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1.
《Journal of infection and chemotherapy》2019,25(6):470-472
We herein report a case of Klebsiella pneumoniae (K. pneumoniae) spondylitis and bacteremia in a 90-year-old man with diabetes mellitus who had undergone sigmoidectomy and had a fecalith. Two months prior to admission, he had received antimicrobial treatment for 2 weeks for K. pneumoniae bacteremia whose entry was unclear and he was readmitted to our hospital owing to fever and stomachache. K. pneumoniae was isolated from two sets of blood cultures, and computed tomography and magnetic resonance imaging revealed inflammation and destruction of the 8th and 9th thoracic vertebra. The diagnosis was spondylodiscitis secondary to K. pneumoniae bacteremia. Although the entry point for K. pneumoniae was unclear, we suggest that inflammation of the mucosa around the fecalith might have caused the Enterobacteriaceae bacteremia. 相似文献
2.
Objective To investigate the clinical effects of total hip arthroplasty (THA) for bony ankylosis in patients with ankylosing spondylitis and the significance of postoperative rehabilitation. Meth-ods From October 1998 to May 2007, 28 patients (46 hips) suffered from ankylosing spondylitis with hip bony ankylosis underwent THA. There were 27 males, 1 female, with the mean age of 38.9 years (range 22 to 58 years). Posterior lateral hip incision was performed in 34 hips, and modified anterior lateral combined with lateral hip incision in 12 hips. Forty hips applied cementless THA and 6 hips applied mixed THA. Har-ris scores, VAS scores and total hip range of motion in all patients were compared pre-and postoperatively to evaluate the clinical effects. Results All patients were followed up from 10 months to 64 months, with the mean time of 38.2 months. No paralysis, decubitus, and lung infection were found. Joint dislocation hap-pened in 1 case 2 weeks after operation, and was cured with close reduction. Heterotopic bone formation with Brooker Ⅰ was found in 6 hips and Brooker Ⅱ in 2 hips. Harris score increased from 28.3±10.3 preop-eratively to 82.7±7.6 postoperatively. VAS score changed from 3.5±1.4 preoperatively to 3.8±1.8 postopera-tively, and no significance was found. The hip movement range increased from 15.6°±9.3° preoperatively to 133.7°±17.6° postoperatively. Bony ankylosis in all patients disappeared and the hip function improved sig-nificantly after operation. Conclusion THA is the optimal method to treat the ankylosing spondylitis with hip bony ankylosis. Early rehabilitation is necessary to improve hip function. 相似文献
3.
强直性脊柱炎(ankylosing spondylitis,AS)是以中轴关节慢性炎症为主的原因不明的全身性免疫性疾病。其特点为几乎全部累及骶髂关节,常发生椎间盘纤维环及其附近韧带钙化和骨性强直,也可累及外周关节并造成关节软骨及骨的破坏,晚期可发生脊柱及外周关节强直、畸形以致严重功能受损[1]。所以我们必须强调重视AS骨质破坏发生机制的研究,有利于寻找有效药物,减少致残。1骶髂关节炎组织学研究较系统的骶髂关节炎组织学研究表明,AS的5个阶段不同程度存在滑膜炎、骨髓黏液样变、浅表软骨破坏、肌腱端炎、关节内纤维赘、新骨形成和骨性强直等众多病理表现;其中滑膜炎和软骨下骨髓黏液样变较肌腱端炎更能合理解 相似文献
4.
Summary T-cell subpopulations and natural killer (NK) cells from peripheral blood, synovial fluid and synovial membranes from patients with seronegative spondyloarthropathies were investigated. Thirty-four patients with ankylosing spondylitis, sixteen patients with psoriatic arthropathy and six patients with pauciarticular juvenile chronic arthritis were studied. All the patient groups had normal proportions of T4+ and T8+ cells as well as normal T4/T8 ratios in peripheral blood. In the synovial fluids the T4/T8 ratios were reduced in ankylosing spondylitis and psoriatic arthropathy (p<0.05). Although both the T4 and T8 subpopulations were reduced, the T4/T8 ratios in the synovial membranes of patients with these two disorders tended to be within the normal range of that of peripheral blood. Increased numbers of T-cells in the synovial fluid from patients with ankylosing spondylitis expressed class II MHC antigens. The natural killer cell activity was normal in peripheral blood and synovial fluids of patients with ankylosing spondylitis and psoriatic arthropathy while it tended to be reduced, although not significantly, in pauciarticular juvenile chronic arthritis. Synovial membranes were almost devoid of NK cell activity. The number of Leu 7+ cells were reduced in synovial fluid of patients with psoriatic arthropathy (p<0.04), but not as significantly as in the two other patient groups. 相似文献
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6.
