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21.
Bernard Farrell 《Journal of diabetes science and technology》2007,1(2):245-250
The continuous glucose monitor market is just starting to develop. Current trends in the availability of diabetes information tools highlight the need for standard data presentation for continuous glucose monitors. These trends and their implications are discussed. This article proposes a set of standards for blood glucose data presentation. If device manufacturers adopt these standards, they will ensure that their continuous glucose monitors meet both the short-term and the long-term needs of users. This should increase the demand for these monitors and enable future device developments that appeal to a wider range of users. 相似文献
22.
Phase II clinical trials are performed to investigate whether a novel treatment shows sufficient promise of efficacy to justify its evaluation in a subsequent definitive phase III trial, and they are often also used to select the dose to take forward. In this paper we discuss different design proposals for a phase II trial in which three active treatment doses and a placebo control are to be compared in terms of a single‐ordered categorical endpoint. The sample size requirements for one‐stage and two‐stage designs are derived, based on an approach similar to that of Dunnett. Detailed computations are prepared for an illustrative example concerning a study in stroke. Allowance for early stopping for futility is made. Simulations are used to verify that the specified type I error and power requirements are valid, despite certain approximations used in the derivation of sample size. The advantages and disadvantages of the different designs are discussed, and the scope for extending the approach to different forms of endpoint is considered. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
23.
Biostatisticians have frequently uncritically accepted the measurements provided by their medical colleagues engaged in clinical research. Such measures often involve considerable loss of information. Particularly, unfortunate is the widespread use of the so‐called ‘responder analysis’, which may involve not only a loss of information through dichotomization, but also extravagant and unjustified causal inference regarding individual treatment effects at the patient level, and, increasingly, the use of the so‐called number needed to treat scale of measurement. Other problems involve inefficient use of baseline measurements, the use of covariates measured after the start of treatment, the interpretation of titrations and composite response measures. Many of these bad practices are becoming enshrined in the regulatory guidance to the pharmaceutical industry. We consider the losses involved in inappropriate measures and suggest that statisticians should pay more attention to this aspect of their work. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
24.
纸夹板内收位固定与石膏外展位固定治疗Bennett骨折的随机对照试验 总被引:2,自引:0,他引:2
目的:研究比较纸夹板内收位固定与石膏外展位固定治疗Bennett骨折的疗效差异。方法:选择2005年10月至2007年4月门诊就诊的70例Bennett骨折患者,按区组随机的方法分为试验组35例(纸夹板内收位固定)和对照组35例(石膏外展位固定)进行治疗。骨折达到临床愈合拆除固定后,对患者进行为期6个月的随访观察。分别于骨折后6、8、12、16、20及24周按改良的Gabriele评分系统对其患手功能进行量化评分比较。结果:两组的优良率在8、12、16及20周时比较试验组优于对照组,差异有统计学意义(P〈0.05);6周和24周时比较差异无统计学意义(P〉0.05)。两组在功能评分方面,8、12、16、20及24周时比较试验组高于对照组,差异有统计学意义(P〈0.05);6周时积分差异无统计学意义(P〉0.05)。结论:在Bennett骨折的治疗中,纸夹板内收位固定与石膏外展位固定相比能明显加快患手功能的恢复,而且固定轻便、舒适,患者易于接受,可以作为一种有效的固定方法在临床推广。 相似文献
25.
S. M. J. MORTAZAVI S. ASADOLLAHI† M. FARZAN‡ S. SHAHRIARAN§ M. AGHILI¶ S. IZADYAR M. LAK†† 《Haemophilia》2007,13(2):182-188
Repeated intra-articular bleeding with subsequent development of chronic synovitis and cartilage changes, leading to haemophilic arthropathy, is one the most debilitating problems in haemophilic patients. Radiosynovectomy is a familiar therapeutic choice in management of chronic synovitis in haemophilia. We report the treatments results of synoviorthesis with (32)P chromic phosphate with emphasis on clinical aspects. Between 2002 and 2006 we performed 66 procedures in 53 patients. Seven patients were excluded. The remaining 46 patients were followed for an average of 31 months. The mean age of patients at the time of injection was 15.9 years (range: 6-28). There were three repeat injections. According to Fernandez-pallazi and Cavilgia clinical classification (Table 1) [23], nine joints were Stage II and 46 were Stage III. In latest follow-up, 77% of patients reported at least a 50% decrease in bleeding frequency after treatment (P < 0.0001). The need for antihaemophilic factor consumption dropped by about 74% postradiosynovectomy (P < 0.0001). In most of the injected joints, the range of motion remained stable or improved. A trend was found for the number of haemarthrosis to increase after a period of considerable improvement. Synoviorthesis using (32)P effectively reduces the intra-articular bleeding rate and factor concentrate use. Durability of the response seems to be unpredictable, perhaps attributable to the late intervention. An early radiosynovectomy might be more helpful in terms of stability of response to treatment. 相似文献
26.
