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81.
瘤体骨切除灭活再植治疗四肢长骨巨细胞瘤 总被引:21,自引:0,他引:21
体内刮除及灭活植骨治疗骨巨细胞瘤(GCT)的复发率高。我科从1986年6月~1996年2月治疗四肢长骨GCT24例。随访11个月~8年4个月。其中7例采用局部切刮体内灭活植骨和(或)骨水泥充填治疗。结果1例感染,6例复发,1例恶变后死于肺转移。作者自1991年1月采用瘤体骨切除,离体灭活再植,与骨残端体内灭活相结合,骨缺损采用自家腓、髂骨移植,L-梯形加压钢板(L-TCP)或梯形加压钢板(TCP)固定治疗17例,其中12例保留关节,5例做膝关节融合。本组无菌创口感染1例,1例复发。在保留关节的12例中9例关节功能恢复优良,1例尚可,2例差。充分说明瘤段骨切除体外灭活再植术疗效确实,复发率低。保留关节术式适于关节破坏较轻(<=1/2)者,结合关节残端体内灭活和有效的骨结构重建,有利于恢复关节功能。如关节面累及>1/2,宜做骨关节端切除,灭活再植,下肢宜做关节融合或人工关节置换术。 相似文献
82.
Simon Vinitski Carlos Gonzalez Feroze Mohamed Tad Iwanaga Robert L. Knobler Kamil Khalili John Mack 《Magnetic resonance in medicine》1997,37(3):457-469
Our aim was to develop an accurate multispectral tissue segmentation method based on 3D feature maps. We utilized proton density (PD), T2-weighted fast spin-echo (FSE), and T1-weighted spin-echo images as inputs for segmentation. Phantom constructs, cadaver brains, an animal brain tumor model and both normal human brains and those from patients with either multiple sclerosis (MS) or primary brain tumors were analyzed with this technique. Initially, misregistration, RF inhomogeneity and image noise problems were addressed. Next, a qualified observer identified samples representing the tissues of interest. Finally, k-nearest neighbor algorithm (k-NN) was utilized to create a stack of color-coded segmented images. The inclusion of T1 based images, as a third input, produced significant improvement in the delineation of tissues. In MS, our 3D technique was found to be far superior to that based on any combination of 2D feature maps (P < 0.001). We identified at least two distinctly different classes of lesions within the same MS plaque, representing different stages of the disease process. Further, we obtained the regional distribution of MS lesion burden and followed its changes over time. Neuropsychological aberrations were the clinical counterpart of the structural changes detected in segmentation. We could also delineate the margins of benign brain tumors. In malignant tumors, up to four abnormal tissues were identified: 1) a solid tumor core, 2) a cystic component, 3) edema in the white matter, and 4) areas of necrosis and hemorrhage. Subsequent neurosurgical exploration confirmed the distribution of tissues as predicted by this analysis. 相似文献
83.
泪腺肿瘤中P53蛋白表达的意义 总被引:4,自引:0,他引:4
目的了解P53基因在泪腺肿瘤的表达及其临床病理学意义。方法应用免疫组织化学ABC法检测57例泪腺上皮性肿瘤患者和10例正常人泪腺组织中P53蛋白的表达情况,并与病理分级、复发相联系。结果10例正常人泪腺组织中P53表达全部为阴性;恶性肿瘤患者的表达率为48.6%,良性肿瘤中P53达率为18%,二者相比有显著性差异(P<0.025);复发患者阳性率为76.9%,明显高于未复发患为31.8%(P=0.015)。结论P53基因参与了泪腺肿瘤的发生发展并与肿瘤的分化和复发有关。 相似文献
84.
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86.
N. Ya. Popova A. I. Antokhin N. V. Adrianov L. Z. Tret'yakova Yu. A. Romanov 《Bulletin of experimental biology and medicine》1991,112(4):1486-1488
Department of Biology, Medico-Biological Faculty, and Applied Research Laboratory of Ecology, Toxicology, and Metabolism of Medicinal Preparations, attached to the Department of Biochemistry, Medico-Biological Faculty, N. I. Pirogov Second Moscow Medical Institute. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 112, No. 10, pp. 418–419, October, 1991. 相似文献
87.
