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61.
《L'Encéphale》2020,46(2):158-161
In the world of sport, athletes and their trainers see competitive emotions and, in particular, performance anxiety as one of the most important factors likely to influence the outcome of a sports competition. These emotions attract such vast interest because even today they continue to raise many questions. While positive emotions are generally considered to be largely facilitative to an athlete's performance, the link between negative emotions, and particularly competitive anxiety, and performance seems less unanimous. Some view anxiety as a phenomenon which hampers performance; for them, an anxious athlete is a fragile one. Others view anxiety as a driver and give as examples those athletes who only perform well under the pressure of competition and the anxious state it elicits. There is currently no single model for the relationship between anxiety (or emotions) and performance on which everybody agrees, in spite of the fact that the scientific community has been striving for some time to better understand the links between them. Research carried out to confirm these links has produced inconsistent results which are difficult to interpret as the variables measured (anxiety, emotional states, performance) and the framework of the studies (characteristics of the participants, importance of the sports event) most often differ. 相似文献
62.
《Academic pediatrics》2014,14(2):155-158.e1
ObjectiveTo report changes in pediatric clerkship nighttime clinical structures before and after implementation of the 2011 Accreditation Council for Graduate Medical Education (ACGME) resident duty hour standards.MethodsAs part of the 2011 Council on Medical Student Education in Pediatrics (COMSEP) member annual survey, we surveyed leaders of pediatric undergraduate medical education on their medical school's current nighttime clinical structure, changes in nighttime structure between 2010 and 2011, and their school's student duty hour standards.ResultsFifty-six percent (n = 83) of Liaison Committee for Medical Education (LCME)-accredited medical schools responded to the survey. Of received responses, 98% of pediatric clerkships have some form of nighttime clinical experience; 49% of clerkships have medical students stay late, 24% of clerkships utilize night shifts, and 16% use a traditional call structure. Forty-five percent of clerkships report changing their nighttime clinical experience after implementation of the 2011 ACGME duty hour standards; 46% of clerkships that changed had previously used traditional call. Seventy-six percent of clerkships report having medical student duty hour standards at their medical school.ConclusionsThe majority of pediatric clerkships in our survey include nighttime clinical experiences in their curriculum, although variability exists in the type of structure. Additionally, the new ACGME duty hour standards appear to affect clerkships directors' choice of structure. 相似文献
63.
64.
《Journal of pharmaceutical sciences》2019,108(7):2207-2237
This review describes the landscape of novel modalities such as cell and gene therapies, viruses, other novel biologics, oligomers, and emerging technologies, including modern analytics. We summarize the regulatory history and recent landmark developments in some major markets and examine specific chemistry, manufacturing, and controls (CMC) challenges, including suggestions for exploration of potential science-based approaches in support of regulatory strategy development from an industry perspective. In addition, we evaluate the economic factors contributing to patient access to innovation and discuss the impact of regulation. There is a desperate need for a consistent form of regulation where global approaches to regulatory strategies can be harmonized, and specific CMC challenges can be dealt with using the appropriate science and risk-based tools. Although these tools are well described in current guidance documents, the specifics of applicability to complex novel modalities can still result in differing regulatory advice and outcomes. The future goals for efficiently regulating innovative modalities and technologies could be aided by more regulatory harmonization, regulatory education, and industry cooperation through consortia, enabling industry to supply key information to regulators in a transparent yet well-defined manner, and utilizing mutually understood risk-benefit analyses to produce drugs with appropriate safety, efficacy, and quality characteristics. 相似文献
65.
Summary. Primary objective: To determine the median age of natural menopause and factors associated with the timing of menopause in Beirut, Lebanon. Research design: A population-based sample of 298 women were interviewed using a semistructured questionnaire. Methods and procedures: Logit analysis and logistic regression were used to estimate the median age and identify correlates of menopausal status. Main outcomes and results: The median age of natural menopause in Beirut, Lebanon is estimated to be 49.3 years. Not being currently married (odds ratio (OR)=4.19, 95% CI: 1.53, 11.51) and smoking (OR=1.02 for each year of smoking, 95% CI: 1.00, 1.05) are significantly associated with an earlier age at menopause. Women with menstrual bleeding longer than 5 days have later ages at menopause (OR=0.50, 95% CI: 0.26, 0.97). Age at menarche, parity, education and socio-economic status are not statistically associated with the age at menopause. Conclusions: The age at natural menopause in Lebanon is comparable to median ages reported for women in industrialized countries (49.3-51.4). Our results emphasize the role of smoking in determining an earlier age at menopause and indicate that reproductive characteristics affect the timing of menopause. 相似文献
66.
《International journal of audiology》2013,52(3):205-211
The calibration status of bone vibrators in selected audiology clinics was examined with the use of a Beltone mechanical coupler. Outputs of bone vibrators were measured and compared to Hearing Aid Industries Conference (HAIC) Interim Standard values. The results suggest that the status of calibration of bone vibrators, in the 16 clinics sampled, did not conform to HAIC Interim Standards for 76% of the measurements 相似文献
67.
