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Natalie E. West Valeria V. Beckett Raksha Jain Don B. Sanders Jerry A. Nick Sonya L. Heltshe Elliott C. Dasenbrook Donald R. VanDevanter George M. Solomon Christopher H. Goss Patrick A. Flume 《Journal of cystic fibrosis》2017,16(5):600-606
Background
Pulmonary Exacerbations (PEx) are associated with increased morbidity and mortality in individuals with CF. PEx management practices vary widely, and optimization through interventional trials could potentially improve outcomes. The object of this analysis was to evaluate current physician treatment practices and patient outcomes for PEx.Methods
The Standardized Treatment of Pulmonary Exacerbations (STOP) observational study enrolled 220 participants ≥ 12 years old admitted to the hospital for PEx at 11 U.S. CF centers. Spirometry and daily symptom scores were collected during the study. Physicians were surveyed on treatment goals and their management practices were observed. Treatment outcomes were compared to stated goals.Results
The mean (SD) duration of IV antibiotic treatment was 15.9 (6.0) days. Those individuals with more severe lung disease (< 50% FEV1) were treated nearly two days longer than those with > 50% FEV1. Physician-reported FEV1 improvement goals were 10% (95% CI: 5%, 14%) lower for patients with 6-month baseline FEV1 ≤ 50% predicted compared with those with 6-month baseline FEV1 > 50% predicted. There were clinically and statistically significant improvements in symptoms from the start of IV antibiotic treatment to the end of IV antibiotic treatment and 28 days after the start of treatment. The mean absolute increase in FEV1 from admission was 9% predicted at end of IV antibiotic treatment, and 7% predicted at day 28. Only 39% fully recovered lost lung function, and only 65% recovered at least 90% of lost lung function. Treatment was deemed successful by 84% of clinicians, although 6-month baseline FEV1 was only recovered in 39% of PEx.Conclusions
In this prospective observational study of PEx, treatment regimens and durations showed substantial variation. A significant proportion of patients did not reach physician's treatment goals, yet treatment was deemed successful. 相似文献92.
Sulaiman M. Al-Eidi Ashry Gad Mohamed Raid A. Abutalib Abdullah M. AlBedah Mohamed K.M. Khalil 《Journal of acupuncture and meridian studies》2019,12(6):173-181
To evaluate the feasibility of comparing the effect of the traditional Hijamah and the Asian wet cupping techniques in the management of patients with chronic low back pain (CLBP), a randomized clinical trial comparing traditional and Asian wet cupping techniques for CLBP was conducted in two secondary care hospitals in Saudi Arabia. Seventy eligible participants with CLBP were randomized to receive one session of wet cupping using either Asian technique (34 patients) or traditional Hijamah technique (36 patients). Cupping was performed at four sites of the bilateral bladder meridian (BL23, BL24, and BL25). The numeric rating scale, Present Pain Intensity, and Oswestry Disability Questionnaire scores were measured immediately after intervention, at seven days, and 14 days after intervention. In both groups, there was a significant decrease in the numeric rating scale, Present Pain Intensity, and Oswestry Disability Questionnaire scores, immediately after intervention, at seven days, and 14 days after intervention. However, there was no significant difference between the two groups across all the outcome measures up to 14 days after intervention. The study did not show a superiority of one technique compared with the other. Longer follow-up periods and more than one cupping session may be needed to evaluate the difference, if any, between both the techniques.Trial RegistrationNCT02012205. 相似文献
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Mireia Martí-Salvador Laura Hidalgo-Moreno Julio Doménech-Fernández Juan Francisco Lisón Maria Dolores Arguisuelas 《Archives of physical medicine and rehabilitation》2018,99(9):1720-1729
Objective
To investigate the effects of an osteopathic manipulative treatment (OMT), which includes a diaphragm intervention compared to the same OMT with a sham diaphragm intervention in chronic nonspecific low back pain (NS-CLBP).Design
Parallel group randomized controlled trial.Setting
Private and institutional health centers.Participants
Participants (N=66) (18-60y) with a diagnosis of NS-CLBP lasting at least 3 months.Interventions
Participants were randomized to receive either an OMT protocol including specific diaphragm techniques (n=33) or the same OMT protocol with a sham diaphragm intervention (n=33), conducted in 5 sessions provided during 4 weeks.Main Outcome Measures
The primary outcomes were pain (evaluated with the Short-Form McGill Pain Questionnaire [SF-MPQ] and the visual analog scale [VAS]) and disability (assessed with the Roland–Morris Questionnaire [RMQ] and the Oswestry Disability Index [ODI]). Secondary outcomes were fear-avoidance beliefs, level of anxiety and depression, and pain catastrophization. All outcome measures were evaluated at baseline, at week 4, and at week 12.Results
A statistically significant reduction was observed in the experimental group compared to the sham group in all variables assessed at week 4 and at week 12 (SF-MPQ [mean difference ?6.2; 95% confidence interval, ?8.6 to ?3.8]; VAS [mean difference ?2.7; 95% confidence interval, ?3.6 to ?1.8]; RMQ [mean difference ?3.8; 95% confidence interval, ?5.4 to ?2.2]; ODI [mean difference ?10.6; 95% confidence interval, ?14.9 to 6.3]). Moreover, improvements in pain and disability were clinically relevant.Conclusions
An OMT protocol that includes diaphragm techniques produces significant and clinically relevant improvements in pain and disability in patients with NS-CLBP compared to the same OMT protocol using sham diaphragm techniques. 相似文献94.
