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51.
复方红芪减方对周围神经再生影响的实验研究 总被引:4,自引:2,他引:2
目的 研究复方红芪提取液进行减方后对周围神经再生的作用。方法 建立钳夹损伤大鼠双侧坐骨神经的动物模型。按术后每日灌服药物的不同将 40只SD雄性大鼠随机均分为 4组。对照组 :灌服生理盐水 ;复方红芪组 :灌服复方红芪提取液 2ml ;减方组 :灌服复方红芪减方后提取液 2ml;补阳还五汤组 :灌服补阳还五汤 2ml。术后 2周及 4周 ,观察坐骨神经功能指数、运动神经传导速度及单位视野有髓神经纤维计数。结果 坐骨神经功能指数 :红芪组和减方组与对照组、红芪组与减方组的差异均有显著意义 (P >0 .0 5 ) ,且减方组优于红芪组 (P >0 .0 5 )。有髓神经纤维计数 :复方红芪组优于对照组 (P<0 0 1) ,减方组明显优于对照组 (P <0 .0 1) ,而红芪组与减方组间无显著差异。运动神经传导速度 :红芪组、减方组、补阳还五汤组与对照组相比 ,均优于对照组 (P <0 .0 5 ) ,但前 3组间无明显差异。结论 复方红芪减方提取液早期可以促进周围神经再生 ,药效更为专一 ,且优于传统方剂补阳还五汤。 相似文献
52.
The number of colony-forming cells (CFC) in the peripheral blood (PB) of 43 volunteers was examined using a semisolid clonogenic
culture assay. In all, 22 male (age 21–39 years) and 21 female individuals (age 21–39 years) were tested, ten of each group
twice to examine the intraindividual variability of colony-forming cells in PB. A statistically significant sex difference
in the number of CFC, erythroblastic colonies (BFU-E), and granulocyte/macrophage colonies (CFU-GM) in PB was detected in
favor of male individuals. No significant difference between female and male PB was found for the number of CFU-GEMM. The
intraindividual variability of CFC and BFU-E was significantly higher in female donors. These results support previous reports
by others on a potential influence of sex steroids on hematopoiesis.
Received: 8 November 1996 / Accepted: 4 April 1997 相似文献
53.
We present an atypical case of peripheral nervous system (PNS) involvement in Sjogren's syndrome in a 63 year-old woman. Symptoms of an entrapment neuropathy were the first manifestation of the systemic disease and they were subsequently coupled to those of a mononeuritis multiplex. Clinical and laboratory signs for the diagnosis of Sjogren's syndrome became subsequently overt. The mononeuritis multiplex remained clinically limited to the upper limbs and characterized by unusually severe motor symptoms which progressed up to the development of a final complete deplegia. By contrast, sensory symptoms at the upper limbs remained mild over the entire course of the disease and the lower limbs revealed a subclinical sensory-motor damage only during the late stage. 相似文献
54.
我院自1998年6月-2000年9月间,用硅胶管套接法治疗10例陈旧性周围神经损伤患者,取得满意疗效,现报告如下.…… 相似文献
55.
56.
异体硬脊膜桥接周围神经缺损的实验研究 总被引:6,自引:1,他引:5
探讨异体硬脊膜修复周围神经缺损的可行性。方法:采用狗的异体硬脊膜桥接缺损2cm的狗腓总神经,对照组仅切取2cm神经而不作处理。在术后不同时间段作大体观察、神经电生理检测、光镜利电镜检查。结果:再生神经纤维在管腔内呈纵行整齐排列T偕窬宋峤岣弧=崧郏菏5验结果证实异体硬脊膜能成功地引导周围神经再生。 相似文献
57.
