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41.
目的 :通过检测 P73蛋白、P2 1蛋白在乳腺癌中的表达及其与临床病理指标的关系 ,探讨乳腺癌的生物学特性 ,分析它们在乳腺癌的发生、转移中所起的作用。方法 :应用免疫组化 S-P法检测 68例乳腺癌石蜡包埋标本中 P73、P2 1的表达情况。结果 :a.在乳腺癌 - 级与 级之间 P73蛋白阳性率分别为 1 8.75 % ( 9/48)和 60 .0 0 % ( 1 2 /2 0 ) ,差异有显著性 ( P <0 .0 5 )。随着 P73阳性表达率增高 ,乳腺癌的恶性程度增高。b.淋巴结转移组 p2 1的阳性表达率 2 3 .3 3 % ( 7/3 0 )明显低于无淋巴结转移组的阳性率 5 2 .63 % ( 2 0 /3 8) ,差异有显著性( P <0 .0 5 )。c.P73、P2 1之间无相关。结论 :P73、P2 1与乳腺癌的发生、发展有关 相似文献
42.
目的 探讨晕可宁颗粒的主要药效学 ,为临床提供药效学资料及治疗学基础。方法 采用三氯甲烷破坏豚鼠一侧膜迷路感受器模型 ,探讨受试药对眼震颤、摆头及旋转的影响 ;采用内淋巴囊和内淋巴管阻塞手术复制豚鼠膜迷路实验性膜迷路积水模型 ,研究内耳组织平均中阶面积 (SMA)增加率及形态学的变化。结果 抑眩宁阳性对照组、晕可宁颗粒 (8、16g/kg)模型给药组豚鼠眼球震颤次数减少 ,差异有显著意义 (P <0 .0 5 )。成功复制了不同程度膜迷路积水豚鼠模型 ,表现为前庭膜重度膨出 ,前庭阶缩小 ,膜蜗管增大 ,SMA增加率变大 ,差异有显著意义 (P <0 .0 1) ;晕可宁颗粒灌胃后可减轻豚鼠实验性膜迷路积水的程度 ,差异有显著意义 (P <0 .0 1) ;但与空白对照组比较SMA增加率差异无显著意义 (P >0 .0 5 )。结论 晕可宁颗粒可以减轻内淋巴囊积水程度 ,对梅尼埃病症状有对抗治疗作用。 相似文献
43.
《Nutrition reviews》1987,45(10):246-248
Increasing dietary 18:2 n-6/18:3 n-3 causes similar relative changes in fatty acid profiles of phosphatidylethanolamine and phosphatidylcholine from rat neural and erythrocyte membranes. 相似文献
44.
Pseudomonas cepacia has recently emerged as an important nosocomial pathogen. We analyzed a national nosocomial infections database, the National Nosocomial Infections Surveillance (NNIS) system, to describe the epidemiology of endemic nosocomial P. cepacia infections. Between 1980 and 1985, the P. cepacia nosocomial infection rate was 2.4 per 100,000 patient discharges. During this period, there was a significant increase in the P. cepacia infection rate. The highest infection rate was reported from large medical school-affiliated hospitals. Over 90% of the infections were reported from medicine and surgery services. The most frequently reported site of infection was the lower respiratory tract (31%), followed by blood (20%) and the urinary tract (20%). Nosocomial P. cepacia infections are often associated with mortality, particularly when they involve the lung. These data confirm the hypothesis that P. cepacia is an emerging nosocomial pathogen and suggest that the epidemiology of endemic infections differs from that reported for epidemic inflections. 相似文献
45.
目的探讨精神分裂症患者的语词记忆能力与认知电位之间的相互关系。方法对102例精神分裂症患者首先进行了听觉诱发电位P300测定,然后按有无P300潜伏期延长或/和波幅降低分为P300正常与异常组,再采用选择性提醒测验方法对其进行语词记忆测验。结果P300正常组30例在10次语词记忆测验中通过总例数28例,占93.3%,前6次通过的比例为56.7%;而P300异常组72例在10次语词记忆测验中通过的总例数只有43例,占59.7%,前6次通过的比例只有25%;两组之间的差异非常显著(P〈0.001)。P300异常组回忆总数、保持数、长时再现数及恒定长时再现数减少,而不恒定长时再现数、提醒总数及插入数显著增多,两组比较有显著性差异(P〈0.01)。结论P300异常的精神分裂症患者较P300正常的精神分裂症患者存在更严重的语词记忆障碍。 相似文献
46.