Pulmonary Function in Survivors of Wilms' Tumor 总被引:1,自引:0,他引:1
N. J. Shaw O. B. Eden M. E. M. Jenney R. F. Stevens P. H. Morris-Jones A. W. Craft L. Castillo 《Pediatric hematology and oncology》1991,8(2):131-137
The respiratory status of 47 patients surviving childhood Wilms' tumor was studied. The group that had receivedflnnk irradiation (which impinges on the lower lung) (n - 17) had a sisnijGantly lower mean percent predicted for forced expiratory volume in one second, residual volume, and total lung capaci(v when compared to those who had received no irradiation (n - 23). Those patients who had received whole-lung irradiation (n - 3) had sisnijicantly lower transfn. foctor for carbon monoxide and gas transfer per unit lung volume whm compared to the nonirradiated group (n - 23). There was no sipiftiant dimue in the prevalence of respiratory symptoms between the three groups. Patients receiving any form of radiotherapy for Wilms' tumor may have abnormulities o f pulmonary function and should have pulmonary function tests performed as part o f their long-tmn follow-up. 相似文献
88.
Objective To explore the expression and the value of HIF-1α,and ET-1 in judging the prognosis of gastrointestinal stromal tumors (GISTs). Methods The expression of HIF-1α, and ET-1 protein was examined in 76 GISTs by immunohistochemistry S -P methods. Results There was a positive correlation between the expression of HIF-1 α and ET-1 ( P < 0.05 ). The positive expression rate of HIF-1 α and ET-1 was 73.68% (50/76) ,and 65.79% (50/76) respectively,which was related with histologicial grade, tumor diameter, infiltration and metastasis, nuclear division rating of GISTs ( P < 0.05 ), but had no relationship with patients' age, gender, initial position of the tumor ( P > 0.05 ). There was statistically sig-nificant difference in the expression of HIF-1 α and ET-1 in the following groups:among the three classes of very low-risk and low-risk, middle-risk, high-risk, bewteen the diameter < 2 cm and > 5 cm (P < 0.05). The more malignant degree and larger diameter, the more highly positive expression rate ( P < 0.05 ). The positive expression in the groups with infiltration and metastasis, and nuclear division ≥5/50 HP was sig-nificantly higher than the groups without infiltration and metastasis, and nuclear division < 5/50 HP (P < 0.05). Conclusion The expression of HIF-1α had a significant correlation with ET-1. HIF-1α,and ET-1 expression was closely related with the prognosis of GISTs,and can serve as important predictors for survival. 相似文献
89.
神经导航辅助显微手术治疗脑功能区肿瘤 总被引:6,自引:2,他引:4
目的探讨神经导航系统辅助下脑重要功能区肿瘤显微手术的治疗效果和应用价值。方法1999年12月~2002年6月应用StealthStation神经导航系统辅助切除邻近脑重要功能区肿瘤10例,对神经导航系统术中应用的优越性、精确性等进行分析。结果本组平均注册误差为(2.8±0.9)mm,肿瘤和重要解剖功能结构定位准确,肿瘤全切除率77.8%。术后神经功能未受明显影响,无手术并发症及死亡。结论神经导航系统对于切除邻近脑重要功能区肿瘤具有定位准确,动态示踪和实时导航,侵袭性小,安全、可靠等特点,有助于提高肿瘤全切率及降低手术并发症。 相似文献
90.
氮芥抗药性人早幼粒白血病HL60细胞亚系的建立及其生物特性 总被引:1,自引:0,他引:1
用逐步递增药物浓度和软琼脂细胞克隆技术,药物连续作用14个月后获得氮芥(HN2)抗药性人早幼粒白血病HL60细胞亚系,抗件达5~7倍(HL60/NH26),在无HN2培养液中5倍以上抗性维持10个月以上,抗性细胞亚系的生物学特性除倍增时间稍长和克隆形成率略低外其生长曲线,细胞周期细胞DNA指数,形态学,组织化学和染色体分析均与亲代细胞相似。 相似文献