面就近年来国内外心肌细胞缺氧,复氧损伤模型的研究与应用情况进行了综述,并就模型建．立中需要注意的相关问题进行了探讨。为有效复制该模型提供参考。     

复旦大学医科图书馆文献传递统计分析及其启示

从文献文种、类型、年代、满足率、高频申请期刊等方面对复旦大学医科图书馆文献传递的数据统计进行了分析,从中得到的启示是重点建设外文期刊资源、加强灰色文献资源建设、补充高频申请资源,开展馆际协作,实现资源共建共享。     

加强图书馆信息服务，提高本科生毕业论文质量

分析了当前大学生毕业论文写作过程中存在的问题,指出图书馆参与指导大学生撰写毕业论文的优势,提出了培养大学生信息素养、建立协作配合的服务模式、提供知识服务和提高馆员素养等措施,以提高本科生毕业论文质量。     

医院图书馆员进行医学文献分析和评价的可行性

对医院图书馆员进行医学文献分析和评价的可行性进行了探讨,指出了其优势体现在可获得资源丰富、检索技巧熟练、时间充裕以及工作环境优越等方面,其劣势在于医学知识、医学英语水平和循证医学评价技能水平低。     

常用外文全文数据库的分析及其对药学文献信息资源建设的启示

通过对5种常用国外全文数据库进行了分析,探讨了其对药学文献信息资源建设的启示,以期对中国药学文献信息资源建设提供借鉴。     

基于文本挖掘的DNA微阵列表达数据方法研究

DNA微阵列技术是近年来发展起来的一种功能基因组学研究技术.利用DNA微阵列技术,可以从基因组水平上鉴定出相关的功能基因及其表达调控网络,有助于阐明这些基因的生物学功能及其机理.结合文本挖掘的相关研究结果.探讨了DNA微阵列技术的原理和特点,数据的分析和解释,基因的聚类方法和基于文献的DNA微阵列分析.通过基于文献的微阵列分析方法,找出隐舍的、具有语义关联的生物概念,并进行推理,发现隐性的新知识.具体阐述了基于统计、基于自然语言处理、基于关联规则挖掘,基于模式识别的4种分析方法.基于文本挖掘的DNA微阵列技术,有利于发现基因或蛋白质之间的相互作用关系,自动识别生物学名词,提高数据分析效率等.