顶空气相色谱法测定醋酸烯诺孕酮埋植剂中环氧乙烷的残留量

用顶空气相色谱法测定醋酸烯诺孕酮埋植剂中环氧乙烷的残留量，结果表明，线性试验与精密度良好，平均回收率为99．8％，残留量为0．93％。样品在灭菌后，室温放置3天，其环氧乙烷残留量均在0．0001％以下，符合环氧乙烷残留量应不大于0．001％的规定。表明采用顶空气相色谱法测定醋酸烯诺孕酮理植剂中环氧乙烷残留量，方法简便，结果准确，适用于对该产品中环氧乙烷残留量的检测与控制。     

Reaction of surrounding gingiva to permucosal implants of dense hydroxyapatite in dogs

Experimental and histological studies on the reaction of surrounding gingiva to permucosal implants of dense calcium hydroxyapatite were carried out in dogs. Epithelial attachment and connection of supra-alveolar collagen fibres to the implant surface seemed to form a biological seal around implants similar to that around natural teeth. However, excellent oral hygiene is very important for the maintenance of this biological seal.     

基于电刺激的外层型人工视网膜的研究进展

外层型视网膜假体采用了MEMS技术,通过植入到视网膜相应部位的电极来刺激神经节细胞,并且能够在大脑皮层视觉区域引起对应的特征电位反应,最终部分恢复生物体的视觉.这种外层型视网膜植入装置可分为眼外和眼内部分.后者功能相对重要,设计也较为复杂.它是由包含MPDA和微电极的刺激芯片及附属装置组成.本篇文章主体包括四部分:首先是视网膜假体的概况;其次是视网膜生理基础和视网膜假体理论的简介;在第三部分,为设计理念和MPDA的制造过程;最后,是对难题的讨论和未来发展的展望.     

国人股骨假体设计的解剖学基础

目的 :为选择和设计适合中国人的髋关节假体提供参考值。方法 :对 12 9例成人股骨标本进行X线摄片 ,并对其中 2 0例标本行CT扫描 ,测量小转子及其上下 2cm平面处髓腔宽度、前倾角等参数。结果 :小转子处髓腔宽为 ( 2 4.85± 2 .94)mm ,其上 2cm处为 ( 4 2 .47± 5 .14 )mm ,其下 2cm处为 ( 17.87±3 .0 4)mm ,个体间有较大差异。CT测量值与X片测量值无明显统计学差异。结论 :股骨上段的解剖学资料 ,可为选择和设计适合国人的人工髋关节假体提供参考。     

Presence and course of the incisive canal in the human mandibular interforaminal region: two-dimensional imaging versus anatomical observations

The objective of the present study was to evaluate the presence and course of the incisive canal in the mental interforaminal region of the human mandible and to describe the occurrence of anatomical variations. Mandibles of 50 adult human cadavers were retrieved from the Department of Anatomy of the Faculty of Medicine, Katholieke Universiteit Leuven (Leuven, Belgium). Forty mandibles were edentulous, while 10 mandibles were partially dentate. Intra-oral, panoramic and tomographic imaging of the interforaminal region of the human mandible were performed. Afterwards, mandibles were sawn into vertical sections according to the respective tomographic cross-sections. The latter allowed exploration for the presence and course of an anterior prolongation of the mandibular canal. Measurements of the location of the incisive canal towards the base of the mandible were made using a digital-sliding caliper. Results indicated a well-defined incisive canal [mean (SD) inner diameter 1.8 (0.5 mm)], macroscopically observed in 96% of mandibles. The incisive canal was located on average 9.7 mm (SD 1.8 mm) from the lower cortical border and continued towards the incisor region in a slightly downward direction, with a mean (SD) distance to the lower cortical border of 7.2 (2.1) mm. It was concluded that there is an anterior intraosseous extension of the mandibular canal, denoted as the incisive canal. The latter might be considered as a true anterior extension of the neurovascular bundle. Histological and neurophysiological studies are needed to verify this hypothesis and evaluate its potential clinical implications.

