手法复位闭合穿针结合骨折治疗仪治疗儿童肱骨髁上骨折

目的：研究手法复位闭合穿针与骨折治疗仪相结合治疗儿童肱骨髁上骨折的临床疗效。方法：将我院最近2年治疗的112例肱骨髁上骨折的患儿随机分为观察组和对照组两组,每组56例,所有患儿均采用手法整复闭合穿针方法,观察组患儿加用骨折治疗仪治疗,将两组患儿的临床疗效进行对比。结果：观察组患儿骨折愈合速度和恢复情况明显优于对照组。结论：手法复位闭合穿针结合骨折治疗仪治疗儿童肱骨髁上骨折疗效确切,值得在临床上推广应用。     

发际内头皮冠状切口在颧骨颧弓骨折治疗中的应用

目的:观察头皮冠状切口在颧骨颧弓骨折中重建骨骼形态的效果。方法:应用发际内头皮冠状切口进路对21例颧骨颧弓骨折病例进行复位和固定,分析其治疗方法的优越性、效果、并发症及预防措施。结果:21例患者术后面型和功能恢复良好。结论:头皮冠状切口对颧骨颧弓三维结构的重建具有手术视野暴露好,操作方便,复位精确,面部不遗留疤痕等优点。     

良性阵发性位置性眩晕治疗前后生活质量研究

目的:探讨管石复位法(CRP)治疗前后良性阵发性位置性眩晕(BPPV)患者健康相关生活质量(QOL)的变化。方法:采用中文版SF-36健康调查量表(SF-36)和汉化英文版眩晕障碍量表(DHI),分别对86例施行CRP的BPPV患者(治疗组)和120名健康体检者(对照组)进行QOL的调查与评估,并将2组的结果进行对比。结果:通过SF-36和DHI评估显示,BPPV患者治疗前SF-36的维度计分均低于对照组,DHI各条目计分均高于对照组,差异均有统计学意义(均P<0.05)。BPPV患者治疗后3个月SF-36和DHI量表得分与对照组差异均无统计学意义(均P>0.05)。结论:CRP可明显改善BPPV患者的QOL;SF-36和汉化DHI量表能有效评估BPPV患者的QOL。     

中医针灸联合手法治疗对椎动脉型颈椎病患者临床症状、治疗效率及预后的影响

目的探讨中医针灸联合手法治疗对椎动脉型颈椎病患者临床症状、治疗效率及预后的影响。方法采用随机数字表法将2014年1月~2015年1月我院收治的80例椎动脉型颈椎病患者分为观察组(40例)和对照组(40例),对照组采用中药内服联合中医针灸治疗,观察组采用中药内服、中医针灸配合推拿手法治疗,观察两组患者的临床症状、治疗效率及预后情况。结果与对照组(80.0%)相比较,观察组治疗总有效率(92.5%)显著更优(P0.05);治疗后观察组各项症状积分均显著优于对照组(P0.05);治疗后观察组TMFV和PSV值显著高于对照组(P0.05),PI和RI值显著低于对照组(P0.05)。结论中医针灸联合手法治疗椎动脉型颈椎病的疗效显著,能明显改善临床症状,促进脑部血液供应,降低复发率。     

Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning

Aims

Alzheimer's disease (AD) and type 2 diabetes (T2D) are two of the most common diseases in elderly population and they have a high rate of comorbidity. Study has revealed that T2D is a major risk factor of AD, and thus exploring therapeutic approaches that can target both diseases has drawn much interest in recent years. In this study, we tried to explore drugs that could be potentially used to prevent or treat both AD and T2D via a drug repositioning approach.

Methods

We first searched the known drugs that may be effective to T2D treatment based on the network distance between the T2D-associated genes and drugs deposited in the DrugBank database. Then, via molecular docking, we further screened these drugs by examining their interaction with islet amyloid polypeptide (IAPP) and Aβ42 peptide, the key components involved in the pathogenesis of T2D or AD. Finally, the binding between the selected drug candidates and the target proteins was verified by molecular dynamics (MD) simulation; and the potential function of the drug candidates and the corresponding targets were analyzed.

