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101.
目的 探讨AQT90 FLEX免疫分析仪床旁快速检测全血D-二聚体(D-dimer)的临床性能并评估其在老年患者中的应用价值.方法 参考我国卫生行业标准《D-二聚体定量检测》(WS/T 477-2015)中提供的设备性能评价方法,对AQT90 FLEX免疫分析仪检测全血D-二聚体(D-dimer)进行性能评价.选择2015年北京大学第一医院老年科60岁及以上住院患者,同时采取静脉血193份(男158份,女35份),比较AQT90 FLEX免疫分析仪和ACL TOP全自动凝血仪测定D-二聚体结果的相关性.结果 高值和低值样品的批内不精密度分别为2.619%和2.767%;携带污染率为0.12%;AQT90 FLEX免疫分析仪与ACL TOP全自动凝血仪检测结果的相关系数为0.9491 (P<0.01),AQT90 FLEX免疫分析仪检测结果为2.52,ACL TOP全自动凝血仪检测结果+0.15,在女性、高龄患者,倍数关系略增加.结论 AQT90 FLEX免疫分析仪床旁测定全血D-二聚体浓度精密度高,与ACL TOP全自动凝血仪检测结果相关性好,AQT90 FLEX免疫分析仪的检验结果约为ACL TOP全自动凝血仪检验结果的2.52倍.将其应用于门急诊及重症监护室老年人群的血栓性疾病筛查结果可靠. 相似文献
102.
Mark Trump Darren M. Palathinkal Lauren BeaupreDave Otto Paul LeungA. Amirfazli 《The Knee》2011,18(3):193-201
Various anterior cruciate ligament (ACL) graft-fixation devices exist. In this in vitro study a comparison of biomechanical characteristics of the Cross-Pin and button type fixation devices under practical rehabilitation loads was done. Forty bovine knees and hoof extensor tendons were harvested. After disarticulation, the femoral end of an ACL was prepared with either fixation, using the extensor tendon as graft. The mechanical test was either a single load to failure or load to failure after cycling loads. Twenty specimens were loaded to failure at a rate of 1 mm/s, remaining specimens were cycled between 50 and 250 N for 1000 cycles then failure tested in a similar manner. Results show that both forms of fixation are able to withstand loads that exceed those observed in performing functional activities. Activity-specific stiffness (loads comparable to walking, jogging and stair descent) was lower than linear stiffness for both EndoButton and Cross-Pin, without prior cycling. After cycling, activity-specific stiffness increased to linear stiffness values for the Cross-Pin for all activities. Thus, suggesting that the Cross-Pin provides a more rigid fixation after initial implantation over a wider range of activities, which would theoretically permit a more aggressive rehabilitation protocol and possibly an earlier return to regular activity. In contrast, activity-specific stiffness increased above linear stiffness values for the EndoButton only under heavier loads (jogging and stair descent). Dynamic stiffness was higher and displacement lower for Cross-Pin throughout the cycle test. These results indicate, in ACL reconstruction, that graft complex stiffness should be considered at relevant loads only. 相似文献
103.
Anatomic variations of the anterior cruciate ligament (ACL) are very rare. The prevalence of congenital aplasia or hypoplasia of the ACL is 0.017 per 1,000 live births. The normal ACL consists of the anteromedial (AMB) and posterolateral bundles (PLB). Together, they attach to a fossa on the posteromedial aspect of the lateral femoral condyle. The PLB fibrils are smaller and shorter than those of the AMB. We report an ACL variation that had not been previously described, in which the PLB was attached to an intraarticular accessory ossicle, without causing knee instability. The large accessory ossicle caused pain. We reviewed the anatomy, anomalies, and variation in the ACL. 相似文献
104.
Diermann N Schumacher T Schanz S Raschke MJ Petersen W Zantop T 《Archives of orthopaedic and trauma surgery》2009,129(3):353-358
Introduction Recently, several publications investigated the rotational instability of the human knee joint under pivot shift examinations
and reported the internal tibial rotation as measurement for instrumented knee laxity measurements. We hypothesize that ACL
deficiency leads to increased internal tibial rotation under a simulated pivot shift test. Furthermore, it was hypothesized
that anatomic single bundle ACL reconstruction significantly reduces the internal tibial rotation under a simulated pivot
shift test when compared to the ACL-deficient knee.
Methods In seven human cadaveric knees, the kinematics of the intact knee, ACL-deficient knee, and anatomic single bundle ACL reconstructed
knee were determined in response to a 134 N anterior tibial load and a combined rotatory load of 10 N m valgus and 4 N m internal
tibial rotation using a robotic/UFS testing system. Statistical analyses were performed using a two-way ANOVA test.
