首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   280篇
  免费   3篇
  国内免费   2篇
儿科学   1篇
妇产科学   2篇
基础医学   9篇
口腔科学   5篇
临床医学   26篇
内科学   86篇
皮肤病学   1篇
神经病学   14篇
外科学   8篇
综合类   17篇
预防医学   16篇
药学   76篇
中国医学   2篇
肿瘤学   22篇
  2023年   10篇
  2022年   37篇
  2021年   29篇
  2020年   23篇
  2019年   31篇
  2018年   18篇
  2017年   19篇
  2016年   17篇
  2015年   5篇
  2014年   19篇
  2013年   12篇
  2012年   11篇
  2011年   10篇
  2010年   4篇
  2009年   9篇
  2008年   3篇
  2007年   6篇
  2006年   3篇
  2005年   2篇
  2004年   4篇
  2003年   2篇
  2001年   5篇
  1999年   3篇
  1998年   2篇
  1996年   1篇
排序方式: 共有285条查询结果,搜索用时 31 毫秒
81.
82.
《REV BRAS REUMATOL》2014,54(2):152-154
A rheumatoid arthritis patient was treated for two years with methotrexate and lefluno- mide combination therapy. The evolution was uneventful until she had clopidogrel, simv- astatin, isosorbide, aspirin and omeprazole added to medication due to acute myocardial infarction. Four weeks after this, she was hospitalized with severe leukopenia.  相似文献   
83.
84.
The increasing challenge of multiple chronic diseases (multimorbidity) requires more evidence-based knowledge and effective practice. In order to better understand the existing evidence on multimorbidity, we performed a systematic review of systematic reviews on multimorbidity with pre-established search strategies and exclusion criteria by searching multiple databases and grey literature. Of 8006 articles found, 53 systematic reviews (including meta-analysis and qualitative research synthesis performed in some reviews) that stated multimorbidity as the main focus were included, with 79% published during 2013–2016. Existing evidence on definition, measurement, prevalence, risk factors, health outcomes, clinical practice and medication (polypharmacy), and intervention and management were identified and synthesised. There were three major definitions from three perspectives. Seven studies on prevalence reported a range from 3.5% to 100%. As six studies showed, depression, hypertension, diabetes, arthritis, asthma, and osteoarthritis were prone to be comorbid with other conditions. Four groups of risk factors and eight multimorbidity associated outcomes were explored by five and six studies, respectively. Nine studies evaluated interventions, which could be categorized into either organizational or patient-oriented, the effects of these interventions were varied. Self-management process, priority setting and decision making in multimorbidity were synthesised by evidence from 4 qualitative systematic reviews. We were unable to draw solid conclusions from this overview due to the heterogeneity in methodology and inconsistent findings among included reviews. As suggested by all included studies, there is a need for prospective research, especially longitudinal cohort studies and randomized control trials, to provide more definitive evidence on multimorbidity.  相似文献   
85.
The association between drugs and falls has been widely studied in the past 3 decades, with increasingly robust evidence of a causal link. Both specific classes of drugs and the total number of drugs taken are associated with falls. This review examines some of the reasons why older people are at greater risk of drug-related adverse events such as falls. We discuss the role of drugs in general and polypharmacy (the concurrent use of multiple drugs) on the risk of falling, with a focus on community-dwelling older people. We critically appraise the evidence that specific classes of drugs, such as benzodiazepines and antidepressants, increase the risk of falling and that falls can be prevented through interventions that target medications.  相似文献   
86.
BACKGROUND AND AIM: Antiepileptic drugs are associated with bone loss and fractures. Data in children is scarce and the impact of new therapies and of low vitamin D is not clear. This study assessed predictors of bone mineral density (BMD) in 225 ambulatory patients with epilepsy. METHODS: BMD and detailed clinical information were obtained from 137 adults mean age of 31 years, on therapy for a mean of 11.7 years, and 88 children mean age of 13 years, on therapy for an average of 4.7 years. RESULTS: Hypovitaminosis D was common in epileptic patients. BMD was reduced in adults but not children with epilepsy, by 0.3-0.6 SD depending on the skeletal site measured, compared to controls. Duration of treatment, but not vitamin D levels, was negatively correlated with BMD at the hip in adults. Bone density was reduced with the use of both enzyme and non-enzyme-inducing drugs, with both mono- and polytherapy, and was most severely reduced at the spine and hip with the use of enzyme-inducing drugs. In the multivariate analyses, polytherapy in children and duration of therapy and enzyme-inducing drugs in adults were independent predictors of BMD. CONCLUSION: Antiepileptic drug therapy is associated with low bone density at clinically relevant skeletal sites, projecting into a possible doubling of fracture risk. Age, therapy duration, polypharmacy and the use of enzyme-inducing drugs were risk factors. Newer drugs may be associated with deleterious effects on bone. Skeletal monitoring with varying intervals, depending on the individual risk profile, is indicated.  相似文献   
87.