《Expert review of anticancer therapy》2013,13(8):1159-1167
Soft-tissue sarcomas (STSs) are a heterogeneous group of rare malignant tumors predominantly arising from the embryonic mesoderm. The mainstay of curative therapy is the complete surgical resection of all tumor manifestations with negative histological margins. However, up to 50% of patients will develop distant metastases during the course of their disease. The prognosis for those patients is grim with a 5-year overall survival of less than 10%. First-line systemic therapy with ifosfamide and doxorubicin results in overall response rates of only 20% by conventional response evaluation criteria in solid tumors (RECIST). However, stabilization of disease can be seen in a greater proportion. Therefore, the role of the RECIST criteria has been questioned and the implementation of new imaging studies (e.g., FDG-PET) has shown promising results in assessing early tumor response to therapy. Furthermore, a broader insight into the molecular pathways of sarcomagenesis has been gained in recent years, revealing intriguing targets for new therapeutic approaches (e.g., VEGF, VEGF receptor, IGF receptor, EGF receptor, mTOR and cyclin-dependent kinases). In addition, a growing body of evidence is linking specific genetic aberrations with clinical outcome (e.g., SYT–SXX translocation in synovial sarcoma). With further insight into the biology of STS and the combination of new treatment options with modern imaging techniques, we will most certainly be able to improve clinical outcome in patients with STS in the upcoming years. 相似文献
68.
This paper updates a British Nutrition Foundation (BNF) Briefing Paper on this topic, published in 2011. Healthy eating and being physically active are particularly important for children and adolescents. This is because their nutrition and lifestyle influence their wellbeing, growth and development. There remains considerable room for improvement in the diets of British schoolchildren, according to findings of the government's National Diet and Nutrition Surveys (NDNS), but some improvements have been made in the past decade. Although intakes of saturated fatty acids and non‐milk extrinsic sugars have decreased in recent years, on average, they are still above recommended upper levels. Average contribution of fat to total energy intake has dropped below the recommended upper level of 35%, but fibre intakes remain low. With regard to micronutrients, many teenage girls are consuming low amounts of iron, but there is also evidence of low intakes of vitamin A, riboflavin, calcium, magnesium, potassium, selenium, iodine and zinc. New data on micronutrient status is now available for 11–18 year‐olds, and reveals low levels of vitamin D, riboflavin and iron (mainly in girls). Low vitamin D intake and status is a particular problem in some ethnic minority groups, especially South Asian children. There is also some evidence of socio‐economic inequalities; for example, children from families with higher incomes tend to have higher intakes of fruits and vegetables compared with children from families with lower incomes. This paper also discusses how dietary patterns can influence the micronutrient intake and status of schoolchildren, as well as the risk of overweight and obesity. Since publication of the Briefing Paper in 2011, new physical activity guidelines have been published and, for the first time, these are UK‐wide guidelines. Also for the first time, UK‐wide data on physical activity levels in schoolchildren are available (for 7‐year‐old children). Physical activity levels vary little between the UK regions, with the exception of Northern Ireland where fewer children meet the UK recommendations than in other regions. The data highlight significant differences between boys and girls (with girls generally being less active) and significant differences between ethnic groups. In particular, children from the Bangladeshi, Indian and Pakistani ethnic groups are less likely to meet the recommended levels of physical activity compared with other children. Obesity remains a major problem among British schoolchildren and there is a stark socio‐economic gradient, with levels of obesity being highest in the most socially deprived children. This paper also discusses various health issues in children, including iron deficiency anaemia, oral health, bone development, food allergy and intolerance, and cognitive function in children, updating the previous paper with the latest statistics and evidence. The findings of the NDNS serve to emphasise the importance of a whole school approach to good nutrition embracing the school curriculum as well as the food and drink available in schools (as highlighted in the recently published School Food Plan). School food provision has seen many changes over recent years, with school food standards now in place in all UK regions, most recently Wales. Various evaluations of the impact of school food standards, mainly in England, have highlighted improvements in the diets of schoolchildren, not only in the school setting but in their diets overall. However, there remains room for improvement. This paper also briefly describes a selection of initiatives and organisations of relevance to child nutrition. 相似文献
69.
《Journal of clinical neuroscience》2014,21(4):554-558
Cerebrovascular anastomosis (for example in the management of Moyamoya disease or complex aneurysms) is a rarely performed but essential procedure in neurosurgery. Because of the complexity of this technique and the infrequent clinical opportunities to maintain skills relevant to this surgery, laboratory training is important to develop a consistent and competent performance of cerebrovascular anastomosis. We reviewed the literature pertaining to the training practices surrounding cerebrovascular anastomosis in order to understand the ways in which trainees should best develop these skills. A wide variety of training methods have been described. These may be classified into five general categories, according to training materials used, being synthetic material, living animal, animal carcass, human cadaver, and computer simulation. Ideally, a novice begins training with non-biological material. After gaining sufficient dexterity, the trainee will be able to practice using biological materials followed by high fidelity models prior to actual surgery. Unfortunately, the effectiveness of each model has generally, to our knowledge, only been judged subjectively. Objective quantification methods are necessary to accelerate the acquisition of competence. 相似文献
70.