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91.
目的建立同时测定清肾颗粒中蒽醌类衍生物的含量测定方法。方法采用薄层扫描法对清肾颗粒中芦荟大黄素、大黄酸、大黄素、大黄素甲醚、大黄酚进行含量测定。展开剂为正己烷-乙酸乙酯-甲酸(30∶10∶0.5),扫描波长λS=435 nm,参比波长λR=650nm。结果芦荟大黄素的线性范围是0.023 6~0.118 1μg(r=0.998 13),平均回收率101.32%,RSD=2.44%(n=6);大黄酸的线性范围是0.060 0~0.300 0μg(r=0.998 61),平均回收率为101.31%,RSD=1.45%(n=6);大黄素的线性范围是0.045 0~0.225 0μg(r=0.998 41),平均回收率为100.82%,RSD=2.36%(n=6);大黄素甲醚线性范围是0.046 7~0.233 3μg(r=0.99681),平均回收率为100.87%,RSD=2.80%(n=6);大黄酚线性范围是0.032 5~0.162 5μg(r=0.997 56),平均回收率为105.35%,RSD=2.49%(n=6)。结论该方法简便、快捷、准确,可用于清肾颗粒中蒽醌类衍生物的含量测定。 相似文献
92.
目的探讨望江南蒽醌苷(AG)对环磷酰胺(CTX)造成的免疫低下小鼠的保护作用。方法体外,将小鼠胸腺和脾淋巴细胞与不同浓度的AG共培养,用MTT法检测AG对胸腺和脾淋巴细胞增殖的影响;体内,腹腔注射CTX形成免疫抑制模型。结果体内试验中,与模型对照组小鼠相比,能显著升高外周血的白细胞数,增强腹腔巨噬细胞的吞噬功能,能促进胸腺/脾淋巴细胞增殖,增加胸腺指数和脾指数。结论AG具有免疫增强作用。 相似文献
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94.
Experimental sensitization of guinea pigs with 6 azo and anthraquinone dyes used frequently as disperse dyes for fabrics (stockings, pantyhose) revealed that the blue dyes were moderate sensitizers while the red, yellow and orange dyes were only weak ones. This was found to be in contrast with the order based on the frequency of observed allergic sensitization, which showed the yellow and orange dyes at the top of the list and the blue dyes at the bottom. 相似文献
95.
在1,4-二羟基蒽醌的2,3位上,引入烷胺甲基侧链,合成了6个新化合物。另合成在2位引入烷胺甲基,3位为甲基的新化合物9个。大多数化合物在体内外呈现较微弱的抗肿瘤活性。 相似文献
96.
97.
Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway 总被引:1,自引:0,他引:1
BACKGROUND AND PURPOSE: Rhein, an anthraquinone compound isolated from rhubarb, has been proved effective in treatment of experimental diabetic nephropathy (DN). To explore the mechanism of its therapeutic effect on DN, rhein was tested for its effect on the hexosamine pathway. EXPERIMENTAL APPROACH: The influence of rhein on cellular hypertrophy, fibronectin synthesis, glucose uptake, glutamine: fructose 6-phosphate aminotransferase (GFAT) activity, UDP-N-acetylglucosamine (UDP-GlcNAc) level and TGF-beta1 and p21 expression was evaluated in MCGT1 cells, a GLUT1 transgenic rat mesangial cell line. GFAT activity in normal rat mesangial cells in high glucose concentrations and in vitro was also measured. KEY RESULTS: Significantly increased fibronectin synthesis, cellular hypertrophy, much higher GFAT activity and UDP-GlcNAc level and increased TGF-beta1 and p21 expression were found in MCGT1 cells cultured in normal glucose concentration. Rhein treatment decreased all these features of MCGT1 cells but did not exert a direct effect on GFAT enzymatic activity. CONCLUSIONS AND IMPLICATIONS: There was over-activity of the hexosamine pathway in MCGT1 cells, which may explain the higher expression of TGF-beta1 and p21, the cellular hypertrophy and the increased expression of extracellular matrix (ECM) components in the cells. By inhibiting the increased activity the hexosamine pathway, rhein decreased TGF-beta1 and p21 expression and thus contributed to the decreased cellular hypertrophy and ECM synthesis. Inhibition of the hexosamine pathway may be one of the mechanism through which rhein exerts its therapeutic role in diabetic nephropathy. 相似文献
98.
99.
A series of anthraquinone‐imide‐based dimers, C5*‐AQI‐Si2, C5*‐AQI‐Si3, C5*‐AQI‐Si4, and C5*‐AQI‐Si8, have been prepared by the hydrosilylation of N‐(hex‐5‐enyl)‐6‐(4′‐((S)‐2‐methylbutoxy)phenyl)anthraquinone‐2,3‐dicarboxylic imide and hydride‐terminated siloxanes with different lengths. Their liquid crystalline behaviors, and piezochromic and near‐infrared electrochromic properties have been characterized by DSC, wide‐angle X‐ray diffraction, cyclic voltammetry, and UV–vis–NIR spectroscopy. Although anthraquinone imide is not liquid crystalline by itself, all the dimers formed a smectic A mesophase. Under moderate pressure, the color of the dimers changed from light yellow to deep red. Upon reduction to a radical anionic state, the dimers exhibited an intense NIR absorption at 844 nm. These anthraquinone‐imide‐based dimers are probably the first multifunctional molecules with combined liquid crystalline, mechanochromic, and NIR electrochromic properties.
100.
目的 测定恩施巴戟天中总蒽醌类化合物的含量,为恩施巴戟天的进一步开发利用奠定基础.方法 以0.5%醋酸镁甲醇液为显色剂,利用紫外可见分光光度仪在509nm处来测定恩施巴戟天中总蒽醌的含量.结果 对照品在0~5.2mg/L范围内,吸光度值与浓度呈良好线性关系(r=0.9992),回归方程为A=0.04285C-0.004... 相似文献