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51.
《中国海洋药物》杂志刊载论文的引文分析 总被引:1,自引:0,他引:1
采用文献计量学方法,对1989年-1993年《中国海洋药物》杂志刊载论文的引文进行了分析。结果表明,此间共刊载论文181篇,共有引文1301条,每篇论文平均引文量为7.98条。自引率为12.76%,在全部引文中,期刊占65.10%,图书占27.60%,其中占7.30%;语种分布中文占65.72%,英文占29.13%,日文占5.07%,俄文占0.08%。10年文献累计利用率,中文为83.27%,外文 相似文献
52.
53.
江苏历代医家,医籍及其地域分布研究 总被引:1,自引:0,他引:1
顾奎兴 《南京中医药大学学报》1999,15(4):233-235
整理研究了江苏自后汉至民国的二千年间,见于著录的4150名医家和3715部医著的时代和地域分布,宋以后,尤其是明清时期,江南一带社会相对安定,封建朝廷南迁,为江苏的经济文化发展提供了历史机遇、也是江苏中医发展的极盛时期。这一时期涌现的医家、医籍分别占总数的98.6%、96.8%。说明了社会的稳定进步、生产力的发展提高、经济科技的繁荣发达是医学发展的基础和源泉。 相似文献
54.
Reid E 《Journal of neurology》1999,246(11):995-1003
The hereditary spastic paraplegias are a complex group of neurodegenerative conditions which are characterised by slowly
progressive lower limb spasticity. This article describes the main clinical features of pure and complicated hereditary spastic
paraplegias and summarises recent advances in our understanding of the molecular genetics of these conditions.
Received: 2 June 1999 Accepted: 7 August 1999 相似文献
55.
Genetic manipulation of mammary epithelium by transplantation 总被引:2,自引:0,他引:2
Genes can be introduced into mammary epitheliumin vivo by the tissue reconstitution method. Primary cultures of mammary epithelial cells are prepared, a gene introduced using retrovirus vectors, and the cells transplanted into a mammary fat pad from which the normal epithelium has been removed. The cells reform an epithelium in which some cells express the introduced gene. The technique is reviewed and compared with the mammary-specific expression of genes in transgenic mice. To model the development of neoplasia, particularly the preneoplastic changes caused by a single oncogene alone, several oncogenes have been expressed this way—myc, Ha-ras, erbB, erbB2,Wnt-1, andhst/FGF-4. Each caused a different alteration to the growth pattern of the epithelium, such as altered branching, premature alveolus development, distorted duct structure, or altered hormone sensitivity. Insights into normal development have also been obtained by inappropriate expression of genes such asWnt-4. 相似文献
56.
Spinal neurinomas and meningiomas in children 总被引:3,自引:0,他引:3
Summary The literature on spinal neurinomas (N) and meningiomas (M) in children is reviewed, and five personal cases of N are added (one in the context of Recklinghausen's disease). The cases of N totalled 151, and of M 69, accounting respectively for 10.9% and 4.3% of childhood spinal tumours and 2.6% and 1.3% of spinal N and M of all ages. Sixty-one cases of N (16 in the context of Recklinghausen's disease) and 26 cases of M (5 in the context of Recklinghausen's disease) are analyzed in detail. N occurs chiefly between ages 9 and 15 years, the sex ratio is 3 2, all levels of the spinal canal are equally affected, and extradural N or conditions with an extradural component (48%) are more frequent than in adults (26.9%). M occurs chiefly between 12 and 15 years, the sex ratio is 3 2, the prevalence of the thoracic segment (47.8%) is less marked than in adults (81%), and the frequency of the extradural site (10.6%) is close to the sum of the extradural and dumb-bell lesions in adults (11.1%). In children vertebral signs,i.e., spinal rigidity and tenderness, and spasm of paravertebral muscles, are more intense, earlier, and more frequent than in adults, and the clinical history is shorter. The chances of recovery from neurological deficits are greater, as are those of malignant degeneration. 相似文献
57.
Stubbs JH Haw CM Staley CJ Mountjoy CQ 《Acta psychiatrica Scandinavica》2000,102(5):390-3; discussion 393-4
OBJECTIVE: Schizophrenic patients who are only partially responsive to clozapine pose a therapeutic challenge. In these circumstances some clinicians would consider adding in a second antipsychotic. We present a case report and review evidence for the efficacy of such augmentation strategies. METHOD: Single case report and literature review. RESULTS: The total number of patients in studies and case reports of combining clozapine with other antipsychotics is small. There has been only one randomized controlled trial. This found the addition of sulpiride to clozapine resulted in clinical improvement in some patients. CONCLUSION: Further randomized controlled studies of augmentation of clozapine therapy are needed to provide scientific justification for this clinical practice. 相似文献
58.
59.
针刺对大脑功能的影响 总被引:1,自引:0,他引:1
本文综述了近10年应用电生理和影像方法研究针刺与大脑功能的文献,认为观察结果的多样性说明了针刺治疗的双向性。在今后的研究中,应综合运用多种方法,以准确阐明大脑在针刺后的时空变化。 相似文献
60.
神经肽对针灸免疫调节影响的研究进展 总被引:6,自引:1,他引:6
本文综述了阿片样肽9脑啡肽,内啡肽,强啡肽),P物质等神经肽类物质对针灸免疫调节作用的影响。神经肽在针灸免疫调节中的作用机制。提出今后应深入研究神经肽对于神经,内分泌,免疫等系统之间的相互作用。 相似文献