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Electronic Supplementary Material The french version of this article is available in the form of electronic supplementary material and can be obtained by using the Springer Link server located at .D. van Steenberghe is holder of the Prof. P-I. Brånemark Chair in Osseointegration     

Interaction of biodegradable β-whitlockite ceramics with bone tissue: An in vivo study

The biodegradation of different porous β-whitlockite materials are studied by in vivo experiments, radiographie follow-ups and light microscopy observations. The materials were implanted in rabbit tibiae for 16 mnth. Micropores play an important role in the biodegradation rate. The resorbing materials evoke an inflammation with plasma cells. The resorption starts in the medulla, and the phagocytosed particles are removed to the lymph nodes. Normal bone function can be restored after all the implant material is resulted.     

中国汉族人与美国高加索白人膝关节几何形态的比较

背景:有研究显示中国人膝关节胫骨近端前后径和横径均小于美国高加索人,所以在膝关节形态学方面存在一定差异,因此常发生进口假体系统应用于国人后出现匹配度不高的现象。目的:测量中国人和美国人股骨远端、胫骨近端的几何形态学参数,比较其差异。方法:选择北京清华长庚医院骨科拟行前交叉韧带重建的中国汉族患者50例,以及美国匹兹堡大学运动医学中心拟行前交叉韧带重建的高加索白人后裔患者40例,对90例受试者膝关节进行CT扫描,使用AW Volume Share 5软件进行三维重建,利用Geomagic软件对胫骨近端和股骨远端的各项参数进行测量。结果与结论:①股骨近端测量参数中,中国人的外侧胫骨平台内外径小于美国人(P=0.027),外侧胫骨平台后倾角大于美国人(P<0.05);两组间胫骨平台内外径、内侧胫骨平台外径、内侧胫骨平台前后径、外侧胫骨平台前后径与内侧胫骨平台后倾角比较差异均无显著性意义(P>0.05);②股骨远端测量参数中,中国人的股骨远端横径、外侧髁内外径、内侧髁前后径、外侧髁前后径及髁间窝高度均小于美国人(P<0.05),股骨外翻角大于美国人(P<0.05);两组间内侧髁内外径、髁间窝宽度及滑车沟宽度比较差异无显著性意义(P>0.05);③结果表明,中国人与美国人在膝关节形态学的多个参数存在差异,有必要针对中国人设计更为个体化的膝关节假体。     

长效抗生育埋植剂CaproF体内药物释放的研究

目的对可降解长效抗生育埋植剂CaproF的体内药物释放动力学进行评价。方法将CaproF植入Wister大鼠皮下。每隔一定时间处死动物,取出埋植剂,用紫外分光光度法测药物残留量,计算单位长度埋植剂平均每日药物释放量。放射免疫法测定左炔诺孕酮(LNG)血药浓度。结果CaproF埋植剂在60、120、180、360、720d药物平均释放速率分别为(11.0±3.0)、(11.7±3.7)、(8.0±1.2)、(7.3±0.4)、(9.3±0.9)μg/(d·cm),并可维持基本恒定的血药浓度。结论左炔诺孕酮CaproF埋植剂植入体内后,平均药物释放速率达到7.6μg/(d·cm),并可维持2年的基本稳定释放。     

Directly bone-anchored implants for fixation of aural epistheses

In cases of missing outer ears, generally, epistheses are attached to eye-glasses which gives insecure attachment and a fairly poor cosmetic result. A new method for stable episthesis attachment is being tested in Gothenburg, Sweden. Threaded, cylindrical titanium implants are inserted with a meticulous technique in the temporal bone of the patient. At the next stage, 3–4 months later, the implants are connected to abutments which are allowed to penetrate the skin, To these abutments a silicone episthesis is attached. Presently, 7 patients who had no outer ear because of congenital disorders, hereditary diseases or status post trauma or tumour surgery have been operated and followed for up to $\text{1}\text{2}$ have been no problems reported with the bone anchorage or the skin penetration.     

Intracerebral implantation of progesterone: re-examination of the brain sites responsible for facilitation of sexual receptivity in estrogen-primed ovariectomized rats.

Ovariectomized female rats were tested for sexual receptivity following SC priming with threshold doses of estradiol benzoate and intracerebral 27 ga implants of either progesterone or cholesterol. All females were repeatedly tested under both intracerebral hormone implant conditions. Cholesterol implants failed to activate receptivity, while progesterone implants in the interpeduncular-ventral tegmental area produced near maximal levels of receptivity within 30 min after implantation. Progesterone implants in the medial hypothalamus, anterior hypothalamus, preoptic area, pons, mesencephalic reticular formation and lateral mesencephalon failed to activate sexual receptivity.