Ask-Upmark Kidney and Tubulointerstitial Nephritis in a Woman with Severe Renal Failure

Abstract

Ask-Upmark kidney is a rare diagnosis of segmental hypoplasia in pediatric population clinically characterized by severe hypertension potentially treatable with partial to total nephrectomy. Although originally was described only as a congenital anomaly, recent data suggest to be caused by vesicoureteral reflux, either in utero or in early childhood and pyelonephritis. The case we reported indicates that Ask-Upmark kidney should be considered as potential cause of hypertension and renal failure both in children and adults. The renal biopsy is necessary for early diagnosis and may consent to normalize blood pressure with nephrectomy; however, if renal damage is severe and progressive with tubulointerstitial nephritis, surgical management is excluded and renal transplant should be considered.     

Corticosteroid treatment exacerbates nephrotic syndrome in a zebrafish model of magi2a knockout

1. Download high-res image (304KB)
2. Download full-size image

     

急诊拇趾断层甲床游离移植治疗手指甲床部分缺损

目的：探讨急诊应用拇趾断层甲床游离移植治疗手指甲床缺损的疗效。方法：回顾性分析2007年1月--2011年3月期间治疗的外伤引起指甲床部分缺损15例（15指）患者的临床资料，均急诊采用同侧拇趾断层甲床游离移植方法治疗，随访时间6～24个月，平均12个月。结果：术后15例均一期全部成活，3～6个月后甲板生长，外观佳。按照吕桂欣等对指甲损伤的修复进行疗效评定，优8例，良5例，差2例，优良率达87％。患者对术后治疗效果较为满意。结论：急诊拇趾甲床断层游离移植修复手指甲床缺损是一种比较简单、实用、有效的术式，且供区隐蔽，适合在基层推广应用。     

Evaluation of the effectiveness of bioactive glass fillers against Candida albicans adhesion to PMMA denture base materials: An in vitro study

BackgroundDentures with antimicrobial properties are desirable for preventing Candida albicans adhesion. This study was to assess the effectiveness of bioactive glass (BAG) on C. albicans adhesion, surface roughness, and hardness of denture base materials.MethodsHeat-polymerized (HP) and autopolymerized (AP) acrylic resins were used to fabricate 240 disk specimens (120/material, 60/C. albicans, 60/surface roughness and hardness). Specimens were divided into five groups (n = 10) based on the BAG concentration: 0.5, 1.5, 3, 5, and 7.5 wt% of the acrylic powder, with a control group comprised of unmodified specimens. Direct culture method was used to assess C. albicans adhesion. A profilometer and Vickers hardness test were used to measure surface roughness and hardness respectively. Analysis of variance (ANOVA) and post hoc Tukey’s test were used for data analysis (α = 0.05).ResultsBAG addition significantly decreased the C. albicans count when compared with the control group (P < 0.001) for both HP and AP. Regarding surface roughness, there was no change in the HP acrylic resins (P > 0.05), while the AP acrylic resins exhibited significantly higher surface roughness with BAG addition (P < 0.001). The hardness of the HP and AP acrylic resins were significantly higher with the addition of BAG (P < 0.001).ConclusionsThe addition of BAG to HP and AP acrylic resins effectively decreases C. albicans adhesion. The roughness of AP acrylic resins increases with the addition of BAG, while the hardness of both HP and AP acrylic resins increase with the addition of BAG.