全文获取类型
收费全文 | 12651篇 |
免费 | 938篇 |
国内免费 | 306篇 |
专业分类
耳鼻咽喉 | 92篇 |
儿科学 | 268篇 |
妇产科学 | 34篇 |
基础医学 | 688篇 |
口腔科学 | 19篇 |
临床医学 | 1620篇 |
内科学 | 5894篇 |
皮肤病学 | 6篇 |
神经病学 | 95篇 |
特种医学 | 347篇 |
外科学 | 2673篇 |
综合类 | 1358篇 |
现状与发展 | 1篇 |
预防医学 | 209篇 |
眼科学 | 205篇 |
药学 | 337篇 |
3篇 | |
中国医学 | 30篇 |
肿瘤学 | 16篇 |
出版年
2024年 | 25篇 |
2023年 | 340篇 |
2022年 | 573篇 |
2021年 | 888篇 |
2020年 | 826篇 |
2019年 | 829篇 |
2018年 | 751篇 |
2017年 | 414篇 |
2016年 | 341篇 |
2015年 | 476篇 |
2014年 | 852篇 |
2013年 | 729篇 |
2012年 | 484篇 |
2011年 | 615篇 |
2010年 | 461篇 |
2009年 | 492篇 |
2008年 | 441篇 |
2007年 | 437篇 |
2006年 | 456篇 |
2005年 | 408篇 |
2004年 | 317篇 |
2003年 | 305篇 |
2002年 | 261篇 |
2001年 | 242篇 |
2000年 | 213篇 |
1999年 | 206篇 |
1998年 | 158篇 |
1997年 | 149篇 |
1996年 | 137篇 |
1995年 | 128篇 |
1994年 | 126篇 |
1993年 | 104篇 |
1992年 | 87篇 |
1991年 | 73篇 |
1990年 | 67篇 |
1989年 | 59篇 |
1988年 | 43篇 |
1987年 | 62篇 |
1986年 | 50篇 |
1985年 | 56篇 |
1984年 | 54篇 |
1983年 | 29篇 |
1982年 | 34篇 |
1981年 | 20篇 |
1980年 | 21篇 |
1979年 | 16篇 |
1978年 | 12篇 |
1976年 | 10篇 |
1974年 | 3篇 |
1973年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
21.
目的 探讨抗菌处理对肺动脉瓣膜细胞活性和组织结构的影响因素及优化同种瓣膜的制备方法。方法 3组猪肺动脉瓣叶(n=6)浸泡在含抗生素的DMEM液中,在不同温度下孵育6h或24h。然后通过XTT比色法测定瓣膜细胞活性,用免疫组织化学荧光染色检测瓣膜细胞和细胞外基质,并行光镜观察。结果 抗菌时间为24h,37℃抗菌组与4℃抗菌组的瓣膜细胞活性与瓣膜组织结构无明显区别。抗菌6h组的瓣膜细胞活性与瓣膜组织结构明显优于抗菌24h组。结论 抗菌时间为24h时,抗菌温度对瓣膜细胞活性及结构完整性无明显影响。抗菌时间缩短至6h,有利于瓣膜细胞活性与结构完整性的保持。 相似文献
22.
Makoto Kamada Kenji Ohsaka Susumu Nagamine Hidemitsu Kakihata 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2003,51(10):552-556
Acute aortic dissection complicated with acute myocardial infarction (AMI) is the most fatal situation. We experienced the
successful treatment for acute type A aortic dissection complicated with inferior AMI following aortic valve replacement (AVR).
A 60-year-old man had had AVR for aortic regurgitation. Sixteen months after the AVR, he had a sudden onset of severe chest
pain with complete atrioventricular block. Immediately, temporary pacing and cardiac catheterization were conducted, showing
the occlusion of the right coronary artery due to acute type A aortic dissection. On his way to our hospital, direct current
shock was conducted 3 times for ventricular fibrillation. We replaced the ascending aorta combined with coronary artery bypass
grafting and the postoperative course was uneventful. The key to treat acute aortic dissection complicated with AMI is early
accurate diagnosis, prompt temporary pacing for bradycardia, defibrillation for lethal arrhythmia and insertion of a perfusion
catheter if possible. These preoperative hemodynamic stabilization gives us the chance to save these patients. 相似文献
23.
心脏瓣膜置换术后中远期疗效分析 总被引:8,自引:0,他引:8
目的 分析探讨心脏瓣膜置换术的中远期疗效。方法 1978年至 2 0 0 1年 12月 ,行瓣膜置换手术 2 14 1例 ,同期随访 16 81例 ,计 80 2 1 1人·年 ,平均 4 77人·年。通过回顾病因、手术方式、瓣膜类型等因素 ,观察术后病人心功能改善情况 ,病死率及并发症等 ,采用t检验 ,多因素回归等统计学方法分析。结果 92例死亡。总体生存率 5年为 (92 3± 2 2 ) % ,10年生存率为 (90 1± 2 7) %。并发症有血栓栓塞、机械瓣膜功能障碍、瓣周漏、溶血、机械瓣膜感染性心内膜炎。术后心功能 (NYHA)与术前比较有明显的提高。结论 1.机械瓣置换术后中远期疗效满意 ,病死率及并发症均较低 ;与术前心功能和手术种类直接相关 ;2 .使用保留瓣下结构及三尖瓣成形术对术后心功能恢复有明显效果 ;3.术中良好心肌保护是提高手术成功率的关键。 相似文献
24.
