原发性肺腺癌胃转移1例

原发性肺癌胃转移患者罕见,患者往往有相对典型但不具有特征性的消化系统症状,当患者已经开始化疗后易误诊系化疗所致症状而忽略消化道转移的可能。赣州市人民医院病理科近期诊断肺原发腺癌胃转移患者1例,镜下肿瘤细胞分化较差;免疫组织化学结果示:TTF-1(+),NapsinA(+),CDX-2(-),提示肺来源。     

MiR-520a对胃癌SGC7901细胞增殖、侵袭、迁移以及顺铂药物敏感性的影响

目的:探讨miR-520a在胃癌中的表达以及对胃癌细胞生物学功能的影响。方法:通过real-time PCR检测miR-520a在胃癌组织和胃癌细胞中的表达。采用慢病毒在胃癌细胞SGC7901中过表达miR-520a,在体外观察miR-520a对胃癌细胞增殖、凋亡、侵袭和迁移以及对顺铂(DDP)敏感性的影响。并通过异种移植瘤实验观察过表达miR-520a对胃癌细胞在裸鼠体内生长的影响。结果:与癌旁正常组织相比,miR-520a在胃癌组织中的表达明显降低。与正常胃黏膜上皮细胞GES-1相比,miR-520a在胃癌SGC7901细胞中的表达明显降低,且在顺铂耐药SGC7901/DDP细胞中的表达更低。miR-520a过表达能够促进SGC7901细胞凋亡,抑制细胞增殖、侵袭和迁移。miR-520a过表达促进SGC7901细胞对DDP的药物敏感性增加。异种移植瘤实验发现miR-520a过表达的细胞在裸鼠体内形成的肿瘤生长速度减慢。结论:miR-520a可抑制胃癌发生与发展,提高胃癌细胞对顺铂的敏感性。     

营养管理在胃癌加速康复外科治疗病人中的应用

[目的]探讨营养管理在胃癌加速康复外科治疗病人中的应用效果。[方法]选择在我科住院确诊为胃癌行胃癌D2根治术的病人101例,按时间先后顺序分为对照组52例、观察组49例。对照组按常规护理,观察组术后进行规范营养管理,由营养师根据病人情况配制专用口服营养液,按时按量供应。比较两组病人进食时间、进食量、术后排气时间、腹胀情况及舒适度评分。[结果]两组病人术后肛门排气时间、进食时间差异无统计学意义(P>0.05);观察组术后前3 d进食量、腹胀情况、舒适度均优于对照组(P<0.05)。[结论]对胃癌加速康复外科治疗病人术前、术后进行规范营养管理,能促进病人肠功能恢复,增加进食量,提高舒适度。     

基于加速康复外科理念的护理策略在腹腔镜胃癌根治术中的应用效果

目的研究基于加速康复外科理念的护理策略在腹腔镜胃癌根治术中的应用效果。方法选取我院收治的94例行腹腔镜胃癌根治术的患者作为研究对象,根据随机双盲法分为观察组(47例,基于加速康复外科理念的护理)和对照组(47例,常规护理)。比较两组的术后观察指标及并发症发生情况。结果观察组的术后发热时间、首次排便时间、首次肛门排气时间、静脉输液停止时间、早期下床时间及住院时间均短于对照组,住院费用少于对照组(P<0.05)。观察组的并发症总发生率明显低于对照组(P<0.05)。结论应用基于加速康复外科理念的护理策略可明显缩短行腹腔镜胃癌根治术患者住院时间,促进患者肠道功能恢复,有效减少并发症的产生,减轻患者经济负担。     

Comparison of embolic agents for varices during transjugular intrahepatic portosystemic shunt for variceal bleeding: Tissue gel or coil?

