全文获取类型
收费全文 | 2178篇 |
免费 | 72篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 29篇 |
妇产科学 | 7篇 |
基础医学 | 726篇 |
口腔科学 | 90篇 |
临床医学 | 150篇 |
内科学 | 61篇 |
皮肤病学 | 3篇 |
神经病学 | 752篇 |
特种医学 | 116篇 |
外科学 | 139篇 |
综合类 | 62篇 |
预防医学 | 53篇 |
眼科学 | 1篇 |
药学 | 29篇 |
中国医学 | 21篇 |
肿瘤学 | 5篇 |
出版年
2023年 | 7篇 |
2022年 | 24篇 |
2021年 | 41篇 |
2020年 | 55篇 |
2019年 | 52篇 |
2018年 | 57篇 |
2017年 | 66篇 |
2016年 | 38篇 |
2015年 | 37篇 |
2014年 | 86篇 |
2013年 | 104篇 |
2012年 | 68篇 |
2011年 | 91篇 |
2010年 | 65篇 |
2009年 | 110篇 |
2008年 | 95篇 |
2007年 | 84篇 |
2006年 | 110篇 |
2005年 | 75篇 |
2004年 | 63篇 |
2003年 | 60篇 |
2002年 | 65篇 |
2001年 | 41篇 |
2000年 | 35篇 |
1999年 | 41篇 |
1998年 | 36篇 |
1997年 | 29篇 |
1996年 | 34篇 |
1995年 | 45篇 |
1994年 | 45篇 |
1993年 | 30篇 |
1992年 | 26篇 |
1991年 | 31篇 |
1990年 | 39篇 |
1989年 | 30篇 |
1988年 | 13篇 |
1987年 | 24篇 |
1986年 | 25篇 |
1985年 | 23篇 |
1984年 | 35篇 |
1983年 | 24篇 |
1982年 | 42篇 |
1981年 | 35篇 |
1980年 | 25篇 |
1979年 | 28篇 |
1978年 | 36篇 |
1977年 | 14篇 |
1976年 | 8篇 |
1975年 | 4篇 |
1973年 | 4篇 |
排序方式: 共有2267条查询结果,搜索用时 15 毫秒
31.
PURPOSE One finding in patients with constipation is the paradoxical puborectalis contraction, i.e. , activation of the sphincter muscles during straining instead of relaxation. The aims of this study were to evaluate the
importance of needle placement in sphincter-electromyography and to evaluate a strain/squeeze index in constipated patients
and control subjects.
METHODS We investigated consecutively 194 constipated patients and 16 control subjects with integrated electromyography during straining
and squeezing and calculated a strain/squeeze index. The examination was performed in the puborectalis and in the external
anal sphincter muscle through hook-electrodes.
RESULTS There was a strong correlation between indices in the puborectalis muscle and in the external anal sphincter muscle (r = 0.70–0.80, P < 0.001). Forty-seven patients (24 percent) had a mean index of greater than 50 compared with none in the control group (P = 0.01). Mean overall index in patients was 24 (range, 0–306) vs. 18 (range, 0–45) in controls (P = 0.12). Patients with an index greater than 50 had impaired rectal evacuation (P < 0.001), increased threshold for urge (P < 0.05), and tended to have fewer stools (P = 0.06).
CONCLUSION Quantification of paradoxical contraction in the puborectalis and external anal sphincter with a strain/squeeze index differentiates
patients in whom paradoxical activity may be a cause of constipation. An index above 50 may be of pathologic significance.
Correlations between activity in the puborectalis and external anal sphincter muscle were strong which suggests that investigation
in one of them is sufficient.
Reprints are not available. 相似文献
32.
《Gait & posture》2022
BackgroundBalance is an important determinant of physical function and falls risk. The ability to withstand external perturbations is important when walking on icy or uneven surfaces, whether the perturbations are bilateral or unilateral.Research questionThis study sought to determine the effect of unilateral and bilateral standing perturbations on leg muscle activity in healthy older adults.MethodsParticipants experienced unilateral and bilateral standing perturbations of the treadmill. Surface electromyography (EMG) from lower limb muscles was recorded unilaterally. EMG onset latency and root mean square (RMS) amplitude of the muscle bursts were calculated.ResultsOlder adults demonstrated a combined ankle/hip strategy, along with pre-activation and co-contraction of muscles in response to unilateral and bilateral stance perturbations. As well, older adults demonstrated higher levels of EMG, but no difference in the latency of burst onset, in bilateral than unilateral perturbation types.SignificanceWhen the stance limb was perturbed in the bilateral condition, the older adults responded with a Gastrocs EMG burst nearly 100% of the maximum EMG. The high level of EMG used, especially in the Gastrocs, during the bilateral perturbations may reduce the safety factor for falls in older adults. Older adults responded to the different perturbation demands by modulating EMG amplitude as opposed to the onset timing of EMG. 相似文献
33.
Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction 总被引:18,自引:0,他引:18
Bercík P Wang L Verdú EF Mao YK Blennerhassett P Khan WI Kean I Tougas G Collins SM 《Gastroenterology》2004,127(1):179-187
BACKGROUND & AIMS: We established the concept that transient enteric infection may lead to persistent gut dysfunction, evident in vitro, in nematode-infected mice. The present study determined whether gut dysfunction in this model involves motor and sensory changes reminiscent of changes found in patients with postinfective irritable bowel syndrome (PI-IBS) and investigated underlying mechanisms. METHODS: Mice infected up to 70 days previously with Trichinella spiralis (Tsp) underwent videofluoroscopy with image analysis to assess upper gastrointestinal motility. Pseudoaffective responses to colorectal distention (CRD) were assessed using a barostat and validated by single fiber recordings from spinal nerves during CRD. Tissues were examined at different time points for histology, immunohistochemistry, and cytokine analysis. Some mice received dexamethasone intraperitoneally on days 23-25 PI or Tsp antigen orally on days 29, 43, and 57 PI. RESULTS: From day 28 PI, no discernible inflammation was present in the gut. Frequency and propagation velocity of intestinal contractions decreased, and retroperistalsis increased at days 28 to 42 PI. CRD induced an allodynic and hyperalgesic response in PI mice, which was accompanied by increased single unit discharge. Gavage of Tsp antigen induced T-cell responses and sustained gut dysfunction for 70 days PI. Administration of dexamethasone postinfection normalized dysmotility and visceral hyperalgesia. CONCLUSIONS: Long-lasting gut dysmotility and hyperalgesia develop in mice after transient intestinal inflammation. These changes are maintained by luminal exposure to antigen and reversed by corticosteroid treatment. The findings prompt consideration of this as a model of PI-IBS. 相似文献
34.
《Gait & posture》2021
BackgroundAn age-related decline in standing balance control in the medio-lateral direction is associated with increased risk of falls. A potential approach to improve postural stability is to change initial foot position (IFP).Research questionsIn response to a lateral surface perturbation, how are lower extremity muscle activation levels different and what are the effects of different IFPs on muscle activation patterns and postural stability in younger versus older adults?MethodsTen younger and ten older healthy adults participated in this study. Three IFPs were tested [Reference (REF): feet were placed parallel, shoulder-width apart; Toes-out with heels together (TOHT): heels together with toes pointing outward; Modified Semi-Tandem (M-ST): the heel of the anterior foot was placed by the big toe of the posterior foot]. Unexpected lateral translations of the standing surface were applied. Electromyographic (EMG) activity of the lower extremity muscles, standard deviation (SD) of the body’s CoM acceleration (SD of CoMAccel), and center of pressure (CoP) sway area were compared across IFPs and age.ResultsActivation levels of the muscles serving the ankle and gluteus medius were greater than for the knee joint muscles and gluteus maximus in the loaded leg across all IFPs in both groups. TOHT showed greater EMG peak amplitude of the soleus and fibularis longus compared to REF, and had smaller SD of CoMAccel and CoP sway area than M-ST. Compared to younger adults, older adults demonstrated lower EMG peak amplitude and delayed peak timing of the fibularis longus and greater SD of CoMAccel and CoP sway area in all IFPs during balance recovery.SignificanceDuring standing balance recovery, ankle muscles and gluteus medius are important active responders to unexpected lateral surface perturbations and a toes-out IFP could be a viable option to enhance ankle muscle activation that diminishes with age to improve postural stability. 相似文献
35.
E. Y. K. Ng W. L. Siauw W. E. W. Goh 《Journal of medical engineering & technology》2013,37(5):203-209
Currently the best indicator for surgical treatment of arteriosclerosis is the degree of stenosis. Although X-ray angiography is currently the standard, cost and morbidity are distinct disadvantages. By modelling stenosis and studying its biofluid mechanics, one can apply its results in the field of arterial disease research. This formed the motivation for this work. A non-Newtonian (power law) incompressible Navier-Stokes (N- S) solver was developed using the method of operator splitting and artificial compressibility. The vehicle used is the computational fluid dynamics (CFD) numerical library FASTFLO. The power-law model developed is then used to do a parametric study of the effect of 'n' on blood flow mechanics where 'n' is the power index that determines the haematocrit of blood. A pulsatile pressure wave over a cardiac cycle of a second was used to simulate transient flow over a hypothetical twodimensional stenotic geometry. By comparing the different velocity pressure, wall shear stress and viscosity profiles, it has been found when 'n' increases, the vortex formation and peak wall shear stress decreases (magnitudes of < 1.5 Pa). Since the formation of vortices and lowoscillatory wall shear stress on the stenotic wall is detrimental to the well-being of the arterial tract, it can therefore be inferred that there might be a relationship between the diseased state of blood (power law) and early genesis of atherosclerosis. However, the conclusion of this paper marks the advent of new research directions in this field of study. 相似文献
36.
