大鼠脑出血后延髓内脏带内儿茶酚胺能神经元的Fos表达

目的 观察大鼠脑出血后延髓内脏带儿茶酚胺能神经元的Ｆｏｓ表达。方法 尾壳核局部注射胶原酶制作脑出血模型,用抗Ｆｏｓ蛋白和抗酪氨酸羟化酶（ＴＨ）的双重免疫组织化学方法（ＡＢＣ法）,观察延髓内脏带内Ｆｏｓ蛋白表达及其与ＴＨ阳性神经元的共存。结果 有大量的Ｆｏｓ阳性细胞出现在延髓内,它们主要局限在延髓内脏带内,并以孤束核（ＮＴＳ）与延髓腹外侧区（ＶＬＭ）较为密集。ＮＴＳ和ＶＬＭ内Ｆｏｓ／ＴＨ双标细胞占Ｔ     

Problems related to dorsal root entry zone lesions

Summary Several clinical problems related to the dorsal root entry zone lesions (DREZLs) in 15 patients with chronic pain are presented and discussed in terms of ratings of pain relief following surgery, development of sensory or motor weakness and postmortem histologies. Subjective pain relief exceeding 70% was achieved at around 2 weeks after the operations in most patients (13/15), and then decreased in some to 30 from 70% in the follow-up observations. Our new objective pain relief score was tested in these patients. A significant positive correlation between subjective pain relief and our objective pain relief scale was found, but some discrepancies between them were also found during the follow-up. Sensory loss, motor weakness, paraesthesia and a new pain were found as complications in 12, 7, 4 and 6 patients, respectively. Postmortem histological findings of the spinal cord in two patients with systemic lupus erythematosus and uterine cancer, who received bilateral DREZLs twice and bilateral DREZLs plus commissural myelotomy, respectively, indicate that care should be taken to avoid extension of the coagulation beyond the dorsal horn.     

论提高粗纱牵伸质量问题(Ⅰ)——牵伸型式、牵伸部件与牵伸质量

文中主要讨论了“D”型牵伸的结构特点,同时分析了“牵伸区不集束、集束区不牵伸”的优越性。其次,对牵伸罗拉的表面结构和扭矩及其与提高粗纱牵伸质量之间的关系作了阐述。最后说明采用小模数牵伸齿轮的优点。     

用毛细管电泳拆分手性药物美索巴莫的方法研究

 目的采用3种环糊精为毛细管电泳手性选择剂，研究美索巴莫对映体的拆分方法。方法用区带毛细管电泳模式，探讨β-环糊精、二甲基-β-环糊精和羧甲基-β-环糊精对美索巴莫对映体的拆分之影响，确定拆分美索巴莫对映体的最佳条件。此外，还探讨了手性识别机制。结果以β-环糊精和二甲基-β-环糊精作为手性选择剂时，不能使美索巴莫对映体达到基线分离，而羧甲基-β-环糊精能获得很好的分离结果。结论在拆分碱性药物对映体时，可在低pH下以酸性衍生化环糊精作为手性选择剂。     

特区经济学的理论前提

实行特殊政策和实施特殊管理体制是世界经济特区共有的基本特征。正是这两个基本特征构成了特区经济学的两个理论前提。对经济特区实行特殊政策和实施特殊管理体制进行理论分析 ,目的在于为构筑特区经济学的理论体系作理论上的准备     

短毛细管区带电泳快速测定增效联磺片中三组分含量

目的:在短毛细管上应用毛细管区带电泳法快速测定增效联磺片中磺胺甲嗯唑(SMZ)、磺胺嘧啶(SD)及甲氧苄氨嘧啶(TMP)三组分的含量。方法:采用未涂层弹性石英毛细管(35cm×50 μm,有效长度20 cm),以咖啡因为内标(IS),检测波长214 nm(0.01 AUFS),电压10 kV,重力进样(10 cm×5 s),温度15℃,运行缓冲液为20 mmol·L-1硼砂溶液(磷酸调pH6.0)。每次电泳运行前用0.1 mol·L-1氢氧化钠溶液、水及缓冲溶液各冲洗毛细管3 min。结果:SMZ、SD、TMP的线性范围分别为0.0398-0.199,0.0399-0.200,0.0160-0.0800 mg·mL-1。平均回收率(n=9)分别为99.4％,99.0％,99.8％;RSD均小于1.5％。结论:该法简便快捷,准确可靠,灵敏度高。     

Dipole-source analysis in a realistic head model in patients with focal epilepsy

PURPOSE: By the use of three different head models in EEG dipole analysis, we tried to model the origin of interictal and ictal epileptic activity as precisely as possible. Further, as a control, a second evaluation was made by an independent group to control for interindividual reliability of the dipole source analysis. With the realistic head model (CURRY) considering cortex, skull, and skin segmentation, the spike source was located. METHODS: In five patients with mesial temporal epileptogenesis, confirmed by successful epilepsy surgery, the spike source was close to the hippocampus, with a mean distance of the dipole source from the hippocampus of 13.6 mm (range, 9-17.2 mm). In one case the ictal EEG also could be analyzed and resulted in a dipole-source localization comparable to the interictal source. RESULTS: In both head models using either pure cortex segmentation only or a concentric three-shell model, the dipole source was systematically dislocated in a more superior position. Data analysis by a second group with independently chosen EEG samples and identical individual head model resulted in deviations of <5.3 mm. Data analysis using independently selected spikes and independently segmented head models resulted in deviations < or =16.7 mm. CONCLUSIONS: In four cases of extratemporal epileptogenesis, the origin of interictal epileptiform discharges was localized to the suspected primary epileptogenic zone.     

简易灭虫药纸的制备与效果观察

目的开发使用方便的野外宿营地虫害防制技术。方法按配方将药物附着在市售包装纸上,检验合格后进行实验室和现场灭臭虫试验,并作稳定性观察。结果实验室试验,接触药纸1~15 m in,臭虫24 h杀灭率100%,现场试验,20 d臭虫密度下降率97%以上,对其他爬行昆虫也有一定的作用,药纸有效期1年。结论简易灭虫药纸可以有效地防制野外爬行昆虫的危害。     

重庆市三峡水库开县消落区居民营养知识、态度、行为调查

目的:了解重庆市三峡水库消落区居民营养知识、态度、行为的情况及相关影响因素,为今后针对消落区居民进行的营养健康教育提供参考依据。方法:用整群抽样的方法对开县消落区102户的居民(农村50户,城镇52户)进行入户问卷调查。结果:大多数开县消落区居民对铁、疾病(如糖尿病、高血压等)相关营养以及食物营养价值的知识较贫乏;营养知识的掌握程度与居民的文化程度、体质指数有关。而饮食与疾病关系、花钱预防疾病以及食物价格与营养价值关系的认知态度不是很理想;营养知识越多、居民地在城镇、家人有慢性病患者、Engel指数越低则居民营养态度越好。在行为上,消落区居民饮食一般比较咸,经常吃腌腊肉、咸菜,淘米次数比较多,仅有77·5%的居民平时关注营养宣传;营养知识越多、初中以上文化程度的居民对营养行为趋于科学合理。结论:开县消落区居民亟需营养健康教育,并可以通过营养知识—态度—行为模式对居民发挥作用,以增加科学营养知识,增强健康营养意识,优化膳食结构和养成科学合理的饮食行为习惯。