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41.
Background:The clinical failure after prostatic artery embolization (PAE) with conventional particles was relatively high,in treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hy... 相似文献
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43.
《Experimental and toxicologic pathology》2014,66(8):383-389
Coal dust is a pollutant found in coal mines that are capable of inducing oxidative stress and inflammation, but the effects on lung metaplasia as an early step of carcinogenesis remain unknown. The purpose of the present study was to evaluate the effects of PM10 coal dust on lung histology, MUC5AC expression, epidermal growth factor (EGF) expression, and epidermal growth factor receptor (EGFR) expression. An experimental study was done on male Wistar rats, which were divided into the following groups: control groups exposed to coal dust for 14 days (at doses of 6.25 mg/m3, 12.5 mg/m3, and 25 mg/m3), and the groups exposed to coal dust for 28 days (at doses of 6.25 mg/m3, 12.5 mg/m3, and 25 mg/m3). EGF expressions in rat lungs were measured by ELISA. EGFR and MUC5AC were measured by a confocal laser scanning microscope. The bronchoalveolar epithelial image of the group exposed to coal dust for 14 and 28 days showed a epithelial rearrangement, hyperplastic (metaplastic) goblet cells, and scattered massive inflammatory cells. The pulmonary parenchymal image of the group of exposed to coal dust for 14 and 28 days showed scattered inflammatory cells filling up the pulmonary alveolar networks, leading to an appearance of thickened parenchymal alveoli until emphysema-like structure. There was no significant difference in MUC5AC, EGF, and EGFR expressions for 14-d exposure (p > 0.05). There was no significant difference in EGF and EGFR expressions for 28-d exposure (p > 0.05), but there was a significant difference in MUC5AC expression (p < 0.05). We concluded that subchronic inhalation of coal dust particulate matter 10 induces bronchoalveolar reactive hyperplasia and rearrangement of epithelial cells which accompanied by decrease expression MUC5AC in male rats. 相似文献
44.
Yong June Yang Jun Sung Koh Hyo Jung Ko Kang Joon Cho Joon Chul Kim Soo-Jung Lee Chi-Un Pae 《Journal of Korean medical science》2014,29(8):1145-1151
This is the first study to investigate the influence of depression, anxiety and somatization on the treatment response for lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH). The LUTS/BPH patients were evaluated with the Korean versions of the International Prostate Symptom Score (IPSS), the Patient Health Questionnaire-9 (PHQ-9), the 7-item Generalized Anxiety Disorder Scale (GAD-7) and the PHQ-15. The primary endpoint was a responder rate defined by the total score of IPSS (≤ 7) at the end of treatment. The LUTS/BPH severity was significantly higher in patients with depression (whole symptoms P = 0.024; storage sub-symptom P = 0.021) or somatization (P = 0.024) than in those without, while the quality of life (QOL) was significantly higher in patients with anxiety (P = 0.038) than in those without. Anxious patients showed significantly higher proportion of non-response (odds ratio [OR], 3.294, P = 0.022) than those without, while somatic patients had a trend toward having more non-responders (OR, 2.552, P = 0.067). Our exploratory results suggest that depression, anxiety and somatization may have some influences on the clinical manifestation of LUTS/BPH. Further, anxious patients had a lower response to treatment in patients with LUTS/BPH. Despite of limitations, the present study demonstrates that clinicians may need careful evaluation of psychiatric symptoms for proper management of patients with LUTS/BPH.
Graphical Abstract
相似文献45.
王宁博 《中国CT和MRI杂志》2020,(5):35-37
目的探讨1.5T磁共振(MRI)多b值扩散加权成像(DWI)及表观扩散系数(ADC)值定量分析在前列腺癌(PCa)与前列腺增生(BPH)诊断中的价值。方法将我院经病理活检证实为前列腺疾病的232例患者作为研究对象,其中PCa者100例,BPH者132例。所有患者均进行常规1.5TMRI扫描和多b值DWI检查,比较不同b值两组ADC值。结果PCa患者DWI上可见局灶性(或弥漫性)高信号,ADC图显示有对比周围组织较低的低值区;BPH患者DWI显示前列腺增生结节,呈高或稍高信号,ADC图显示有对比周围组织较低的低值区。不同b值下,PCa组ADC值均存在差异,其中b值=1500s/mm^2时的ADC值小于b值=800、1000s/mm^2时的ADC值(P<0.05),b值=1000s/mm^2时的ADC值小于b值=800s/mm^2时的ADC值(P<0.05);b值=800、1000、1500s/mm^2时,PCa组ADC值均低于BPH组(P<0.05)。ROC曲线分析显示当b值=1500s/mm^2时,ADC值诊断效果最佳,所得阈值为1.013×10^-3mm^2/s,敏感度为96.00%,特异度为93.94%。结论1.5TMRI多b值DWI及其ADC值定量分析可有效鉴别PCa和BPH,可在临床推广应用。 相似文献
46.
