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21.
目的探讨护理干预对首发精神分裂症病人生活质量的影响。方法将80例首发精神分裂症病人随机分为研究组和对照组各40例,两组均予以利培酮系统治疗,研究组在此基础上,予以综合性护理干预措施,时间为8同,随后进行为期半年的随访,采用阴性症状与阳性症状量表(PANSS)及生活质量综合评定问卷(GQOLI)分别于治疗前及随访结束时进行评估。结果随访结束时,两组病人的PANSS总分及阴性、阳性症状评分均较治疗前明显降低(P〈0.01).但研究组明显优于对照组(P〈0.01);并且研究组GQOLI评分显著高于对照组(P〈0.01)。结论护理干预有助于改善首发精神分裂症病人的精神症状,提高其生活质量。 相似文献
22.
目的 评价解剖钢板结合连续被动运动(CPM)功能锻炼在治疗胫骨平台骨折中的应用价值.方法 2003年5月至2005年10月本院34例胫骨平台骨折行解剖复位、解剖钢板内固定并在术后进行CPM功能锻炼.结果 术后对患者行X线检查示骨折实现解剖复位或接近解剖复位.23例患者经5~30个月随访骨折均愈合,无植骨坏死发生.CPM功能锻炼后运动功能恢复优良率为82.6%(19/23).结论 采用关节面的解剖复位、解剖钢板及牢固固定后配合术后CPM功能锻炼对于胫骨平台骨折有很好的疗效. 相似文献
23.
24.
Elionora Peña Assumpta Caixàs Concepción Arenas Rocio Pareja Josep León-Mengíbar Mercedes Rigla Timothy R. Powell Narcís Cardoner Araceli Rosa 《Surgery for obesity and related diseases》2021,17(1):185-192
BackgroundBariatric surgery is currently the most effective long-term treatment for severe obesity. However, interindividual variation in surgery outcome has been observed, and research suggests a moderating effect of several factors including baseline co-morbidities (e.g., type 2 diabetes [T2D] and genetic factors). No data are currently available on the interaction between T2D and variants in brain derived neurotrophic factor (BDNF) and its effect on weight loss after surgery.ObjectivesTo examine the role of the BDNF Val66Met polymorphism (rs6265) and the influence of T2D and their interaction on weight loss after bariatric surgery in a cohort of patients with severe obesity.SettingUniversity hospital in Spain.MethodsThe present study evaluated a cohort of 158 patients with obesity submitted to bariatric surgery (Roux-en-Y gastric bypass or sleeve gastrectomy) followed up for 24 months (loss to follow-up: 0%). During the postoperative period, percentage of excess body mass index loss (%EBMIL), percentage of excess weight loss (%EWL), and total weight loss (%TWL) were evaluated.ResultsLongitudinal analyses showed a suggestive effect of BDNF genotype on the %EWL (P = .056) and indicated that individuals carrying the methionine (Met) allele may experience a better outcome after bariatric surgery than those with the valine/valine (Val/Val) genotype. We found a negative effect of a T2D diagnosis at baseline on %EBMIL (P = .004). Additionally, we found an interaction between BDNF genotype and T2D on %EWL and %EBMIL (P = .027 and P = .0004, respectively), whereby individuals with the Met allele without T2D displayed a greater %EWL and greater %EBMIL at 12 months and 24 months than their counterparts with T2D or patients with the Val/Val genotype with or without T2D.ConclusionOur data showed an association between the Met variant and greater weight loss after bariatric surgery in patients without T2D. The presence of T2D seems to counteract this positive effect. 相似文献
25.
This long-term follow-up study examined patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and only sensory
symptoms at first presentation, with emphasis on the development of motor symptoms and long-term disability. From all CIDP
patients referred to our Department between 1987 and 1995, seven had only sensory symptoms at first clinical presentation.
