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31.
用紫外分光度法直接溯定复方卡托普利片中氢氯噻嗪的含量及均匀度。测定波长为272±1nm,平均回收率100.2%,变异系数0.3%,吸收度与氢氯噻嗪的浓度在1~10μg/ml 范围内具有线性关系。 相似文献
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Yoshihiro Hanaki Satoru Sugiyama Kazumi Taki Tadayuki Kato Shohachi Suzuki Takayuki Ozawa Prof. M.D. 《Heart and vessels》1988,4(3):149-152
Summary The present study was designed to clarify whether or not a difference between arterial and venous lactate (content/u50422055h6rl568/xxlarge916.gif" alt="Delta" align="BASELINE" BORDER="0">lactate) levels is useful for evaluation of mitochondrial function in ischemia-reperfused myocardium. In the first experiment, 12 dogs were divided into 2 groups: 10-min occlusion of the left anterior descending coronary artery (LAD) followed by 10-min reperfusion, or 30-min occlusion followed by 40-min reperfusion, were performed. The lactate levels in the femoral artery and the great cardiac vein were measured enzymatically. content/u50422055h6rl568/xxlarge916.gif" alt="Delta" align="BASELINE" BORDER="0">Lactate was reversed immediately after occlusion. Ten min and 20 min were required for the recovery of content/u50422055h6rl568/xxlarge916.gif" alt="Delta" align="BASELINE" BORDER="0">lactate in the 10-min-occlusion with 10-min-reperfusion, and 30-min-occlusion with 40-min-reperfusion groups, respectively. In the second experiment, 36 dogs were divided into 6 groups: 10-min occlusion of LAD; 10-min occlusion with 10-min reperfusion; 30-min occlusion; and 30-min occlusion with 10-, 20-, or 40-min reperfusion were performed. Mitochondria from normal and occluded or reperfused areas were prepared, and the respiratory function of the mitochondria was measured polarographically. No significant decreases in the mitochondrial function were observed in the 10-min-occlusion, and 10-min-occlusion with 10-min-reperfusion groups. On the other hand, respiratory function of mitochondria was impaired by 30-min occlusion and was not improved by 10- or 20-min reperfusion. Significant recovery in the mitochondrial function was observed after 40-min reperfusion. That is, differing recovery time courses between content/u50422055h6rl568/xxlarge916.gif" alt="Delta" align="BASELINE" BORDER="0">lactate and the mitochondrial function were observed. 相似文献
35.
L. Laurian Z. Oberman E. Hoerer E. Graf 《Journal of neural transmission (Vienna, Austria : 1996)》1988,73(3):167-176
Summary In a previous study we observed that calcitonin increases content/m05j170173261525/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-endorphin, ACTH, and cortisol secretion. We assumed that calcitonin might have a modulatory role on the pituitary function. The present study was initiated to clarify whether this effect is due to a direct pituitary stimulation or to an indirect stimulation through CRF (corticotropin releasing factor).Fourteen healthy subjects, aged 30–60 years were investigated. All the subjects received 100IU Salmon calcitonin Sandoz i.v. at 8a.m. (time 0). Plasma content/m05j170173261525/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-endorphin, ACTH and cortisol were estimated every 30min from – 30 to 120 min by specific radioimmunoassay. The same parameters were estimated a second time, at the same intervals, when cyproheptadine 8 mg (7 subjects) and 40 mg propranolol (7 subjects) were given per os at – 30 min and calcitonin i.v. at time 0. content/m05j170173261525/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-endorphin, ACTH and cortisol levels (Mean ±SEM) rose significantly after calcitonin (peak value at 30–90 min) from 5.2 ±0.7 to 15.1±2.6 pmol/l; from 43.0±2.7 to 70.7±4.1 pg/ml and from 10.6±1.5 to 19.6 ±2.1 content/m05j170173261525/xxlarge956.gif" alt="mgr" align="MIDDLE" BORDER="0">g/100 ml respectively (p< 0.0001 by analysis of variance and covariance and repeated measures). Propranolol 40 mg (per os) administered at time – 30 did not alter the response of content/m05j170173261525/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-endorphin, ACTH and cortisol to calcitonin (infused at time 0).Cyproheptadine, the antiserotonergic substance that inhibits the synthesis and release of CRF completely inhibited the stimulatory effect of calcitonin.We conclude that probably calcitonin has a modulatory role on the hypothalamo-pituitary adrenal axis and that it acts at the hypothalamic level probably by stimulating CRF secretion. 相似文献
36.
Ryozo Oishi Yoshinori Itoh Tamotsu Fukuda Yasunori Araki Kiyomi Saeki 《Journal of neural transmission (Vienna, Austria : 1996)》1988,73(1):65-69
Summary The size of the neuronal and non-neuronal histamine pools in the brain of three different strains of rats was measured by assuming that the content/l072557712553u57/xxlarge945.gif" alt="agr" align="BASELINE" BORDER="0">-fluoromethylhistidine-induced maximal decrement of histamine represents the size of the neuronal pool. Although the total histamine levels in the brain showed a considerable interstrain variation, no significant interstrain difference was observed in the neuronal histamine level. These results suggest that the size of the neuronal histamine pool in the brain is relatively stable, whereas the size of the non-neuronal histamine pool is variable. 相似文献
37.
