Population Based Survival of Female Breast Cancer Cases in Riyadh Region,Saudi Arabia

Breast cancer is the most frequent tumor among Saudi women, accounting to 19.8% of female cancers. The ‍present study was conducted to determine 5-year survival for all cases of invasive breast cancer that occurred during ‍1994-96 in the province of Riyadh (n=316). The overall observed survival probability of the study population at 1, 3 ‍and 5 years was 93.9%, 79.2% and 59.6%, respectively. The 5 year survivals for the younger (< 40 years), older (50 ‍+ years) and 40-49 years patients were 60.6%, 51.6% and 69.2% respectively, the differences not reaching statistical ‍significance. While there was not a great deal of variation in the 5-year survival between cases with regional (55.6%), ‍distant metastasis (57.6%) and extent of disease unknown (56.7%) cases, localized (67.5%) cases had a clearly better ‍prognosis. An increased but not significant hazard was seen for the cases with regional and distant metastasis disease, ‍1.40 and 1.11 respectively, compared to localized cases. The 5-year survival for duct carcinomas (62.8%) was greater ‍than for adenocarcinomas (55.6%) and lobular carcinomas (50.0%).     

The Effect of Harsh Environmental Conditions on Concrete Plastic Shrinkage Cracks: Case Study Saudi Arabia

Due to climate change and population expansion, concrete structures are progressively being subjected to more extreme environments. As the environment affects plastic shrinkage directly, there is a need to understand the effect of environmental changes on plastic shrinkage cracking. This paper examines the plastic shrinkage crack development parametrically at low, mid, and high drying environmental conditions, corresponding to different environments in three Saudi cities. The effects of water-cement ratios and quantities of recycled tire steel fibers (RTSF) in concrete are also investigated. The different environmental conditions for the plastic shrinkage tests were simulated in a specially designed chamber as per ASTM C1579, 2006. A digital image processing (DIP) technique was used to monitor crack initiation and development. Through the use of the crack reduction ratio (CRR), it was found that 30 kg/m³ of RTSF can control plastic shrinkage cracks at low and mid conditions. For the more extreme (high) conditions, the use of 40 kg/m³ of RTSF fiber was sufficient to completely eliminate surface plastic shrinkage cracks. This work can help develop more sustainable concrete structures in a wider set of environmental conditions and help mitigate the impact of climate change on concrete infrastructure.     

The relationship between walking and depression,anxiety, and stress among a sample from Jazan,Saudi Arabia: A cross-sectional investigation

This study is aiming to investigate the association between walking and depression, anxiety and stress among adults from Jazan, Saudi Arabia. This study was a cross-sectional investigation where data was collected via an online self-administered questionnaire. The questionnaire had 4 components that measured demographics of the sample, presence of depression, anxiety and stress, and walking history. Differences in median scores of depression, anxiety, and stress according to the measured characteristics were tested via the Mann–Whitney U test. Multivariable logistic regression was performed to estimate odds of reporting depression, anxiety, and stress according to the measured characteristics. A total of 472 adult subjects participated in the current study. The median age of the participants was 23 years, and 52% were males. Half of the participants had variable degrees of depression and anxiety while 39% of the participants had variable degrees of stress. Gender appeared to have the strongest influence on level of depression, anxiety, and stress among the recruited sample (odds ratio 1.8, 2.1, 1.6 respectively (P values < .01). Upon stratifying the sample according to gender, marital status seems to have an association with depression, anxiety, and stress among females (P values < .05). Among males, only walking more than 3 days was associated with the reduction of anxiety (P value .005) and depression (P value .06). This study identified gender difference where walking was not associated with mental health among women but relatively associated among males.     

