Osteoid osteoma mimicking Brodie's abscess in a 13‐year‐old girl

Osteoid osteoma is a solitary, benign lesion of bone causing significant nocturnal pain. Magnetic resonance imaging (MRI), computed tomography (CT), and bone scan are commonly used in this diagnosis. A case of osteoid osteoma of the distal femur mimicking chronic osteomyelitis with Brodie's abscess is reported and discussed. Initial radiographs and MRI showed a lesion of the distal femur consistent with subacute osteomyelitis with a Brodie's abscess. Because primary malignant tumor could not be eliminated, surgical biopsy was carried out. Histological examination showed a typical nidus consistent with the diagnosis of osteoid osteoma. Subacute osteomyelitis (Brodie's abscess) may be difficult to distinguish from other malignant or benign bone lesions as osteoid osteoma. CT usually is recommended as the best imaging procedure to identify the nidus and confirm the diagnosis. MRI also can be used for this purpose. Surgical biopsy remains mandatory for unclear lesions before deciding on appropriate treatment.     

CT-guided percutaneous radiofrequency ablation of spinal osteoid osteoma

Background  This study evaluated the feasibility, efficacy and safety of CT-guided percutaneous radiofrequency ablation in patients with spinal osteoid osteoma.

Methods  Two patients suffered spinal osteoid osteoma were treated with CT-guided percutaneous radiofrequency ablation under local anesthesia. Lesions located in sacral vertebrae and cervical vertebrae, which were adjacent to nerve root and spinal canal respectively. Tumors were treated under 90°C radiofrequency temperature lasting 4 minutes by an electrode placement. Visual analog scale was used to evaluate the pain improvement.

Results  No complications were observed pre- and post-operation. Patients recovered to normal activities immediately and achieved complete pain relief in 24 hours. No symptoms were recurrent in 5 months and 4 months follow up. Mild scoliosis has been recovered in case 2.

Conclusions  CT-guided percutaneous radiofrequency ablation of spinal osteoid osteoma is safe, effective and has more clinical benefits. The long-term outcome needs further observation.

     

Osteoid osteoma of the patella: report of two cases

Osteoid osteoma is very rarely located in the patella, and can represent a significant diagnostic challenge, resulting in a delay of treatment. Patients with osteoid osteoma of the patella often present with knee pain that is also a typical symptom of trauma or of other diseases such as arthritis, which are much more common than osteoid osteoma. We present two young male patients diagnosed with osteoid osteoma of the patella. Each of these patients had a history of intense knee pain; however, accurate diagnosis of osteoid osteoma in the patella had been delayed for more than one year. Computed tomography (CT) scans or magnetic resonance imaging (MRI) showed a circumscribed lesion of the patella in both patients, whereas X-ray examination (posteroanterior projection) was not able to detect the tumor. Different surgical procedures were performed in these patients for resection of the tumors, and the pathology findings confirmed the diagnosis of osteoid osteoma. Both patients recovered completely from surgery.

     

Osteoid osteoma causing subtalar joint arthralgia: A case report

The authors describe a juvenile patient with an osteoid osteoma in the foot-a relatively rare location for this type of lesion. The appearance of this lesion in a juxtaarticular location is even more rare. An 11-year-old boy with a 6-month history of limping secondary to subtalar joint pain presented with a juxtaarticular osteoid osteoma located within the calcaneus. The lesion was present beneath the sinus tarsi and the subtalar joint region. Plain radiographs showed equivocal changes; however, magnetic resonance imaging clearly showed a central nidus. The lateral aspect and midbody of the calcaneus showed a spherical focus of diminished signal on both the T1- and T2-weighted images. This focus had a surrounding rim of significantly diminished signal on all sequences. Thus, findings were most consistent with an osteoid osteoma, although a Brodie abscess could not be ruled out. Surgical excision was performed and led to complete resolution of pain and limping. The pathology report confirmed the diagnosis of osteoid osteoma.     

