全文获取类型
收费全文 | 1253篇 |
免费 | 53篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 43篇 |
妇产科学 | 13篇 |
基础医学 | 70篇 |
口腔科学 | 4篇 |
临床医学 | 123篇 |
内科学 | 121篇 |
皮肤病学 | 40篇 |
神经病学 | 75篇 |
特种医学 | 32篇 |
外科学 | 149篇 |
综合类 | 163篇 |
预防医学 | 138篇 |
眼科学 | 24篇 |
药学 | 228篇 |
中国医学 | 66篇 |
肿瘤学 | 31篇 |
出版年
2023年 | 15篇 |
2022年 | 39篇 |
2021年 | 51篇 |
2020年 | 40篇 |
2019年 | 38篇 |
2018年 | 38篇 |
2017年 | 29篇 |
2016年 | 38篇 |
2015年 | 24篇 |
2014年 | 83篇 |
2013年 | 86篇 |
2012年 | 64篇 |
2011年 | 79篇 |
2010年 | 62篇 |
2009年 | 58篇 |
2008年 | 65篇 |
2007年 | 63篇 |
2006年 | 46篇 |
2005年 | 40篇 |
2004年 | 33篇 |
2003年 | 19篇 |
2002年 | 24篇 |
2001年 | 23篇 |
2000年 | 15篇 |
1999年 | 18篇 |
1998年 | 20篇 |
1997年 | 24篇 |
1996年 | 16篇 |
1995年 | 14篇 |
1994年 | 19篇 |
1993年 | 14篇 |
1992年 | 11篇 |
1991年 | 9篇 |
1990年 | 6篇 |
1989年 | 3篇 |
1988年 | 7篇 |
1987年 | 16篇 |
1986年 | 5篇 |
1985年 | 11篇 |
1984年 | 10篇 |
1982年 | 9篇 |
1981年 | 3篇 |
1979年 | 7篇 |
1978年 | 2篇 |
1977年 | 6篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1974年 | 6篇 |
1973年 | 3篇 |
1970年 | 2篇 |
排序方式: 共有1327条查询结果,搜索用时 78 毫秒
1.
章新亮 《江西中医学院学报》2010,22(5):10-12
《诸病源侯论》论毒邪篇幅之多,明目之清,发前人所未发,打破传统束缚,注重临床实际。如其提出毒邪判断要以阴阳为纲;毒邪向内为病重,向外为病轻;赤白为轻,青紫黑为重;过肘膝为重,以及伤肠胃心肝脾肾均有不同的症状特征,提示了六淫从化于毒,毒邪与六淫有不同表现等问题,值得一读。 相似文献
2.
ABSTRACT. A double balloon technique was used for anal tonometry in 22 infants. The weight was less than 2500 g in 10 of the infants. Ileus or delayed passage of meconium was seen in 9 infants. Thirteen infants had not revealed any symptoms of intestinal obstruction during the first week of life. In all cases, except one, it was possible to demonstrate reflexes from the internal anal sphincter. In 18 infants normal curves were registered from the internal anal sphincter. None of these developed Hirschsprung's disease. In 3 infants a pathological pattern of contractions of the internal anal sphincter was demonstrated. Two of them proved to have Hirschsprung's disease. In the third case normal reflexes were registered after one year. Possibly the innervation of rectum and the internal anal sphincter was disrupted during the neonatal period in connection with enterocolitis and ileus, thus representing a reversible case of achalasia. 相似文献
3.
Neurological disorders induced by long-term exposure to organic solvents typically have a slowly progressive clinical course, which may be arrested or even reversed following discontinuation of exposure. We report an unusual case of rapidly progressive toxic leukoencephalomyelopathy in a 29-year-old man who had worked at a chemical factory that used toluene for the manufacture of nylon 66 for 5 years. He presented with progressive weakness of legs, recurrent seizures, and cognitive decline. Widespread white-matter changes in the brain and spinal cord, and myelodysplastic syndrome were noted. He died 6 months after the onset of his symptoms, and autopsy showed discrete multifocal demyelination and necrosis in the central nervous system, and dysplastic cells of erythroid, myeloid, and megakaryotic lineages in blood vessels. The co-occurrence of leukoencephalomyelopathy and myelodysplastic syndrome highlights the vulnerability of the white matter and bone marrow to injury from organic solvents. Intravascular congestion of dysplastic hematopoietic cells might have led to his unusually rapid progression of leukoencephalomyelopathy. 相似文献
4.
