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31.
通心络胶囊对冠心病治疗效果的临床对照观察 总被引:1,自引:0,他引:1
欧宁 《中西医结合心脑血管病杂志》2007,5(7):575-576
目的观察通心络胶囊对冠心病(CHD)常见临床症状的改善效果。方法对照组维持原有药物治疗不变,治疗组在此基础上加服通心络胶囊4粒/次,3次/日,疗程4周。病人接受观察前进行常规化验检查,检测心率、血压、心功能等指标。疗程结束时对上述指标再进行检查,并观察病人的临床症状改善情况。结果两组病人的胸痛、胸闷、气憋、心悸、乏力等常见临床症状均有改善,且治疗组明显优于对照组(P〈0.05);治疗组每搏量和心排血量的较对照组提高较为明显(P〈0.01)。结论加服通心络胶囊治疗CHD能增强西药的治疗效果,进一步改善CHD病人的常见临床症状。 相似文献
32.
In the attempt to gain a broader understanding of the causal relationships behind work-related symptoms of pain in the human
shoulder, monitoring of arm position is crucial. Different methods have been used with varying accuracy. A video-based stereometry
system, using infra-red light and reflecting markers for motion analysis, has been introduced for measurements in the fields
of ergonomics, biomechanics and sports medicine. The purpose of this study is to investigate the sources of error in using
this system for posture registration of the upper limb. Measurements are performed on a calibration fixture, on a mechanical
model of the upper limb and on a subject with an exoskeleton. Particular, attention is given to inconsistencies and relative
errors due to the finite geometrical precision with which the markers are positioned in the calibration fixture and on the
studied objects, the limited capability to align the objects relative to the coordinate system of the calibration fixture
and the errors connected to angular measurements using protractors etc. It is concluded that the system makes a valuable addition
to existing instruments for non-contact posture measurement, and produces position data with an adequate accuracy in normal
handling. 相似文献
33.
戴其昌 《中国现代应用药学》1998,15(5):45-47
目的:建立测定心脑健胶囊的高效液相色谱法。方法:以Nova-pack C18为分析柱,甲醇-0.04mol/L磷酸-乙腈为流动相,检测波长:254nm,峰面积外标法。结果:回收率与线性范围分别为;EGCG;ECG;GCG;EGC。结论;本法简便,适合心脑健胶囊的含量测定。 相似文献
34.
氧氟沙星及其胶囊的HPLC测定 总被引:7,自引:1,他引:6
改进了氧氟沙星及其胶囊的HPLC测定条件。与卫生部药品标准方法相比,柱放大为提高,拖尾现象减小。 相似文献
35.
目的 通过健康受试者的双交叉试验比较萘普生缓释胶囊与普通片的药物动力学和生物利用度。方法10位健康受试者一次服用这两种制剂500mg,在稳态试验中8位受试者接受两种制剂5天,缓释胶囊500mg每天一次,普通片每天两次,每次250mg。血药浓度用HPLC方法测定。结果 一次服药试验证明该缓释胶囊血药浓度上升缓慢,浓度变化平稳,Gmax为85.9μg/ml,Tpeak为6.0h,而普通片的Cmax为140.4μg/ml,Tpeak为3.2h,两种制剂的生物利用度相当,缓释胶囊与普通片生物等效。通过8位健康受试者交叉连续服用萘普生缓释胶囊与普通片的稳态药代动力学研究表明,到第3天给药后已达到稳态,由第5天给药后的血药浓度测定数据计算其主要的稳态药代动力学参数,缓释胶囊的峰浓度(Cmax)、峰谷比和波动度(DF)明显低于普通片,这些参数分别为73,1μg/ml、1.48和37.7o;而普通片的上述参数分别为 100.8μg/ml、2.51和78.2%。结论 奈普生缓释胶囊具有缓释作用,能较好维持血药治疗浓度。 相似文献
36.
Tamaki Sasaki Tetsuya Sato Yoshiyuki Jyo Nobuya Tanda Hitoshi Tamai Gengo Osawa 《Clinical and experimental nephrology》1997,1(1):32-40
Background We previously found that glomerular epithelial cells play an important role in the formation of adhesive lesions. Glomerular
sclerotic lesions develop after the inital adhesive lesions.
