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71.
Robert H. K. Mak 《Pediatric nephrology (Berlin, Germany)》1998,12(8):637-642
Insulin and branched-chain amino acid (BCAA) metabolism was studied in 14 adolescents with uremia on hemodialysis. Glucose
tolerance was measured by intravenous glucose tolerance tests. Insulin sensitivity was measured by the euglycemia clamp technique.
Insulin secretion during constant hyperglycemia was measured by the hyperglycemic clamp technique. Fasting plasma BCAA concentrations
were compared with data from 8 adolescent controls, whereas insulin indices were compared with 8 young adults controls and
with published normal data in adolescents. The patients could be further sub-divided into two groups with respect to their
growth velocity standard deviation score (GVSDS). Group 1 consisted of 7 patients with GVSDS less than −2. This group demonstrated
insulin resistance, glucose intolerance, and low insulin secretion. This group also had low plasma valine, leucine, and isoleucine
concentrations compared with control values. Group 2 consisted of 7 patients with GVSDS more than −2. This group demonstrated
insulin resistance, but normal glucose tolerance and normal insulin secretion. Plasma valine, leucine, and isoleucine concentrations
in group 2 were not different from control values. Total plasma BCAA correlated with glucose tolerance index and with insulin
secretion, but not with insulin sensitivity. Growth failure in uremia is associated with glucose intolerance, hypoinsulinemia,
and low plasma BCAA concentrations. Impaired utilization of conventional energy sources leading to preferential oxidation
of BCAA may contribute to reduced anabolism and growth failure in uremia.
Received October 8, 1997; received in revised form February 3, 1998; accepted February 6, 1998 相似文献
72.
Intimal hyperplasia and hemodynamic factors in arterial bypass and arteriovenous grafts: a review 总被引:3,自引:0,他引:3
Stenosis at the graft–vein junction caused by intimal hyperplasia (IH) is the major cause of failure of vascular access grafts used for hemodialysis. There is a strong relationship between hemodynamic factors and formation of IH. The hemodynamic pattern and the location of IH are different in arterial bypass grafts (ABGs) compared with arteriovenous grafts (AVGs). In an ABG, end-to-side anastomosis of the expanded polytetrafluoroethylene graft and artery produces hemodynamic changes around the junction. IH develops at the arterial floor and the toe and heel of the distal anastomosis. Low shear stress and oscillating shear forces at the arterial floor and the heel plus a high wall sheer stress (WSS) gradient at the toe probably promote IH development. Compliance mismatch between the graft and artery causes turbulence that may contribute to IH formation. The blood flow rate in AVGs is 5–10 times greater than that in ABGs. High flow causes turbulence that injures endothelial cells and eventually results in IH. The peak WSS in AVGs is about 6N/m2, much higher than that in ABGs. Excessively high WSS may effect IH formation in AVGs. Several venous cuff or patch anastomotic designs have been used in attempts to regulate hemodynamic factors in grafts. In ABGs, these designs appear to help decrease IH formation. In AVGs, however, they generally have not improved patency rates. In a high-flow system such as an AVG, more drastic changes in anastomotic design may be required. 相似文献
73.
Tadech Boonpiyathad Willem van de Veen Oliver Wirz Milena Sokolowska Beate Rückert Ge Tan Atik Sangasapaviliya Panitan Pradubpongsa Rattanaporn Fuengthong Pattarawat Thantiworasit Sunee Sirivichayakul Kiat Ruxrungtham Cezmi A. Akdis Mübeccel Akdis 《The Journal of allergy and clinical immunology》2019,143(3):1077-1086.e10
74.
75.
Carlo Cervia Jakob Nilsson Yves Zurbuchen Alan Valaperti Jens Schreiner Aline Wolfensberger Miro E. Raeber Sarah Adamo Sebastian Weigang Marc Emmenegger Sara Hasler Philipp P. Bosshard Elena De Cecco Esther Bächli Alain Rudiger Melina Stüssi-Helbling Lars C. Huber Annelies S. Zinkernagel Onur Boyman 《The Journal of allergy and clinical immunology》2021,147(2):545-557.e9
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76.
Zuochen Du Anwei Chen Lu Huang Xin Dai Qiuyue Chen Di Yang Liling Li Heather Miller Lisa Westerberg Yuan Ding Xuemei Tang Masato Kubo Liping Jiang Xiaodong Zhao Hua Wang Chaohong Liu 《The Journal of allergy and clinical immunology》2021,147(5):1907-1923.e6
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77.
James W. Verbsky Mary K. Hintermeyer Pippa M. Simpson Mingen Feng Jody Barbeau Nagarjun Rao Carlyne D. Cool Luis A. Sosa-Lozano Dhiraj Baruah Erin Hammelev Alyssa Busalacchi Amy Rymaszewski Jeff Woodliff Shaoying Chen Mary Bausch-Jurken John M. Routes 《The Journal of allergy and clinical immunology》2021,147(2):704-712.e17
78.
Hanisah Sharif Swati Acharya Gopal Krishna R. Dhondalay Gilda Varricchi Shoshanna Krasner-Macleod Wannada Laisuan Amy Switzer Madison Lenormand Elena Kashe Rebecca V. Parkin Yi Yi Merve Koc Oleksandra Fedina Gemma Vilà-Nadal Gianni Marone Aarif Eifan Guy W. Scadding David J. Fear Mohamed H. Shamji 《The Journal of allergy and clinical immunology》2021,147(2):663-676
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79.
80.
Pierre Marschall Ruicheng Wei Justine Segaud Wenjin Yao Pierre Hener Beatriz Falcon German Pierre Meyer Cecile Hugel Grace Ada Da Silva Reinhard Braun Daniel H. Kaplan Mei Li 《The Journal of allergy and clinical immunology》2021,147(5):1778-1794
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