全文获取类型
收费全文 | 35745篇 |
免费 | 2745篇 |
国内免费 | 381篇 |
专业分类
耳鼻咽喉 | 138篇 |
儿科学 | 742篇 |
妇产科学 | 188篇 |
基础医学 | 4613篇 |
口腔科学 | 341篇 |
临床医学 | 3095篇 |
内科学 | 4229篇 |
皮肤病学 | 282篇 |
神经病学 | 467篇 |
特种医学 | 2435篇 |
外国民族医学 | 3篇 |
外科学 | 3997篇 |
综合类 | 4461篇 |
预防医学 | 1578篇 |
眼科学 | 144篇 |
药学 | 2364篇 |
10篇 | |
中国医学 | 808篇 |
肿瘤学 | 8976篇 |
出版年
2024年 | 64篇 |
2023年 | 442篇 |
2022年 | 965篇 |
2021年 | 1214篇 |
2020年 | 1085篇 |
2019年 | 962篇 |
2018年 | 981篇 |
2017年 | 1095篇 |
2016年 | 1079篇 |
2015年 | 1187篇 |
2014年 | 2288篇 |
2013年 | 2257篇 |
2012年 | 1935篇 |
2011年 | 2335篇 |
2010年 | 1711篇 |
2009年 | 1838篇 |
2008年 | 1922篇 |
2007年 | 1814篇 |
2006年 | 1619篇 |
2005年 | 1365篇 |
2004年 | 1215篇 |
2003年 | 1107篇 |
2002年 | 925篇 |
2001年 | 899篇 |
2000年 | 829篇 |
1999年 | 762篇 |
1998年 | 604篇 |
1997年 | 552篇 |
1996年 | 469篇 |
1995年 | 490篇 |
1994年 | 406篇 |
1993年 | 307篇 |
1992年 | 300篇 |
1991年 | 232篇 |
1990年 | 210篇 |
1989年 | 168篇 |
1988年 | 153篇 |
1987年 | 137篇 |
1986年 | 105篇 |
1985年 | 134篇 |
1984年 | 141篇 |
1983年 | 76篇 |
1982年 | 91篇 |
1981年 | 76篇 |
1980年 | 88篇 |
1979年 | 44篇 |
1978年 | 56篇 |
1977年 | 32篇 |
1974年 | 24篇 |
1973年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
101.
目的初步探讨减瘤手术在晚期肺癌治疗方面的实用价值。方法选择2006年1月至2008年1月笔者所在医院收治的的中晚期肺癌患者20例,采用减瘤手术治疗。选择同时期15例剖胸探查肺肿物活检患者作为对照组。研究分析两组患者术后生存质量及生存时间的差异。结果减瘤组患者生存质量较好率为40.0%,对照组为20.0%,两组间比较差异有统计学意义(χ^2=7.21,P〈0.05)。生存质量评分减瘤组为(35.3±8.2)分,对照组为(27.9±7.1)分,两组间比较差异有统计学意义(t=6.59,P〈0.05)。平均生存时间减瘤组患者为11.6个月,对照组为10.3个月,两组间比较,差异无统计学意义(t=2.41,P〉0.05)。结论减瘤手术可改善中晚期或已有远处转移的肺癌患者的生存质量。 相似文献
102.
