Experimental Study of Physiological Advantages of Assist Circulation Using Oscillated Blood Flow

Abstract: To estimate the effect of oscillated blood flow on hemodynamics in an awake condition, left ventricular assist circulation using oscillated blood flow was performed on 3 adult goats as chronic animal examination. A vibrating flow pump (VFP) was used for generating high-frequency oscillated flow. The blood flow rate of assisted circulation was approximately 1.0 L/min, and the driving frequency of VFP was 25 Hz. Systemic vascular resistance and arterial impedance were calculated in this study. Systemic vascular resistance during assist circulation was decreased compared with that without assistance. Oscillated blood flow may be effective in decreasing vascular resistance. Moreover, it was suggested from the study of arterial impedance that motive characteristics of the vascular wall against changing blood pressure may keep their normal reaction. Therefore, oscillated blood flow may be used for left ventricular assist circulation as concluded from the study of the characteristics of blood vessels.     

动脉栓塞治疗中疼痛与止痛药应用分析

目的：研究正常应用止痛药可保证动脉栓塞治疗的顺利进行。材料与方法：以Ｓｅｌｄｉｎｇｅｒ法行股动脉穿刺插管。导管前端达靶动脉栓塞，术中酌情应用止痛药。结果：及时应用止痛药的病人能忍受栓塞治疗，栓塞治疗达到预期目的。结论：动脉栓塞的疼痛病理因素有血管痉挛性、组织缺血性和组织坏死性，各组织器官表现不同的疼痛反应。术中多使用利多卡因。     

Calculations and experimental studies of the lineshape of the lactate doublet in PRESS-localized 1H MRS

Accurate quantification of NMR metabolites by spectral modeling requires assumed lineshape functions. For singlet resonances, a combination of Lorentzian and Gaussian lineshapes is sufficient, but for weakly J-coupled resonances such as lactate, more complex lineshapes are necessary. In this work, the lactate lineshape is calculated for the PRESS sequence using standard RF pulses, and compared with experimental measurements. A similar comparison is made for PRESS-localized spectroscopic imaging, in which the lineshape varies from voxel to voxel across the field of view. These observations have important implications for the quantification of lactate in experimental and human studies.     

三康胶囊对高原人体运动自由基代谢和血乳酸的影响

目的:探讨三康胶囊对高原人体运动自由基代谢和血乳酸(BLA)的影响。方法:对进驻海拔3 700 m高原1年的10名健康青年在服药前和服药第15 d,分别采用自行车功量计进行渐增负荷运动,测定血清中超氧化物歧化酶(SOD)活性和丙二醛(MDA)、BLA含量。结果:服药后较服药前运动后SOD[(121.2±16.9)Vs(99.6±14.0)]增高,而MDA[(3.97±0.17)Vs(4.31±0.18)]和BLA[(5.11±0.31)Vs(6.22±0.46)]降低,有非常显著差异(P<0.01)。结论:三康胶囊能明显抑制高原运动造成的自由基损伤,具有提高运动能力,延缓运动性疲劳发生的作用,是一种很有前景的抗缺氧、抗疲劳、抗幅射纯中药制剂。     

经股动脉溶栓治疗下肢动脉急性栓塞

目的 :探讨经股动脉溶栓等内科综合措施治疗腊国动脉以下部位急性动脉栓塞的效果。方法 :对 15例该部位动脉急性栓塞患者采用穿刺患侧股动脉滴注尿激酶或重组组织型纤溶酶元激活剂 (rt PA)进行溶栓 ,结合抗凝、扩管等治疗。结果 :本组 12例血管再通 ,溶栓再通率 80 0 % ;尿激酶再通率 6 6 7% (4 6 ) ,rt PA 88 9% (8 9) (P >0 0 5 )。溶栓 72h未再通者继续溶栓仍未再通。本组未发生肢体坏疽及出血并发症 ,患肢运动功能完全恢复。结论 :经股动脉溶栓治疗对腊国动脉以下部位的单支动脉急性栓塞效果良好 ,结合长期抗凝治疗能有效防止再栓塞     

