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Exenatide and Sitagliptin Decrease Interleukin 1β, Matrix Metalloproteinase 9, and Nitric Oxide Synthase 2 Gene Expression But Does Not Reduce Alveolar Bone Loss in Rats With Periodontitis
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![点击此处可从《Journal of periodontology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Renata M. Moraes Gabriela M. G. Lima Felipe E. Oliveira Ana Carolina V. Brito Rodrigo C. Pereira Luciane D. Oliveira Patrícia P. Barros Gilson C. N. Franco Ana Lia Anbinder 《Journal of periodontology》2015,86(11):1287-1295
Background: New drugs for the treatment of diabetes, glucagon‐like peptide‐1 (GLP‐1) receptor agonists and inhibitors of dipeptidyl peptidase‐4 (DPP‐4) have shown pleiotropic effects on bone metabolism and anti‐inflammatory properties. The aim of this study is to evaluate the effects of exenatide (GLP‐1 agonist) and sitagliptin (DPP‐4 inhibitor) during periodontitis induction by ligature insertion in rats. Methods: Forty rats were divided into four groups: 1) animals with induced periodontitis that received exenatide (EG); 2) animals with induced periodontitis that received sitagliptin (SG); 3) animals with induced periodontitis and without drug treatment (LG); and 4) animals without induced periodontitis and without drug treatment (controls). The drugs were administered for 28 days. On the day the animals were sacrificed, blood was collected for analysis of glucose and DPP‐4 levels. The gene expressions of prostaglandin‐endoperoxide synthase 2, tissue inhibitor of metalloproteinase 1, Dpp4, nitric oxide synthase 2 (Nos2), interleukin 1β (Il1b), and matrix metalloproteinase 9 (Mmp9) in the gingiva; support and alveolar bone loss; connective tissue attachment; and the quantity of gingival collagen were evaluated. Results: Exenatide and sitagliptin treatments have led to a lower percentage of weight gain but did not influence glycemia. Sitagliptin reduced the serum concentration of DPP‐4. Interestingly, although the gene expression profile has revealed a downregulation of Mmp9, Nos2, and Il1b in both EG and SG compared to LG, a significant protective effect was not observed on alveolar bone and collagen tissue in this model. Conclusion: Regardless of the reduction of the expression of Il1b, Nos2, and Mmp9, the drugs were not effective in the stabilization or reduction of alveolar bone loss and collagen degradation in rats. 相似文献
975.
Marginal Bone Preservation in Single‐Tooth Replacement: A 5‐Year Prospective Clinical Multicenter Study
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![点击此处可从《Clinical implant dentistry and related research》网站下载免费的PDF全文](/ch/ext_images/free.gif)
976.
Changes of Marginal Bone Level in Patients with “Progressive Bone Loss” at Brånemark System® Implants: A Radiographic Follow‐Up Study over an Average of 9 Years
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977.
Ifeoma Nkiruka Menakaya Olabisi Hajarat Oderinu Ilemobade Cyril Adegbulugbe Olufemi Peter Shaba 《Saudi Dental Journal》2015,27(4):187-193
Objective
To compare the incidence of postoperative pain after the use of calcium hydroxide powder mixed with normal saline or 0.2% chlorhexidine digluconate as intracanal medicament.Participants
Fifty-five subjects aged 17–60 years with teeth diagnosed to have apical periodontitis.Intervention
Two-visit conventional root canal treatment of seventy teeth. The teeth were divided by randomization (balloting) into two groups: control group and experimental group, each with thirty-five teeth treated with calcium hydroxide mixed with normal saline or with 0.2% chlorhexidine digluconate as intracanal medicament respectively. Incidence of postoperative pain was assessed using the universal pain assessment tool and whether or not analgesic was taken.Main outcome measured
Incidence of post-operative pain.Result
Postoperative pain occurred only at 1-day and 1-week reviews. In the control group, the overall incidence of pain was the same at both review periods (5.7%), while the experimental group showed a slight decrease in incidence between 1-day (17.2%) and 1-week (11.4%) reviews. Incidence of flare-ups was more in the experimental group (11.4%) than in the control group (5.7%). No significant statistical differences between the two groups were observed (p > 0.05).Conclusion
The incidence of postoperative pain was lower in the normal saline treatment group, but the difference was not statistically significant. 相似文献978.
Partially Edentulous Arches: A 5‐Year Survey of Patients Treated at the Fluminense Federal University Removable Prosthodontics Clinics in Brazil
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![点击此处可从《Journal of prosthodontics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
979.
980.