Caroline Van De Wauwer Arne P. Neyrinck Nele Geudens Filip R. Rega Geert M. Verleden Erik Verbeken Toni E. Lerut Dirk E.M. Van Raemdonck 《European journal of cardio-thoracic surgery》2007,31(6):1125-1133
Objective: The use of non-heart-beating donors (NHBD) has been propagated as an alternative to overcome the scarcity of pulmonary grafts. Formation of microthrombi after circulatory arrest, however, is a major concern for the development of reperfusion injury. We looked at the effect and the best route of pulmonary flush following topical cooling in NHBD. Methods: Non-heparinized pigs were sacrificed by ventricular fibrillation and divided into three groups (n = 6 per group). After 1 h of in situ warm ischaemia and 2.5 h of topical cooling, lungs in group I were retrieved unflushed (NF). In group II, lungs were explanted following an anterograde flush (AF) through the pulmonary artery with 50 ml/kg Perfadex® (6 °C). Finally, in group III, lungs were retrieved after an identical but retrograde flush (RF) via the left atrium. Flush effluent was sampled at intervals to measure haemoglobin concentration. Performance of the left lung was assessed during 60 min in our ex vivo reperfusion model. Wet-to-dry weight ratio (W/D) of both lungs was calculated as an index of pulmonary oedema. IL-1ß and TNF- protein levels in bronchial lavage fluid from both lungs were compared between groups. Results: Haemoglobin concentration (g/dl) was higher in the first effluent in RF versus AF (3.4 ± 1.1 vs 0.6 ± 0.1; p < 0.05). Pulmonary vascular resistance (dynes × s × cm−5) was 975 ± 85 RF versus 1567 ± 98 AF and 1576 ± 88 NF at 60 min of reperfusion (p < 0.001). Oxygenation (mmHg) and compliance (ml/cmH2O) were higher (491 ± 44 vs 472 ± 61 and 430 ± 33 NS, 22 ± 3 vs 19 ± 3 and 14 ± 1 NS, respectively) and plateau airway pressure (cmH2O) was lower (11 ± 1 vs 13 ± 1 and 13 ± 1 NS) after RF versus AF and NF, respectively. No differences in cytokine levels or in W/D ratios were observed between groups after reperfusion. Histology demonstrated microthrombi more often present after AF and NF compared to RF. Conclusion: Retrograde flush of the lung following topical cooling in the NHBD results in a better washout of residual blood and microthrombi and subsequent reduced pulmonary vascular resistance upon reperfusion. 相似文献
103.
蛇毒治疗不能解释肺动脉高压的研究 总被引:1,自引:1,他引:0
本通过对不能解释的肺动脉高压患,进行右心导管测定肺动脉平均压(PAMP)作为主要对照指标,观察蛇毒制品(精制溶栓酶)的急性药物试验和近期药物试验。发现该药物在近期有理想的降低PAMP作用,症状及胸片、超声心动图异常也明显取得改善,提示其可能为治疗该病的理想药物。 相似文献
104.
A. Mäkipernaa O. Koskimies J. Jääskeläinen A. -M. Teppo M. A. Siimes 《European journal of pediatrics》1991,150(6):444-447
In order to obtain more information on the long-term effects of treatment of Wilm's tumour we investigated 30 subjects treated at the Children's Hospital between 1960 and 1976. All had been nephrectomized and in 4 the length of the remaining kidney was subnormal. In the other subjects kidney length was related to follow up time and age at follow up. Blood pressure was elevated in 5 subjects. Urinary albumin excretion deviated only slightly from normal. Tubular functions were well preserved in all subjects. In this small series we were unable to establish any relation between the abnormalities observed and the treatment given. Our results suggest that, despite wide interindividual variation those who survive Wilm's tumours seldom have long-term renal complications. 相似文献
105.
G. Amir S. Silberman Z. Neeman R. Udassin D. Seror E. Rosenmann 《Pediatric surgery international》1991,6(4-5):353-356
A 7 1/2-year-old girl with an inflammatory pseudotumor of the lung is presented. The nature of the lesion was not recognized pre-or intraoperatively. The lesion was rubbery, yellowish, and well-defined but not encapsulated. Histologically, a spindle-cell lesion with a storiform pattern and chronic inflammatory-cell infiltrate was seen. The immunological and ultrastructural studies supported an inflammatory origin. The lesion corresponds to the fibrous histiocytoma variant of inflammatory pseudotumor of the lung, as defined recently by Matsubara et al. [17]. This must be distinguished from rare benign neoplasms of the lung such as benign fibrous histiocytoma, leiomyoma, Schwannoma, and histiocytosis. 相似文献
106.
107.
