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71.
抗CD25抗体预防移植物抗宿主病在儿童白血病半匹配骨髓移植中的应用 总被引:1,自引:0,他引:1
目的 探讨抗 CD2 5抗体用于预防儿童白血病半匹配未去 T细胞骨髓移植重度移植物抗宿主病 (GVHD)的疗效。 方法 10例儿童白血病患者接受 HL A2 - 3位点不合半匹配骨髓移植 ,移植方法除了供者应用粒细胞集落刺激因子 (GCSF)2 5 0μg促进骨髓及受者应用环孢素 A(CSA ) ,甲氨蝶呤 (MTX) ,抗胸腺细胞球蛋白 (ATG)和霉酚酸酯 (MMF)预防 GVHD综合措施外 ,加用抗 CD2 5单克隆抗体预防 GVHD,剂量各为 2 0 m g,在移植前 2 h和移植后第 4天应用 ,采髓后未去 T细胞输注 ,移植结果与前期未用 Simulect移植组比较。 结果 10例移植后均获造血重建 ,粒细胞大于 0 .5× 10 9/ L 中位天数是19 d,血小板大于 2 0× 10 9/ L 的中位天数是 2 2 d,骨髓植活直接证据检测证实为完全供者造血。无 1例发生急性 ~ GVHD,未用 Sim ulect对照组急性 ~ GVHD为 5 0 % ,差异有显著性意义。可评价慢性 GVHD的 8例均发生慢性 GVHD,均为局限性慢性 GVHD。中位随访 12个月 (范围 9~ 2 4个月 ) ,2例移植相关死亡 ,1例移植后 14个月复发死亡 ,实际无病生存率是 70 % ,与对照比较差异无显著性意义。 结论 本研究儿童半匹配未去 T细胞骨髓移植应用 Sim ulect,明显降低急性重症 a GVHD发生 ,减少移植相关死亡 ,临床应用安全可行。 相似文献
72.
M. Grant B. Ferrell G. M. Schmidt P. Fonbuena J. C. Niland S. J. Forman 《Quality of life research》1992,1(6):375-384
This study was designed to assess the reliability and validity of a Quality of Life (QOL) instrument on a sample of 179 allogeneic Bone Marrow Transplant (BMT) survivors. The QOL-BMT tool was developed specifically for this population and was based on the investigators' prior research and a conceptual model of Quality of Life. Patients who were at least 100 days post BMT completed the 30 item visual analogue questionnaire. The instrument measured physical symptoms (e.g., weight loss, frequent colds, skin changes, cataracts, sexual problems), psychological to illness, social concerns (e.g., relationship adjustment, return to work), and spiritual well-being (e.g., sense of control, future goals). Psychometric analysis of the instrument included measures of reliability and validity. The study findings demonstrate the unique aspects of QOL dimensions in BMT survivors and the value of QOL assessment in clinical practice and research.This study was supported by the City of Hope National Medical Center, NCI Cancer Center Core Grant, R30 CA 33572 and the City of Hope BRSG Grant Support. 相似文献
73.
Koichi Murata Yasuaki Nakagawa Takashi Suzuki Masahiko Kobayashi Seiya Kotani Takashi Nakamura 《Knee surgery, sports traumatology, arthroscopy》2007,15(10):1261-1263
Intraosseous ganglia of the glenoid are rare, and their etiology is unknown. This report describes a case of an intraosseous
ganglion about to cause fracture of the glenoid. The patient was a 61-year-old woman with a painful left shoulder with a limited
range of motion. Her symptoms did not improve after non-operative treatment. Arthroscopic examination showed a cartilage defect
and erosion in the posteroinferior portion of the glenoid, behind which computed tomography (CT) showed a cystic lesion of
the glenoid. There was no communication between the cyst and the joint space. The patient was treated by curettage and an
autogenous cancellous bone graft from the iliac crest. Two years after the operation, the patient was almost free from pain,
and CT showed good integration of the bone graft. 相似文献
74.