Peripheral blood CD3 and CD4 T-lymphocyte reduction correlates with severity of liver cirrhosis 总被引:2,自引:0,他引:2
L. Lombardo A. Capaldi G. Poccardi P. Vineis 《International Journal of Clinical & Laboratory Research》1995,25(3):153-156
Summary Immunological disturbances with impairment of immune function and a higher incidence of lymphoproliferative disorders and
other malignancies have been described in liver cirrhosis patients. To investigate the pathogenetic mechanism(s) involved
in such associated we looked for a possible imbalance in peripheral blood T-lymphocyte subpopulations in patients with liver
cirrhosis of differing severity. Immunophenotyping and counts of peripheral blood T-lymphocyte subpopulations were carried
out using monoclonal antibodies conjugated with different fluorochromes in 31 consecutive cirrhotic patients and 23 matched
healthy volunteers. Univariate and multivariate analyses of lymphocyte phenotype counts were performed and odds ratios were
computed. Statistically significant associations, according to both univariate and multivariate analyses, were found between
case/control status and mean CD3 and CD4 T-lymphocyte counts (P<0.0001). A strong correlation was found between the Pugh’s index and CD3 and CD4 lymphocyte counts, with a clear reduction
of these phenotypes with increasing liver cirrhosis. Median CD3 and CD4 values were 2,283 and 1,329/μl respectively among
controls and 896, 801, and 492/μl and 515, 514, and 307/μl, respectively in categories A, B, and C of Pugh’s classification.
Very high odds ratios were found using the median values of CD3 and CD4 as a threshold. There was a statistically significant
decrease for each of the T-cell phenotypes studied (CD2, CD3, CD4, CD8, CD16, CD19, CD20, CD56, CD57) between patients and
controls (P<0.0001). The progressive and severity-related decrease in mean peripheral blood CD3 and CD4 counts in liver cirrhosis suggests
a progressive impairment of protective immune function and may be a factor facilitating malignancy in cirrhotic patients. 相似文献
58.
Demetrius Moskophidis Elisabeth Laine Rolf M. Zinkernagel 《European journal of immunology》1993,23(12):3306-3311
Antiviral cytotoxic memory CD8+ T cells adoptively transferred to mice which are persistently infected with lymphocytic choriomeningitis virus WE or DOCILE initially proliferated extensively; they either caused the death of the recipient or, alternatively, disappeared within a few days. Apparently, the complete and coordinated induction and stimulation by widely distributed viral antigen caused these memory T cells to die before virus had been eliminated from the host. Thus memory T cells are as susceptible to peripheral exhaustion/deletion as unprimed T cells. These results indicate possible limitations of exclusively CD8+ T cell-mediated adoptive immunotherapy against viral infections or tumors. 相似文献
59.
预变神经段修复神经缺损的实验研究 总被引:5,自引:2,他引:3
目的探讨不同预变时间组移植神经对神经再生的影响。方法以SD大鼠的不同预变时间组的尺神经作为移植神经,修复其正中神经的缺损。实验侧按移植神经预变时间的不同分为0、1、2、3、4、8周共6组,每组6只SD大鼠。移植后12周,检测实验侧趾屈肌群的张力、最大收缩力、再生神经的形态及神经轴突的截面积。结果用预变1周的尺神经修复正中神经后,其趾屈肌群的张力及最大收缩力的恢复率达到正常对照组的81.1%及85.9%。显微镜下观察,预变1周组和其它各时间组相比,其再生的神经轴突最多,发育最成熟。结论用预变1周的神经段修复神经缺损,其神经再生能力最佳 相似文献
60.
肾病患儿免疫细胞对肾小球上皮细胞合成基质的影响 总被引:1,自引:0,他引:1
目的为了明确免疫细胞对肾小球上皮细胞(glomerularepithelialcelGEC)合成功能的直接作用。方法应用肾小球细胞体外培养,同位素掺入及放射免疫技术,以总胶原,层粘连蛋白,Ⅲ型前胶原及Ⅳ型胶原的合成为观察指标,动态研究了不同病理类型原发性肾病综合征(INS)患儿外周血单个核细胞(peripheralbloodmononuclearcelPBMC)对GEC生物功能的影响。结果(1)肾病极期未经激素治疗组(未治组)PBMC上清明显促进了GEC合成层粘连蛋白;(2)未治PBMC上清抑制了GEC合成总胶原;(3)未治组PBMC上清促进了Ⅲ型前胶原的合成,而对Ⅳ型胶原的合成无明显影响;(4)肾病患儿PBMC的上述作用与是否足量激素治疗有关,而与尿蛋白能否阴转、肾组织病理类型、肾病临床类型等无直线相关关系。结论原发性肾病患儿循环免疫细胞可影响GEC合成细胞外基质的功能。免疫细胞的这种活性可被激素治疗改变。 相似文献