Results

From multiple resources, 734 T2D-associated genes were collected, and a list of 1109 drug candidates for T2D was obtained. We found that hypericin had the lowest binding energy and the most stable interaction with either IAPP or Aβ42 peptide. In addition, we also found that the target genes regulated by hypericin were differentially expressed in the tissues related to the two diseases.

Conclusion

Our results show that hypericin may be able to bind with IAPP and Aβ42 stably and prevent their accumulation, and thus could be a promising drug candidate for treating the comorbidity of AD and T2D.     

中医手法复位对肱骨髁上骨折疗效分析

目的：分析临床对肱骨髁上骨折时给予患者实施中医手法复位后的临床效果。方法：择取我科室在近期内接诊的73例肱骨颗上骨折患者,并按照治疗形式的不同将患者分为两组,将其中实施切开复位内固定治疗的36例患者记为A组,将其中实施中医手法复位后微创穿针夹板外固定治疗的37例患者记为B组。结果：在疼痛、稳定性等自我评价项目上比较,A组患者与B组患者组问比较,差异明显（P〈O．05）;组间在治愈率、并发症发生机率方面比较,也均具有明显的差异（P〈O．05）。结论：对肱骨髁上骨折患者实施中医手法复位后加微创穿针夹板外固定治疗的临床效果非常理想,应在各医院进行推广实施。     

手法复位在腰椎间盘突出症中的运用

目的：分析探讨手法复位方式在腰椎间盘突出患者中的应用效果。方法：研究对象为我院在2013年1月～2013年6月期间收治的腰椎间盘突出症患者60人,均通过手法复位方式来进行治疗,而后分析其临床效果。结果：60人案例中,其中治愈人数为36人,好转人数为20人,无效人数为4人,总体有效率达到93．33％。结论：通过手法复位方式对于腰椎间盘突出症病患有较好的临床疗效,该保守治疗方式更加易于人们接受,安全有效值得,临床推广。     

硬膜外麻醉下手法复位治疗急性腰椎间盘突出症疗效观察

目的：观察硬膜外麻醉下手法复位治疗急性腰椎间盘突出症的临床疗效。方法：运用日本骨科学会下腰痛评分法（M-JOh）,分析60例急性腰椎间盘突出症,予以硬膜外麻醉下手法复位临床症状与效果的关系,并与单纯手法复位治疗组,于手法复位3天,1月后复查。结果：疗效结果改善率为68．48％,对照组46．4％,按分级疗效治疗组显效率83．33%,对照组优良率5O%;平均改善指数和改善率均高于对照组。结论：硬膜外麻醉下手法复位是治疗急性腰椎间盘突出症保守治疗方法之一,有比较好的临床效果,运用量化评价方法易于评价临床疗效。     

Automatic repositioning of MRSI voxels in longitudinal studies: impact on reproducibility of metabolite concentration measurements

PURPOSE: To study an automatic repositioning method to reduce variability in longitudinal MRSI exams based on a priori image registration. Longitudinal proton MR spectroscopic imaging ((1)H MRSI) exams to study the effects of disease or treatment are becoming increasingly common. However, one source of variability in such exams arises from imperfect relocalization of the MRSI grid in the follow-up exams. MATERIALS AND METHODS: Six healthy subjects were each scanned three times during the course of 1 day. In each follow-up exam a manually placed MRSI grid was acquired in addition to the automatically repositioned MRSI grid. Then coefficients of variance between baseline and follow-up scans were calculated for N-acetylaspartate, creatine, and choline. In addition, the overall MRSI grid overlap and individual voxel overlaps were also calculated for both the visually and automatically repositioned voxels. RESULTS: Streamlined workflow, reduced variability of metabolite concentration measurements, and increased voxel overlaps are noted when this automatic repositioning procedure is compared to the visual MRSI grid repositioning approach. CONCLUSION: Our results suggest that this approach is able to improve reproducibility in longitudinal MRS exams.