臭氧水灭菌效果的试验观察

目的 测定高效电解臭氧消毒治疗机在不同浓度、对不同菌株的杀菌效果，为其临床应用提供依据。方法 在不同条件下，用臭氧水对菌悬液进行消毒，定量培养，计算杀菌率。结果 在5mg/L浓度下对标准菌株大肠埃希菌(ATCC8099)、金黄色葡萄球菌(ATCC25923)、白色念珠菌(ATCCl0231)作用1min杀灭率可达100％，对枯草杆菌芽胞(ATCC9372)作用10min杀灭率可达99．99％；用临床菌株试验，在5mg/L浓度下作用0．5min，对金黄色葡萄球菌、大肠埃希菌、白色念珠菌的杀灭率为100％，在1．25mg/L浓度对金黄色葡萄球菌、大肠埃希菌、白色念珠菌、铜绿假单胞菌的杀灭率均＞99．3％。结论 高效电解臭氧消毒治疗机产生的臭氧水具有快速、高效杀菌作用。     

无臭氧高浓度空气负离子发生器的研制

本文介绍一种输出负离子浓度高，几乎无臭氧的空气负离子发生器。此发生器能有效地抑制臭氧产生，提高治疗效果，而且具有体积小，重量轻，耗电省，安全可靠的特点。适合医院，家庭做治疗和保健用。     

O3对大鼠深部呼吸道损伤的可靠指示物——克拉氏细胞蛋白

为探讨大气污染物引起肺组织损伤的毒性作用机理以及血清克拉氏细胞蛋白（ＣＣ１６）作为反映肺组织深部损伤潜在指示物的可能性，选用ＳＤ大鼠进行不同浓度的ＳＯ２和Ｏ３暴露。３０￣５０ｐｐｍＳＯ２气体暴露４，１２小时及两周均不能引起大鼠血清和支气管肺泡灌洗液中细胞总数、乳酸脱氢酶、总蛋白、克拉氏细胞蛋白（ＣＣ１６）和溶酶体酶活性的明显改变。１．０，０．５，０．３８，０．２５及０．２０ｐｐｍＯ３气体暴露７小时     

经皮穿刺臭氧盘内注射治疗腰椎间盘突出症

微创介入治疗技术是椎间盘突出症治疗技术的一个重要发展方向。从经皮穿刺切吸术到胶原酶溶解术是一个重大转变和进步,使手术操作明显简化,而仍取得良好的疗效。近年来国内外使用O3盘内注射方法治疗椎间盘突出症取得成功,但其适应证、禁忌证方面尚少有报道。我院康复医学中心自     

Functional and pathologic consequences of a 52-week exposure to 0.5 PPM ozone followed by a clean air recovery period

Male Fischer 344 rats were exposed to 0.5 ppm ozone for 20 hr/day, 7 days/week, for 52 weeks after which they were allowed to recover in clean filtered air for 12 weeks. Pulmonary function testing, which included measurements of lung volumes, expiratory air flows, and DL_co, was performed before the initiation of exposure, after 26 and 52 weeks of exposure, and after the 12 week recovery. Control animals were tested at the same times but exposed only to clean filtered air. Another group, periodically sacrificed for histopathologic evaluation, was similarly exposed to ozone but allowed to recover in clean air for 24 weeks. The 52 weeks of ozone exposure produced small but statistically significant changes in several of the functional measurements when compared to clean air controls (FRC + 7.0%; RV + 11.2%; DL_co - 7.3%). These measurements returned to control levels with 3 months of recovery. All other parameters showed no significantly different values between the 2 groups throughout the exposure and recovery periods. After both 6 and 12 months of ozone exposure, microscopic evaluation revealed a slight inflammatory response in the alveolar duct walls and septa of the immediately adjacent alveoli. This response included the accumulation of mononuclear cells and fibroblasts, thickening of alveolar septa, and a slight increase in macrophage population. With 6 months of recovery, the inflammation had all but disappeared. There remained only a slight dilation and thickening of an occasional alveolar duct and its adjacent alveoli. We conclude that the functional changes seen in the lungs in response to the ozone insult were the result of the observed inflammation in the distal areas of the lung, and the lesions produced were reversible to the extent that they could not be detected functionally after recovery. This work was presented in part at the Annual Meeting of the American Thoracic Society, Anaheim, California, May, 1985. This research was conducted at the General Motors Research Laboratories in facilities fully accredited by the American Association of Laboratory Animal Care.     