Results Single bundle ACL reconstruction reduced the anterior tibial translation under a simulated KT-1000 test significantly compared
to the ACL-deficient knee (P < 0.05). After reconstruction, there was a statistical significant difference to the intact knee at 30° of knee flexion.
Under a simulated pivot shift test, anatomic single bundle ACL reconstruction could restore the intact knee kinematics. Internal
tibial rotation under a simulated pivot shift showed no significant difference in the ACL-intact, ACL-deficient and ACL-reconstructed
knee.
Conclusion In conclusion, ACL deficiency does not increase the internal tibial rotation under a simulated pivot shift test. For objective
measurements of the rotational instability of the knee using instrumented knee laxity devices under pivot shift mechanisms,
the anterior tibial translation should be rather evaluated than the internal tibial rotation.
This study was supported in part by a grant of the German Speaking Association of Arthroscopy (AGA). 相似文献
105.
Choongsoo S. Shin Ajit M. Chaudhari Chris O. Dyrby Thomas P. Andriacchi 《Journal of orthopaedic research》2009,27(6):730-735
Reduced quadriceps contraction has been suggested as an adaptation to prevent anterior tibial translation in anterior cruciate ligament (ACL)-deficient knees. This theory has been supported by a recent study that peak knee flexion moment (thought to be created by a decrease of quadriceps contraction) during walking was negatively correlated with patellar ligament insertion angle (PLIA) in ACL-deficient knees, but not in contralateral, uninjured knees. In addition, the PLIA was significantly smaller in ACL-deficient knees than in contralateral, uninjured knees. However, it is unknown whether ACL reconstruction restores the PLIA or whether the relationship between the PLIA and knee flexion moments previously observed in ACL-deficient knees disappears. This study tested the following hypotheses: (1) The PLIA of ACL-reconstructed knees is significantly smaller than the PLIA of uninjured contralateral knees; (2) Peak knee flexion moment (balanced by net quadriceps moment) during walking is negatively correlated with the PLIA in ACL-reconstructed knees. The PLIA of 24 ACL-reconstructed and contralateral knees were measured using MRI, and peak knee flexion moments during walking were measured. Results showed that the PLIA of ACL-reconstructed (22.9 ± 4.4°) knees was not significantly smaller (p = 0.09, power = 0.99) than the PLIA of contralateral (24.1 ± 4.8°) knees. Peak knee flexion moment was not correlated with the PLIA following ACL reconstruction (R2 = 0.016, power = 0.99). However, the magnitude of the knee flexion moment remained significantly lower in ACL-reconstructed knees. In summary, this study has shown that the PLIA of ACL-reconstructed knees returned to normal and that patients no longer adapt their gait in response to the PLIA, though quadriceps function did not return to normal levels. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 730–735, 2009 相似文献
106.
Kurt P. Spindler Martha M. Murray James L. Carey David Zurakowski Braden C. Fleming 《Journal of orthopaedic research》2009,27(5):631-638
Many anterior cruciate ligament (ACL) reconstructions have increased laxity postoperatively. We hypothesized that enhancing an ACL graft with a collagen‐platelet composite (CPC) would improve knee laxity and graft structural properties. We also hypothesized the platelet concentration in the CPC would affect these parameters. Twelve goats underwent ACL reconstruction with autologous patellar tendon graft. In six goats, a collagen‐platelet composite was placed around the graft (CPC group). In the remaining six goats, the collagen scaffold only was used (COLL group). Three goats were excluded due to complications. After 6 weeks in vivo, anterior–posterior (AP) laxity and tensile properties of the ACL reconstructed knees were measured and normalized against the contralateral intact knee. At a knee flexion angle of 30°, the average increase in AP laxity was 40% less in the CPC group than the COLL group (p = 0.045). At 60°, the AP laxity was 30% less in the CPC group, a difference that was close to statistical significance (p = 0.080). No differences were found between treatment groups with respect to the structural properties (p > 0.30). However, there were significant correlations between serum platelet concentration and AP laxity (R2 = 0.643; p = 0.009), maximum load (R2 = 0.691; p = 0.006), and graft stiffness (R2 = 0.840; p < 0.001). In conclusion, use of a CPC to enhance healing of an allograft ACL reconstruction inversely correlated with early sagittal plane laxity and the systemic platelet count was highly predictive of ACL reconstruction graft strength and stiffness at 6 weeks. These findings emphasize the importance of further research on delineating the effect of platelets in treating of ACL injuries. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 631–638, 2009 相似文献
107.
