Progress in clinical trial of histone deacetylase （HDAC） inhibitors for non-small cell lung cancers

Histone deacetylase （HDAC） inhibitors, which represent a structurally diverse group of molecules, have emerged as a novel therapeutic class of molecules with significant anticancer potential. Vorinostat and romidepsin, known as the first generation of HDAC inhibitors, were approved in the United States for the treatment of T-cell lymphomas. Preliminary activity of HDAC inhibitors has also been observed in non-small cell lung cancer （NSCLC） in combination with the existing treatment regimens, of which is the focus of the current review.     

宫颈癌IMRT与BT联合应用研究进展

BT是宫颈癌根治性放疗的重要组成部分。随着放疗技术不断发展,对于盆腔体外IMRT后残存肿瘤体积大、伴有宫旁浸润的宫颈癌患者,有学者提出了BT同步IMRT的治疗技术。本文回顾近年来IMRT与BT综合应用在宫颈癌治疗中的研究进展。     

Retirement and health: Evidence from England

This paper utilizes census records, inpatient records, comprehensive surveys, and mortality records from England to trace out the effect of reaching retirement age on retirement status and health outcomes. Applying a regression discontinuity design leveraging the pension age, I find that retirement substantially improves well-being and reported health. I find no immediate effect of retirement on behavioral outcomes and no evidence of changes to cognitive ability, utilization, or mortality. While prior literature has considered the effects of retirement on specific outcomes, this paper systematically examines the full range of health-related outcomes with administrative and survey data in a unified context.     

中医药治疗颈性眩晕的研究进展

颈性眩晕是常见的骨科疾病,主要以老年人为主,已严重影响了人们的生活与工作。近年来中医通过多种特色疗法取得了很好疗效。但目前没有统一的辨证分型和理法方药,还需进一步研究。     

产前认知辅导对初产妇分娩方式及产程时间的影响

目的探讨产前认知辅导对初产妇分娩方式及产程时间的影响。方法选取2016年1~12月间我院妇产科收治的初产妇80例,依据随机数字表法分为产前常规检查组(n=40)和产前认知辅导组(n=40)。对两组初产妇的分娩方式、配合分娩情况及自然分娩初产妇的各阶段产程时间进行统计分析。结果产前认知辅导组初产妇的自然分娩率为75.0%(30/40)显著高于产前常规检查组52.5%(21/40)(P0.05),剖宫产率、社会因素剖宫产率、难产率分别为22.5%(9/40)、5.0%(2/40)、22.5%(9/40)均显著低于产前常规检查组42.5%(17/40)、25.0%(10/40)、45.0%(18/40)(P0.05),配合好比例[72.5%(29/40)]显著高于产前常规检查组[35.0%(14/40)](P0.05),配合一般、配合差比例[22.5%(9/40)、5.0%(2/40)]均显著低于产前常规检查组[42.5%(17/40)、22.5%(9/40)](P0.05),自然分娩初产妇的第二产程、总产程时间均显著短于产前常规检查组(P0.05)。结论产前认知辅导能够有效提升初产妇的自然分娩率,降低初产妇的剖宫产率,并缩短自然分娩初产妇的产程时间。     

精密注塑机的最新技术进展及发展趋势

本文通过分析注塑机锁模结构、驱动方式的变化,从精密、高效、节能、环保等方面,阐述了精密注塑机的最新技术进展及发展趋势.     

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?? Sjögren syndrome??SS??is classified as primary Sjögren syndrome??pSS??and secondary Sjögren syndrome??sSS??. It is an autoimmune exocrinopathy characterised by lymphocytic infiltration of exocrine glands in multiple sites??including both lacrimal and salivary glands??so the patients often suffer from dry mouth and dry eyes. Now the pathogeny and its pathogenesis is still  under study??and this review will elaborate from the aspects of cytokines??antibody??gene??virus and so on.     

小儿喘息性疾病的诊断与临床治疗研究进展

目的 对近年来小儿喘息性疾病的诊断与临床治疗研究进展作一综述.方法 通过医学数据库检索相关文献,根据有代表性的文献,对相关内容进行分析、归纳、整理.结果 儿童哮喘病主要包括支气管哮喘、喘息性支气管炎、毛细支气管炎三种呼吸疾病.各类喘息性疾病均有相关诊断标准.小儿喘息性疾病的临床治疗药物主要以西药为主,包括吸入皮质激素、β2受体激动剂、干扰素及抗生素等.结论 对小儿喘息性疾病的正确认识及合理治疗非常重要.     

PiCCO临床应用的研究进展

本文介绍了脉搏指示连续心排量监测(pulse index continuous cardiac output,PiCCO)监测仪的基本原理和使用方法,简述了热稀释方法及分析动脉压力波形得到的两部分参数,分析了监测全心舒张末期容积(the monitoring end diastolic volume,GEDV)、胸内血容量(intrathoracic blood volume,ITBV)、血管外肺水(extravascular lung water,EVLW)、PVV、SVV等参数的临床意义,PiCCO的临床应用及注意事项,并得出PiCCO是一种可靠地有创血流动力学监测措施,可以准确的反映机体容量状况,指导液体治疗,且对肺水肿有很高的预测价值的结论。     

Reproduction, social behavior, and aging trajectories in honeybee workers

While a negative correlation between reproduction and life span is commonly observed, specialized reproductive individuals outlive their non-reproductive nestmates in all eusocial species, including the honeybee, Apis mellifera (L). The consequences of reproduction for individual life expectancy can be studied directly by comparing reproductive and non-reproductive workers. We quantified the life span consequences of reproduction in honeybee workers by removal of the queen to trigger worker reproduction. Furthermore, we observed the social behavior of large cohorts of workers under experimental and control conditions to test for associations with individual life expectancy. Worker life expectancy was moderately increased by queen removal. Queenless colonies contained a few long-lived workers, and oviposition behavior was associated with a strong reduction in mortality risk, indicating that a reproductive role confers a significant survival advantage. This finding is further substantiated by an association between brood care behavior and worker longevity that depends on the social environment. In contrast, other in-hive activities, such as fanning, trophallaxis, and allogrooming did not consistently affect worker life expectancy. The influence of foraging varied among replicates. An earlier age of transitioning from in-hive tasks to outside foraging was always associated with shorter life spans, in accordance with previous studies. In sum, our studies quantify how individual mortality is affected by particular social roles and colony environments and demonstrate interactions between the two. The exceptional, positive association between reproduction and longevity in honeybees extends to within-caste plasticity, which may be exploited for mechanistic studies.