目的分析MRI弥散加权成像磁共振弥散加权成像(DWI)在前列腺增生和前列腺癌诊断鉴别中的应用。方法将2017年1月~2019年1月在本院经手术或穿刺活检病理确诊的前列腺病变患者病变类型对应前列腺增生组、前列腺癌组;另筛选同期于本院行健康体检的30名志愿者作为对照组。比较三组MRI-DWI参数,并绘制受试者工作特征(ROC)曲线分析MRI-DWI参数对前列腺病变、前列腺癌的诊断鉴别价值。结果与对照组比较,前列腺癌组D、ADC显著较低,f显著较高(P<0.5);与前列腺增生组比较,前列腺癌组D、ADC显著较低,D~*、f显著较高(P<0.05);但前列腺增生组、对照组比较差异无统计学意义(P>0.05);单一MRI-DWI参数诊断前列腺疾病时ADC曲线下面积值(AUC)最高,以1.001×10^-3mm^2/s为cut-off,灵敏度为59.00%、特异度96.70%;联合诊断时特异性上升至100.00%;单一参数诊断前列腺癌时同样以ADCAUC值最高,1.269×10^-3mm^2/s为cut-off,其预测前列腺癌的灵敏度为100.00%、特异度高达86.10%;与联合诊断一致。结论MRI-DWI扫描在前列腺增生及前列腺癌鉴别诊断有较高效能,值得临床推介。 相似文献
47.
目的 探讨前列腺囊腺瘤的临床病理学特点,提高对该病的诊断及治疗水平.方法 回顾性分析1例病理诊断为前列腺囊腺瘤患者的主要症状,诊治情况,结合文献对该病的临床表现、诊断、病理学特征、治疗及预后进行讨论.结果 患者男性,51岁,2008年无明显诱因出现尿频、尿急、排尿困难症状,曾诊断“前列腺炎”,行药物治疗.2012年6月上述症状加重,行彩超检查提示:前列腺肥大并腺体内实性占位;行前列腺穿刺提示:前列腺增生,PINⅡ-Ⅲ级.于外院行TURP治疗,恢复良好.术后1个月开始反复出现血尿.2012年12月7日,急诊以“血尿待查”收入院.入院后完善CT、MRI、膀胱镜等相关检查,诊断为“膀胱颈部占位病变”行经尿道诊断性电切术,将肿物彻底切除.术后病理:前列腺囊腺瘤.组织学特点:前列腺腺体增生,间质纤维组织增生、充血,无细胞异形性,无核分裂像.免疫组化:PSA(+),PSAP(+).结论 前列腺囊腺瘤是一种少见的前列腺来源的良性肿瘤,前列腺囊腺瘤在形态学上具有独特的组织结构,多表达PSA和PSAP. 相似文献
48.
目的 观察应用前列腺汽化电切术(TUVP)联合围术期用药治疗良性前列腺增生症(BPH)合并慢性前列腺炎(CP)的临床疗效及安全性.方法 选取本院自2009年5月至2012年3月收治的85例BPH合并CP患者作为研究对象,所有患者均给予TUVP治疗,术前给予抗生素、受体阻滞剂,术后给予胆碱能受体阻滞剂,观察治疗效果及并发症情况.结果 (1)本组85例患者手术均获成功,手术平均时间(45.2±10.3)min,术中平均出血量(38.5±11.2)mL,切除前列腺组织净重平均(36.2±9.8)g.术后尿液转清时间为4 ~31h,平均(12.4±3.5)h.术后拔管平均时间为(2.3±0.8)d.对所有患者随访6~18个月,尿频、尿不尽等临床症状均明显减轻甚至消失,无复发病例.(2)85例患者治疗后较治疗前IPSS、QOL及MFR各项指标均明显改善,比较有显著性差异(P<0.01).(3)术后出现尿道出血2例,尿路感染1例,无膀胱痉挛、尿失禁、尿道狭窄病例.结论 应用TUVP联合围术期用药治疗BPH合并CP效果理想,且并发症少、术后恢复快,值得推广应用. 相似文献
49.
目的 评估前列腺电切治疗前列腺增生症(BPH)患者下尿路症状(LUTS)和勃起功能障碍(ED)的疗效.方法 选择96例BPH合并ED患者,予以前列腺电切治疗.采用国际前列腺症状评分(IPSS)、国际勃起功能障碍症状评分(IIEF-5)来评估治疗前后的疗效.结果 患者治疗前后的IPPS评分比较,差异有统计学意义(P<0.05),患者治疗前后的IIEF-5评分比较,差异无统计学意义(P>0.05).结论 前列腺电切可有效治疗前列腺增生症的LUTS,但对ED无明显改善. 相似文献
50.
Patricia do Socorro Queiroz Feio Camilla Borges Ferreira Gomes Alexandre Simões Nogueira Luciana Yamamoto Almeida José Vassallo Fernando Augusto Soares Oslei Paes Almeida Jorge Esquiche León 《Head and neck pathology》2013,7(3):258-262
The 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has become a standard procedure for the diagnosis, staging, and restaging in lymphoma patients. However, a relative high rate of false-positive results has been reported. We report a case of a 40-year-old man with a previous history of a nodal follicular lymphoma, stage IVA, treated with R-CHOP, which showed strong 18F-FDG uptake in the Waldeyer’s tonsillar ring during his follow-up, being considered highly suspicious of relapsed lymphoma. A surgical removal of the palatine tonsils and adenoids was performed, which showed reactive follicular hyperplasia. Furthermore, bone marrow biopsy revealed absence of neoplasia. The patient is still in follow-up with no signs of recurrent lymphoma. This case illustrates that, despite the high sensitivity for the detection of recurrent lymphoma, 18F-FDG uptake should be interpreted with great caution and confirmatory studies should be performed before any therapy. 相似文献