蛔虫变应原致过敏性鼻炎豚鼠模型建立

为了建立蛔虫变应原致过敏性鼻炎的实验动物模型,将健康豚鼠３０只,随机分为致敏组（ｎ＝２０）和对照组（ｎ＝１０）。致敏组经腹腔、四肢皮下注射蛔虫变应原免疫４周后,鼻腔雾化吸入蛔虫变应原;对照组以生理盐水代替变应原。结果致敏组１８只出现鼻痒、喷嚏、流清涕等过敏性鼻炎的临床症状（评分〉５分）,鼻腔分泌物涂片见大量嗜酸性粒细胞,以及鼻粘膜水肿、粘膜嗜酸性粒细胞和肥大细胞浸润等组织学变化,而对照组无上述变化     

类固醇激素在变应性鼻炎治疗中的应用

目的：对类固醇激素在变应性鼻炎治疗中的应用作一综述,方法：对类固醇激素在变应性鼻炎治疗中的应用加以分析,整理。结果：展现类固醇激素在变应性鼻炎治疗领域的最新成果,结论：选择合适的应用方法,有地临床医师运用类固醇激素在主为应性鼻炎的治疗中提高疗效,避免或尽量减少副作用的发生。     

Effect of intranasal structure-normalizing surgery on allergic rhinitis: A primary report of 41 cases

The heatment of allergic rhinitis is yet qUite a challeopng and intrigUing Pchem, and there has not beeneradicable modality. Dings often relieve symptomS tempowhly. Selechve nerve block surgerys such as section andelectroCauterization of Vidian nerve, anterior ethlnoidalnerve and sphenoplatine nerve, have brought us a newProspect, but long-term results still need checking andthey are not considend to be adopted until Ph~otherapy and ilnlnunotherapy come to failu.[l]. Clinically, allergic rh…     

sIL—4和细胞间粘附分子及总IgE在呼吸道炎症中的表达

目的探讨可溶性白细胞介素－4（solubleinterleukin－4,sIL－4）、细胞间粘附分子－1（in-tercellaradhesionmolecule－1,ICAM－1）在过敏性鼻炎（allergicrhinitis,AR）、咳嗽变异性哮喘（coughvariableasthma,CVA）、哮喘和慢性支气管炎发病中的作用。方法采用酶标法测定12例AR、21例CVA、29例哮喘缓解期、27例哮喘发作期、11例慢性支气管炎患者和10例正常健康人血标本。结果（1）sIL－4：CVA、哮喘发作期和慢支组高于正常组（P＜0．05）。AR、哮喘缓解期与正常组比较无显著性差异。（2）ICAM－1：各组均高于正常组（P＜0．05）。哮喘发作组又高于AR组和哮喘缓解组（P＜0．05）。（3）总IgE：除慢支组外其余各组均高于正常组（P＜0．05）。结论sIL－4、ICAM－1参与气道炎症的形成过程,且其含量的高低与咳嗽的发生呈平行发展关系。     

Allergen-antibody complexes can efficiently prevent seasonal rhinitis and asthma in grass pollen, hypersensitive patients

We have prepared antigen-antibody complexes from grass pollen allergens and autologous specific antibodies isolated by immunoadsorption from the serum of allergic patients. These complexes were inoculated into patients in a double-blind trial to evaluate their effect on grass pollen-related rhinitis and bronchial asthma. Thirty-eight grass pollen-hypersensitive patients were allocated to three groups; patients in the first two groups were treated with antigen-antibody complexes at different ratios and dosages and were compared with the third group who received the placebo carrier buffer alone. In addition, we treated a fourth group who had already received antigen-antibody complex inoculation during the previous pollen season. Injections were given every 2 weeks during the pollen season, starting 5 weeks prior to it. Tolerance was excellent with no signs of local or systemic side effects. The treatment prevented nasal symptoms while enabling the patients to reduce antihistamine intake. Bronchial asthma was virtually absent in the treated groups even though no bronchodilators or corticosteroids had to be taken. Specific IgE antibodies did not increase during the pollen season nor did IgG "blocking" antibodies. Inoculation of allergen-antibody complexes could provide a valuable alternative for the treatment of immediate hypersensitivity to airborne allergens as it appears to be safe and rapidly efficacious. This treatment offers several advantages compared to conventional hyposensitization and is characterized by the absence of an increase in specific IgG antibodies.     

