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101.
Colin M. Bosma Nashwa Mansoor Chiara S. Haller 《Archives of physical medicine and rehabilitation》2018,99(8):1576-1583
Objective
To investigate the relation between posttraumatic stress (PTS) symptom severity and health-related quality of life (HRQoL) after severe traumatic brain injury (TBI).Design
Longitudinal prospective multicenter, cohort study on severe TBI in Switzerland (2007–2011).Setting
Hospital, rehabilitation unit, and/or patient’s living facility.Participants
Patients with severe TBI (N=109) were included in the analyses. Injury severity was determined using the Abbreviated Injury Score of the head region after clinical assessment and initial computed tomography scan.Interventions
Not applicable.Main Outcome Measures
HRQoL (Medical Outcomes Study 12-Item Short-Form Health Survey Physical and Mental Component Summaries) and self-reported emotional, cognitive, and interpersonal functioning (Patient Competency Rating Scale for Neurorehabilitation).Results
Multilevel models for patients >50 and ≤50 years of age revealed significant negative associations between PTS symptom severity and interpersonal functioning (P<.001 and P=.002), respectively. Among patients ≤50 years of age, PTS symptom severity was significantly associated with total functioning (P=.001) and emotional functioning (P<.001). Among all patients, PTS symptom severity was significantly associated with cognitive functioning (P<.001) and mental HRQoL (P=.01).Conclusions
Findings indicate that PTS symptoms after severe TBI are negatively associated with HRQoL and emotional, cognitive, and interpersonal functioning. 相似文献102.
BACKGROUND: The time course of changes in health-related quality of life (HRQOL) following discharge from the ICU and during a general ward stay has not been studied. We therefore studied the immediate impact of critical illness on HRQOL and its recovery over time. METHODS: In a prospective study, all patients admitted to the ICU for > 48 h who ultimately survived to follow-up at 6 months were included. The Medical Outcomes Study 36-item short form was used to measure HRQOL before ICU admission, at discharge from the ICU and hospital, and at 3 and 6 months following discharge from the ICU and hospital. An age-matched healthy Dutch population was used as a reference. RESULTS: Of the 451 included patients, 252 could be evaluated at 6 months (40 were lost to follow-up, and 159 died). Pre-ICU admission HRQOL in survivors was significantly worse compared to the healthy population. Patients who died between ICU admission and long-term follow-up had significantly worse HRQOL in all dimensions already at ICU admission when compared to the long-term survivors. HRQOL decreased in all dimensions (p < 0.001) during ICU stay followed by a rapid improvement during hospital stay, gradually improving to near pre-ICU admission HRQOL at 6 months following ICU discharge. Physical functioning (PF), general health (GH), and social functioning (SF) remained significantly lower than pre-ICU admission values. Compared to the healthy Dutch population, ICU survivors had significantly lower HRQOL 6 months following ICU discharge (except for the bodily pain score). CONCLUSIONS: A sharp multidimensional decline in HRQOL occurs during ICU admission where recovery already starts following ICU discharge to the general ward. Recovery is incomplete for PF, GH, and SF when compared to baseline values and the healthy population. 相似文献
103.
Monia Garofolo Eleonora Russo Roberto Miccoli Daniela Lucchesi Laura Giusti Veronica Sancho-Bornez Giuseppe Daniele Stefano Del Prato Giuseppe Penno 《Journal of diabetes and its complications》2018,32(6):550-557
Aims
Albuminuric and non-albuminuric phenotypes of chronic kidney disease (CKD) may have different cardiovascular risk and survival in type 1 diabetes (T1DM). Herein we estimated risk of major vascular outcomes by the EURODIAB PCS score and determined all-cause mortality rate in 774 T1DM according to CKD phenotypes.Methods
We evaluated the distribution of CKD phenotypes [no CKD, stages 1–2, non-albuminuric stage ≥3 (Alb?CKD), albuminuric stage ≥3 (Alb+CKD)], the EURODIAB risk score for major vascular outcomes [low- (LS), intermediate- (IS), and high- (HS) risk] and all-cause mortality over a follow-up of 8.25?±?2.34?years.Results
Out of 774 subjects, 692 (89.4%) had no CKD, 53 (6.8%) CKD stages 1–2, 17 (2.2%) Alb?CKD and 12 (1.6%) Alb+CKD; 466 (60.2%) had LS, 205 (26.5%) IS and 103 (13.3%) HS. Distribution of HS was: no CKD, 9.1%; CKD stages 1–2, 34.0%; Alb?CKD, 64.7%; Alb+CKD, 91.7% (P?<?0.0001). Mortality increased from no CKD, 3.0%; to stages 1–2, 15.1% (HR 4.504); Alb?CKD, 29.4% (8.573); Alb+CKD, 50.0% (20.683, P?<?0.0001). Accounting for age and sex, HRs for mortality compared to no CKD were: CKD stages 1–2, 3.84 (P?=?0.001); Alb?CKD, 2.97 (P?=?0.046); Alb+CKD, 7.44 (P?<?0.0001). Adjusting for sex and the EURODIAB score, HRs for mortality compared to no CKD were: CKD stages 1–2, 2.57 (P?=?0.027); Alb?CKD, 2.77 (P?=?0.058); Alb+CKD, 4.58 (P?=?0.003).Conclusions
In our T1DM cohort, one fifth of those with CKDs were non-albuminuric. This phenotype was associated with higher risk of major outcomes and similar rate of mortality as compared to CKD stages 1–2. The greatest risk and highest mortality occur in patients with Alb+CKD. 相似文献104.
