西洋参根中4-羟基-3-甲氧基-苯甲醛的分离鉴定

 目的对西洋参(Panax quinquefolius L.)进行化学成分研究。方法利用D101大孔树脂吸附-低压硅胶干柱色谱对西洋参醇提液进行分离,根据化合物的理化性质和光谱数据鉴定其结构。结果从西洋参(Panax quinquefolius L.)根中分离得到一个化合物,经核磁、质谱、紫外和红外光谱法鉴定为4-羟基-3-甲氧基苯甲醛。结论首次从西洋参根中分离得到4-羟基-3-甲氧基苯甲醛,其为镇静抗惊厥药物。     

4种治疗脑梗死药物的成本-效果分析

目的对三七总苷、巴曲酶、尿激酶、奥扎格雷等4种药物治疗急性脑梗死进行成本 效果分析。方法将110例脑梗死患者分为A、B、C、D 4组，分别应用三七总苷、巴曲酶、尿激酶、奥扎格雷等4种药物治疗。运用药物经济学比较其成本 效果。 结果4种方案成本分别为587.72，2 498.401，4 060.00和2 839.20元。有效率分别为61.54%，92.86%，96.30%和93.10%。在方案A的基础上每再获得1个单位效果，方案B、C、D所需追加的成本依次为61.01，99.89和71.34元。结论采用巴曲酶治疗急性脑梗死为最佳方案。     

三七中黄酮成分的含量测定

目的 考察不同产地，不同规格，不同采收期三七中的黄酮含量的变化规律。为三七的质量评价提供依据。方法 采用紫外分光光度法，在249nm处测定槲皮素的量。结果 不同产地，不同采收期和不同规格的三七中黄酮含量有明显差异。结论 产地，采收期和规格对三七黄酮含量具有重要影响。     

西洋参经验鉴别的体验与探讨

西洋参经验鉴别是判断 其优劣，区分真伪的有效而简便的方法。通过研究西洋参经验鉴别的文献，西洋参种植、采收、加工和干燥过程对其质量的影响，总结多年来西洋参鉴别的工作经验，对西洋参药材在形体、质量、表面纹理、横断切面及滋味气味等层面，提出一些西洋参经验鉴别的观点。     

西洋参喷施ABT生根粉增产试验

西洋参喷施ＡＢＴ生根粉能够促进生长发育，茎高、茎粗、叶长、叶宽都有明显增长，且减少发病率，叶绿素含量提高２．２７％。参根单产提高３１．５１％。     

血塞通分散片对大鼠急性心肌缺血的保护作用

目的：观察血塞通分散片对急性心肌缺血的保护作用。方法：采用结扎大鼠冠状动脉左前降支造成急性心肌缺血的模型，通过观察体表心电图以及对心肌梗死范围、血清超氧化物歧化酶、丙二醛、乳酸脱氢酶、肌酸激酶、游离脂肪酸含量的测定，探讨血塞通分散片对心肌缺血的保护作用。结果：血塞通分散片25mg／kg、50mg／kg、100mg／kg对大鼠急性心肌缺血有不同程度的保护作用。100mg／kg能显著减少30min后的缺血性心电图中ST段异常上移；50mg／kg和100mg／kg均能显著缩小心肌梗死的范围，并明显增加血清超氧化物歧化酶的含量和减少血清中肌酸激酶的含量；100mg／kg能显著降低血清乳酸脱氢酶水平；3个剂量都能使血清丙二醛和游离脂肪酸水平下降。结论：血塞通分散片对急性心肌缺血有保护作用，其机制可能与其抑制心肌脂质过氧化损伤有关。     

人参,西洋参及三七总皂甙对大鼠血小板功能及血栓形成的抑制作用

体外试验表明人参总甙(SPG),西洋参总甙(SPQ)和三七总甙(SPNG)均能抑制胶原诱导的大鼠血小板聚集,其IC_(50)分别为0.583,1.012及0.815mg·ml~(-1),对胶原诱导引起的血小板5-HT释放,在0.5mg·ml~(-1)时,SPG,SPQ及SPNG的抑制率分别为20％,4％及16％,对血小板内cAMP含量,在35mg·kg~(-1)iv后,SPG,SPQ及SPNG均能使其显著增加.体内试验,对大鼠的实验性血栓,SPNG在80mg·kg~1 ig 1.5～2 h后有显著的抑制作用,但同样剂量的SPG无效Rg_1 20mg·kg~1 ig能显著抑制血栓形成,iv能显著抑制凝血酶所致DIC的血小板数目减少,FDP的增加,但对纤维蛋白原,凝血酶原时间的改变则无明显的拮抗作用。     

根腐对三七的皂苷含量影响

目的:对比分析根腐三七与正常三七中总皂苷及R1、Rg1、Rb1三种单体的含量,为根腐三七的质量评价及利用提供依据.方法:同田对比正常三七、根腐三七及不同腐烂程度三七的皂苷含量与单体成分,用HPLC法测定单体皂苷含量,大孔吸附树脂吸附比色法测定总皂苷含量.结果:三七根腐后比正常三七总皂苷含量平均降低了30.88%,R1、Rg1、Rb1三种单体平均含量分别降低了25.53%、11.26%、17.82%.结论:三七的皂苷含量随根部腐烂程度的增加而减少,根部腐烂对R1、Rg1、Rb1三种单体皂苷的比例无显著影响.     

Ginsenoside RB<Subscript>1</Subscript> the anti-ulcer constituent from the head of<Emphasis Type="Italic">Panax ginseng</Emphasis>

We previously reported that the butanol (BuOH) fraction of the head of Panax ginseng exhibited gastroprotective activity in peptic and chronic ulcer models. In order to identify the active constituent, an activity-guided isolation of the BuOH faction was conducted with a HCl x ethanol-induced gastric lesion model. The BuOH fraction was passed through a silica-gel column using a chloroform-methanol gradient solvent system, and six fractions (frs. 1-6) were obtained. The active fr. 5 was further separated by silica-gel column, to yield 6 subfractions (subfrs. a-f). Subfr. d was composed of ginsenosides Re, Rc and Rb1. The most active constituent was ginsenoside Rb1 (GRb1), a protopanaxadiol glycoside, which was investigated for its anti-ulcer effect. Gastric injury induced by HCl x ethanol, indomethacin and pyloric ligation (Shay ulcer) was apparently reduced with oral GRb1 doses of 150 and 300 mg/kg. GRb1 at these dosage significantly increased the amount of mucus secretion in an ethanol-induced model. The anti-ulcer effects were consistent with the result of histological examination. These results suggest that the major active constituent in the head of Panax ginseng is GRb1, and that anti-ulcer effect is produced through an increase in mucus secretion.     

Promotion of hair growth by ginseng radix on cultured mouse vibrissal hair follicles

A 70% methanol extract from red ginseng (steamed and dried roots of Panax ginseng C. A. Meyer, a kind of Ginseng Radix) had superior activity to that of white ginseng (peeled and dried root of P. ginseng, another kind of Ginseng Radix) in a hair growth promoting assay using mouse vibrissal follicles in organ culture. Of the major constituents of P. ginseng, ginsenoside-Rb(1) (G-Rb(1)) exhibited activity, but ginsenoside-Rg(1) (G-Rg(1)) and -Ro (G-Ro) were ineffective. Additionally, 20(S)-ginsenoside-Rg(3) (20(S)-G-Rg(3)) formed by the processing of red ginseng from the crude root of P. ginseng also showed hair growth promoting activity. These results indicate that Ginseng Radix possesses hair growth promoting activity, and its bioactive components are partially attributable to the ginseng saponin components mentioned above.