《中国海洋药物》杂志刊载论文的引文分析

采用文献计量学方法,对１９８９年－１９９３年《中国海洋药物》杂志刊载论文的引文进行了分析。结果表明,此间共刊载论文１８１篇,共有引文１３０１条,每篇论文平均引文量为７．９８条。自引率为１２．７６％,在全部引文中,期刊占６５．１０％,图书占２７．６０％,其中占７．３０％;语种分布中文占６５．７２％,英文占２９．１３％,日文占５．０７％,俄文占０．０８％。１０年文献累计利用率,中文为８３．２７％,外文     

江苏历代医家,医籍及其地域分布研究

整理研究了江苏自后汉至民国的二千年间,见于著录的４１５０名医家和３７１５部医著的时代和地域分布,宋以后,尤其是明清时期,江南一带社会相对安定,封建朝廷南迁,为江苏的经济文化发展提供了历史机遇、也是江苏中医发展的极盛时期。这一时期涌现的医家、医籍分别占总数的９８．６％、９６．８％。说明了社会的稳定进步、生产力的发展提高、经济科技的繁荣发达是医学发展的基础和源泉。     

The hereditary spastic paraplegias

The hereditary spastic paraplegias are a complex group of neurodegenerative conditions which are characterised by slowly progressive lower limb spasticity. This article describes the main clinical features of pure and complicated hereditary spastic paraplegias and summarises recent advances in our understanding of the molecular genetics of these conditions. Received: 2 June 1999 Accepted: 7 August 1999     

Genetic manipulation of mammary epithelium by transplantation

Genes can be introduced into mammary epitheliumin vivo by the tissue reconstitution method. Primary cultures of mammary epithelial cells are prepared, a gene introduced using retrovirus vectors, and the cells transplanted into a mammary fat pad from which the normal epithelium has been removed. The cells reform an epithelium in which some cells express the introduced gene. The technique is reviewed and compared with the mammary-specific expression of genes in transgenic mice. To model the development of neoplasia, particularly the preneoplastic changes caused by a single oncogene alone, several oncogenes have been expressed this way—myc, Ha-ras, erbB, erbB2,Wnt-1, andhst/FGF-4. Each caused a different alteration to the growth pattern of the epithelium, such as altered branching, premature alveolus development, distorted duct structure, or altered hormone sensitivity. Insights into normal development have also been obtained by inappropriate expression of genes such asWnt-4.     

Spinal neurinomas and meningiomas in children

Summary The literature on spinal neurinomas (N) and meningiomas (M) in children is reviewed, and five personal cases of N are added (one in the context of Recklinghausen's disease). The cases of N totalled 151, and of M 69, accounting respectively for 10.9% and 4.3% of childhood spinal tumours and 2.6% and 1.3% of spinal N and M of all ages. Sixty-one cases of N (16 in the context of Recklinghausen's disease) and 26 cases of M (5 in the context of Recklinghausen's disease) are analyzed in detail. N occurs chiefly between ages 9 and 15 years, the sex ratio is 3 2, all levels of the spinal canal are equally affected, and extradural N or conditions with an extradural component (48%) are more frequent than in adults (26.9%). M occurs chiefly between 12 and 15 years, the sex ratio is 3 2, the prevalence of the thoracic segment (47.8%) is less marked than in adults (81%), and the frequency of the extradural site (10.6%) is close to the sum of the extradural and dumb-bell lesions in adults (11.1%). In children vertebral signs,i.e., spinal rigidity and tenderness, and spasm of paravertebral muscles, are more intense, earlier, and more frequent than in adults, and the clinical history is shorter. The chances of recovery from neurological deficits are greater, as are those of malignant degeneration.     

Augmentation with sulpiride for a schizophrenic patient partially responsive to clozapine

OBJECTIVE: Schizophrenic patients who are only partially responsive to clozapine pose a therapeutic challenge. In these circumstances some clinicians would consider adding in a second antipsychotic. We present a case report and review evidence for the efficacy of such augmentation strategies. METHOD: Single case report and literature review. RESULTS: The total number of patients in studies and case reports of combining clozapine with other antipsychotics is small. There has been only one randomized controlled trial. This found the addition of sulpiride to clozapine resulted in clinical improvement in some patients. CONCLUSION: Further randomized controlled studies of augmentation of clozapine therapy are needed to provide scientific justification for this clinical practice.     

针刺的中枢调节机制研究进展

针刺作为一种有效的辅助治疗手段已被广泛应用于临床。近年来对针刺的镇痛作用及对功能性疾病的调节作用研究颇多 ,除应用传统电生理学方法外 ,还采用了分子生物学、免疫组织化学、脑功能成像等先进的技术来探讨针刺对脑的经典神经递质、神经激素、神经元代谢等的影响 ,为针刺的中枢调节机制提供了理论基础。本文主要就针刺的中枢作用及方法学等方面加以讨论     

纳米药物的研究现况

纳米药物具有特异性、靶向性、定量准确、易吸收等特点。本从纳米药物的口服制剂、自乳化释药系统、中枢神经给药系统、基因治疗等方面，阐述了纳米药物的最新研究动态和发展趋向。     

黄芪注射液临床应用进展

目的：对黄芪注射液临床应用及其疗效进行综述。方法：通过查阅近期国内部分期刊杂志，对黄芪注射液在肺心病、老年肺结核、脑中风、冠心病、流行性出血热、病毒性心肌炎、甲亢、肝病及肾病等临床应用新进展进行综述。结果：黄芪注射液辅助治疗上述疾病疗效满意。结论：黄芪注射液是治疗心脑血管疾病、肾病、肝病等的有效药物。