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61.
62.
目的:利用一种改进的三箱社交装置评价动物的社交偏好程度,并探索该方法的可行性。方法:采用注意力缺陷多动障碍(ADHD)大鼠作为社交障碍模型动物,以同源大鼠(WKY)大鼠和Wistar大鼠作为对照组,模型组采用治疗ADHD的临床常用中成药小儿黄龙颗粒(1.88 g/kg、3.75 g/kg)灌胃给药16 d。利用改进的三箱社交箱,以待测鼠在陌生鼠侧密切交流区的时间、频次、路程及相关比例作为行为学指标,检测该方法对社交行为评价的可行性。结果:与Wistar大鼠组比较,模型组大鼠与WKY组大鼠在密切交流区域及有陌生鼠侧区域的时间显著减少(P<0.01),其他指标如频次、路程及比例也均有不同程度减少,小儿黄龙颗粒两剂量均能增加模型大鼠上述各指标数值。结论:该方法能准确捕捉动物的社交行为特征,实现对动物社交偏好程度的全面、客观评价。 相似文献
63.
综合医院确诊的39例肺结核患者转诊结果随访调查 总被引:1,自引:0,他引:1
目的;了解并评价综合医院内科确诊的活动性肺结核病例转诊结果。方法:对我院呼吸内科1995年8月-1998年8月确认的39例活动性肺结核患者(不包括结核性胸膜炎)转往结构防治专业机构的结果进行信访和电话随访。结果:仍的39例活动性肺结核患者中有35例在确诊后1周内结核病接受0.5a-1a的全地化疗,33例获得良好效果,2例死亡,死因分别为肺间质纤维化合并感染肺心病及呼吸衰竭。3例慢性纤维空洞型肺结核 相似文献
64.
In the management of craniosynostosis, there is a need for quantitative assessment of treatment methods and outcome. Radiology and pressure studies are well documented, but so far little attention has been given to cerebral blood flow changes and their possible relevance. This paper reports our initial experience using transcranial Doppler sonography to calculate the cerebrovascular resistance and cerebral blood velocities in the major basal vessels before and after surgery for craniosynostosis. Ten patients were studied using the Scimed 2-MHz probe through the temporal and frontal windows of the skull. Measurements were taken under standard physiological conditions before, during and after surgery. Preliminary results suggest that this non-invasive technique may be helpful in predicting and assessing the outcome following surgery for craniosynostosis. 相似文献
65.
C. Pestoni M. V. Lareu M. S. Rodríguez I. Muñoz F. Barros A. Carracedo 《International journal of legal medicine》1995,107(6):283-290
The 5 tetranucleotide short tandem repeats, HUMTHOI, HUMVWA31/A, HUMF13A1, HUMFES/FPS and HUMLPL were studied using different electrophoretic methods and PCR amplification conditions in order to optimize the typing conditions. A genetic population study in the population of Galicia was carried out and the allele and genotype frequencies are given. Compliance with the Hardy-Weinberg equilibrium was tested using different statistical parameters, with clear advantages resulting in favor of using the exact test (Guo-Thompson method) instead of conventional chi-square methods. Some statistical parameters of forensic interest (PD, CE, h) were also calculated. There were no mutations found in a total of 73 paternal meioses and 101 maternal meioses. Abnormal electrophoretic mobility was found in the AT-rich STR HUMF13AI under non-denaturing conditions and, therefore, the use of denaturing conditions is absolutely necessary. No "stutter" bands were found, although double peaks in the HUMFES/FPS system were observed in some samples. The advantage of using automated sequencers with fluorescent technology is also reported. 相似文献
66.
Rosenson-Schloss RS Vitolo JL Moghe PV 《Medical & biological engineering & computing》1999,37(2):257-263
Leukocytes adherent to the surfaces of both vascular biomaterials and normal blood vessels experience blood flow induced shear stress. The goal of the reported studies was to investigate the effect of fluid flow on the morphology, phagocytic function and stress response induction in adherent immune cells. Shear approximating arterial, venous and intermediate levels were applied onto glass-adherent IC21 macrophages in a temperature-controlled parallel plate flow system. The results indicate that fluid flow induces a shear-dependent physiological stress response in adherent macrophages and that significant morphological changes accompany macrophage responses to shear stress. In addition, arterial flow conditions induce not only significant cell polarisation, but also enhanced phagocytic ingestion in glass-adherent IC21 macrophages. These findings suggest that blood flow induced shear stress may not only be consequent to adherent leukocyte activation, but may also be integral to the regulation of adherent leukocyte behaviour in vivo. 相似文献
67.