原发性强直性脊柱炎的早期临床特点 总被引:2,自引:0,他引:2
目的 探讨原发性强直性脊柱炎(AS)的早期临床特点。方法 120例AS的早期临床特点。结果 该组病人的发病出现16-20岁和30-35岁两上发作年龄高山峰,初发年龄较低;外周关节受累的频率较脊柱高;下肢大和骶骼关节常易受累,其中髋关节,膝关节、踝关节和胸锁关节受累的频率分别为79%,85%,57%和63%,小关节受累少见,虹膜为和主动脉关闭不全的发生率12.5%和4.5%,未发现有前更炎和类风湿结 相似文献
7.
Summary The purpose of this research was to investigate psychological factors associated with ankylosing spondylitis (AS), focusing on possible differences between members and nonmembers of self-help groups for people with this form of chronic disease. Analysis of health locus of control beliefs along 3 dimensions: internality powerful others and chance, showed that members of National Ankylosing Spondylitis Society (NASS) self-help groups placed significantly less reliance on powerful others for control of health than did nonmembers. This pattern of beliefs may be related to the nature of AS, which is incurable, progressive, unpredictable and difficult to diagnose. It may therefore appear to the patient that health care professionals have little to offer them. People who join a self-help group may also feel less reliant on medical personnel to control their health. Group members also differed from nonmembers in terms of belief in the value of exercise for AS, frequency of exercise, tendency to seek information about the disorder and perceived social support. A combination of psychosocial and medical variables discriminated between members and nonmembers at a rate of 71.9% accuracy. Results indicate that NASS self-help group members appear to comply more with exercise treatment and also receive a valuable source of social support from fellow members. This investigation demonstrates the utility of including psychosocial variables in the study of chronic disease. 相似文献
8.
研究诱导型一氧化氮合酶 (inducible nitric oxide synthase, iNOS)在电离辐射导致的神经细胞凋亡中的作用。 方法:以单剂量2.0 Gy γ射线照射出生后 0 d的 Wistar大鼠,用 ABC法检测照射后第 0.5、1、2、4、6、8、12、24、48小时大脑皮质内iNOS的表达。结果:照射组各时间点均有不同程度的iNOS表达,第6小时达峰值。各对照组未见iNOS表达。结论:iNOS所具有的神经毒作用可能是电离辐射导致的发育中脑神经细胞凋亡的重要因素。 相似文献
9.
Prof. Dr. M. Østensen 《Der Gyn?kologe》2003,36(11):985-992
Zusammenfassung Schwangerschaften bei Frauen mit Konnektivitiden sind häufig mit Risiken für Mutter und Kind verbunden. Ausschlaggebend sind der Umfang der Organbeteiligung, das Vorhandensein von Autoantikörpern und die Art der medikamentösen Behandlung. In dieser Übersicht werden die Besonderheiten einer Schwangerschaft bei rheumatoider Arthritis, systemischem Lupus erythematodes und ankylosierender Spondylitis vorgestellt. Risiken für die Mutter sind aktive Krankheit oder ein Schub während der Schwangerschaft. Risiken für den Schwangerschaftsverlauf und das Kind sind spontaner Abort, Präeklampsie, intrauterine Wachstumsstörung, Prämaturität und Krankheit des Neugeborenen. Das Vorliegen von Antiphospholipidantikörpern und Antikörpern gegen SS-A und SS-B erfordert eine sorgfältige Überwachung der Schwangerschaft. Eine medikamentöse Therapie erfolgt bei aktiver Krankheit während der Schwangerschaft oder prophylaktisch, um einen Schub zu vermeiden. Bei Konnektivitiden sollten die Schwangerschaften geplant sein und in einem Zustand der Remission und bei stabiler medikamentöser Therapie erfolgen. Regelmäßige Kontrolle und Überwachung des Fetus sind Bedingung für einen unkomplizierten Schwangerschaftsverlauf. 相似文献
10.