PurposeWe aimed to compare treatment efficacy, safety and material cost between tissue gel and coil regarding variceal embolization during transjugular intrahepatic portosystemic shunt (TIPS).Materials & Methods: This retrospective study including cirrhotic patients with variceal bleeding treated with TIPS combined with variceal embolization between January 2016 and August 2017. Patients were divided into three groups according to embolic agents used in variceal embolization: tissue gel group (Group A), combination group (Group B), and coil group (Group C). The primary endpoint was 1-year rebleeding rate after TIPS creation. The secondary endpoints included shunt dysfunction, overt hepatic encephalopathy, liver function, and embolic agents-related expense.ResultsA total of 60 patients (30, 10, and 20 in Group A, B, and C) were included. Variceal rebleeding occurred in 3 (10%), 0 (0%), and 4 (20%) patients within one year after TIPS creation in Group A, B, and C, respectively. Stent dysfunction occurred in 2 (3.3%) patients and 9 (15.0%) patients experienced overt hepatic encephalopathy. No significant differences were observed between three groups regarding primary and secondary endpoints except embolic agents-related expense, with a significantly lower cost in Group A when compared to the other two groups. Stent dysfunction occurred in two patients, with one patient in Group A developed acute occlusion caused by thrombus and another patient in Group C underwent stent stenosis during follow-up.ConclusionsCompares to coil alone or combines with coil, tissue gel has similar treatment efficacy and safety, but with significantly lower cost for variceal bleeding during TIPS.     

胃恶性肿瘤患者血液高凝状态的相关研究

近年来,胃恶性肿瘤患者血栓并发症的发生率明显升高,已成为患者常见的死亡原因.血液高凝状态又称为血栓前状态,本文探讨血液高凝状态与胃恶性肿瘤的关系,以及恶性肿瘤患者血液高凝状态形成的相关危险因素、发生机制及预防.进而通过对血液高凝状态的认识来提高对胃恶性肿瘤患者血栓预防的效果,以期减少相关不良反应的发生.     

Morphological analysis of vagal input to gastrin releasing peptide and vasoactive intestinal peptide containing neurons in the rat glandular stomach

Vagal preganglionic efferents to the rat stomach were labeled anterogradely by injecting the fluorescent carbocyanine dye DiA into the dorsal motor nucleus in vivo. Enteric neurons were labeled in toto by intraperitoneal administration of Fluorogold, and neurochemically characterized by simultaneous single- and double-label immunocytochemistry. Single peptide immunocytochemistry revealed that in all three major areas of the stomach, about one-third of all gastrin-releasing peptide immunoreactive (GRP-IR) neurons in the myenteric plexus, received vagal contacts. Because the proportion of GRP-IR neurons was 32% in the fundus, 23% in the corpus, and only 8% in the antrum, the absolute number of vagally contacted GRP-IR neurons per cm² was also different. Double-label immunocytochemistry revealed colocalization of vasoactive intestinal peptide immunoreactivity (VIP-IR) in 45%, and of enkephalin immunoreactivity (ENK-IR) in about 30%, of the GRP-IR myenteric neurons. A subpopulation of myenteric neurons colocalized GRP-IR and VIP-IR and projects almost exclusively to the gastrin cell-rich basal mucosa of the antrum and the oxyntic mucosa of the corpus. Another subpopulation containing GRP-IR, but not VIP-IR, projects mainly to the myenteric plexus itself and the external muscle layers, particularly the longitudinal muscle. A third group of neurons containing VIP-IR but not GRP-IR projects heavily to the circular muscle layer, the muscularis mucosae, and to other myenteric neurons. Vagal input to these three subpopulations seems not to be selective, in that an equal proportion of about 20 to 30% of each group was vagally contacted. Vagal inputs to these neurochemically and topographically distinct enteric neurons provide the basis for the physiological vagal control of gastrin release, gastric acid secretion, and gastric motility. © 1996 Wiley-Liss, Inc.     

MALAT1参与胃癌发生发展机制的研究进展

长链非编码RNA(lncRNA)是一种长度>200 nt、不能编码蛋白质,但在细胞生理活动中具有重要调控功能的RNA.研究发现,lncRNA涉及许多病理生理过程,与肿瘤的发生发展密切相关.肺腺癌转移相关转录本1(MALAT1)是lncRNA家族中的重要成员,在胃癌组织及细胞中高表达,且在胃癌的发生发展中发挥重要而复杂的...