105.
目的探讨后路单开门颈椎管扩大椎板成形术治疗颈椎后纵韧带骨化症患者的临床效果.方法将200例颈椎后纵韧带骨化症患者,根据手术方法不同分为研究组与对照组,每组100例,分别予以后路单开门椎管扩大成形术及前路椎体次全切减压融合术,术后观察12个月.于术前及术后1个月、12个月采用日本矫形外科协会评分系统评定神经功能,采用视觉模拟疼痛评分法评定疼痛状况;比较两组颈椎矢状位参数、颈椎脊髓整体后移距离、脊髓前缘后移距离、脊髓膨胀度.结果(1)术后1个月、12个月两组日本矫形外科协会评分系统评分均显著高于术前(P<0.01),视觉模拟疼痛评分法评分均显著低于术前(P<0.01);术前及术后1个月、12个月两组日本矫形外科协会评分系统、视觉模拟疼痛评分法评分比较差异均无统计学意义(P>0.05).(2)术后12个月两组颈椎矢状面轴向距离均较术前显著增大(P<0.01);术前及术后12个月两组颈椎Cobb角、颈椎矢状面轴向距离比较差异均无统计学意义(P>0.05).(3)术后12个月研究组颈椎脊髓整体后移距离为(2.21±0.54)mm、脊髓前缘后移距离为(1.85±0.37)mm,脊髓膨胀度测定值显著大于对照组(P<0.01).结论后路单开门颈椎管扩大椎板成形术治疗颈椎后纵韧带骨化症患者临床效果显著,对患者的颈椎脊髓整体后移距离、脊髓前缘后移距离、脊髓膨胀度的改善作用显著优于前路椎体次全切减压融合术. 相似文献
106.
107.
108.
目的探讨胆囊切除术后综合征(PCS)预防与临床因素的关系。方法对我院2000年1月~2009年1月收治的68例高度怀疑胆囊切除术后综合征患者的资料进行回顾性分析。结果经过CT、B超、胃镜、肝功能等查因分析,证实30例为PCS,主要与急性炎症期手术、术式选择不当、术前病程过长等因素相关;其余38例患者虽然出现PCS相同的症状,但与胆囊切除无关,不能诊断为PCS。结论 PCS的发生与临床因素密切相关,术者严格规范操作可以减少PCS发生;查因可有助于正确判断PCS。 相似文献
109.
《Drug delivery》2013,20(3):123-129
Nano-emulsions are innovative colloidal systems characterized by high kinetic stability, low viscosity, and optical transparency, which make them very attractive in many dermatological applications. Furthermore their small size seems to favor the topical administration of actives which scarcely cross the skin. In the light of these interesting features, the present study was aimed to the evaluation, in vitro and in vivo, of glycyrrhetic acid (GA) release through the skin from the nanoemulsion system. GA-loaded nanoemulsion (GAN) was prepared by phase inversion temperature (PIT) method, and was characterized in order to determine mean droplet size and its stability during a well-defined storage period. Further Cryo-TEM studies were performed to obtain information regarding nanoemulsion structure. The GA release pattern from nanoemulsion was evaluated in vitro, to determine its percutaneous absorption through excised human skin (stratum corneum and epidermis, SCE), and in vivo evaluating GA topical anti-inflammatory activity on healthy human volunteers by the UVB-induced erythema model. Nanoemulsions prepared by PIT method showed a mean droplet diameter of 210?nm that drastically changed during a storage of 5 weeks at room temperature. In vitro and in vivo evidence showed that the nanoemulsion system significantly increased the transdermal permeability of GA in comparison to a control O/W emulsion (GAO/W) containing the same amount of active compound. 相似文献
110.