Prevalence of adverse birth outcomes and associated factors in Jazan,Saudi Arabia: A cross-sectional study

This study aimed to measure the prevalence of adverse birth outcomes and associated factors among mothers from the Jazan region in Saudi, Arabia. This was a cross-sectional investigation where data was collected via a semi-structured questionnaire. The questionnaire was completed during interviews to assess data regarding the participants’ demographics, morbidity, the reported adverse birth outcomes, and maternal complications during pregnancy. Chi-squared and Fisher’s Exact tests were both used to compare the distribution of demographic and obstetric risk factors according to the historical presence of adverse birth outcomes. A total of 1315 women with a combined history of 4950 pregnancies were involved in the current investigation. The mean age of the participants was 33.1 years. The total number of adverse birth outcomes was 1009. The most frequently reported adverse birth outcome was miscarriage (12.1%), followed by premature birth (2.3%) and underweight birth (1.9%). Reports of a minimum of 1 adverse birth outcome were higher among women who reported family incomes of more than 10,000 Saudi Arabian Riyal (SAR), women who were first-degree cousins of their husbands, and women with less than a secondary level education (P values <.05). This study found a relatively high prevalence of miscarriage. Further investigations are needed to assess factors associated with this high frequency level of miscarriage. Furthermore, these findings have preventive and clinical implications concerning pregnant women with a history of obesity, anemia, consanguinity, and hypertension. The goal is to target them with a better range of antenatal care services to reduce the incidence of potential adverse birth outcomes.     

Pharmacy practice research in Saudi Arabia; A bibliometrics analysis from (2000 to 2021)

BackgroundPharmacy is a growing profession in the Kingdom of Saudi Arabia which has experienced tremendous changes in the past 20 years. Pharmacy practice or clinical pharmacy have an attention ever since the emerging of PharmD programs throughout the Saudi universities. As a result, the number of affiliated faculty in the pharmacy practice departments has increased dramatically in the past 20 years and thus significant changes in research output were observed.ObjectivesThe main objective is to conduct a bibliometric analysis and evaluate the research output of pharmacy practice faculty in Saudi Universities from 2000 to 2021MethodsA systematic search was conducted using Scopus database to explore the research output from pharmacy practice affiliated faculty from 2000 to 2021. The following search terms AFFILORG (“Pharmacy Practice Department” OR “Department of Pharmacy practice” OR “Clinical Pharmacy Department” OR “Department of Clinical Pharmacy” OR “Department of Pharmacy Services”) AND AFFILCOUNTRY (“Saudi Arabia” OR “KSA” OR “Kingdom of Saudi Arabia”) were used. Only original research papers were retrieved and analyzed using MS Excel (v16.0), MS Access (v16.0), Bibexcel (v2017), VOS viewer, and Biblioshiny.ResultsIn the past two decades, most publications with pharmacy practice departments affiliation were pharmacy practice research irrelevant (only 1075 out of 2809). King Saud University and King Abdulaziz University were the top performing institutes, and median of 5-year impact factor for journals was more than 3 for most of the top 10 institutes. 19% of the total retrieved articles were review publications were the rest majorly classified as cross-sectional studies.ConclusionThe research contribution of pharmacy practice departments in Saudi Arabia has been improving. Key recommendations are to promote more applied and interventional research, increase publications in top journals, and enhance national collaborations.     

Adopting global tools for the advancement of pharmacy practice and workforce in Saudi Arabia

BackgroundThe continuing expansion of the pharmacist’s role necessitates continuous evaluation of current practice to identify strategies for improvements. The International Pharmaceutical Federation (FIP) has developed tools to support stakeholders in identifying development needs and planning advancement strategies. The aim of this research was to utilise the FIP Global Competency Framework, version 2 (GbCF v2), and FIP Development Goals (DGs) to evaluate competencies related to pharmacy practice in Saudi Arabia, and to understand the strategies needed to develop and improve the current practice.MethodsThe study involved four phases. Phase 1 involved translation of the FIP GbCF v2 into the Arabic language. Phase 2 was a consensus panel validation to establish the initial relevance of the competencies to current practice. Phase 3 included a national survey distributed to all registered pharmacists in Saudi Arabia. The final phase was conducted through mapping ‘not relevant’ competencies to FIP DGs to identify priorities.ResultsThe translation phase yielded a bilingual framework that could be utilized by pharmacists in Saudi Arabia. The initial validation phase identified 61 behavioral statements (from 124 in the GbCF v2) as ‘highly relevant’ or ‘relevant’ to pharmacy practice. Findings from the national survey identified a list of ‘not relevant’ competencies that could highlight gaps in current practice. The final mapping phase generated a list of three FIP DG priorities: DG5 (competency development), DG8 (working with others) and DG11 (impact and outcomes).ConclusionThe study indicated that competencies in the GbCF v2 were relevant to pharmacists practicing in the country. However, some competencies were perceived as ‘not relevant’ to current practice and these highlighted gaps in the current practice that need attention. Mapping ‘not relevant’ competencies to FIP DGs should be used as a starting point towards developing strategies, systems, and protocols to advance pharmacy practice in Saudi Arabia.     