物理治疗防治腰椎间盘突出臭氧消融术后症状"反跳"

目的探讨物理治疗防治腰椎间盘突出臭氧消融术后症状“反跳”的效果。方法腰椎间盘突出患者80例，随机分为观察组和对照组各40例，均行CT引导下臭氧消融治疗。观察组患者术后3天起采取超短波和半导体激光联合物理治疗，对照组不进行物理治疗，术后1个月采用改良Macnab法对两组患者的疗效及症状反跳情况进行评价。结果观察组患者术后1个月显效35例（87．50％），有效5例（12．50％），反跳1例；对照组显效30例（75．00%），有效8例（20．00％），无效2例（5．00％），反跳5例；两组结果具有极显著性差异（χ^2检验，P〈0．01）。结论臭氧消融术后辅助物理治疗不仅可提高显效率，并可减少术后症状反跳的发生。     

Atmospheric particulate matter and ozone under heat-wave conditions: do they cause an increase of mortality in Croatia?

In August 2003 Croatia experienced a heat-wave period during which elevated concentrations of particulate matter (PM10) and ozone in ambient air were measured. By applying the model of Stedman and Rooney et al., it was shown that a significant part of excess mortality during this period can be attributed to PM10 and ozone in ambient air.     

三氧联合放疗治疗鼻咽癌22例疗效观察

目的评价三氧联合放疗治疗鼻咽癌的近期疗效和急性口腔咽粘膜反应。方法 46例鼻咽癌患者随机分为三氧联合调强放疗组(实验组)和调强放疗组(对照组),观察近期疗效及急性口腔粘膜反应。结果实验组和对照组有效率分别为95.5%和95.8%,差异无统计学意义(p>0.05)。实验组急性口腔粘膜反应明显较对照组减轻(p<0.05)。结论鼻咽癌放疗期间联合三氧治疗可能有助于减轻急性口腔粘膜反应,但对近期疗效影响不大。     

三氧治疗对鼻咽癌放疗患者血清HIF-1α和VEGF水平的影响

目的探讨三氧治疗对鼻咽癌放疗患者血清HIF-1α和VEGF水平的影响。方法 40例鼻咽癌患者随机分为三氧联合调强放疗组(实验组)和调强放疗组(对照组),每组20例。应用ELISA法检测两组治疗前、中、后的HIF-1α和VEGF水平。结果实验组治疗后HIF-1α与治疗前相比差异无统计学意义(p>0.05),治疗后VEGF低于治疗前水平(p<0.05)。对照组治疗后HIF-1α和VEGF均高于治疗前,具有显著统计学差异(p<0.01)。实验组治疗后HIF-1α和VEGF均低于对照组,且具有显著统计学差异(p<0.01)。结论三氧治疗可降低鼻咽癌放疗患者血清HIF-1α和VEGF水平。     

臭氧联合射频微创介入手术治疗颈腰椎间盘突出症的疗效分析

目的观察联合应用臭氧髓核消融和射频靶点热凝方法治疗颈腰椎间盘突出症的疗效。方法选取2012年1月至2012年6月来我院就诊治疗的120例颈、腰椎间盘突出症患者,在CT引导下,行臭氧髓核消融联合射频靶点热凝治疗,统计并记录患者临床治疗资料。结果手术前和术后1天、1周、1月VAS评分依次为8.11、1.88、1.79、0.53,术后显著下降;术后3天和3月按照MacNab方法进行评估,其有效率分别为86.67%和89.17%,均提示手术疗效显著。结论联合应用臭氧髓核消融术和射频靶点热凝术治疗颈椎间盘突出症和腰椎间盘突出症疗效显著,安全性高,操作简单,值得临床推广应用。