S. Turkish P. H. Yu A. J. Greenshaw 《Journal of neural transmission (Vienna, Austria : 1996)》1988,74(3):141-148
Summary A behavioural test involving potentiation of the effects of an acute injection of content/x7271302rh6v77j5/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-phenylethylamine (10 mg kg–1 i.p.) was used to assess the time-course of type-B MAO inhibition after administration of (–)deprenyl (5 mg kg–1 i.p.) and of MD 240928 (20 mg kg–1 i.p.) respectively. Potentiation of the effects of content/x7271302rh6v77j5/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-phenylethylamine was observed 1 h after injection of (–)deprenyl or MD 240928. This effect was still evident 120 h after administration of (–)deprenyl but not 24 h after administration of MD 240928. Comparisons of ex vivo estimates of MAO activity yielded a corresponding time-course for the recovery of this enzyme. The extent of MAO inhibition required for potentiation of the effects of content/x7271302rh6v77j5/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-phenylethylamine was inferred from a comparison of the behavioural test results and the ex vivo MAO activity observed after (–)deprenyl administration. These comparisons indicate a significant underestimation of MD 240928-induced MAO inhibition using ex vivo measures. This underestimation is interpreted as evidence fordilution effects in the ex vivo assay of MAO inhibition. The potentiation of effects of content/x7271302rh6v77j5/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-phenylethylamine under the present conditions is proposed as a useful and simple test for effects of reversible type-B MAO inhibitors. 相似文献
38.
Prospect for enzyme therapy in glycogenosis II variants: a study on cultured muscle cells 总被引:4,自引:0,他引:4
A. T. van der Ploeg P. A. Bolhuis R. A. Wolterman J. W. Visser M. C. B. Loonen H. F. M. Busch A. J. J. Reuser 《Journal of neurology》1988,235(7):392-396
Summary Impairment of skeletal muscle function is the common feature of distinct clinical forms of glycogenosis type II. In the present study, muscle cultures from different patients were used to investigate the cause of clinical heterogeneity and the feasibility of enzyme replacement therapy. The activity of acid content/u0864817np01rk54/xxlarge945.gif" alt="agr" align="BASELINE" BORDER="0">-glucosidase appears to be the primary factor in determining the extent of lysosomal glycogen storage in muscle, and thereby the clinical severity of the disease. Neutral content/u0864817np01rk54/xxlarge945.gif" alt="agr" align="BASELINE" BORDER="0">-glucosidases do not seem influencial. Correction of the enzymatic defect was achieved in skeletal muscle cultures from patients by administration of a content/u0864817np01rk54/xxlarge8220.gif" alt="ldquo" align="MIDDLE" BORDER="0">high-uptakecontent/u0864817np01rk54/xxlarge8221.gif" alt="rdquo" align="MIDDLE" BORDER="0"> form of acid content/u0864817np01rk54/xxlarge945.gif" alt="agr" align="BASELINE" BORDER="0">-glucosidase, purified from human urine. The enzyme reaches the lysosomes, including the glycogen storage vacuoles, and the lysosomal glycogen content is reduced to control level. In normal muscle cells 20% of the total cellular glycogen pool is segregated in lysosomal compartments. This percentage is higher than in fibroblasts, which may partly explain why muscles are more prone to store glycogen. The relevance of this study for enzyme therapy is discussed. 相似文献
39.
Adult-onset rod disease with abundant intranuclear rods 总被引:2,自引:0,他引:2
Summary The third case of adult-onset rod disease (nemaline myopathy) with abundant myofibrillar as well as intranuclear rods is described. The 61-year-old woman suffered from progressive weakness of proximal extremities and of the neck, mimicking polymyositis. Muscle biopsy revealed a striking myopathic pattern, with intranuclear rods occurring in 31% of the fibres. On light and electron microscopy and by immunohistochemical study, the rods differed from myofibrillar rods. The absence of content/x83816k16684k231/xxlarge945.gif" alt="agr" align="BASELINE" BORDER="0">-actinin in intranuclear rods suggests an enhanced readiness of actin filaments to bind to diverse proteins, instead of overproduction of content/x83816k16684k231/xxlarge945.gif" alt="agr" align="BASELINE" BORDER="0">-actinin as the pathogenetic basis of the rod formation. 相似文献
40.
Summary In Denmark it is legal to grow opium poppies for the production of poppy seeds and until 1986 for decoration purposes, too. Danish poppy capsules contain 0.3–5 mg morphine per capsule and the content of morphine in opium exuded from the capsules may amount to 24%. This has resulted in misuse as both fresh and dried poppy capsules have been used for the production of content/x3253h740tg5801p/xxlarge8220.gif" alt="ldquo" align="MIDDLE" BORDER="0">opium teacontent/x3253h740tg5801p/xxlarge8221.gif" alt="rdquo" align="MIDDLE" BORDER="0">. During the period 1982–1985, seven casualties occurred among drug addicts in Denmark which were solely or partly caused by these opium poppies. 相似文献