Kaisa M. Heiskanen Silvia Münzing Fritz Krombach Kai M. Savolainen 《Archives of toxicology》1997,71(10):627-632
The effects of linoleic acid, linoleic acid anilide, and arachidonic acid on the expression of CD11b/CD18, CD11c/CD18 integrins
and l-selectin on human neutrophils were studied by flow cytometry in a whole blood assay. None of these compounds had any effect
on the basal expression of CD11b, CD11c, or l-selectin in the concentration range of 20–100 μM. However, linoleic acid at a concentration of 1000 μM slightly up-regulated
CD11b and CD11c by a factor of 2.1 and 1.7, respectively. Linoleic acid, linoleic acid anilide, and arachidonic acid did not
affect the formyl-methionyl-leucyl-phenylalanine induced up-regulation of CD11b or CD11c. However, linoleic acid and linoleic
acid anilide slightly inhibited the phorbol myristate acetate (PMA)-induced expression of CD11b, which was decreased by 27
and 21% at concentrations of 100 and 1000 μM, respectively. Likewise, arachidonic acid at 40 μM inhibited the PMA-induced
expression of CD11b by 19%. Our results suggest that linoleic acid, linoleic acid anilide, and arachidonic acid do not dramatically
affect the expression of leukocyte adhesion molecules in a whole blood assay.
Received: 17 February 1997 / Accepted: 5 May 1997 相似文献
5.
手术治疗小儿先天性巨结肠42例,其中Duhamel术9例,Swenson术11例,Soave术6例,Rehbein术10例,直肠后壁肌切除4例,直肠肛管纵切心形斜吻合术2例。术后污粪、便秘、小肠结肠炎及肛门狭窄发生率21%。认为:手术疗效是与术前充分准备,选择适宜术式,术中精细操作,术后加强护理,精心喂养等直接相关 相似文献
6.
目的:探究Her2阴性晚期胃癌患者采用阿帕替尼进行治疗的疗效及毒副作用。方法:按照不同治疗方法将本院就诊的Her2阴性晚期胃癌患者分为阿帕替尼组(AP组)和替吉奥组(TI组),各46例,分析比较两组患者的临床疗效、生活质量、毒副作用及远期疗效。结果:治疗后,AP组11例、TI组6例患者出现部分缓解,AP组患者RR、DCR数值明显比TI组高(P<0.05);AP组患者生活质量明显优于TI组(P<0.05)。AP组和TI组患者均出现血小板减少、蛋白尿、肝功能异常等不良反应,但未出现Ⅳ级毒副作用,其中AP组患者高血压、血小板减少的发病率分别为63.52%、76.73%,TI组患者发病率分别为62.45%、78.11%, AP组出现毒副作用的患者人数与TI组比较无明显差异(P>0.05)。随访3年结果显示,AP组患者3年生存率为10.86%,TI组患者为0,AP组患者总生存率明显高于TI组(P<0.05)。结论:阿帕替尼对Her2阴性晚期胃癌患者的临床疗效及远期治疗效果较佳,虽然治疗后也会出现一定的毒副作用,但与替吉奥治疗后出现的毒副作用相近,且患者身体承受程度较佳。阿... 相似文献
7.
8.
9.
Acute toxic inhalation by irritant, and particularly oxidant, gases has until recently been considered to be no more complicated conceptually than a chemical burn of the epithelial surface. More recently, however, toxic inhalation has been appreciated to be a complex process involving biochemical, morphological and functional changes which are quantitatively similar, although inducible by different agents. Recent advances in pulmonary pathophysiology, inhalation toxicology, and particularly endothelial biology have clarified the events occurring at the moment of, and immediately following, exposure to oxidant gases. Studies of the pathophysiologic mechanisms associated with toxic inhalation by oxidant gases have been relatively static, however. Implications of recent findings in related fields illuminate the pathophysiology of toxic inhalation. Several principal speakers in this workshop are collaborating in an effort to develop a research facility for the study of toxic inhalation injury. This would be an international registry to serve as a teaching and research facility for documentation of cases of occupational and environmental toxic inhalation, considered as lung injury resulting from the inhalation of a toxic substance in a workplace setting or an uncontrolled release affecting residents of a community. The registry, as proposed, would encourage submissions by clinicians and institutions of a data set on each patient and on each incident; the registry would further encourage long-term follow-up of subjects and documentation of residual effects.Work presented at the 23rd Congress on Occupational and Environmental Health in the Chemical Industry (Medichem 1995) The Chemical Industry as a Global Citizen - Balancing Risks and Benefits, 19–22 September 1995, Massachusetts Institute of Technology, Cambridge, Massachusetts 相似文献
10.