杀菌性通透性增强蛋白对失血性休克的保护作用及其机理 总被引:2,自引:0,他引:2
分别在失血和复苏开始即刻iv杀菌性/通透性增强蛋白(BPI)1.5和3.5mgkg-1,观察BPI对大鼠失血性休克转归的影响.结果显示,BPI治疗能明显改善失血性休克大鼠肝肾功能,提高休克动物存活率(BPI组81%vs休克对照组44%,P<0.05),BPI组大鼠复苏后与休克前的血浆内毒素(0.20±0.04vs0.24±0.05kUL-1)水平无明显变化,血浆肿瘤坏死因子α和白介素6水平较休克前明显升高,但均显著低于休克对照组.提示BPI对失血性休克大鼠具有一定的保护作用,其机理可能与BPI拮抗休克时内源性内毒素活性,抑制细胞因子反应有关. 相似文献
108.
E. Zuskin J. Mustajbegovic E. N. Schachter D. Pavicic A. Budak 《International archives of occupational and environmental health》1997,70(6):413-418
A follow-up investigation was performed on 49 female workers studied 2 years earlier in a vegetable-pickling plant. Acute
and chronic respiratory symptoms and ventilatory capacity measurements were recorded during the original and the follow-up
studies. Maximal expiratory flow-volume (MEFV) curves were recorded during the Monday morning work shift. The forced vital
capacity (FVC), 1-s forced expiratory volume (FEV1), and flow rates at 50% and the last 25% of the FVC (FEF50, FEF25) were
measured. There were small increases in the prevalence of chronic symptoms between the two studies for both smokers and nonsmokers,
but these did not reach statistical significance. Five workers at the time of the initial study had a diagnosis of occupational
asthma; only one of these was still working at the time of follow-up. Workers lost to the follow-up had lower lung function
than those seen at follow-up. In workers who were followed, larger than expected mean annual declines were noted for all ventilatory
capacity parameters in both smokers (FVC 0.070 l, FEV1 0.070 l; FEF50 0.355 l/s, FEF25 0.270 l/s) and nonsmokers (FVC 0.045
l, FEV1 0.045 l, FEF50 0.285 l/s; FEF25 0.130 l/s). The decrease was particularly pronounced for FEF50 and FEF25. The accelerated
decline in ventilatory capacity tests noted in the female nonsmokers suggests an independent effect on lung function of work
exposure in this environment. Our data confirm that work in the pickling industry, particularly in small, poorly regulated
plants, has deleterious effects on respiratory function.
Received: 24 September 1996 / Accepted: 19 June 1997 相似文献
109.
评价酶联免疫检测血清CYFRA21—1对非小细胞肺癌的诊断价值 总被引:8,自引:0,他引:8
目的评价检测CYFRA21┐1对非小细胞肺癌的诊断价值。方法用ELISA法测定70例肺癌(LC)其中47例非小细胞肺癌(NSCLC),3例小细胞肺癌(SCLC)和20例未分型肺癌、64例肺部良性疾病患者及40例健康人血清CYFRA21┐1浓度。试验的诊断性能用相对操作特征(ROC)分析法估测之。结果测得全阈诊断准确率(OveralDiag┐nosticAccuracies)LC为0.75、NSCLC为0.76,SQC为0.83,ADE为0.67和SCLC为0.38。在相应于特异性为0.95的界定值3.47μg/L处,各型的灵敏度分别为SQC0.62,LC0.53,NSCLC0.51,ADE0.48和SCLC0.00。结论结果显示CYFRA21┐1是NSCLC较灵敏和特异的一个标志物。未观察到TNM各期间该标志物的平均水平有明显的差异;然而异常升高水平的患者的比例随病期的进展而显著增加,提示一系列检测CYFRA21┐1水平可能有助于监查NSCLC患者的疗效。 相似文献
110.
Patrick Fransen MD Jacques Favre MD Philippe Maeder MD Heinz Fankhauser MD 《Journal of clinical neuroscience》1994,1(4):274-276
Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum) is a rare pseudo-neoplastic disorder of the cerebellum with typical MRI findings. A 25-year-old man presenting with progressive neck pain, dizziness, and impaired vision is reported. CT and MRI revealed a left cerebellar haemispheric mass and obstructive hydrocephalus. Lhermitte-Duclos disease was histologically confirmed after surgical removal of the lesion. The typical MRI appearance of a nonenhancing haemispheric cerebellar mass with preservation and exaggeration of the normal gyral pattern allows pre-operative diagnosis of this condition. The literature is reviewed and clinical presentation, radiology and histopathology are discussed. 相似文献