These were investigated according to a standard protocol, including a quantified clinical neurological examination and nerve
conduction studies. The mean duration of the disease before weakness developed was 3.1 years, but varied considerably (0.8–6.3
years). At follow-up, weakness developed in five patients and persisted in three of them. Five patients were not seriously
incapacitated by their disease (Rankin 1 or 2), four of them being in remission now and one showing a very slow progression
of disease. Two patients were moderately disabled (Rankin 3); one had severe persistent sensory ataxia and only weakness during
relapses and one had stepwise progression and moderate weakness. Motor nerve conduction studies revealed that the most notable
worsening in the entire group of patients was a decrease in distal compound muscle action potential amplitudes, indicating
the development of distal conduction block or axonal degeneration. These findings show that CIDP with only sensory symptoms
is a transient clinical stage that precedes the appearance of weakness in about 70% of patients. The long-term prognosis does
not differ from that of patients with CIDP who have weakness at the beginning of the disease.
Received: 3 December 1998 Received in revised form: 17 May 1999 Accepted: 2 July 1999 相似文献
26.
Inflammation markers in nasal lavage, and nasal symptoms in relation to relocation to a newly painted building: a longitudinal study 总被引:1,自引:0,他引:1
Wieslander G Norbäck D Wålinder R Erwall C Venge P 《International archives of occupational and environmental health》1999,72(8):507-515
Introduction: There is a need to evaluate possible health effects of ventilation improvements and emissions from new buildings, in longitudinal
studies. New methods to study biological effects on the eyes and upper airways are now available. Material and methods: A longitudinal study was performed on 83 trained social workers in two offices in Uppsala, Sweden. The exposed group (n= 57) moved to a newly redecorated building nearby. Low emitting building material had been used, including a new type of
solvent-free water-based paint. The control group (n= 26) worked in the same office during the study period (November 1995 to February 1996). Hygiene management was carried out
in both offices, at the beginning and the end of the investigation. Tear film stability (BUT) was measured. Nasal patency
was measured by acoustic rhinometry, and eosinophilic cationic protein (ECP), myeloperoxidase (MPO), lysozyme and albumin
were analyzed in nasal lavage fluid (NAL). Results: The relocation resulted in an increase in the personal outdoor airflow rate from 11 to 22 l/s. Indoor concentrations of terpenes
were higher in the new building, and powdering of the new linoleum floor was observed. Measurements showed low levels of volatile
organic compounds (VOC), formaldehyde, carbon dioxide (CO2), nitrogen dioxide, respirable dust, and microorganisms in the air of all buildings. The move resulted in an increased nasal
patency and an increase of ECP and lysozyme in NAL, after adjusting for changes in the control group. No changes were observed
for nasal or ocular symptoms. A seasonal effect, with a decrease of ECP, was observed in the control group. Conclusion: A well-ventilated office building can be redecorated without any major ocular or nasal effects, or measurable increase of
indoor air pollution if low-emitting building materials are selected. In agreement with previous evidence, the improved ventilation
flow may explain the increase of nasal patency. The increase of ECP and lysozyme in NAL suggested an inflammatory effect in
the new building. Since this building had increased ventilation flow, increased concentrations of terpenes, and powdering
from the polish on the new linoleum floor, identification of causative agents was difficult. The hygiene measures did not
give any evidence that emissions from the new type of solvent-free water-based paints or building dampness were responsible
for the observed nasal effects. Considering the higher emissions of VOC reported from older types of water-based latex paints
and solvent-based wall paints, the new type of solvent-free water-based paint seems to be a good choice from the hygiene point
of view.
Received: 21 December 1998 / Accepted: 20 June 1999 相似文献
27.
目的 通过对 2 1例植入埋藏式心脏复律除颤器 (ICD)的临床应用分析 ,探讨ICD在恶性室性心律失常中的治疗作用、参数设定、并发症及随访结果。方法 2 1例均植入成功 ,其中单腔ICD 18例 ,双腔ICD 3例。心室起搏阈值 0 3~ 0 9(0 6 8± 0 2 1)V ,R波振幅 5 5~ 2 0 (10 0± 3 8)mV ,除颤阻抗 14~ 73(5 0 2±9 3)Ω ,除颤阈值 5~ 15 (12 5± 4 7)V。随访 3~ 5 7(2 5 3± 11 7)月 ,17例接受了成功的ICD治疗 ,2例发生误放电治疗 ,经重新调整参数后未再发生误放电 ,1例出现囊袋血肿 ,经处理好转 ,2例因电池耗竭更换了ICD装置 ,2例死亡 ,其中 1例为自杀 ,另 1例拒绝治疗和随访 ,室颤反复发作死亡。结果 ICD能有效转复恶性心律失常 ,双腔ICD能提高对室性和室上性快速性心律失常的鉴别 ,降低不适当ICD治疗 ;加强随访及时调整参数更能准确识别和治疗快速室性心律失常 相似文献
28.