Background
The purpose of this retrospective cohort study was to investigate the influence of parameters of malalignment on knee function 5?years post TKA and, additionally, to explore alterations in patellar height after TKA.Methods
All 661 patients undergoing TKA between 2010 and 2011 were considered for inclusion. Preoperative and 1-year postoperative short-leg radiographs were assessed for malalignment parameters: coronal tibial angle (cTA), sagittal tibial angle (sTA), femoral flexion angle (FFA) and mediolateral tibial mismatch. Patellar height was measured using the modified Insall-Salvati ratio. We determined improvements in knee function utilizing the Knee Society Score (Function score, KSS-F), Oxford Knee Score (OKS) and Algofunctional index (AI). Influences of malalignment parameters were analyzed univariate and selected (p?<?0.10) for multivariate linear regression analysis. Inter-observer reproducibility was assessed by test–retest analysis of 30 randomly selected radiographs and calculation of an intra-class correlation coefficient (ICC) for all radiographic parameters.Results
Three-hundred and four patients were included. Multivariate regression showed degrees of cTA malalignment to be significantly associated with only the KSS-F (β?=?? 3.52). Correction of coronal deformity was stronger associated with knee function (KSS-F β?=?2.81; AI β?=?? 0.36). Patellar height was significantly reduced after TKA (1.51 vs 1.44). Decrease of patellar height was weakly associated with the OKS (β?=?10.69). ICC scores were: cTA 0.81, sTA 0.57, IS 0.72, FFA 0.75.Conclusion
Postoperative coronal tibial plate alignment and correction of preoperative coronal deformity are associated with improved knee function 5?years post TKA. Decrease in patellar height was weakly associated with knee function. Short-leg radiography can be a sufficient screening tool for prosthesis alignment. 相似文献95.
目的：评估Catquest 9SF -CN量表应用于白内障手术人群的反应度，并结合校标法和分布法确定最小临床重要差异值（MCID）。方法：前瞻性队列研究。对纳入温州医科大学附属眼视光医院的213例白内障术前患者进行Catquest 9SF -CN量表调查。术后1～3个月对来院复查的患者再次进行量表调查和7个选项的校标条目调查。分析量表的天花板和地板效应，通过配对t检验分析手术前后量表得分和视力的差异，采用效应值、标准化反应均数和变化率三个指标联合评估量表的反应度。然后根据术前视力、术前并发症（有/无）和术眼数量（单眼/双眼）分组，计算手术带来的得分变化。通过单因素方差分析（根据术前视力分组）或独立样本t检验（根据并发症或者术眼数量分组）分析组间差异。分布法通过1个效应值、1个测量标准误和1/2个得分变化标准差估算MCID，校标法通过校标选项和得分变化的线性回归分析估算MCID，最后根据平均值法确定取值。结果：共144人完成Catquest 9SF -CN量表的随访调查。量表术前的天花板和地板效应为4.2%，术后提高至17.3%。手术带来的量表总得分变化为（10.4±7.7）分，logMAR视力变化为（0.3±0.3），两者有相关性（r=0.30， P<0.001），且各自手术前后的差异具有统计学意义（t视力=13.44，t得分=16.75，P<0.001）。量表的效应值、标准化反应均数和变化率分别是1.71，1.40和44.46%。有完整随访资料的患者根据术前视力分成3组，或者根据术眼数量分成2组后，组间的得分变化差异均无统计学意义。根据并发症分组后，差异有统计学意义（t=2.90，P=0.004）。分布法中1个效应值、1个测量标准误和1/2个得分变化标准差估算MCID分别为1.71分，2.12分和3.96分。校标法中量表得分变化和校标条目选项存在显著相关（r=-0.35，P<0.001），回归公式中的β系数为3.74，用来估计MCID值。结合分布法和校标法取平均值得到最终MCID值2.88分。结论：Catquest 9SF-CN量表适用于白内障生活质量评估，在中国白内障手术前后的反应度良好，并建立了MCID值2.88分作为应用参考。 相似文献
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Total knee replacement: Are there any baseline factors that have influence in patient reported outcomes? 
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