HU-308药物涂层对骨质疏松大鼠种植体周骨组织影响的实验研究

目的:观察HU-308药物缓释涂层对骨质疏松大鼠种植体周骨密度、类骨质形成和骨吸收的影响.方法:60只6月龄未交配雌性wistar大鼠,随机分为两组,A组15只,B组45只,A组切除双侧卵巢旁等量脂肪组织,B组通过双侧去卵巢手术建立骨质疏松模型.建模成功后B组45只大鼠随机均分为3组:C、P、H组,每组15只,术后3个月在所有大鼠双侧胫骨骭骺端按组别植入种植体,A、C组植入碱热处理种植体,P组植入肝素/壳聚糖涂层种植体,H组植入携带HU-308的肝素/壳聚糖涂层种植体.分别于种植术后4周、8周、12周随机处死各组大鼠5只,带种植体的胫骨制作不脱钙骨组织磨片,经甲苯胺蓝染色后,光镜观测并计算种植体螺纹内骨密度(BD)、类骨质周长百分数(％O.Pm)和骨吸收周长百分数(％Er.Pm).结果:4周和8周时,A组和H组BD、％O.Pm显著高于C和P组(P＜0.05),A组和H组％Er.Pm显著低于C和P组(P＜0.05).H组除BD低于A组外(P＜0.05),其余指标与A组差异无统计学意义(P＞0.05);12周时,A组BD显著高于C、P和H组(P＜0.05),％O.Pm、％Er.Pm显著低于C、P和H组(P＜0.05),而C、P和H组之间BD、％O.Pm、％Er.Pm差异无统计学意义(P＞0.05).结论:骨质疏松改变可使种植体周骨密度降低,抑制新骨形成,促进骨吸收;HU-308药物涂层在种植体植入早期可提高骨质疏松大鼠种植体周围骨密度,促进新骨形成,抑制骨吸收.     

7例足踝部骨样骨瘤的诊断与治疗分析

背景：骨样骨瘤是于1935年由Jaffe首次报道的一种良性成骨性疾患,具有界限清晰的局限性病灶。最常见的部位为股骨、胫骨等长干骨,而足踝部的骨样骨瘤较为少见。目的：研究足踝部骨样骨瘤的临床特点以及外科治疗效果。方法：回顾性分析2010年1月至2013年10月在我院足踝中心确诊的7例足踝部骨样骨瘤的临床资料,其中男5例,女2例,平均发病年龄21.5岁。受累部位：距骨5例,跟骨2例。发病至确诊时间平均为16个月（8~25个月）,症状为疼痛,服用非甾体抗炎药可缓解。2例发病之前有相关部位的外伤史。3例曾于我院或外院诊断为其他疾病,并行相关手术治疗。1例外院确诊骨样骨瘤,手术切除后1年复发。所有患者均接受肿瘤刮除＋植骨治疗。结果：术后平均随访14个月（2~24个月）,患者疼痛症状均消失,未见病灶复发,无植骨反应,无病理性骨折。结论：足踝部骨样骨瘤发病少见,其临床表现容易与其他疾病相混淆。所以,需要密切结合患病部位的临床表现、完善的影像学检查和准确的组织活检做出明确诊断,并给以相应治疗。     

The Linkage Region in the Polypeptide of Pig Costal Cartilage Proteoglycan

Proteoglycan from pig costal cartilage and fragments obtained by proteolytic digestion were characterized by equilibrium ultracentrifugation and amino acid analysis.

The proteoglycan extractable in 4 M guanidinium chloride yielded, after proteolytic digestion with trypsin and chymotrypsin, a chondroitin sulfate peptide containing four chains of polysaccharide. The unextractable residue yielded chondroitin sulfate peptide containing only two chains. The amino acid composition indicated a fairly uniform spacing between all four chains with an average of eight amino acid residues between the serine residues involved in linkage.

Following the alkaline sulfite elimination-addition reaction, free peptide was isolated and found to contain one unsubstituted serine residue for every two linked glycosidically. Glycine and glutamic acid were the only two amino acids sufficiently abundant to be part of an invariant sequence near to serine residues destined to be glycosy-lated. The linkage region of the polypeptide also contains some substituted serine residues which do not carry a full chondroitin sulfate chain.     

Arthroscopic removal of juxtaarticular osteoid osteoma of the elbow

A case of a 42-year-old male patient with symptomatic juxtaarticular osteoid osteoma of the capitulum humeri is presented. After the clinical diagnosis was confirmed with plain radiographs, bone scan, computer tomography and magnetic resonance imaging, the patient underwent arthroscopic removal of the lesion. A partial synoviectomy was performed first and then the center of the lesion was marked with Kirschner wire using the X-ray monitoring. The marked lesion was transarticularly removed with a motorized shaver device. Post-operatively, the patient reported prompt relief of pain that had not reoccurred during 1 year of follow up. To the authors’ knowledge, this is the first report of the arthroscopic removal of juxtaarticular osteoid osteoma of the humeral capitulum which promises to be an effective and less invasive alternative to the existing treatment options.     

Primary intraosseous odontogenic carcinoma with osteoid/dentinoid formation

Primary intraosseous carcinoma/odontogenic carcinomas are extremely rare malignant odontogenic tumours that are thought to arise from residues of odontogenic epithelium. An unusual case of primary intraosseous carcinoma arising de novo in a previously unreported site of posterior maxilla is described. The tumour was characterized by sheets of pleomorphic round-to-ovoid cells and marked osteoid/dentinoid formation with foci of globular mineralization.     

Osteoid osteoma as a cause of hip pain in a young athlete

We report a case of osteoid osteoma as a cause of hip pain in a young athlete. Excision of the lesion resulted in complete relief of the symptoms.