Comparative study between the protective effects of Saudi and Egyptian antivenoms, alone or in combination with ion channel modulators, against deleterious actions of Leiurus quinquestriatus scorpion venom

This study compared efficacy of two polyvalent antivenoms (Saudi Arabian and Egyptian), against lethality and pathophysiological changes of Leiurus quinquestriatus quinquestriatus (LQQ) scorpion venom in mice. Additionally, the study examined whether treatment with selected ion channel modulators, lidocaine, nimodipine or amiodarone would be effective, alone or combined with the antivenoms.The protein concentration of the Saudi antivenom was 1/3 of Egyptian, indicating lesser immunogenicity, while both preservative contents were within limits. In immunodiffusion experiments, both exhibited prominent precipitin bands indicating high concentrations of specific antibodies. Neutralizing capacities (60-70 LD₅₀) stated on labels were confirmed. Both antivenoms significantly (P < 0.001) prolonged survival time (from 26.9 ± 1.18 min, 100% dead with venom to 224-300 min, 0-30% dead) of envenomed mice, whether injected iv before or 5 min after venom. Injection of either antivenom plus ion channel modulators, gave comparable results to that observed in mice treated with antivenoms alone. The Na⁺ channel blocker lidocaine and the Ca²⁺ channel blocker nimodipine on their own significantly protected the animals (P < 0.05), but to a lesser extent.The two antivenoms, significantly ameliorated the venom-evoked changes in serum LDH (P < 0.001) and CKMB (P < 0.01) plus cardiac TNFα and nitrate/nitrite levels (P < 0.001). When combined with lidocaine or nimodipine, the effects were not greater than antivenom alone. Moreover, the antivenoms ameliorated characteristic venom-evoked changes in the isolated perfused Langendorff hearts. Lidocaine and amiodarone were more effective than nimodipine.In Conclusion both Saudi and Egyptian antivenoms protected mice from the pathological and lethal effects of LQQ scorpion. Sodium and calcium channel blockers, lidocaine and nimodipine, may be useful when antivenoms are not available.     

Causes of low vision and blindness in south western Saudi Arabia

The authors studied 1,681 consecutive patients who attended their ophthalmic outpatient clinics over a period of 12 months to determine the patients' visual acuity status and the causes of any visual loss. Using the World Health Organization criteria for definition of visual acuity status, 1004 (59.7%) patients had normal vision. Four hundred and thirty-one (25.6%) patients had low vision or visual impairment and 246 (14.6%) patients were blind. Twenty-eight (1.9%) patients had no light perception in both eyes. Cataract, both in isolation and co-existing with other ocular pathology, was the major cause of both low vision and blindness (58.5% and 81.7%, respectively). A concerted attack on cataract alone will markedly reduce blindness and low vision in this region.     

Molecular Detection of Candidatus Orientia chuto in Wildlife,Saudi Arabia

Scrub typhus is a zoonosis caused by 3 species of Orientia bacteria, including Candidatus Orientia chuto. This species is known only from a human case in Dubai and infections in wildlife in Kenya. We report molecular detection of Candidatus O. chuto in 2 wild rodent species from Saudi Arabia.