乳腺癌术后早期发现复发转移方法的回顾性分析 总被引:1,自引:0,他引:1
目的:分析乳腺癌患者术后早期发现复发转移的方法。方法:回顾性分析126例早期乳腺癌术后发生复发转移患者的临床资料.包括最早发生复发转移的部位及其发现方法(症状、自查、医生查体和血液学、影像学检查)。结果:80例(63.5%)在常规随诊时发现复发转移,其中影像学或血液学检查发现65例(51.6%),查体发现15例(11.9%);28例(22.2%)经自查发现病变;仅18例(14.3%)因症状而就诊。结论:乳腺癌术后常规随诊是早期发现复发转移的主要方法.其中影像和血液学检查是必要的。 相似文献
29.
Interaction between mothers and infants born at risk during the first six months of corrected age 总被引:1,自引:0,他引:1
L Schermann-Eizirik B Hagekull G Bohlin K Persson G Sedin 《Acta paediatrica (Oslo, Norway : 1992)》1997,86(8):864-872
Abstract The effects of preterm birth and the perinatal infant health condition on mother-infant interactions were analysed in 278 mother-infant pairs, divided into four groups according to infants' gestational age at birth: group 1. 23–31 weeks; group 2,32–36 weeks; group 3, 37–42 weeks; and group 4, a control group of healthy full-term infants. The methodological approach was based on observation of the pairs at 2,4 and 6 months of infants" corrected age (± 1 week) during undressing of the infant and face-to-face interaction. It was found that mother-infant pairs with preterm infants (groups 1 and 2) did not differ in interactional variables from those of the control group. On the other hand, the birth of a full-term infant in need of neonatal intensive care (group 3) affected maternal and infant interactive behaviour. Additionally, infants from group 3 did not show stability in their interactive behaviour between any ages of measurement. This result suggests that interactive behaviour of full-term infants in need of neonatal intensive care are rather unpredictable during their first 6 months of life, which might have contributed to the less optimal interactive pattern observed for their mothers compared with mothers of the control group. 相似文献
30.
To identify virological parameters (serostatus of hepatitis B surface antigen [HBsAg] and antibodies to hepatitis C virus [anti-HCV], HCV genotypes and HCV-RNA titer) and other clinico-biological and lifestyle variables that may influence or predict the development of hepatocellular carcinoma (HCC) in cirrhosis, we followed 100 cirrhotic patients without HCC, who visited Kyushu University Hospital between 1985 and 1987, until the end of 1995 (follow-up rate: 98%; average follow-up period: 5.3 years). After elimination of 4 patients who developed HCC or were censored within the initial 6 months, 37 (39%) out of 96 patients developed HCC during follow-up. As compared with HBsAg(+) patients, anti-HCV(+) HBsAg(–) patients demonstrated significantly elevated HCC risk (adjusted hazard ratio [HR]=5.85, 95% confidence interval [CI] 1.65–20.67). Genotype 1 HCV infection was not associated with increased risk compared with genotype 2 (HR = 0.64, 95% CI 0.21–1.99). For genotype 1 HCV infection, patients with HCV-RNA levels <1 Meq/ml tended to present lower risk than patients with ≥1 Meq/ml ( P = 0.03). Male sex, advanced Child's class, lower serum albumin, and higher serum aminotransferase and α-fetoprotein were also found to be strong predictors. Overall, drinking and smoking habits were not associated with significantly elevated risk. Among virological parameters, anti-HCV positivity and, possibly high HCV-RNA titer, were predictive of HCC occurrence in cirrhosis in our clinical setting. 相似文献