Boron-11 imaging with a three-dimensional reconstruction method.

A three-dimensional projection reconstruction technique is described for imaging boron-11 distributions, with potential application to boron neutron capture therapy. The method samples a spherical volume of k space uniformly to obtain a 32 x 32 x 32 matrix with voxel size of 0.42 cm3. A signal-to-noise ratio (S/N) of 3 was obtained in 8.5 minutes in a phantom containing 75 micrograms/mL of boron in borocaptate sodium (BSH). Images were obtained in a dog after cessation of an intravenous infusion of BSH and again 30 minutes later, with a maximum boron S/N of about 12. Boron levels in the brain dropped about 6%-8% and were more diffusely distributed on the images obtained 30 minutes after BSH infusion.     

Visualizing three-dimensional flow with simulated streamlines and three-dimensional phase-contrast MR imaging.

Three-dimensional (3D) velocity maps acquired with 3D phase-contrast magnetic resonance (MR) imaging contain information regarding complex motions that occur during imaging. A technique called simulated streamlines, which facilitates the display and comprehension of these velocity data, is presented. Single or multiple seed points may be identified within blood vessels of interest and tracked through the velocity field. The resulting trajectories are combined with a 3D MR angiogram and displayed with 3D volume visualization software. Mathematical analysis highlights potential applications and pitfalls of the technique, which was implemented both in phantoms and in vivo with excellent results. For example, single streamlines reveal helical flow patterns in aneurysms, and multiple streamlines seeded in the common carotid artery reveal branch filling-time relationships and slow filling of the carotid bulb. The technique is helpful in understanding these complex flow patterns.     

管电压对体模及接尘者数字化X线胸片图像的影响

目的 探讨不同管电压下对比度细节体模(CDRAD2.0)及职业性接尘者数字化X线胸片(DR)的图像质量.方法 对CDRAD2.0体模进行高仟伏及不同管电压的DR成像,由3位阅片者对其图像进行分析,计算并比较影像质量因子(IQF);同时选择136例粉尘作业人员,拍摄高仟伏X线胸片和不同管电压下的DR片,参照高仟伏胸片分别对DR片的10个解剖部位进行评分,比较DR与高仟伏图像间的差异.结果 在CDRAD2.0体模中,3位阅片者DR图像的IQF值均在120 kV条件下达到最小,平均IQF值为22.25.经随机效应模型的方差分析,不同管电压下的DR图像的平均IQF值的差异有统计学意义(F=13.775,P＜0.01).120 kV的DR图像与高仟伏图像IQF均值的差异无统计学意义(t=-0.58,P=0.979).在接尘者中,120 kV投照条件下的DR图像对解剖情况的显示最接近高仟伏模拟图像,均值与0(基本等同于高仟伏片)的差异无统计学意义(P＞0.05).结论 在CDRAD2.0体模或接尘者中,120kV管电压下的DR图像质量基本等同于高仟伏片.     

Acoustic radiation force impulse (ARFI) ultrasound imaging of pancreatic cystic lesions

Purpose

To evaluate the ARFI ultrasound imaging with Virtual Touch tissue quantification in studying pancreatic cystic lesions, compared with phantom fluid models.

Materials and methods

Different phantom fluids at different viscosity or density (water, iodinate contrast agent, and oil) were evaluated by two independent operators. From September to December 2008, 23 pancreatic cystic lesions were prospectively studied. All lesions were pathologically confirmed.

Results

Non-numerical values on water and numerical values on other phantoms were obtained. Inter-observer evaluation revealed a perfect correlation (rs = 1.00; p < 0.0001) between all measurements achieved by both operators per each balloon and fluid.Among the pancreatic cystic lesions, 14 mucinous cystadenomas, 4 pseudocysts, 3 intraductal papillary-mucinous neoplasms and 2 serous cystadenomas were studied. The values obtained ranged from XXXX/0-4,85 m/s in mucinous cystadenomas, from XXXX/0-3,11 m/s in pseudocysts, from XXXX/0-4,57 m/s in intraductal papillary-mucinous neoplasms. In serous cystadenomas all values measured were XXXX/0 m/s. Diagnostic accuracy in benign and non-benign differentiation of pancreatic cystic lesions was 78%.

Conclusions

Virtual Touch tissue quantification can be applied in the analysis of fluids and is potentially able to differentiate more complex (mucinous) from simple (serous) content in studying pancreatic cystic lesions.     

Comparison of velocity-encoded MR imaging and fluid dynamic modeling of steady and disturbed flow.

The contrast of flow-encoded magnetic resonance (MR) images obtained in vivo and the accuracy of velocity measurements are complicated by the presence of complex flow states. The effects of complex flow states on MR flow-encoded images were studied and quantitative flow information was obtained with an MR phase-subtraction technique. Regions of complex flow, including flow stagnation and separation and laminar flow, could be clearly identified on the phase images. The MR imaging velocity measurements were validated by comparison with numerical simulation results for three-dimensional velocity distributions. The velocity MR images and the profiles obtained from the simulation generally agreed well for flow rates of 660 and 1,680 mL/min. This agreement lends support to both the fluid dynamic model and the physical basis of the phase imaging technique and establishes the validity of flow-encoded phase imaging as an in vivo flow quantitation method, especially under low Reynolds number flow conditions.     

