Sunbed-induced melanoma in a rheumatoid patient

Summary The development in a rheumatoid patient of a cutaneous malignant melanoma following repeated exposure to UV-A Radiation from a sunbed for its supposed therapeutic effect, is described. A causal-effect relationship is proposed and the potential risks to other arthritic patients and in particular those with pigmented skin lesions, is highlighted.     

Malignant hyperthermia syndrome—Evidence for denervation changes in human skeletal muscle

Summary The presence of denervation-like changes and abnormal mitochondria in the muscle of carriers of the malignant hyperthermia syndrome suggest a neuropathic basis for the human syndrome. A defect in mitochondrial ATP synthesis resulting from denervation, and potentiated by some general anaesthetics, may be the primary muscle fibre lesion in the human malignant hyperthermic syndrome.     

Radiology and pathology of malignant fibrous histiocytomas of the soft tissues: A report of ten cases

Malignant fibrous histiocytomas (MFH) are believed to originate from histiocytes and are composed of malignant cells with spindle or round shapes. We evaluated ten MFH of the soft tissues by plain roentgenograms, computed tomography (CT), and angiography and subdivided them into four grades of anaplasia and five predominant histologic variants. The variants of MFH demonstrated different vascular patterns. The extension of the lesions could be determined by CT and angiography. CT is the method of choice in the assessment of size and extent of MFH of the soft tissues. When intra-arterial chemotherapy is indicated the angiograms obtained at each catheter placement may substitute CT in follow-up studies obviating additional diagnostic procedures.     

Intraarterial 1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy for the treatment of malignant gliomas of the brain: a preliminary report

In a clinical trial, 10 patients with malignant gliomas underwent partial resection of their tumors and were treated by intraarterial 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) chemotherapy. The drug was given at least 1 month after the completion of postoperative radiotherapy in total doses of 270-280 mg/m2 in two sessions separated by a 48-hour interval (the two sessions with interval were equal to one course). This therapy was repeated every 8-10 weeks. Four patients had three courses and the other six patients had two courses of chemotherapy. This therapy was the only antitumor chemotherapy for this group of patients. Our preliminary results demonstrate the safety of this new procedure and suggest that intraarterial BCNU chemotherapy may be more effective, and has a better tolerance and less toxicity, than intravenous BCNU chemotherapy. Furthermore, it was demonstrated that, in the case of one patient, higher antitumor activity resulted from intraarterial BCNU chemotherapy as compared to intravenous BCNU therapy.     

BACOP、BECOP方案交替应用治疗难治性恶性淋巴瘤21例

以ＢＡＣＯＰ、ＢＥＣＯＰ方案交替应用治疗难治性恶性淋巴瘤２１例。其中完全缓解４例（１９．０５％），部分缓解１２例（５７．１４％），总有效率为７６．１９％。毒副反应主要为消化道反应、脱发、骨髓抑制及发热，均属轻度或可逆性反应。故认为ＢＡＣＯＰ与ＢＥＣＯＰ方案交替应用是难治性及复发性恶性淋巴瘤较为理想的化疗方案。     

吡柔比星为主联合化疗治疗口腔颌面部晚期恶性肿瘤的临床分析

目的：应用吡柔比星（ＴＨＰ）为主联合化疗与免疫治疗及全身营养支持的综合性治疗口腔颌面部晚期恶性肿瘤。方法：５４例患者进行临床观察分析。结果：常规检查，肿瘤范围，肿瘤直径测量。治疗结果满意，总有效率达６８．５％，同时明显改善了患者营养不良状况。结论：ＴＨＰ治疗口腔颌面部各种恶性肿瘤疗效肯定，辅助免疫治疗及营养支持治疗可提高化疗的效果     

Histological observations on the regrowth of malignant gliomas after radiotherapy and chemotherapy

Summary The reproliferation of glioblastomas after radiation and chemotherapy has been studied in 25 tumors by means of whole mount histological preparations. The tumors have been subdivided into four groups according to the radiation dose and the distance from the end of radiation. After 4,000 rad vessel proliferations and mitoses stop, while vessel degenerations and astrocytes with deformed nuclei appear. Six months after 6,000 rad have been delivered, repopulation phenomena are clearly evident and are mainly represented by mitoses both in parenchyma and in the vessel walls, circumscribed necroses with pseudopalisadings, proliferations of formerly degenerated vessels, etc.The brain adjacent to tumor (BAT) has a great importance since it is one of the reproliferating sites, even though it may be unrecognizable for the occurrence of radiation damages.     

恶性脑膜瘤MRI表现与病理对照研究

目的：研究ＭＲＩ诊断恶性脑膜瘤特征性表现的可靠性及限制。材料和方法：回顾性分析５０例恶性脑膜瘤的ＭＲＩ表现，与手术病理相对照，同时随机抽取同期５０例良性脑膜瘤加以比较研究。结果：５０例恶性脑膜瘤中，男女之比为１．５：１；ＭＲＩ显示恶性脑膜瘤多呈不规则形（３５／５０），轮廓常呈分叶状（１５／５０），结节状（１２／５０）和锯齿状（８／５０），包膜常不完整（２８／５０），瘤内信号多不均匀（２１／５０），造影后瘤内不均匀强化多见（２６／４０），脑膜尾征以粗短不规则为特征（９／１３），与良性组比较有统计学意义（ｘ２检验：Ｐ＜０．０５）。病灶部位、大小、边缘及瘤周水肿良、恶性者比较无统计学意义。结论：本组术前定位诊断正确率为１００％，定性诊断正确者仅１例，回顾性分析定性诊断正确率可达８６％。因此提高认识、足够重视，恶性脑膜瘤的术前定性诊断正确率将明显提高。     

Untersuchungen über Relationen zwischen entzündlicher Infiltration,Zelltyp und Prognose beim malignen Melanom

Zusammenfassung Die Tumoren von 253 Kranken mit operativ behandelten, primären malignen Melanomen der Haut wurden histologisch untersucht. Hierbei fand sich keine Relation zwischen Zelltyp des Tumors und Ausbildung einer zelligentzündlichen Infiltration. Die Intensität der entzündlichen Infiltrate der malignen Melanome erwies sich jedoch als signifikant für die Prognose. Eine starke zelligentzündliche Begleitreaktion in der Tumorperipherie ist beim malignen Melanom der Haut mit einer signifikant verlängerten Überlebenszeit der Tumorträger korreliert.

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Der Deutschen Forschungsgemeinschaft sei für die Unterstützung dieser Untersuchungen gedankt.     

Besteht eine Beziehung zwischen dem Grad der Atypie des vorherrschenden Tumorzelltyps und der Prognose eines Melanoms?

Ohne Zusammenfassung

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Mit Unterstützung der Deutschen Forschungsgemeinschaft.