全文获取类型
收费全文 | 4257篇 |
免费 | 350篇 |
国内免费 | 268篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 134篇 |
妇产科学 | 27篇 |
基础医学 | 218篇 |
口腔科学 | 8篇 |
临床医学 | 528篇 |
内科学 | 873篇 |
皮肤病学 | 4篇 |
神经病学 | 11篇 |
特种医学 | 322篇 |
外科学 | 1423篇 |
综合类 | 523篇 |
预防医学 | 132篇 |
眼科学 | 3篇 |
药学 | 377篇 |
中国医学 | 133篇 |
肿瘤学 | 149篇 |
出版年
2024年 | 12篇 |
2023年 | 58篇 |
2022年 | 94篇 |
2021年 | 115篇 |
2020年 | 105篇 |
2019年 | 89篇 |
2018年 | 66篇 |
2017年 | 86篇 |
2016年 | 111篇 |
2015年 | 130篇 |
2014年 | 255篇 |
2013年 | 313篇 |
2012年 | 236篇 |
2011年 | 251篇 |
2010年 | 224篇 |
2009年 | 245篇 |
2008年 | 264篇 |
2007年 | 257篇 |
2006年 | 264篇 |
2005年 | 215篇 |
2004年 | 166篇 |
2003年 | 143篇 |
2002年 | 134篇 |
2001年 | 124篇 |
2000年 | 107篇 |
1999年 | 73篇 |
1998年 | 61篇 |
1997年 | 85篇 |
1996年 | 47篇 |
1995年 | 50篇 |
1994年 | 50篇 |
1993年 | 27篇 |
1992年 | 30篇 |
1991年 | 21篇 |
1990年 | 35篇 |
1989年 | 26篇 |
1988年 | 28篇 |
1987年 | 29篇 |
1986年 | 30篇 |
1985年 | 16篇 |
1984年 | 23篇 |
1983年 | 11篇 |
1982年 | 26篇 |
1981年 | 16篇 |
1980年 | 20篇 |
1979年 | 24篇 |
1978年 | 14篇 |
1976年 | 11篇 |
1975年 | 10篇 |
1974年 | 16篇 |
排序方式: 共有4875条查询结果,搜索用时 0 毫秒
31.
目的观察胰高血糖素对胆道梗阻大鼠肝脏葡萄糖和酮体合成作用的影响。方法大鼠胆道结扎48小时后,用胶原酶灌流后分离肝细胞,加入胰高血糖素温育,用分光光度计按标准酶学方法检测葡萄糖、乙酰乙酸和三羟基丁酸。结果在基础或最大刺激条件下,加胰高血糖素结扎组、假手术组葡萄糖异生均明显大于未加胰高血糖素组(P<0.05),加胰高血糖素对结扎组和假手术组的酮体异生无促进作用。结论胰高血糖素对胆道梗阻48小时大鼠肝细胞的糖异生存在有意义的刺激作用,对酮体异生则无刺激作用 相似文献
32.
Qian Z Maynar M Usón-Garallo J Sanchez-Margallo F Lima-Rodriguez MA Lima-Rodrigues JR Kim JK Gonzalez-Roman A Castañeda WR 《Academic radiology》1999,6(5):317-320
RATIONALE AND OBJECTIVES: The purpose of the study was to evaluate a method of producing obstruction of the common bile duct and concomitant biliary duct dilatation in an animal model. MATERIALS AND METHODS: Laparoscopic placement of a double-balloon occlusion device was used to produce common bile duct obstruction and bile duct dilatation in pigs. RESULTS: One week after the procedure, common bile duct obstruction and dilatation of the biliary tree were demonstrated with either percutaneous transhepatic cholangiography or percutaneous cholecystography. CONCLUSION: The use of this method is technically feasible and provides a useful subacute and chronic animal model of common bile duct obstruction and dilatation of the biliary tree for percutaneous interventional training and research purposes. 相似文献
33.
E. Petzinger 《Naunyn-Schmiedeberg's archives of pharmacology》1981,316(4):345-349
Summary Cholic acid inhibits the uptake of demethylphalloin (DMP), in a competitive manner. The bile acid increases the Michaelis constant but not V
max of the inward transport. The inhibition constant K
i for cholate was found to be 8 M. Cholate competes for the transport system but not for intracellular binding of phallotoxins. Various experimental data presented in this paper exclude an accumulation of phallotoxins in hepatocytes by intracellular binding only.Preincubation of hepatocytes with small concentrations of either (3H)-demethylphalloin or (14C)-cholate and subsequent treatment with high concentrations of the nonlabelled compounds reduces the intracellular concentration of both radioactive substrates. In accordance with earlier findings the above results suggest a common component needed for the transport of both phallotoxins and cholic acid.This work was supported by the Deutsche Forschungsgemeinschaft 相似文献
34.