浅谈静脉留置针的临床应用和护理 总被引:3,自引:0,他引:3
神兆敏 《安徽卫生职业技术学院学报》2005,4(2):52-53
目的:体会静脉留置针的临床应用和护理、总结经验.方法:观察48例住院患者静脉留置针的使用方法,日常护理及并发症的处理.结果:提高了护理工作的效率,减轻了病人穿刺时的痛苦.结论:护理人员除要熟练掌握操作规程、严格无菌操作外,还应严密观察病人的病情变化.要有高度责任心,从而减轻病人的痛苦. 相似文献
27.
不同临床和病理分型对肝门部胆管癌切除术预后的影响 总被引:2,自引:0,他引:2
目的 研究临床和病理分型与肝门部胆管癌切除术疗效的关系。方法总结1993年至2004年在解放军总医院肝胆外科手术切除的肝门部胆管癌198例病例资料。结果临床分型Ⅰ型34例,Ⅱ型60例,Ⅲa型27例,Ⅲb型33例,Ⅳ型19例,Ⅴa型6例。Ⅴb型19例。病理高分化腺癌35例,中分化腺癌52例,低分化腺癌54例,三者的中位生存期分别为29.5、11、5.5个月;病理切缘阴性者与切缘阳性者生存率有显著性差异(P 〈0.05)。手术并发症出现率41.4%,围手术期死亡1例。结论肝门部胆管癌根据临床分型进行相应的手术治疗;病理切缘阴性是影响预后的主要因素之一;围手术期正确处理,是减少手术并发症,提高患者生活质量和延长生存期的关键。 相似文献
28.
Two thousand nine hundred and ninety-four reports of OSHA-reportable occupational injury or illness cases in 1984 from member companies of a national trade association of semiconductor manufacturing firms were analyzed. The 37 participating manufacturing facilities represented 16 companies employing over 95,000 persons, or approximately one-third of the U.S. work force for this industry in 1984. The annual incidence rate for all reportable injuries and illnesses was 2.7 per 100 full-time employees (FTE) for men and 3.7 per 100 FTE for women. Strains, sprains, or dislocations were the most frequently reported incidents (N = 956 [31.9%]), followed by cuts, lacerations, punctures, scratches, and abrasions (N = 445 [14.9%]), and chemical burns (N = 401 [13.4%]). Increased work-loss days per case were associated with manufacturing sites that did not have an employee health clinic on the premises, with custodial occupations, and with female gender. 相似文献
29.
Boris A. Zelle MD Andrea S. Herzka MD Christopher D. Harner MD James J. Irrgang PhD PT ATC 《Operative Techniques in Orthopaedics》2005,15(1):76
Clinical outcomes data can be used to facilitate patient management decisions, assess clinician and organizational performance, and to provide evidence for the effectiveness of surgery and rehabilitation. The validity of the inferences made from outcomes data are dependent on the validity of the outcomes measures themselves and the circumstances under which the data were collected, analyzed, and interpreted. Clinical outcomes may include measures of impairment of body structure and function, activity limitation, and participation restriction. However, because the relationship between impairment and the resulting activity limitation and participation restriction is not direct, and because activity limitations and participation restrictions are of the utmost concern to the athlete, the primary clinical outcome should be measures of activity limitation and participation restriction. Activity limitation and participation restriction may be measured either through direct observation of performance or by general or specific measures of health related quality of life. Clinical outcomes data must be collected systematically to ensure valid inferences from the data. 相似文献
30.
Dean McMillan Richard P. Hastings Jon Coldwell 《Journal of Applied Research in Intellectual Disabilities》2004,17(4):255-265
Background There is a high rate of physical violence in populations with intellectual disabilities, and this has been linked to problems for the victim, the assailant, members of staff and services. Despite the clinical significance of this behaviour, few studies have assessed methods of predicting its occurrence. The present study examined clinical and actuarial methods of predicting violence in a forensic intellectual disability hospital. Methods The sample for the study consisted of people resident in the hospital during a 1‐year period (n = 124). Clinical prediction used a risk rating made by members of the person's clinical team, whereas actuarial prediction used the number of violent incidents in the 6‐months before the date of the clinical risk assessment. Computerized hospital records of violence in the 6 months after the assessment were used to examine the predictive accuracy of the two methods. Results The clinical method produced an area under the curve of 0.74 (95% CI: 0.65–0.83) in a receiver–operating characteristic curve analysis. The value for the actuarial method was 0.77 (95% CI: 0.69–0.86). Both methods performed at levels significantly above chance, but no one method was found to be superior to the other. Conclusions These findings suggest that it is possible to predict who is at risk of violence in forensic populations with intellectual disabilities. Here, the authors discuss the clinical implications of these findings and the clinical application of risk prediction within clinical services. 相似文献