目的 探讨CyclinD1,P16在胶质瘤复发前后表达改变及其意义。方法 采用免疫组织化学LsABC法对 4 5例复发胶质瘤瘤组织、瘤旁脑组织和 10例正常脑组织CyclinD1,P16蛋白表达进行检测 ,统计分析CyclinD1,P16表达水平与胶质瘤分级、肿瘤复发的关系。结果 正常脑组织 ,瘤旁脑组织和胶质瘤组织CyclinD1表达依次升高 ,而P16的表达依次下降 ;肿瘤复发CyclinD1表达增强 ,P16的表达减弱。结论 CyclinD1与P16的表达与胶质瘤恶性进程和复发密切相关。 相似文献
47.
生物活性陶瓷与细胞外基质骨形成对Ca、P、ALP影响 总被引:2,自引:0,他引:2
目的:通过钙(Ca)、磷(P)及碱性磷酸酶(ALP)评价,探讨生物活性陶瓷及细胞外基质与骨细胞相互作用机理,为骨替代材料成骨效应提供依据。方法:选用多种材料进行蒸馏水及血浆接触,体外成骨细胞培养及体内骨诱导试验。采用原子吸收,钼蓝比色及速率法分析化学性能,血浆、细胞冻溶液及组织匀浆中Ca、P、ALP的变化规律。结果:材料组体内、外接触Ca、P、ALP值高于对照组。细胞外基质复合材料组高于相应的非复合材料组。TGF-β1加材料高于BMP复合材料组,而不同材料有所不同,TCP材料高于其它材料。结论:生物活性陶瓷材料均有不同程度的Ca、P离子释放,细胞外基质及Ca、P离子可提高成骨细胞活性,异位骨形成及ALP活性。 相似文献
48.
Alcohol is an important risk factor for human oesophageal cancer. There is evidence from epidemiological studies that some
specific alcoholic drinks, e.g. Calvados apple brandy, are associated with a greater risk than others. Alcohol induces cytochrome
P450 2E1 (CYP2E1) and the hypothesis was tested that different alcoholic beverages, containing a variety of alcoholic compounds,
could differentially induce expression of cytochrome P450 enzymes. Twelve groups of five rats each were treated for 3 days
with different alcoholic beverages (ethanol alone, whisky, farm-produced or commercial Calvados brandy, beer, cider, wine)
adjusted to 4, 10 or 20% of ethanol in drinking water. Immunoblotting using a monoclonal antibody specific for rat CYP2E1
revealed a single protein band in liver microsomes. Densitometric quantitation of microsomal proteins demonstrated a significant
two-, three- and sixfold increase in band intensity after treatment with ethanol concentrations of 4, 10 and 20% respectively,
compared to control rats drinking water alone. There was a dose-dependent increase in liver microsomal metabolism of CYP2E1
substrates (para-nitrophenol and dimethylnitrosamine) in ethanol-treated rats. However, there were no significant differences
in the level of CYP2E1 protein or enzymatic activity between the different alcoholic beverages at the same ethanol concentration.
There was a slight increase in hepatic CYP1A-related enzymatic activities in the alcohol-treated rats compared to the controls,
but no difference between the treated groups either with dose of ethanol or type of beverage. These data show that induction
of CYP2E1 with acute alcohol treatment is predominantly determined by the ethanol content of the beverage.
Received: 10 February 1997 / Accepted: 26 May 1997 相似文献
49.
Schistosoma mansoni infection, both in humans and in animal models, is known to induce granulomas in the liver and intestine. It has also been
reported that in humans the eggs of this parasite can reach the brain, causing psychiatric and neuropathological disorders.
Whether this also occurs in rodents is unknown. To answer this question, mice were infected with this parasite and the central
nervous system (CNS) examined at various time intervals. The results show that schistosomiasis induced granulomas in several
regions of the CNS and increased nerve growth factor (NGF) levels in the cortex, hypothalamus and brain stem, but not in the
hippocampus. The infection also caused paw hyperalgesia, as determined by the hot-plate test, and a local increase in NGF,
but not in substance P. These findings indicate that the murine model of infection can be used for studying mechanisms leading
to human neuroschistosomiasis and suggest that the neuropathological disorders and the sensory deficits observed in human
schistosomiasis are associated with impaired levels of NGF in the peripheral and central nervous system.
Received: 18 January 1996 / Revised, accepted: 16 April 1996 相似文献
50.