补肾活血方药对慢性再生障碍性贫血患者骨髓细胞体外影响的实验研究 总被引:3,自引:0,他引:3
目的 研究补肾活血方药对慢性再生障碍性贫血 (CAA)患者骨髓细胞体外增殖的影响 ,探讨其治疗CAA的机制。方法 采用细胞培养 ,光镜下观察补肾活血中药作用于CAA患者骨髓细胞后的形态学 ;3 H TdR掺入和液体闪烁技术方法 ,检测补肾活血中药对CAA患者骨髓细胞的增殖变化。结果 加入补肾活血中药组 ,CAA患者骨髓细胞培养第 4 8小时见细胞丛明显增多 ,72h见大量集落形成 ;3 H TdR掺入法显示 ,补肾活血中药组骨髓细胞的增殖 ,以每孔 75g L最有效。在 5 0~ 10 0g L范围内 ,与对照组比较差异有显著性 (P <0 .0 1) ;2 5g L和 12 5g L组与对照组比较差异无显著性 (P <0 .0 5 )。结论 补肾活血方药在体外有促进CAA患者骨髓细胞增殖的作用 ,为补肾活血中药治疗CAA提供了实验与理论依据 相似文献
75.
The mechanical and morphological properties of bone beneath internal fixation plates of differing rigidity 总被引:5,自引:0,他引:5
L Claes 《Journal of orthopaedic research》1989,7(2):170-177
The internal fixation of diaphyseal fractures by bone plates is a well recognized treatment. The normal physiological stress of bone is reduced by plates that cause a negative balance of bone-remodeling processes. Many investigators have shown that the degree of stress protection is dependent on the rigidity of the plates. It was the aim of this study to quantify mechanical and morphological changes at different locations in a plated diaphyseal bone as a function of differing plate rigidity. Two types of plates with the same size but different materials were used. The stainless steel plates had a modulus of elasticity and bending stiffness 3.2 times higher than the carbon fiber reinforced carbon plates. Both types of plates were applied to the intact right and left femora of six foxhounds for 6 months. The stiffer stainless steel plates led to a significantly higher bone loss and correspondingly greater loss of mechanical properties. These effects were greatest directly beneath the plate and less with increasing distance from the plate. 相似文献
76.
Bone remodeling during the development of osteoporosis in paraplegia 总被引:11,自引:0,他引:11
Professeur A. Chantraine B. Nusgens Ch. M. Lapiere 《Calcified tissue international》1986,38(6):323-327
Summary Osteoporosis developing during the first weeks after the onset of traumatic paraplegia was studied with cortical and cancellous
samples of iliac crest and tibia of 14 patients, and compared to normals. We used a procedure of bone particle fractionation
(according to degree of mineralization) that allowed us to establish a profile reflecting the metabolic remodeling of bone
and to analyze the organic matrix of the newly synthesized tissue. In paraplegics, we observed a large increase in the proportion
of little calcified bone in the cortical as well as in the cancellous bone. Based on amino acid analyses, we found a decreased
number of hydroxyproline residues in the newly synthesized organic matrix from paraplegia bone resulting either from an alteration
of the prolyl hydroxylation or from the presence of an excess of noncollagen polypeptides. These results, together with previously
published data reporting increased urinary hydroxylproline and calcium kinetic parameters, suggest an enhanced rate of skeletal
remodeling in acute paraplegia. When investigated 2 years after injury, the patterns of distribution approach that of normal
subjects. 相似文献
77.
目的 采用改进的Mitchell术式矫正拇外翻畸形。方法 对Mitchell术式进行改进 ,术中缩短第 1跖骨 ,内侧舌状骨瓣旋后外翻嵌入截骨近端髓腔 ,拇收肌联合腱移位于第 1跖骨头外侧 ,并松解第 1跖趾外侧关节囊等综合整形。结果 共 63例 (1 0 1足 )应用Mitchell术式并得到 2年以上的随访 ,总优良率达 91 % ,疗效满意。结论 本术式针对拇外翻畸形的病理解剖及其症状多方面矫正 ,使术后的外形和功能得到全面改善 ,可同时适用中老年患者 相似文献
78.
High energy laser has emerged to be an important surgical tool in medical technology. However, the application of laser energy
to drill or cut a bone is still in an experimental state. In order to estimate the adequacy of laser heating of bone surface
and at the same time minimize the damage to the bone tissue, we developed a mathematical model of the temperature distribution
in bone due to laser irradiation. The thermal analysis shows that the temperature distribution depends on several parameters,
including the density, the specific heat, and the thermal conductivity of the osseous tissue. 相似文献
79.