BackgroundThere have been very few studies involving swan motion during pilates exercises, and there is also insufficient scientific evidence to support the fact that Pilates swan motion strengthens specific muscles.ObjectivesFirstly, the purpose of this study was to evaluate the effect of 5 types Pilates swan motion (swan basic (SB), swan push-up (SP), swan holding posture (SH), form roller-based swan (SF), and circle-based swan (SC)) on muscle activity of deltoideus p. acromialis (DA), infraspinatus (IP), trapezius (TP), latissimus dorsi (LD), and erector spinae (ES). Secondly, the purpose of this study was to suggest an effective Pilates swan motion for strengthening muscle strength of each targeted muscle.MethodsTwenty-four healthy men in their 20s participated and all participants were measured muscle activity in DA, IP, TP, LD, and ES muscles by electromyography (EMG) during 5 Pilates swan motions (SB, SP, SH, SF, & SC). The measured values were expressed as relative voluntary contraction (%RVC) values based on the SB.ResultsThe %RVC values representing the muscle activity of DA and TP were significantly higher in SH and SP than in SC, SF, and SB (p < .001). The %RVC values of IP and LD were significantly higher in SH and SC than in SF, SP, and SB (p < .001). The %RVC value of ES was were significantly higher in SH than in SP, SC, SF, and SB (p < .001).ConclusionThe application of SP, SC, and SH Pilates swan motion is an effective method to activate the back muscles of the trunk. 相似文献
37.
38.
Judith Drenthen Ellen M. Maathuis Gerhard H. Visser Pieter A. van Doorn Joleen H. Blok Bart C. Jacobs 《Journal of the peripheral nervous system : JPNS》2013,18(1):25-29
Typical Miller Fisher syndrome (MFS) lacks limb muscle weakness, but some patients may unpredictably progress to severe Guillain‐Barré syndrome. The compound muscle action potential (CMAP) scan is a recently developed non‐invasive, painless, and reproducible method for detecting early changes in motor nerve excitability. This technique was used to monitor subclinical limb motor nerve dysfunction during disease course in typical MFS. Three Miller Fisher patients with preserved limb muscle strength and normal routine nerve conduction studies were included. Frequent serial CMAP scanning of the median nerve was performed during acute phase and follow‐up and was related to clinical course and outcome. All patients showed an abnormal increase in the range of stimulus intensities at the day of hospital admission, indicating reduced motor nerve excitability already at the earliest stage of disease. Median nerve dysfunction progressed in parallel or even before clinical deterioration, and improved with clinical recovery. Our study shows that typical MFS is a more general neuropathy, affecting peripheral motor nerves even in patients with preserved limb strength and conduction velocity. CMAP scanning is a sensitive technique for early detection of subclinical motor nerve dysfunction and for monitoring disease activity in immune‐mediated neuropathies. 相似文献
39.
Daniele Manfredini Lorenzo Favero Matteo Michieli Luigi Salmaso Francesco Cocilovo Luca Guarda-Nardini 《Journal of the American Dental Association (1939)》2013,144(4):397-405
BackgroundThe authors conducted a study in patients with temporomandibular joint (TMJ) osteoarthritis to assess whether treatment-related changes in pain levels and chewing ability coincide with a change in jaw kinesiographic (KG) parameters.MethodsThe authors selected 34 patients with a diagnosis of TMJ osteoarthritis that met Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) to undergo a cycle of five weekly arthrocentesis procedures with injections of 1 milliliter hyaluronic acid. They performed a permutation test to assess the correlation between changes across time (from baseline to end of treatment) in two clinical outcome parameters—pain level and chewing ability—and changes across time in the KG outcome parameters.ResultsThe authors observed improvement across time in both chewing ability (F = 8.328; P = .005) and pain level (F = 10.903; P = .002). The authors observed no significant changes in any KG variables. With minor exceptions, no significant correlations were shown between changes in the clinical and KG parameters during the treatment period.ConclusionsTreatment-related changes in pain levels and chewing ability in patients with TMJ osteoarthritis do not coincide with changes in KG parameters.Practical ImplicationsIf one assumes pain variables to be the primary outcome measures in assessing treatment of TMJ osteoarthritis, KG recordings of the jaw are not useful for monitoring TMJ osteoarthritis in the clinical setting. 相似文献