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71.
72.
p53 gene in treatment of hepatic carcinoma: Status quo 总被引:9,自引:1,他引:8
Hepatocellular carcinoma(HCC)is one of the 10 most common cancers worldwide.There is no ideal treatment for HCC yet and many researchers are trying to improve the effects of treatment by changing therapeutic strategies.As the majority of human cancers seem to exhibit either abnormal p53 gene or disrupted p53 gene activation pathways,intervention to restore wild-type p53 (wt-p53)activities is an attractive anti-cancer therapy including HCC.Abnormalities of p53 are also considered a predisposition factor for hepatocarcinogenesis.p53 is frequently mutated in HCC.Most HCCs have defects in the p53-mediated apoptotic pathway although they carry wt-p53.High expression of p53 in vivo may exert therapeutic effects on HCC in two aspects(1)High expression of exogenous p53 protein induces apoptosis of tumor cells by inhibiting proliferation of cells through several biologic pathways and(2)Exogenous p53 renders HCC more sensitive to some chemotherapeutic agents.Several approaches have been designed for the treatment of HCC via the p53 pathway by restoring the tumor suppression function from inactivation,rescuing the mutated p53 gene from instability,or delivering therapeutic exogenous p53.Products with p53 status as the target have been studied extensively in vitro and in vivo.This review elaborates some therapeutic mechanisms and advances in using recombinant human adenovirus p53 and oncolytic virus products for the treatment of HCC. 相似文献
73.
抗生素质量分析研究的新进展 总被引:3,自引:0,他引:3
介绍了中国药典2005年版中收载抗生素品种的特点以及新技术、新方法在新版药典中的应用情况;并对人用药品注册技术要求国际协调会ICH最新增加的指导原则做了介绍;指出现在国内抗生索品种研发存在的几个主要误区;同时简要介绍抗生素分析方法的最新动态。 相似文献
74.
David Steinhaus 《Journal of cardiovascular translational research》2008,1(4):252-253
A 1957 power blackout in Minnesota prompted C. Walton Lillehei, MD, a pioneer in open heart surgery, to ask Earl Bakken, the
co-founder of Medtronic, Inc., to create a battery-operated pacemaker for pediatric patients. That conversation led to the
development of the first external battery-operated pacemaker. That first bulky device is far removed from the tiny implantable
computers available to heart patients today. Now, the size of two silver dollars stacked on top of one another, a pacemaker
is prescribed for a person whose heart beats too slowly or pauses irregularly. Slightly larger devices have more recently
evolved from pacing and regulating the heartbeat to being able to provide therapeutic high voltage shocks when needed to stop
runaway fast heart rates, recording heart activity, and other physiologic functions, even resynchronizing the heart’s chambers—all
while providing information on the patient’s condition and device performance to the doctor remotely or in the office. 相似文献
75.
肺动脉高压的研究进展 总被引:2,自引:0,他引:2
肺动脉高压是以肺血管阻力进行性增加为临床特征的一组威胁生命的疾病,近10年来,肺动脉高压的研究取得了显著的进展,涉及2003年威尼斯会议修改的肺动脉高压的命名和分类、遗传基因的发现、应用分子生物学技术探讨其发病学以及内科和外科治疗效果的改善。前列环素及其类似物和内皮素受体拮抗剂的临床研究,使肺动脉高压在治疗的安全性和有效性方面均取得了长足的进步。 相似文献
76.
《The Indian journal of tuberculosis》2021,68(4):510-515
There has been a substantial leap in our understanding and the management of tuberculosis over the past couple of decades. New diagnostic tests, regimens and drugs have emerged. With a background of milestones in the management of tuberculosis, we review the advances made in the diagnosis and treatment of pulmonary tuberculosis. Since India accounts for 27% of word's burden of tuberculosis, the changes in RNTCP have been highlighted. 相似文献
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78.
肝纤维化是由于基质金属蛋白酶(matrix metalloproteinases,MMPs)及其组织抑制因子(tissue inhibitor of metalloproteinasas,TIMPs)比例失调,造成细胞外基质大量沉积在细胞间质中,引起的病理改变。目前研究发现MMP-9在肝纤维化形成过程中有诱发和促进作用,但也有一些相反的意见,认为其具有逆转肝纤维化的作用,与肝纤维化呈负相关。因此,本文就近年来对MMP-9功能的研究作一概述。 相似文献
79.
80.
Byron W. Benson Diane J. Flint Hui Liang Michael J. Opatowsky 《Head and neck pathology》2014,8(4):383-391
Advances in dental and maxillofacial imaging are delineated along with the advantages and disadvantages of each imaging modality. The imaging modalities that are included are intraoral radiography, panoramic radiography, cone-beam computed tomography, multidetector computed tomography, magnetic resonance imaging, nuclear medicine, and ultrasound. 相似文献