Ultra-low-dose coronary artery calcium screening using multislice CT with retrospective ECG gating

The aim of this study was to reduce radiation exposure in multislice CT (MSCT) coronary artery calcium screening using different tube settings, and to determinate its impact on the detection and quantification of coronary artery calcification. Forty-eight patients underwent routine MSCT coronary artery calcium scoring (Somatom VolumeZoom, Siemens, Forchheim, Germany) with retrospective ECG-gated data acquisition. Scanning was performed with a 4×2.5-mm collimation. In each patient data acquisition was performed twice using tube settings of 120 kVp with 133 mAs (protocol 1) and of 80 kVp with 300 mAs (protocol 2). Together with the 80-kVp protocol additional online ECG-related tube current modulation (ECG pulsing) was used. Three-millimeter overlapping slices (increment 1.5 mm) were calculated for each data set. Semi-automated calcium quantification was performed calculating absolute Ca-hydroxylapatite mass. In addition to patient examinations, the radiation exposure for both protocols was evaluated using computed tomography dose index (CTDI) phantom measurements. Protocol 2 showed a significantly lower patient radiation exposure than protocol 1 (0.72 vs 2.04 mSv; p<0.0001). The CTDI phantom measurements revealed a 65% reduction of radiation dose. Calcium scoring results of both protocols showed a high correlation (r=0.99; p<0.0001) for absolute Ca-Hydroxylapatite mass measurements. Using 80-kVp protocols patient radiation exposure can be significantly reduced in MSCT coronary artery calcium screening without affecting the detection and quantification of coronary artery calcification; therefore, this technique should be used with retrospective ECG-gated cardiac CT examinations in patients with regular sinus rhythm.     

MR angiography with a cardiac-phase--specific acquisition window.

A method for cardiac-phase-specific magnetic resonance (MR) angiography is presented. An electronics module permits incrementing of phase-encoding gradients and storage of incoming data only during a chosen portion of the cardiac cycle. Suppression of stationary material is maintained by delivering radio-frequency pulses at constant TR throughout the cycle. Imaging of a pulsatile flow phantom demonstrates that acquiring data only during systole substantially increases the signal intensity of flowing material. In addition, phase-encoding ghost artifacts are eliminated from the neighborhood of the vessel. Image acquisition time is minimized by acquiring only the low-frequency phase-encoding lines in the cardiac-phase-specific mode. In healthy volunteers, greatly improved MR angiograms of the lower extremities are obtained. Fat saturation and magnetization transfer further enhance vessel/background contrast. Acquiring data only during systole ensures rapid inflow for all phase-encoding lines, permitting a near-longitudinal section orientation without in-plane saturation. This substantially reduces total acquisition time relative to axial acquisition.     

Artifactual echoes in B-mode images due to multiple scattering

In B-mode images, echoes, which appear to arise from inherently anechoic regions due to scattering from neighbouring echogenic regions, can be considered artifactual. We have observed multiple scatter contributions to such artifactual echoes in images of plane boundaries between random scattering phantoms and anechoic regions. For the strongest scattering phantom studied, multiple scatter echoes were 3-9% of the average phantom signal using two sharply focused transducers, an annular array in pulse echo mode, and an annular array/cone hybrid. Multiple scatter was less than 5% for a conventional transducer. Echo amplitudes were also measured in normal excised human liver and breast tissue. It was estimated that artifactual echoes due to multiple scatter would be negligible in B-mode images of liver. However, for breast imaging, the level of artifactual echoes was estimated to be similar to that found for our strongest scattering phantom.     

MRI quality control: six imagers studied using eleven unified image quality parameters

Quality control of the magnetic resonance imagers of different vendors in the clinical environment is non-harmonised, and comparing the performance is difficult. The purpose of this study was to develop and apply a harmonised long-term quality control protocol for the six imagers in our organisation in order to assure that they fulfil the same basic image quality requirements. The same Eurospin phantom set and identical imaging parameters were used with each imager. Values of 11 comparable parameters describing the image quality were measured. Automatic image analysis software was developed to objectively analyse the images. The results proved that the imagers were operating at a performance level adequate for clinical imaging. Some deficiencies were detected in image uniformity and geometry. The automated analysis of the Eurospin phantom images was successful. The measurements were successfully repeated after 2 weeks on one imager and after half a year on all imagers. As an objective way of examining the image quality, this kind of comparable and objective quality control of different imagers is considered as an essential step towards harmonisation of the clinical MRI studies through a large hospital organisation.     

The impact of dose reduction on the quantification of coronary artery calcifications and risk categorization: A systematic review

Multiple dose reduction techniques have been introduced for coronary artery calcium (CAC) computed tomography (CT), but few have emerged into clinical practice while an increasing number of patients undergo CAC scanning. We sought to determine to what extend the radiation dose in CAC CT can be safely reduced without a significant impact on cardiovascular disease (CVD) risk stratification. A systematic database-review of articles published from 2002 until February 2018 was performed in Pubmed, WebOfScience, and Embase. Eligible studies reported radiation dose reduction for CAC CT, calcium scores and/or risk stratification for phantom or patient studies. Twenty-eight studies were included, under which 17 patient studies, 10 phantom/ex-vivo studies, and 1 study evaluated both phantom and patients. Dose was reduced with tube voltage reduction and tube current reduction with and without iterative reconstruction (IR), and tin-filter spectral shaping. The different dose reduction techniques resulted in varying final radiation doses and had varying impact on CAC scores and CVD risk stratification. In 78% of the studies the radiation dose was reduced by ≥ 50% ranging from (CTDI_vol) 0.6–5.5 mGy, leading to reclassification rates ranging between 3% and 21%, depending on the acquisition technique. Specific dose reduced protocols, including either tube current reduction and IR or spectral shaping with tin filtration, that showed low reclassification rates may potentially be used in CAC scanning and in future population-based screening for CVD risk stratification.