Martha M. Murray Matthew Palmer Eduardo Abreu Kurt P. Spindler David Zurakowski Braden C. Fleming 《Journal of orthopaedic research》2009,27(5):639-645
In this study, we hypothesize that supplementation of suture repair of the anterior cruciate ligament (ACL) with platelet‐rich plasma (PRP) will improve the biomechanics of the repair. Six 30‐kg pigs underwent bilateral suture repair of the ACL. One side was treated with suture repair alone, while the contralateral side was treated with suture repair augmented with PRP. After 14 weeks in vivo, anterior–posterior (AP) knee laxity and the tensile properties of the repaired ligament were measured. The addition of PRP to the suture repairs did not improve AP knee laxity at 30° (p = 0.73) or 60° (p = 0.65). It also did not improve the maximum tensile load (p = 0.64) or linear stiffness (p = 0.42) of the ACL repairs after 14 weeks in vivo. The model had 80% power to detect a 30% improvement of biomechanical properties with PRP; thus, we are confident that a clinically meaningful effect as a result of adding PRP is unlikely. Use of PRP alone to supplement suture repair of the ACL is ineffective in this animal model. Published by Wiley Periodicals, Inc. J Orthop Res 27: 639–645, 2009 相似文献
108.
M.P. Palmer E.L. Abreu A. Mastrangelo M.M. Murray 《Journal of orthopaedic research》2009,27(7):964-971
Collagen‐platelet composites have recently been successfully used as scaffolds to stimulate anterior cruciate ligament (ACL) wound healing in large animal models. These materials are typically kept on ice until use to prevent premature gelation; however, with surgical use, placement of a cold solution then requires up to an hour while the solution comes to body temperature (at which point gelation occurs). Bringing the solution to a higher temperature before injection would likely decrease this intra‐operative wait; however, the effects of this on composite performance are not known. The hypothesis tested here was that increasing the temperature of the gel at the time of injection would significantly decrease the time to gelation, but would not significantly alter the mechanical properties of the composite or its ability to support functional tissue repair. Primary outcome measures included the maximum elastic modulus (stiffness) of the composite in vitro and the in vivo yield load of an ACL transection treated with an injected collagen‐platelet composite. In vitro findings were that injection temperatures over 30°C resulted in a faster visco‐elastic transition; however, the warmed composites had a 50% decrease in their maximum elastic modulus. In vivo studies found that warming the gels prior to injection also resulted in a decrease in the yield load of the healing ACL at 14 weeks. These studies suggest that increasing injection temperature of collagen‐platelet composites results in a decrease in performance of the composite in vitro and in the strength of the healing ligament in vivo and this technique should be used only with great caution. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 964–971, 2009 相似文献
109.
Anatomic variations between Japanese and Caucasian populations in the healthy young adult knee joint
Our objective was to characterize variations in mechanical knee alignment, tibial torsion, tibial width, and ACL laxity measurements between Japanese and Caucasian populations in the healthy, young adult knee joint. Seventy young adult subjects participated in this study, including 23 Japanese and 47 Caucasian subjects. Coronal magnetic resonance images of the hip, knee, and ankle were acquired for analysis. Japanese subjects had a significantly higher (p = 0.04) varus alignment (1.64 ± 0.43° standard error) than Caucasians (0.55 ± 0.33°), while women exhibited a more valgus alignment (0.16 ± 0.52°) than men (0.94 ± 0.42°, p = 0.04). Significant differences were found in tibial torsion and ACL laxity (p < 0.01) between ethnicities, with Japanese exhibiting lower tibial torsion (33.4 ± 10.0°) and higher ACL laxity (7.5 ± 0.4 mm) measurements compared to Caucasians (38.9 ± 9.5° and 5.7 ± 0.3 mm, respectively). Significant differences between genders were found in hip‐knee‐ankle alignment (p = 0.04), tibial width (p < 0.0001), and ACL laxity (p < 0.01) measurements. Measurements were reliable between observers and for repeated positioning. Our study provides new insight into anatomical and geometric differences in the knee joint between Japanese and Caucasians, as well as between females and males. Further consideration of these results may improve development of implants to accommodate for these differences, and understanding of characteristics leading to increased prevalence of knee OA in certain populations. The use of magnetic resonance imaging to obtain these measurements also allows soft tissue structure characterization without exposure to ionizing radiation. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 相似文献
110.