大动脉调转手术(Switch手术)的临床应用

目的　目前Switch手术是治疗TGA或Tausing -Bing畸形的常规、根治性手术。国内大部分患儿就医较晚 ,心内合并畸形较多 ,且绝大多数患者合并重度肺动脉高压。,能否行Switch手术和手术后疗效如何 ,为此 ,本文进行了研究。方法　对 2 7例患者实施Switch手术。男 19例 ,女 8例。年龄 3d～ 6岁 ,平均 ( 10 1± 5 7)月。新生儿 7例 ,1岁以上儿童 6例。体重 2 7～ 16kg ,平均( 6 3± 2 8)kg。 5例室间隔完整的TGA ,18例TGA合并VSD ,3例Tausing -Bing畸形 ,1例矫正性大动脉转位。 10例合并ASD ,17例合并PDA。 2 0例合并重度肺动脉高压。 1例先天性肺动脉瓣二瓣化 ,左室流出道狭窄。 1例合并右侧并列心耳。 2 3例患者冠状动脉开口位于常见位置 ;4例患者冠状动脉走行异常 ,3例为左右冠状动脉共同开口于右后冠状窦 ,左前降支单独开口于左后冠状窦 ,其中 1例左前降支走行于主动脉壁内 ,距离 1cm ;1例为左右冠状动脉分别开口于右侧冠状窦 ,左前降支单独开口于左侧冠状窦。 3例术前应用PGE1治疗。 1例患儿行肺动脉Banding +体肺分流手术。 1例患儿行房间隔球囊扩张术。全部患者经正中切口 ,在全麻、低温、低流量体外循环下完成手术。经右心房切口 ,用涤纶片修补VSD。在两大动脉瓣上方 ,横断两大动脉 ,将左右冠状动     

Delayed-onset muscle damage and lipid peroxidation in man after a downhill run

Lipid peroxidation initiated by free radical reactions is associated with tissue necrosis in a variety of conditions. We have measured serum lipid peroxide concentrations (as total thiobarbituric acid-reactive substances, TBARS) and creatine kinase (CK), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) activities and subjective muscle soreness in 16 men before and after a 45-minute downhill treadmill run. TBARS concentrations and enzyme activities were increased after exercise, with peak values observed at 6 hours (TBARS, LDH) or 24 hours (CK, AST) after exercise. Serum LDH activity returned to preexercise levels by 48 hours after exercise and TBARS by 72 hours after exercise: CK and AST activities remained elevated 72 hours after exercise. Leg mucle soreness also increased, with the greatest degree of soreness seen at 24 or 48 hours after exercise. Subjects with the greatest increase in CK, LDH, and AST also showed the highest serum TBARS concentration. This suggests a possible relationship between free radical generation and exercise-induced muscle damage.     

Lactate dehydrogenase-X: an isozyme particularly sensitive to gossypol inhibition

The activities of lactate dehydrogenase (all isozymes and isozyme-X alone) in the presence of a wide range of gossypol were examined in ejaculated mature boar spermatozoa. It was found that LDH-X, a characteristic isozyme located mainly in primary spermatocytes, is more sensitive than the other isozymes to gossypol inhibition. Its possible role in the male antifertility effect of gossypol is discussed.     

Treatment of urinary fistulas after resection of horseshoe kidneys by selective arterial embolization

Two patients presenting with urinary fistulas following partial resection of hydronephrotic kidneys were successfully treated with selective arterial embolization causing functional ablation of the remaining renal parenchyma. This technique is simpler than surgical reexploration.     

Unusual cause of recurrent arterial embolism: floating thrombus in the aortic arch surgically removed under hypothermic cardiocirculatory arrest

A 46-year-old fully active, asymptomatic man suffered two episodes of major peripheral arterial embolism within 2 months. Heart disease was ruled out by appropriate investigations. Further diagnostic evaluation (angiography, CAT scan) revealed the extremely rare finding of a “floating mass” in the transverse aortic arch suspected to be the source of embolization. This mass was successfully removed using the technique of hypothermic cardiocirculatory arrest. The histological diagnosis was an aged intraluminal thrombus and moderate atherosclerosis of the thoracic aorta. For prevention of recurrent arterial embolism in cases without an initially apparent cause and site of origin, a thorough diagnostic, and in a given patient, an aggressive surgical approach for the elimination of the embolic source are advocated.