Plexiform ameloblastoma presenting as a sinonasal tumor

Ameloblastomas are the most frequent odontogenic tumours, accounting for 1% of all tumours of the maxilla and mandible. Sinonasal ameloblastomas are most common between the ages of 55 and 65, and mandibular ameloblastomas between 40 and 50. Incidence is higher in males than in females, and there are no differences between races. These locally aggressive tumours originate in the mandible in 80% of cases and in the maxilla in 15–20%. We report an unusual primary nasosinusal ameloblastoma presented in a 68-year-old male. The tumour was completely resected by (para)lateral rhinotomy and treated with postoperative radiotherapy. Histological analysis demonstrated a plexiform ameloblastoma. The patient remains well without disease after 50 months of postoperative follow-up.     

Ameloblastoma of the maxilla. Case report

A basal cell maxillary ameloblastoma became obvious as an asymptomatic swelling of the left buccal sulcus and alveolar process, although a large extension into the maxillary sinus up to the nasal conchae and the orbital floor had already occurred. The painless and slow growth of the lesion, the thin bone of the upper jaws, the adjacent cavities and the vital structures are the main factors for delay in recognition and thus the potentially lethal result of a maxillary ameloblastoma. A review of location, age, sex and race predilection, clinical course, radiographic appearance, histological types and treatment methods in made.     

Cystic Granular Cell Ameloblastoma

Ameloblastoma is a locally aggressive benign epithelial odontogenic tumor, while unicystic ameloblastoma is a relatively less aggressive variant. Although rare in unicystic or cystic ameloblastoma, granular cell change in ameloblastoma is a recognized phenomenon. The purpose of the present article is to report a case of cystic granular cell ameloblastoma in 34-year old female.     

Ameloblastic fibrosarcoma of the maxillary sinus in an infant: a case report with long-term follow-up

Ameloblastic fibrosarcoma (AFS) or ameloblastic sarcoma is an extremely rare odontogenic neoplasm. The authors report AFS in the maxillary sinus of a 4-month-old boy. The tumor was composed of odontogenic epithelium, resembling that of ameloblastoma, and a mesenchymal part exhibiting features of fibrosarcoma. We also found some areas with deposition of dentinoid material closely adjacent to the ameloblastic epithelium. Although AFS has occurred in a wide age range, this is the first report of this tumor in infancy with long-term follow-up.     

胫骨造釉细胞瘤手术方法选择

目的:探讨胫骨造釉细胞瘤手术方法选择的应用价值。方法:胫骨造釉细胞瘤患者5例,男4例,女1例;年龄14⁶1岁,平均37.8岁。5例行手术治疗,先后多次复发。早期行病灶刮除、自体骨、异体骨或人工骨植骨术,全部复发。复发后又先后行瘤段切除、自体游离腓骨移植术,瘤段切除、异体骨移植术。最终4例行截肢术。结果:术后随访10个月³年,平均12.4个月。病灶刮除植骨术后复发5例,3例再行瘤段切除、自体游离腓骨髂骨移植术,其中2例复发;2例再行瘤段切除、异体骨移植术,均复发。复发的4例均采取截肢治疗。出现肺转移1例,行肺转移灶切除术;出现骨转移1例,行髋关节离断术,随访末期死亡0例。结论:虽然胫骨造釉细胞瘤有很高的复发率,但经过积极正确的手术方法治疗,预后尚好。     

成釉细胞瘤预后评估——基于SEER数据库的研究

目的 成釉细胞瘤(AM)是罕见牙源性肿瘤,易复发、浸润生长,本研究旨在探讨成釉细胞瘤预后因素。方法 基于SEER数据库筛选成釉细胞瘤 207例,构建Cox回归模型并绘制诺莫图预测总生存。回顾性分析湖南省肿瘤医院 61例临床资料,用Cox回归分析影响复发的独立因素。结果 基于SEER数据库评估,年龄、肿瘤大小、手术方式、放疗均是影响AM患者总生存的重要因素,构建列线图,一致性指数为0.821,表明预测模型具有中等准确度。受试者工作曲线显示1、3、5、10年的曲线下面积分别为0.852、0.869、0.856、0.879,表明预测模型具有较好的敏感性和特异性。Kaplan-Meier生存分析显示高风险组总生存低于低风险组(P<0.001)。基于回顾性分析,临床症状、手术类型是影响局部复发率的独立因素;面部肿痛,相对于其他症状复发率更低,根治手术相对于姑息手术可降低复发率。结论 年龄、肿瘤大小、手术方式、放疗可能是影响总生存的重要因素;手术方式、临床症状可能是影响复发率的独立因素。     

Mandibular ameloblastoma with intracranial extension and distant metastasis

A case of mandibular ameloblastoma which invaded intracranially through the skull base and developed distant metastasis to the femur is reported. The intracranial extension of the tumor was partially removed three times and the metastasis of the femur was curetted. The remaining tumor temporarily responded to chemotherapy, but the patient died of intracranial tumor regrowth. The period from the initial treatment of the mandibular tumor to death was 21 years.