对肝外胆管梗阻时“软藤征”的再认识 总被引:5,自引:0,他引:5
本文回顾性分析了48例“软藤征”的病因,其中恶性疾病28例(占58.3%),良性疾病20例(占41.7%)。据本文资料,作者认为“软藤征”是肝管分叉部及肝外胆管急性完全(或接近完全)性梗阻时肝内胆管扩张的特征性X线表现,并非恶性梗阻特有,良性梗阻亦常见。作者指出,只要肝内胆管无或仅有轻度炎症,胆管具有良好的弹性和扩张性,不论良、恶性病变都可出现“软藤征”。那种认为当梗阻病变未显示时,仅根据“软藤征”即可作出恶性梗阻诊断的观点很值得商榷。作者认为,“软藤征”的定性及病因诊断主要应根据PTC或ERCP,或二者联合显示梗阻局部病变的形态学特征来确定。 相似文献
35.
36.
216例恶性阻塞性黄疸患者手术疗效的因素分析 总被引:10,自引:0,他引:10
目的 探讨影响恶性阻塞性黄疸临床治疗的预后因素。方法 对1990年1月~1997年12月216例恶性阻塞性黄疸手术患者的17种临床指标进行分析。结果 173例(80.1%)手术后1个月存活,发生并发症81例,发生率37.5%。台术者胆管炎、胆瘘、出血、肾功能衰竭等并发症均高于姑息术者,差异均有显著性(P〈0.01);1月生存率和术后并发症发生率与ASA分级、黄疸持续的时间等有明显关系(P〈0.01 相似文献
37.
Subjective and functional results after total gastrectomy: prospective study for longterm comparison of reconstruction procedures 总被引:7,自引:0,他引:7
Shinya Adachi Satoshi Inagawa Tsuyoshi Enomoto Eiji Shinozaki Tatsuya Oda Toru Kawamoto 《Gastric cancer》2003,6(1):0024-0029
Background:
Many reconstruction procedures have been developed in efforts to resolve patients' complaints after total gastrectomy. However,
there have been few reports of longterm comparisons between reconstruction procedures, especially with regard to the prevention
of duodenal food passage. This study was undertaken to compare the longterm subjective and functional results among Roux-en-Y
esophagojejunostomy (R-Y), R-Y with pouch (P-Y), and jejunal interposition with pouch (P-I) after total gastrectomy.
Methods:
Consecutive patients requiring curative total gastrectomy were enrolled in this prospective study by the envelope method.
Results:
Hospital stay was longer following a P-I than an R-Y or a P-Y. Over 50% of R-Y patients complained of heartburn, and 20%
of R-Y patients showed dumping syndrome throughout the postoperative period, with this rate being significantly different
from rates in the other two groups. P-Y patients complained of early satiety in the late postoperative period, while P-I patients
complained of early satiety in the early postoperative period. The nutritional index in P-I patients was higher than those
in patients with the other two procedures. Gastrointestinal and hepatobiliary dual scintigraphy (GHDS) showed that the rate
of bile reflux with an R-Y was relatively high after surgery. Food reflux with a P-Y was increased (9.4% to 11.1%), but with
a P-I food reflux was decreased at 3 years after surgery (13.3% to 9.9%). Patients with a P-Y had a faster recovery of body,
weight in the early postoperative period; however, at 5 years after operation, body weight recovery with a P-I was greatest.
Conclusion:
Reconstruction should be performed with pouch formation after total gastrectomy with curative intent.
Received: March 7, 2002 / Accepted: September 26, 2002
Acknowledgments This study was partly supported by the University of Tsukuba Research Project.
Offprint requests to: S. Adachi 相似文献
38.
金属支架联合立体定向适形放疗治疗肝门部胆管癌 总被引:14,自引:0,他引:14
目的评价金属支架联合立体定向适形放疗肝门部胆管癌的疗效。方法31例肝门部胆管癌患者行金属支架置入联合立体定向适形放疗,并与23例行单纯支架治疗者进行对比研究。结果联合治疗组生存时间平均为11.1个月;对照组为5.1个月,差异有显著性意义(P<0.01)。结论胆道金属支架置入联合立体定向适形放疗是不能手术肝门部胆管癌的一种有效治疗方法。 相似文献
39.
This study illustrates the local spread of lower bile duct cancer with thin-section helical CT in correlation with the surgical
and pathological findings. Pathologically, 16 patients had pancreatic invasion, 4 had small bowel mesentery invasion, 7 had
extrapancreatic nerve plexus invasion, and 3 patients had vascular invasion. On thin-section helical CT, pancreatic invasion
was correlated to the clarity or non-clarity of the bile duct mass-pancreas border and the presence of an intrapancreatic
mass. Cases with small bowel mesentery and extrapancreatic nerve plexus invasion showed mass or stranding around the superior
mesenteric artery and/or inferior pancreatoduodenal artery. Vascular invasion was seen as tumor contiguity to these vessels.
Received: 28 September 1998; Revised: 30 December 1998; Accepted: 2 April 1999 相似文献
40.