M. Ito T. F. Lang M. Jergas M. Ohki M. Takada T. Nakamura K. Hayashi H. K. Genant 《Calcified tissue international》1997,61(2):123-128
This study examined trabecular bone mineral density (BMD) in Japanese women with and without spinal fracture, and compared
the results to American women with and without fracture. The quantitative computed tomography (QCT) systems used at the University
of California, San Francisco (UCSF) and at Nagasaki University were cross-calibrated. Normative BMD was assessed with the
K2HPO4 liquid phantom in 538 Americans aged 20–85 years, and with the B-MAS200 phantom in 577 Japanese aged 20–83 years. These BMD
were adjusted for use with the Image Analysis solid phantom using the result of cross-calibration. The trabecular BMD in 111
postmenopausal American women (55 with fracture), and in 185 postmenopausal Japanese women (67 with fracture) were compared
for investigation of the difference in BMD values relative to fracture status. The absolute BMD values in Japanese were lower
than those in Americans, and the differences were greater with advancing age. The magnitude of the BMD difference was 8.6,
20.5, 38.1 mg/cm3 in women aged 20–24 years, 40–44 years, 60–64 years, respectively. In premenopausal women, BMD began to decrease at the age
of 20 in Japanese, whereas the peak bone mass was maintained until the age of 35 in the American women. In immediate postmenopausal
women, BMD significantly decreased in both populations. In later postmenopausal women, BMD significantly decreased with age
in the Japanese women but decreased less rapidly in the American women. The aging decrease of BMD was 1.4% and 2.2% per year
in the later postmenopausal American and Japanese women, respectively. The fracture threshold is considered to be lower in
Japanese women. However, the BMD difference between American and Japanese women with fracture was similar to that without
fracture. The Z-scores of fracture subjects versus controls were 2.9 in American and 1.8 in Japanese women. In conclusion,
Japanese women were found to have a lower BMD and lower fracture threshold than American women. The significant decrease of
spinal trabecular BMD in late postmenopause is potentially responsible for the higher prevalence of spinal fracture in Japanese
women.
Received: 18 December 1995 / Accepted: 23 September 1996 相似文献
80.
R. Honkanen M. Tuppurainen H. Kroger E. Alhava E. Puntila 《Calcified tissue international》1997,60(4):327-331
In a retrospective population-based study we assessed whether and how self-reported former fractures sustained at the ages
of 20–34 are associated with subsequent fractures sustained at the ages of 35–57. The 12,162 women who responded to fracture
questions of the baseline postal enquiry (in 1989) of the Kuopio Osteoporosis Study, Finland formed the study population.
They reported 589 former and 2092 subsequent fractures. The hazard ratio (HR), with 95% confidence interval (CI), of a subsequent
fracture was 1.9 (1.6–2.3) in women with the history of a former fracture compared with women without such a history. A former
low-energy wrist fracture was related to subsequent low-energy wrist [HR = 3.7 (2.0–6.8)] and high-energy nonwrist [HR = 2.4
(1.3–4.4)] fractures, whereas former high-energy nonwrist fractures were related only to subsequent high-energy nonwrist [HR
= 2.8 (1.9–4.1)] but not to low-energy wrist [HR = 0.7 (0.3–1.8)] fractures. The analysis of bone mineral density (BMD) data
of a subsample of premenopausal women who underwent dual x-ray absorptiometry (DXA) during 1989–91 revealed that those with
a wrist fracture due to a fall on the same level at the age of 20–34 recorded 6.5% lower spinal (P= 0.140) and 10.5% lower femoral (P= 0.026) BMD than nonfractured women, whereas the corresponding differences for women with a former nonwrist fracture due
to high-energy trauma were −1.8% (P= 0.721) and −2.4% (P= 0.616), respectively.
Our results suggest that an early premenopausal, low-energy wrist fracture is an indicator of low peak BMD which predisposes
to subsequent fractures in general, whereas early high-energy fractures are mainly indicators of other and more specific extraskeletal
factors which mainly predispose to same types of subsequent fractures only.
Received: 21 February 1996 / Accepted: 24 September 1996 相似文献