孟鲁司特治疗变应性鼻炎的疗效观察

目的观察孟鲁司特在变应性鼻炎中的疗效.方法对变应性鼻炎病人作过敏原测试,对照组按照过敏原测试结果作常规脱敏治疗,治疗组在脱敏治疗的同时加用孟鲁司特,随访两个月.观察两组治疗前后的症状评分,计算症状积分下降指数(SSRI);同时,按照ARIA评价治疗前后变应性鼻炎的症状分级,记录治疗后的下降阶梯数.结果无论是症状积分下降指数还是症状分级下降阶梯数,治疗组在显效和良效方面均比对照组好,两组比较差异有显著意义(p＜0.05).结论孟鲁司特能改善变应性鼻炎的症状,变应性鼻炎在脱敏治疗的同时加用孟司特能提高疗效.     

辛芩冲剂治疗变应性鼻炎的疗效和安全性分析

目的：探讨辛芩冲剂对变压性鼻炎的疗效和安全性。方法：确诊为变应性鼻炎的患者142例随机分成两组，试验组（112例）接受辛芩冲剂口服，一次5g，一日3次；对照组（30例）接受千柏鼻炎片口服，一次3片，一日3次，二种药物均用药20天。观察的症状包括喷嚏、流涕、鼻塞和鼻痒，并进行4分法评分，计算出治疗后积分改善率。结果：经过20天的治疗，辛芩冲剂治疗组的临床控制率为27．67％（31／112），显效率为43．75％（49／112），有效率为17．86％（20／112），无效率为10．71％（12／112），总有效率为89．29％（100／112）；千柏鼻炎片治疗组的临床控制率为0％（0／30），显效率为6．67％（2／30），有效率为20．00％（6／30），无效率为73．33％（22／30），总有效率为26．67％（8／30）。经统计学处理两者差异有显著性意义（P＜0．01），辛芩冲剂治疗组明显优于千柏鼻炎片治疗组，辛芩冲剂和千柏鼻炎片治疗组的病人均未发生不良反应。结论：辛芩冲具有疗效好、无毒副作用等优点，是治疗变应性鼻炎的理想药物。     

鼻腔神经部分切断术及下鼻甲粘骨膜下剥离术治疗变应性鼻炎18例临床分析

目的：观察鼻腔神经部分切断术和下鼻甲粘骨膜下血管神经离断术对变应性鼻炎的疗效。方法：对18例常年性变应性鼻炎患者进行鼻腔神经部分切断术与下鼻甲粘骨膜下血管神经离断术。所有病例随访12个月，评价其临床效果。结果：10例临床症状消失，体征明显改善；7例临床症状明显缓解，体征改善；1例无效。总有效率94．4％。结论：鼻腔神经部分切断和下鼻甲粘骨膜下血管神经离断术治疗常年性变应性鼻炎效果显著。     

针灸治疗变应性鼻炎的临床研究概述

将近10年来同内有关针灸治疗变应性鼻炎临床研究的文献进行了综述，整理了针灸对该病的各种治疗方法，总结了变应性鼻炎针灸治疗的规律，评价了针灸治疗该病的疗效及安全性，探讨了今后对变应性鼻炎的临床研究重点。     

益气温阳活血法治疗常年性变态反应性鼻炎30例

将 6 0例常年性变应性鼻炎患者随机分为中药治疗组 (30例 )和西药对照组 (30例 ) ,前者以益气温阳活血中药煎剂进行治疗 ,后者服用抗组胺药治疗 ,疗程均为 2周。观察比较治疗结束后即刻和停药 1个月后的临床疗效 ,以及对鼻分泌物涂片中嗜酸粒细胞计数结果的影响。结果 :治疗结束时 ,治疗组总有效率为 70 0 % ,对照组总有效率为 93 3% ;停药 1个月后 ,治疗组总有效率仍达 5 3 3% ,对照组总有效率则降为 2 3 3% ,差异均有显著性意义 (P <0 0 5 )。提示益气温阳活血中药治疗常年性变应性鼻炎的疗效明显 ,且疗效持续时间较长。