Methods Two series of experiments were done with spontaneously diabetic WBN/Kob rats. These rats develop segmental glomerular sclerotic
lesions with aging. The first series of experiments was intended to clarify the kinetics of glomerular cells on progressive
glomerular damage in these rats. The second series of experiments was designed to study the relationship between proliferation
(judged by % bromodeoxyuridine-positive cells) of glomerlar epithelial cells and sclerotic lesions with adhesions.
Results In the first series, rats having increased proteinuria showed segmental glomerular sclerotic lesions with adhesions. At the
same time, increased labeling indices of tuft cells and epithelial cells of Bowman's capsule were observed. In the second
series, no significant increase in the labeling indices of tuft cells with sclerotic lesions was observed, compared to tuft
cells without sclerotic lesions. In sclerotic lesions with adhesion, bromodeoxyurdine-positive cells were observed that were
not distinguishable as podocytes or epithelial cells of Bowman's capsule. The highest labelling index was noted in the epithelial
cells of Bowman's capsules with sclerosis.
Conclusion This study shows that the proliferation of glomerular epithelial cells (mainly epithelial cells of Bowman's capsule) occurs
in glomerular sclerotic lesions with adhesions. 相似文献
37.
[目的]观察救心胶囊对低密度脂蛋白(LDL)损伤后内皮细胞抗氧化损伤能力的影响,以探讨该复方保护内皮细胞和防治冠心病的作用机制。[方法]运用内皮细胞培养技术,建立LDL损伤模型,并以两种不同的给药方式——无菌中药提取液和载药血清进行分组培养,并观察内皮细胞超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量的变化。[结果]内皮细胞LDL损伤后,其SOD活性显著降低,而MDA含量明显升高,而中药处理后能有效抑制上述改变。[结论]救心胶囊能增强细胞的抗氧化损伤能力,具有良好的保护内皮细胞的作用。 相似文献
38.
To evaluate changes in matrix molecules of the joint capsule, the right knees of 24 skeletally mature female NZW rabbits were immobilized while the contralateral limb served as an unoperated control. The immobilization was discontinued at 8 weeks and the rabbits were divided among four groups (n = 6) based on the number of weeks the right knees were remobilized: 0, 8, 16, or 32. Three rabbits (six knees) that did not have operations provided normal control joint capsules. The mRNA levels for collagen types I, II, and III, and MMP-1 and -13 were significantly increased in the joint capsules of the contracture knees in all groups when compared to normal and contralateral limb joint capsules. In contrast, the mRNA levels for TIMP-1, -2, and -3 were decreased in the joint capsules of the contracture knees in all groups when compared to normal and contralateral limb joint capsules. The mRNA levels for lumican and decorin were increased in the joint capsules of the contracture knees in all groups when compared to normal capsules. Many of the changes observed in this animal model are similar to those observed in human joint capsules from posttraumatic elbow contractures, supporting the value of this rabbit model. 相似文献
39.
且的:观察疏可眠胶囊对小鼠的镇静作用。方法:采用旷野活动法观察疏可眠胶囊不同给药剂量、给药时间对小鼠自主活动的量效、时效作用;对士的宁诱发惊厥小鼠的作用。结果:连续给药7d,疏可眠低中剂量(1g·k~(-1)、2g·kg~(-1))均能显著减少小鼠的自主活动;疏可眠高剂量(3g·kg~(-1))给药后1h~2h自主活动显著减少;给药后2h,呈现量效关系,随着剂量增加小鼠自主活动减少。各剂量组均可延长士的宁诱发小鼠惊厥出现的时间及死亡时间。结论:疏可眠胶囊具有减少小鼠自主活动和抗惊厥作用。 相似文献
40.
Two cases are reported in which, after ACL reconstruction with autologous hamstring grafts, tibial polylactide interference
screws migrated into the knee joint. Clinically, both patients presented with recurrent locking of the joint. In one case,
a broken 15 mm-long tip of the screw was found intra-articularly. In the other case, the whole screw had migrated into the
joint cavity. The degradation process of polylactic acid, operative technique and bone quality are discussed as possible reasons
for these complications. 相似文献