1993年7月~1998年1月为103例(106只眼)难治性青光眼患者施行国产房水引流物(HAD)置入术。术后平均随访328月。术后1年时平均眼压22±1.4kPa。术后1~5年的手术成功率分别为838%,804%,771%,710%及643%。术中联合应用丝裂霉素C的病例,其术后1年时的成功率为895%。术后常见的并发症有持续性浅前房,局限性脉络膜脱离及眼压升高等。认为HAD可用于治疗难治性青光眼。 相似文献
68.
AIM: To determine current clinical practice in the radiological diagnosis of acute pulmonary embolism and assess the use of spiral volumetric computed tomography. METHOD: A survey of 327 acute hospitals including cardiothoracic and orthopaedic tertiary referral centres was undertaken to assess current utilization of lung scintigraphy, spiral computed tomography and pulmonary angiography in the investigation of suspected pulmonary embolism. Responses were received from 215/327 (66%) centres. RESULTS: Lung scintigraphy was provided by 208 hospitals (144 on-site and 64 off-site). Spiral CT services were provided by 111 (52%) hospitals (on- or off-site), 142 (66%) units had access to angiographic facilities. Sixty-three centres out of 215 (29%) offered both on-site lung scintigraphy and spiral CT while only 41/215 (19%) hospitals were able to undertake all three tests on-site. On average, 501 perfusion (Q) or ventilation-perfusion (V/Q) scintigrams were performed per hospital per year with 26 spiral CT studies and just 4.6 pulmonary angiograms. CONCLUSION: These data suggest that lung scintigraphy is frequently the only imaging test in patients other than chest radiography, despite the large number of indeterminate results reported in most series. 相似文献
69.
Purpose. In a patient with internal derangement of the shoulder, the diagnostic method of choice is controversial. Conventional arthrography
can diagnose most rotator cuff tears accurately; however, in many institutions MR arthrography is usually necessary to diagnose
labral tears. We utilized decision tree methodology to compare the cost- effectiveness of conventional arthrography and conventional
MRI with a hypothetical algorithm in which a patient underwent arthrography, performed with admixed gadolinium, which if negative,
was followed by MRI.
Design. The use of double-contrast arthrography alone, conventional MRI alone, and gadolinium-enhanced MRI used as an adjunct to
conventional arthrography were modeled for the diagnosis of full-thickness rotator cuff tears (RCT), partial RCTs, labral
tears, and the absence of cuff/labral tears using decision analysis methodology. English language medical publications were
searched to determine the base probabilities for the accuracy of the diagnostic tests. The outcome utilities ranged from –1
to +1 to reflect the value of correct diagnostic evaluation. Charges for diagnostic tests and appropriate surgical treatments
were based on 1997 Medicare reimbursement rates for professional fees and hospital charges in an outpatient setting. Sensitivity
analyses were performed to evaluate the effects of uncertainty regarding the prevalence of each disease state and the accuracy
of several diagnostic tests.
Results. In the base-case analysis, the average effectiveness of double-contrast arthrography alone, MRI alone and arthrography selectively
followed by MRI were 0.6610, 0.6715, and 0.7204, respectively. The average costs for each of these strategies were $1090,
$2033, and $2339, respectively.
Conclusion. Arthrography performed with admixed diluted gadolinium, which if negative is immediately followed by MRI, was somewhat more
expensive than conventional MRI. However, because of much greater effectiveness, cost-effectiveness was significantly higher
for our proposed algorithm. Conventional arthrography without gadolinium, although less expensive, had severely limited effectiveness.
Received: 4 June 1999 Revision requested: 6 August 1999 Revision received: 30 August 1999 Accepted: 1 September 1999 相似文献
70.
In this study, thirty-eight patients with a variety of upper abdominal diseases were examined with three-dimensional time-resolved
MR angiography (7 sec/data set). Visualisation of arterial and venous anatomy was excellent in the majority of patients. Moreover,
subtraction images could be calculated and organ perfusion could be assessed. It is concluded that this technique opens new
perspectives for a comprehensive evaluation of vascular and parenchymal disease.
Received: 14 April 1998; Revision received: 23 October 1998; Accepted: 9 November 1998 相似文献