Twenty-two percutaneous transluminal balloon valvuloplasty procedures were performed on 21 patients with congenital pulmonary valve stenosis. The peak systolic pressure gradient was immediately reduced from 79.1 +/- 7.4 to 22.2 +/- 1.8 mmHg, (P less than 0.0001) and follow-up cardiac catheterization at 5.3 +/- 0.4 months in 19 patients revealed no further significant change in gradient (23.5 +/- 3.2 mmHg). The best results were obtained when balloons larger than the pulmonary annulus were used, i.e. an immediate residual transvalvular gradient of 22.0 +/- 2.2 mmHg with a balloon/annulus ratio greater than 1, as opposed to 44.2 +/- 5.4 with a balloon/annulus ratio = 1 (P less than 0.001). The angiographically determined cusp thickness of the stenotic pulmonary valves was significantly greater than that of the control group of 24 patients without pulmonary valve stenosis (1.21 +/- 0.09 vs 0.59 +/- 0.02 mmHg, P less than 0.00001). The relationship between this parameter and the residual transvalvular gradient at follow-up was found to be significant (r = 0.77, P less than 0.001). It is concluded that balloon size is a determinant factor in achieving good results with percutaneous balloon valvuloplasty although cusp thickness, a factor to which scant regard has hitherto been paid, also plays a significant role in the residual transvalvular gradient measured at follow-up. 相似文献
25.
26.
目的:观察吸入一氧化氮(NO)对心瓣膜置换术后肺动脉高压患者血流动力学的影响。方法:选择9例心瓣膜置换术后伴肺动脉高压的病人,吸入NO0.003%,观察三个时象点:吸入NO前;开始吸入NO后15分钟;停止吸入NO后15分钟。结果:吸入NO能显著降低肺动脉压和肺循环阻力指数(P<0.01),停止吸入NO15分钟后,肺动脉压和肺循环阻力指数恢复到原有水平。在整个观察过程中,心率、平均动脉压、中心静脉压、肺动脉楔压、体循环阻力指数和心脏指数均无显著变化(P>0.05)。结论:吸入NO具有选择性肺血管扩张作用,是治疗心瓣膜置换术后肺动脉高压的较理想药物。 相似文献
27.
W. N. HABRE E. F. VAN GESSEL CH. MAMIE R. CANTIENI P. M. SUTER 《Acta anaesthesiologica Scandinavica》1994,38(6):612-614
Severe aortic regurgitation was discovered in a young man 21 days after blunt chest trauma and after a prolonged febrile state with positive blood cultures. Using transoesophageal echocardiography (TEE), it was possible to make the differential diagnosis between traumatic rupture and endocarditis as the cause of valvular insufficiency. The use of TEE in the initial evaluation of severe thoracic trauma with an unclear clinical picture is recommended. This method is easy to use at the bedside and gives precise information on the aortic valve and the ascending aorta. 相似文献
28.
Surgically uncorrectable tricuspid valve disease in children is rare. However, when it happens the surgical options are very limited. Tricuspid valve replacement using a mechanical valve or stented bioprosthesis is impractical. Use of homografts in the “anatomic position” has its limitations. We report here the use of an extracardiac homograft connection between the right atrium and right ventricle in a 16-month-old boy in whom severe tricuspid valve stenosis developed after surgical repair of a complex ventricular septal defect associated with dextrocardia and anomalous systemic venous drainage. The patient remains well receiving no cardiac medication 12 months after the procedure. 相似文献
29.
目的采用新型高分子材料制备人工心脏瓣膜,并对其体外流体力学特征作出评价。方法将片状超微孔膨体聚四氟乙烯材料缝制于弹性支架上做成人工心脏瓣膜,以Baxter人工双叶机械瓣作对照,对新型瓣膜进行了静态泄漏和定常流测试。结果两种瓣膜静态泄漏率无显著差异(P>0.05),定常流下高分子瓣膜跨瓣压差更低,两组间存在显著差异(P<0.001)。结论新型高分子人工心脏瓣膜体外流体动力学性能优于Baxter机械瓣。 相似文献
30.
The posterior urethral valve uropathy: Results of treatment 总被引:2,自引:0,他引:2
Nineteen children treated for posterior urethral obstruction due to congenital valve in the University of Benin Teaching Hospital,
Benin City, Nigeria, over a 9-year period have been analysed. Their ages ranged from birth to 12 years. Results show that
associated kidney pathology may be irreversible even after successful excision of the valve. This determines the final prognosis,
which is worse the younger the child at presentation. 相似文献