Falls are a common and serious problem for older adults. This article reviews practical aspects of the evaluation and management of this disorder in the ambulatory setting. Older patients should be screened for falls or changes in mobility as part of their annual health maintenance examination. Most falls are due to multiple factors, including disorders of gait, balance, strength, and vision. Polypharmacy and certain medications contribute to falls in many patients and can be a remediable factor. Many falls can be prevented through individualized multicomponent interventions. Exercise programs, rehabilitation, medication management, and treatment of vitamin D deficiency are the most effective single interventions. Referral to a geriatrician should be considered for patients with other common geriatric syndromes, such as cognitive impairment, incontinence, or depression.  相似文献   
88.
89.
Purpose  To evaluate the effect of a combined or a single educational intervention on the prescribing behaviour of general practitioners (GPs). The primary endpoint was effect on inappropriate prescribing according to the Medication Appropriateness Index (MAI). Methods  General practitioners were randomised to either (1) a combined intervention consisting of an interactive educational meeting plus feedback on participating patients’ medication, (2) a single intervention with an interactive educational meeting or (3) a control group (no intervention). Elderly (>65 years) patients exposed to polypharmacy (≥5 medications) were identified and approached for inclusion. Data on medications prescribed over a 3-month period were collected, and the GPs provided detailed information on their patients before and after the intervention. A pre- and post-MAI were scored for all medications. Results  Of the 277 GPs invited to participate; 41 (14.8%) volunteered. Data were obtained from 166 patients before and after the intervention. Medication appropriateness improved in the combined intervention group but not in the single intervention group. The mean change in MAI and number of medications was −5 [95% confidence interval (CI) −7.3 to −2.6] and −1.03 (95% CI −1.7 to −0.30) in the combined intervention group compared with the group with the educational meeting only and the no intervention group. Conclusions  A combined intervention consisting of an interactive educational meeting plus recommendations given by clinical pharmacologists/pharmacists concerning specific patients can improve the appropriateness of prescribing among elderly patients exposed to polypharmacy. This study adds to the limited number of well-controlled, randomised studies on overall medication appropriateness among elderly patients in primary care. Important limitations to the study include variability in data provided by participating GPs and a low number of GPs volunteering for the study. The trial is not registered in a publicly available database of clinical trials. The trial was conducted in a period prior to June 1, 2007.  相似文献   
90.
目的 分析住院精神分裂症患者抗精神病药物联合治疗率及影响因素.方法 调查1986,1996,2001和2006年4个年份在唐山市6所精神病院出院精神分裂症患者的住院病历,用专门设计的调查表记录患者的社会人口学资料、疾病特征以及患者出院时药物治疗信息.结果 4个年份住院精神分裂症患者出院时抗精神病药物联合治疗率分别为13.2%、18.1%、32.7%和28.9%,差异有显著性(x2=76.431,df=1,P<0.01;趋势卡方检验x2=25.542,df=1,P<0.01);多因素分析表明患者的病程(<18月∶OR=0.686,95%CI∶0.528~0.893,ref:>100月),住院次数(OR=1.117,95%CI∶1.037~1.203),就诊医院(市级A医院:OR=0.736,95%CI∶0.562~0.964;市级B医院∶OR=0.377,95%CI∶0.293~0.486;市级C医院:OR=1.803,95%CI∶1.279~2.540,ref:县级医院)、以及出院年份(1986∶OR=0.421,95%CI∶0.298~0.595;1996∶OR=0.590,95%CI∶0.456~0.764;2001∶OR=1.249,95%CI∶1.023~1.524,ref∶2006)与接受抗精神病药物联合治疗有关.结论 唐山地区住院精神分裂症患者联合抗精神病药物治疗的比例呈上升趋势,抗精神病药物联合治疗率存在医院差别,患者的发病年龄、病程、住院时间和住院次数与抗精神病药物联合治疗有关.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号