2008-2012年SCI收录第88医院论文情况统计分析

<正>笔者所在医院是一所实际开展床位××××张的军队医院。多年来,医院综合实力全面发展,医教研水平不断提高。曾连续25年保持每年有1²项军队二等以上医学科研成果奖。作为科研活动、科技成果表现形式之一的科技论文的产出数量也居于全区同级医院的前列。[1]鉴于目前SCI(Science Citation Index)论文的发表情况已成为国内评价某单位科研水平与能力的重要依据之一,笔者所在医院对SCI论文的关注度也在逐步提高。     

中药髓复康对恒河猴脊髓损伤后神经再生的影响

目的髓复康对恒河猴脊髓损伤后神经再生的影响。方法成年雄性恒河猴14只,其中10只用于制备T12胸髓左侧半横断损伤模型,并将其随机分为髓复康组（S）和模型组（M）,每组5只,另外4只设为正常对照组（N）。通过改良Tarlov法评估恒河猴脊髓神经功能恢复情况;采用原位杂交法检测各组髓鞘相关生长抑制因子（Nogo-A）和生长相关蛋白（GAP-43）的表达量。结果给药30 d后,髓复康组患肢神经功能恢复优于模型组（P〈0.01）;脊髓损伤后各手术组Nogo-A mR-NA的阳性细胞数及阳性产物的OD值均明显升高,其中髓复康组Nogo-A mRNA的阳性细胞数和其阳性产物的OD值都明显低于模型组（P〈0.05）。各手术组GAP-43 mRNA的阳性细胞数及其阳性产物的OD值均明显高于正常组（P〈0.01）;其中髓复康组GAP-43 mRNA的阳性细胞数和其阳性产物的OD值最高,与模型组比较,差异有统计学意义（P〈0.05或P〈0.01）。结论中药髓复康能够对脊髓损伤后恒河猴脊髓中Nogo-A的表达有一定的抑制作用,同时能够上调GAP-43的表达,促进了脊髓损伤后恒河猴运动神经功能的恢复。     

组织工程化软骨修复软骨损伤

背景:目前临床上多采用自体或异体软骨移植、软骨膜或骨膜移植、软骨细胞移植等方法进行软骨损伤修复,但均因取材局限、免疫排斥等导致效果不佳。利用组织工程的方法再造软骨,为软骨缺损的临床修复提供了新的思路与途径。目的:利用SCI数据库文献检索和深度分析功能,对于组织工程软骨的文献资料趋势进行多层次探讨分析,根据检索文献结果分析组织工程软骨的发展趋势。方法:通过计算机检索SCI数据库中2001/2010有关组织工程软骨的文献,检索词为"软骨(cartilage);组织工程(tissueengineering);软骨细胞(chondrocyte/cartilage cell);软骨组织(cartilage tissue);支架材料(scaffold materials);种子细胞(seed cell)",以文字和图表的形式进行统计和结果分析,描述其分布特征。结果与结论:SCI数据库2001-01/2010-12收录组织工程软骨相关文献总计3137篇,中国在该领域的文献产出量逐渐增多,总体呈上升趋势,Biomaterials《生物材料》杂志发表文献量最多。美国在该领域文献产出量多于其他国家,对该领域研究起到重要作用,发表文献较多的机构集中在美国的哈佛大学,莱斯大学,麻省理工学院,哥伦比亚大学,加利福尼亚大学圣地亚哥分校等。     

Effective antibiotic stewardship in spinal cord injury: Challenges and a way forward

Context: Antibiotic stewardship, defined as a multidisciplinary program to reduce the misuse of antibiotics, and in turn, antibiotic resistance, is a high priority. Persons with spinal cord injury/disorder (SCI/D) are vulnerable to receiving multiple courses of antibiotics over their lifetime given frequent healthcare exposure, and have high rates of bacterial infection with multi-drug resistant organisms. Additional challenges to evaluating appropriate use of antibiotics in this population include bacterial colonization in the urine and the differences in the presenting signs and symptoms of infection. Therefore, Veterans Health Administration (VHA) facilities with SCI/D centers need effective antibiotic stewardship programs.

Results: We analyzed the results of a 2012 VHA-wide survey evaluating available antibiotic stewardship resources, and compared the resources present at facilities with SCI/D (n=23) versus non-SCI/D facilities (n=107). VHA facilities with SCI/D centers are more likely to have components of an antibiotic stewardship program that have led to reduced antibiotic use in previous studies. They are also more likely to have personnel with infectious diseases training.

Conclusion: VHA facilities with SCI/D centers have the resources needed for antibiotic stewardship. The next step will be to determine how to implement effective antibiotic stewardship tailored for this patient care setting.     

SCI源期刊近5年关于针刺偏头痛的RCT类研究

目的:通过分析SCI源论文为今后的临床研究提供借鉴、参考;方法:通过Pub Med数据库检索近5年偏头痛的SCI源论文,分析其中的临床治疗类论文(即RCT类论文),进行归纳整理、总结分析。结果:①SCI源论文中假针刺组的设置没有统一的标准,具有随意性;②SCI源论文中对针刺治疗偏头痛疗效有客观指标进行评估;③针刺的安全性及紧急治疗需要列入考虑。结论:针刺治疗对照组的设置仍需进一步的考量与完善。客观评价指标的出现是一大进步,但检查指标还需要更多的试验甚至多中心的试验进行验证。     

Women with Complete Spinal Cord Injury: A Phenomenological Study of Sexuality and Relationship Experiences

The phenomenological study described in this paper examines the sexuality and relationship lived experiences of 15 adult women who sustained complete spinal cord injury between the levels of T6 and L2 verified by a physiatrist. Audiotaped, semi-structured interviews were conducted by an interdisciplinary team of investigators. A set of themes and sequentially consistent patterns emerged from post-injury data that were labelled: Cognitive-genital dissociation, sexual disenfranchisement, sexual exploration, and sexuality reintegration. Sexuality and relationship issues in women with complete SCI are discussed, and indications for future studies and educational implications are presented.     

SCI论文在医院的价值认知定位

目的 通过对SCI论文在医院的价值认知定位进行利弊分析,引导科研工作者正确认识SCI.方法 通过电话、微信的方式调查18家医疗卫生机构是否将SCI论文列为职称评定、奖励的重要指标;通过现场发放问卷的方式调查4所医院221名医、药、技人员对SCI论文及作为评价指标的看法、临床实践转化的认知程度.结果 18家单位均将SCI论文列为职称评定、奖励的重要指标;221名被调查人员中为职称考核做准备的占50.7%;认为评价指标有合理性,但不是唯一的占59.3%;对SCI论文的实践转化不了解的占49.7%.结论 SCI论文能促进医院科研发展、提高个人科研能力,具有作为评价指标的合理性之优势,同时,也造成诱导学术科研的功利之心和歪曲SCI学术价值本质之弊端.